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  1. Article: Encapsulation Properties of

    Sobti, Bhawna / Kamal-Eldin, Afaf / Rasul, Sanaa / Alnuaimi, Mariam Saeed Khalfan / Alnuaimi, Khulood Jaber Jasim / Alhassani, Alia Ali Khsaif / Almheiri, Mariam M A / Nazir, Akmal

    Foods (Basel, Switzerland)

    2023  Volume 12, Issue 9

    Abstract: Double emulsions ( ... ...

    Abstract Double emulsions (W
    Language English
    Publishing date 2023-04-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods12091838
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The Outcome of BNT162b2, ChAdOx1-Sand mRNA-1273 Vaccines and Two Boosters: A Prospective Longitudinal Real-World Study.

    Kamal, Sanaa M / Naghib, Moheyeldeen Mohamed / Daadour, Moataz / Alsuliman, Mansour N / Alanazi, Ziad G / Basalem, Abdulaziz Abdullah / Alaskar, Abdulaziz M / Saed, Khaled

    Viruses

    2023  Volume 15, Issue 2

    Abstract: To date, the effectiveness of COVID-19 vaccines and booster doses has yet to be evaluated in longitudinal head-to-head studies. This single-center longitudinal study assessed the effectiveness of ChAdOx1 nCoV-19, BNT162b2, and mRNA-1273 vaccines and ... ...

    Abstract To date, the effectiveness of COVID-19 vaccines and booster doses has yet to be evaluated in longitudinal head-to-head studies. This single-center longitudinal study assessed the effectiveness of ChAdOx1 nCoV-19, BNT162b2, and mRNA-1273 vaccines and assessed two BNT162b2 boosters in 1550 participants, of whom 26% had comorbidities. In addition, the SARS-CoV-2 antibody dynamics was monitored. A group of 1500 unvaccinated subjects was included as the controls. The study's endpoint was the development of virologically-proven COVID-19 cases after vaccine completion, while the secondary endpoint was hospitalizations due to severe COVID-19. Overall, 23 (4.6%), 16 (3%), and 18 (3.8%) participants vaccinated with ChAdOx1 nCoV-19, BNT162b2, and mRNA-1273, respectively, developed COVID-19 after vaccine completion, with an effectiveness of 89%, 92%, and 90%. Ten COVID-19 cases were reported in participants with comorbidities, three of whom were hospitalized. No hospitalizations occurred after boosters. SARS-CoV-2 antibody levels peaked 2-4 weeks after the second vaccine dose but declined after a mean of 28.50 ± 3.48 weeks. Booster doses significantly enhanced antibody responses. Antibody titers ≤ 154 U/mL were associated with a higher risk of COVID-19 emergence. Thus, COVID-19 vaccines effectively reduced COVID-19 and prevented severe disease. The vaccine-induced SARS-CoV-2 antibody responses declined after 28-32 weeks. Booster doses induced significant maintained responses. SARS-CoV-2 antibody levels may help determine the timing and need for vaccine booster doses.
    MeSH term(s) Humans ; 2019-nCoV Vaccine mRNA-1273 ; BNT162 Vaccine ; COVID-19 Vaccines ; ChAdOx1 nCoV-19 ; Sand ; Longitudinal Studies ; Prospective Studies ; COVID-19/prevention & control ; SARS-CoV-2/genetics ; Vaccines ; mRNA Vaccines ; Antibodies, Viral
    Chemical Substances 2019-nCoV Vaccine mRNA-1273 (EPK39PL4R4) ; BNT162 Vaccine ; COVID-19 Vaccines ; ChAdOx1 nCoV-19 (B5S3K2V0G8) ; Sand ; Vaccines ; mRNA Vaccines ; Antibodies, Viral
    Language English
    Publishing date 2023-01-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15020326
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Pharmacogenetics of hepatitis C: transition from interferon-based therapies to direct-acting antiviral agents.

    Kamal, Sanaa M

    Hepatic medicine : evidence and research

    2014  Volume 6, Page(s) 61–77

    Abstract: Hepatitis C virus (HCV) has emerged as a major viral pandemic over the past two decades, infecting 170 million individuals, which equates to approximately 3% of the world's population. The prevalence of HCV varies according to geographic region, being ... ...

