LIVIVO - Search results -

Search results

Result 1 - 10 of total 29

Search options

Article: Role of Lipid Transfer Proteins (LTPs) in the Viral Life Cycle.

Avula, Kiran / Singh, Bharati / Kumar, Preethy V / Syed, Gulam H

2021 Volume 12, Page(s) 673509

Abstract: Viruses are obligate parasites that depend on the host cell machinery for their replication and dissemination. Cellular lipids play a central role in multiple stages of the viral life cycle such as entry, replication, morphogenesis, and egress. Most ... ...

Abstract	Viruses are obligate parasites that depend on the host cell machinery for their replication and dissemination. Cellular lipids play a central role in multiple stages of the viral life cycle such as entry, replication, morphogenesis, and egress. Most viruses reorganize the host cell membranes for the establishment of viral replication complex. These specialized structures allow the segregation of replicating viral RNA from ribosomes and protect it from host nucleases. They also facilitate localized enrichment of cellular components required for viral replication and assembly. The specific composition of the lipid membrane governs its ability to form negative or positive curvature and possess a rigid or flexible form, which is crucial for membrane rearrangement and establishment of viral replication complexes. In this review, we highlight how different viruses manipulate host lipid transfer proteins and harness their functions to enrich different membrane compartments with specific lipids in order to facilitate multiple aspects of the viral life cycle.
Language	English
Publishing date	2021-06-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2021.673509
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Synthesis of carbon nanotubes-chitosan nanocomposite and immunosensor fabrication for myoglobin detection: An acute myocardial infarction biomarker.

Rabbani, Gulam / Ahmad, Ejaz / Khan, Mohammad Ehtisham / Khan, Anwar Ulla / Zamzami, Mazin A / Ahmad, Abrar / Ali, Syed Kashif / Bashiri, Abdullateef H / Zakri, Waleed

International journal of biological macromolecules

2024 Volume 265, Issue Pt 1, Page(s) 130616

Abstract: The use of single-walled carbon nanotubes (SWCNTs) in biomedical applications is limited due to their inability to disperse in aqueous solutions. In this study, dispersed -COOH functionalized CNTs with N-succinylated chitosan (CS), greatly increasing the ...

Abstract	The use of single-walled carbon nanotubes (SWCNTs) in biomedical applications is limited due to their inability to disperse in aqueous solutions. In this study, dispersed -COOH functionalized CNTs with N-succinylated chitosan (CS), greatly increasing the water solubility of CNTs and forming a uniformly dispersed nanocomposite solution of CNTs@CS. Coupling reagent EDC/NHS was used as a linker with the -COOH groups present on the N-succinylated chitosan which significantly improved the affinity of the CNTs for biomolecules. Myoglobin (Mb) is a promising biomarker for the precise assessment of cardiovascular risk, type 2 diabetes, metabolic syndrome, hypertension and several types of cancer. A high level of Mb can be used to diagnose the mentioned pathogenic diseases. The CNTs@CS-FET demonstrates superior sensing performance for Mb antigen fortified in buffer, with a wide linear range of 1 to 4000 ng/mL. The detection limit of the developed Mb immunosensor was estimated to be 4.2 ng/mL. The novel CNTs@CS-FET immunosensor demonstrates remarkable capability in detecting Mb without being affected by interferences from nonspecific antigens. Mb spiked serum showed a recovery rate of 100.262 to 118.55 % indicating great promise for Mb detection in clinical samples. The experimental results confirmed that the CNTs@CS-FET immunosensor had excellent selectivity, reproducibility and storage stability.
MeSH term(s)	Humans ; Nanotubes, Carbon ; Chitosan ; Myoglobin ; Biosensing Techniques/methods ; Reproducibility of Results ; Diabetes Mellitus, Type 2 ; Immunoassay ; Biomarkers ; Myocardial Infarction ; Nanocomposites ; Electrochemical Techniques/methods
Chemical Substances	Nanotubes, Carbon ; Chitosan (9012-76-4) ; Myoglobin ; Biomarkers
Language	English
Publishing date	2024-03-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2024.130616
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 2374: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Label-free and ultrasensitive electrochemical transferrin detection biosensor based on a glassy carbon electrode and gold nanoparticles.

Rabbani, Gulam / Khan, Mohammad Ehtisham / Khan, Anwar Ulla / Ali, Syed Kashif / Zamzami, Mazin A / Ahmad, Abrar / Bashiri, Abdullateef H / Zakri, Waleed

International journal of biological macromolecules

2023 Volume 256, Issue Pt 1, Page(s) 128312

Abstract: In this study, we developed a label-free and ultrasensitive electrochemical biosensor for the detection of transferrin (Tf), an important serum biomarker of atransferrinemia. The biosensor was fabricated by using glassy carbon electrode (GCE) and ... ...