    Abstract Hepatitis C virus (HCV) has emerged as a major viral pandemic over the past two decades, infecting 170 million individuals, which equates to approximately 3% of the world's population. The prevalence of HCV varies according to geographic region, being highest in developing countries such as Egypt. HCV has a high tendency to induce chronic progressive liver damage in the form of hepatic fibrosis, cirrhosis, or liver cancer. To date, there is no vaccine against HCV infection. Combination therapy comprising PEGylated interferon-alpha and ribavirin has been the standard of care for patients with chronic hepatitis C for more than a decade. However, many patients still do not respond to therapy or develop adverse events. Recently, direct antiviral agents such as protease inhibitors, polymerase inhibitors, or NS5A inhibitors have been used to augment PEGylated interferon and ribavirin, resulting in better efficacy, better tolerance, and a shorter treatment duration. However, most clinical trials have focused on assessing the efficacy and safety of direct antiviral agents in patients with genotype 1, and the response of other HCV genotypes has not been elucidated. Moreover, the prohibitive costs of such triple therapies will limit their use in patients in developing countries where most of the HCV infection exists. Understanding the host and viral factors associated with viral clearance is necessary for individualizing therapy to maximize sustained virologic response rates, prevent progression to liver disease, and increase the overall benefits of therapy with respect to its costs. Genome wide studies have shown significant associations between a set of polymorphisms in the region of the interleukin-28B (IL28B) gene and natural clearance of HCV infection or after PEGylated interferon-alpha and ribavirin treatment with and without direct antiviral agents. This paper synthesizes the recent advances in the pharmacogenetics of HCV infection in the era of triple therapies.
    Language English
    Publishing date 2014-06-24
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2520732-5
    ISSN 1179-1535
    ISSN 1179-1535
    DOI 10.2147/HMER.S41127
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Seroprevalence of

    Elmagzoub, Wisal A / Adam, Nabawia M / Idris, Sanaa M / Mukhtar, Mohamed E / Abdelaziz, Sanaa A / Okuni, Julius B / Ojok, Lonzy / Abd El Wahed, Ahmed / Eltayeb, ElSagad / Gameel, Ahmed A / Eltom, Kamal H

    Veterinary sciences

    2020  Volume 7, Issue 4

    Abstract: Paratuberculosis, caused ... ...

    Abstract Paratuberculosis, caused by
    Language English
    Publishing date 2020-12-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2768971-2
    ISSN 2306-7381 ; 2306-7381
    ISSN (online) 2306-7381
    ISSN 2306-7381
    DOI 10.3390/vetsci7040209
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Application of Mathematical Modeling in Prediction of COVID-19 Transmission Dynamics.

    AlArjani, Ali / Nasseef, Md Taufiq / Kamal, Sanaa M / Rao, B V Subba / Mahmud, Mufti / Uddin, Md Sharif

    Arabian journal for science and engineering

    2022  Volume 47, Issue 8, Page(s) 10163–10186

    Abstract: The entire world has been affected by the outbreak of COVID-19 since early 2020. Human carriers are largely the spreaders of this new disease, and it spreads much faster compared to previously identified coronaviruses and other flu viruses. Although ... ...

    Abstract The entire world has been affected by the outbreak of COVID-19 since early 2020. Human carriers are largely the spreaders of this new disease, and it spreads much faster compared to previously identified coronaviruses and other flu viruses. Although vaccines have been invented and released, it will still be a challenge to overcome this disease. To save lives, it is important to better understand how the virus is transmitted from one host to another and how future areas of infection can be predicted. Recently, the second wave of infection has hit multiple countries, and governments have implemented necessary measures to tackle the spread of the virus. We investigated the three phases of COVID-19 research through a selected list of mathematical modeling articles. To take the necessary measures, it is important to understand the transmission dynamics of the disease, and mathematical modeling has been considered a proven technique in predicting such dynamics. To this end, this paper summarizes all the available mathematical models that have been used in predicting the transmission of COVID-19. A total of nine mathematical models have been thoroughly reviewed and characterized in this work, so as to understand the intrinsic properties of each model in predicting disease transmission dynamics. The application of these nine models in predicting COVID-19 transmission dynamics is presented with a case study, along with detailed comparisons of these models. Toward the end of the paper, key behavioral properties of each model, relevant challenges and future directions are discussed.
    Language English
    Publishing date 2022-01-07
    Publishing country Germany
    Document type Journal Article
    ISSN 2193-567X
    ISSN 2193-567X
    DOI 10.1007/s13369-021-06419-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Encapsulation Properties of Mentha piperita Leaf Extracts Prepared Using an Ultrasound-Assisted Double Emulsion Method

    Sobti, Bhawna / Kamal-Eldin, Afaf / Rasul, Sanaa / Alnuaimi, Mariam Saeed Khalfan / Alnuaimi, Khulood Jaber Jasim / Alhassani, Alia Ali Khsaif / Almheiri, Mariam M. A. / Nazir, Akmal

    Foods. 2023 Apr. 28, v. 12, no. 9

    2023  

    Abstract: Double emulsions (W₁/O/W₂) have long been used in the food and pharmaceutical industries to encapsulate hydrophobic and hydrophilic drugs and bioactive compounds. This study investigated the effect of different types of emulsifiers (plant- vs. animal- ... ...

    Abstract Double emulsions (W₁/O/W₂) have long been used in the food and pharmaceutical industries to encapsulate hydrophobic and hydrophilic drugs and bioactive compounds. This study investigated the effect of different types of emulsifiers (plant- vs. animal-based proteins) on the encapsulation properties of Mentha piperita leaf extract (MLE) prepared using the double emulsion method. Using response surface methodology, the effect of ultrasound-assisted extraction conditions (amplitude 20–50%; time 10–30 min; ethanol concentration 70–90%) on the total phenolic content (TPC) and antioxidant activity (percent inhibition) of the MLE was studied. MLE under optimized conditions (ethanol concentration 76%; amplitude 39%; time 30 min) had a TPC of 62.83 mg GA equivalents/g and an antioxidant activity of 23.49%. The optimized MLE was encapsulated using soy, pea, and whey protein isolates in two emulsifying conditions: 4065× g/min and 4065× g/30 s. The droplet size, optical images, rheology, and encapsulation efficiency (EE%) of the different encapsulated MLEs were compared. The W₁/O/W₂ produced at 4065× g/min exhibited a smaller droplet size and higher EE% and viscosity than that prepared at 4065× g/30 s. The higher EE% of soy and pea protein isolates indicated their potential as an effective alternative for bioactive compound encapsulation.
    Keywords Mentha piperita ; antioxidant activity ; bioactive compounds ; droplet size ; emulsions ; encapsulation ; ethanol ; hydrophilicity ; hydrophobicity ; leaf extracts ; leaves ; pea protein ; peas ; response surface methodology ; rheology ; ultrasonic treatment ; viscosity ; whey protein
    Language English
    Dates of publication 2023-0428
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods12091838
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Hepatitis C virus genotype 4 therapy: progress and challenges.

    Kamal, Sanaa M

    Liver international : official journal of the International Association for the Study of the Liver

    2011  Volume 31 Suppl 1, Page(s) 45–52

    Abstract: The hepatitis C virus genotype 4 (HCV-4) is prevalent in Egypt, the Middle East and Africa. Recently, the epidemiology of HCV-4 has changed and this genotype has begun to cross borders and spread to several regions in Europe through immigration and ... ...

    Abstract The hepatitis C virus genotype 4 (HCV-4) is prevalent in Egypt, the Middle East and Africa. Recently, the epidemiology of HCV-4 has changed and this genotype has begun to cross borders and spread to several regions in Europe through immigration and injection drug use. HCV-4 has been considered a difficult-to-treat genotype based on the low sustained virological response (SVR) rates obtained with conventional interferon (IFN)-based regimens. Pegylated interferons (PEG-IFN) plus ribavirin therapy for chronic HCV-4 has been associated with increased SVR rates of more than 60%. Shorter treatment of chronic HCV-4 patients with rapid and early virological responses has been associated with high SVR rates, better compliance, fewer adverse events and lower costs. Despite this progress, the treatment of HCV-4 non-responders, injection drug users, patients coinfected with human immunodeficiency virus, thalassaemic patients, patients on haemodialysis and patients with HCV-4 recurrence after liver transplantation still represents a significant therapeutic challenge. Treatment of HCV-4 has markedly improved, with higher sustained response rates and the possibility of shorter regimens. Despite the recent progress in the treatment of HCV-4, more research is required to optimize current therapy and include genotype 4 patients in clinical trials on emerging therapies such as specifically targeted antiviral therapy for HCV with protease and/or polymerase inhibitors.
    MeSH term(s) Antiviral Agents/therapeutic use ; Drug Administration Schedule ; Genotype ; Hepacivirus/drug effects ; Hepacivirus/genetics ; Hepatitis C/drug therapy ; Hepatitis C/epidemiology ; Hepatitis C/genetics ; Humans ; Interferon-alpha/therapeutic use ; Pharmacogenetics/methods ; Polyethylene Glycols/therapeutic use ; Precision Medicine/methods ; Recombinant Proteins ; Ribavirin/therapeutic use
    Chemical Substances Antiviral Agents ; Interferon-alpha ; Recombinant Proteins ; Polyethylene Glycols (30IQX730WE) ; interferon alfa-2a (47RRR83SK7) ; Ribavirin (49717AWG6K) ; peginterferon alfa-2a (Q46947FE7K)
    Language English
    Publishing date 2011-01
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Review
    ZDB-ID 2102783-3
    ISSN 1478-3231 ; 1478-3223
    ISSN (online) 1478-3231
    ISSN 1478-3223
    DOI 10.1111/j.1478-3231.2010.02385.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1632: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Antihyperglycemic Effects and Mode of Actions of

    Abdel Aziz, Sarah M / Ahmed, Osama M / Abd El-Twab, Sanaa M / Al-Muzafar, Hessah Mohammed / Amin, Kamal Adel / Abdel-Gabbar, Mohamed

    Evidence-based complementary and alternative medicine : eCAM

    2020  Volume 2020, Page(s) 9276343

    Abstract: The present study aimed to evaluate the antihyperglycemic effects ... ...

    Abstract The present study aimed to evaluate the antihyperglycemic effects of
    Language English
    Publishing date 2020-01-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2020/9276343
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5995: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  9. Article ; Online: Hepatitis C genotype 4 therapy: increasing options and improving outcomes.

    Kamal, Sanaa M

    Liver international : official journal of the International Association for the Study of the Liver

    2009  Volume 29 Suppl 1, Page(s) 39–48

    Abstract: Unlabelled: Hepatitis C virus genotype 4 (HCV-G4) is prevalent in the Middle East and Africa and has spread to several regions in Europe. HCV-G4 represents a major health problem in Egypt, with a prevalence rate of 13%. Recently, HCV-G4 has been ... ...

    Abstract Unlabelled: Hepatitis C virus genotype 4 (HCV-G4) is prevalent in the Middle East and Africa and has spread to several regions in Europe. HCV-G4 represents a major health problem in Egypt, with a prevalence rate of 13%. Recently, HCV-G4 has been spreading in Europe particularly among intravenous drug users (IDU) populations, who represent the main reservoir for HCV in Europe. This article reviews the current therapeutic strategies for HCV-G4 infections in different populations. HCV-G4 has been considered a difficult-to-treat genotype because of the poor sustained virological response (SVR) rates reported with a conventional interferon (IFN)-based regimen. Pegylated IFN and ribavirin combination therapy was associated with significant improvements in SVR rates that currently exceed 60%, particularly with individualized therapy. Lower response rates have been reported in specific situations, namely chronic HCV-G4 infection in IDUs and patients co-infected with human immunodeficiency virus (HIV). Rapid and early virological responses have been useful tools for determination of the duration of therapy.
    In conclusion: therapy of HCV-G4 has shown significant improvements, with higher sustained response rates and possibilities for a shorter duration. More research is required to optimize therapy in special populations such as IDUs and HIV-co-infected patients.
    MeSH term(s) Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Drug Administration Schedule ; Genotype ; HIV Infections/drug therapy ; Hepacivirus/drug effects ; Hepacivirus/genetics ; Hepatitis C/drug therapy ; Hepatitis C/genetics ; Hepatitis C/pathology ; Humans ; beta-Thalassemia/drug therapy
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2009-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2102783-3
    ISSN 1478-3231 ; 1478-3223
    ISSN (online) 1478-3231
    ISSN 1478-3223
    DOI 10.1111/j.1478-3231.2008.01930.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1632: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: First Report on Ovine Paratuberculosis in the Sudan: Diagnosis Using Different Techniques.

    Idris, Sanaa M / Ali, Eva A / Elmagzoub, Wisal A / Okuni, Julius B / Mukhtar, Mohamed E / Ojok, Lonzy / Eltayeb, ElSagad / Abd El Wahed, Ahmed / Eltom, Kamal H / Gameel, Ahmed A

    Animals : an open access journal from MDPI

    2022  Volume 12, Issue 23

    Abstract: Paratuberculosis (PTB) has been reported in the Sudan in cattle and goats for more than 50 years but has never been reported in sheep. However, suspicion of the disease in a breeding flock of sheep in Khartoum North locality was made due to a history of ... ...

    Abstract Paratuberculosis (PTB) has been reported in the Sudan in cattle and goats for more than 50 years but has never been reported in sheep. However, suspicion of the disease in a breeding flock of sheep in Khartoum North locality was made due to a history of unknown cause of loss of weight. Blood and faecal samples were collected from all animals (N = 59): harvested sera were tested for anti-
    Language English
    Publishing date 2022-11-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani12233312
    Database MEDical Literature Analysis and Retrieval System OnLINE

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