Abstract	In this study, we developed a label-free and ultrasensitive electrochemical biosensor for the detection of transferrin (Tf), an important serum biomarker of atransferrinemia. The biosensor was fabricated by using glassy carbon electrode (GCE) and modified with gold nanoparticles (AuNPs) via electroless deposition. The electrochemical characteristics of the GCE-AuNPs biosensors were characterized using cyclic voltammetry and electrochemical impedance spectroscopy analysis. Differential pulse voltammetry was used for quantitative evaluation of the Tf-antigen by recording the increase in the anodic peak current of GCE-AuNPs biosensor. The GCE-AuNPs biosensor demonstrates superior sensing performance for Tf-antigen fortified in buffer, with a wide linear range of 0.1 to 5000 μg/mL and a limit of detection of 0.18 μg/mL. The studied GCE-AuNPs biosensor showed excellent sensitivity, selectivity, long-term storage stability and simple sensing steps without pretreatment of clinical samples. This GCE-AuNPs biosensor indicates great potential for developing a Tf detection platform, which would be helpful in the early diagnosis of atransferrinemia. The developed GCE-AuNPs biosensor holds great potential in biomedical research related to point of care for the early diagnosis and monitoring of diseases associated with aberrant serum transferrin levels. These findings suggest that the GCE-AuNPs biosensor has great potential for detecting other serum biomarkers.
MeSH term(s)	Carbon/chemistry ; Gold/chemistry ; Metal Nanoparticles/chemistry ; Transferrin ; Biosensing Techniques/methods ; Electrodes ; Electrochemical Techniques/methods ; Limit of Detection ; Metal Metabolism, Inborn Errors
Chemical Substances	Carbon (7440-44-0) ; Gold (7440-57-5) ; Transferrin
Language	English
Publishing date	2023-11-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.128312
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 2374: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: A Rare Cause of Recurrent Lower Gastrointestinal Bleed: Colonic Dieulafoy's Lesion.

Achuo-Egbe, Yvette / Hashmi, Syed Salman H / Shady, Ahmed / Khan, Gulam M

Cureus

2021 Volume 13, Issue 12, Page(s) e20384

Abstract: Dieulafoy's lesion accounts for 1%-2% of acute gastrointestinal (GI) bleeding cases, and approximately 2% of Dieulafoy's lesions are present in the colon. We report the case of an 83-year-old female who presented with recurrent gastrointestinal bleeding ... ...

Abstract	Dieulafoy's lesion accounts for 1%-2% of acute gastrointestinal (GI) bleeding cases, and approximately 2% of Dieulafoy's lesions are present in the colon. We report the case of an 83-year-old female who presented with recurrent gastrointestinal bleeding from colonic Dieulafoy's lesion located at the hepatic flexure. She initially presented four weeks prior with melena in the setting of Eliquis use for venous thrombosis, coronary artery disease, and end-stage renal disease. Upper endoscopy revealed esophagitis, gastritis, and duodenitis. Diagnostic colonoscopy and video capsule endoscopy both revealed blood in the colon without an identifiable source. During the second admission for recurrent melena with hemoglobin of 3.9 g/dL, Eliquis was discontinued, and the patient was resuscitated with three units of packed red blood cell transfusions. Repeat colonoscopy revealed a pulsating vessel with active oozing located at the hepatic flexure, consistent with a Dieulafoy's lesion. Hemostatic endoclips and bipolar electrocautery were applied to achieve complete hemostasis. Colonic Dieulafoy's lesions, albeit rare, should be considered in patients presenting with an acute obscure lower GI bleed. Primary hemostasis can be achieved with several endoscopic modalities including epinephrine, hemoclipping, thermocoagulation, or sclerotherapy.
Language	English
Publishing date	2021-12-13
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.20384
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Corporate Social Responsibility and Firm Financial Performance

Waqas Ahmad WATTO / Daniel T H MANURUNG / Komang Adi Kurniawan SAPUTRA / Syed Gulam MUSTAFA

International Journal of Environmental, Sustainability, and Social Science, Vol 1, Iss

A Case of SME’s Sector in Pakistan.

2020 Volume 2

Abstract: The paper assesses its relationship with firm innovation and Organizational performance in a single integrative model by using spss data set of 53 Pakistani SME’s firms. A questionnaire of self-administrative is developed to collect the data. Researcher ... ...

Abstract	The paper assesses its relationship with firm innovation and Organizational performance in a single integrative model by using spss data set of 53 Pakistani SME’s firms. A questionnaire of self-administrative is developed to collect the data. Researcher personally visits of different SME’s firms and collect the data from manager of SME’s firms. The research use 275 questionnaire is distributed in different SME’s sector. In this study the statistical techniques of data analysis are used to investigate and find out the relationship among the Firm performance and the other factors. SPSS version16 is used for reliability analysis, descriptive statistics, regression analysis, correlation analysis, to check either modal is good fit or not. Our results supports a partial mediation effect of innovation performance on the relationship between corporate social responsibility and firm performance, meanwhile the effect of corporate social responsibility on firm performance shrinks upon the adding of innovation performance to the model. The findings may help to understand how corporate social responsibility is an important driver mechanism for companies to be more inventive, proficient and effective.
Keywords	Science ; Q ; Social Sciences ; H
Subject code	650
Language	English
Publishing date	2020-07-01T00:00:00Z
Publisher	Indonesia Strategic Sustainability
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Assessment of normal reference values for thyroid uptake of technetium-99m pertechnetate in a Saudi population.

Alshahrani, Awad / Syed, Gulam M / Khan, Altaf H / Numani, Shah P / Alnaim, Abdulaziz / Alanazi, Faisal / Mahzari, Moeber M

Annals of Saudi medicine

2021 Volume 41, Issue 2, Page(s) 86–90

Abstract: Background: Thyrotoxicosis is a common medical problem. Thyroid nuclear imaging with either I: Objective: Determine normal reference range of Tc-99m pertechne-tate thyroid uptake for thyroid scintigraphy in Saudi Arabia.: Design: Retrospective, ... ...

Abstract	Background: Thyrotoxicosis is a common medical problem. Thyroid nuclear imaging with either I Objective: Determine normal reference range of Tc-99m pertechne-tate thyroid uptake for thyroid scintigraphy in Saudi Arabia. Design: Retrospective, cross-sectional. Setting: Nuclear medicine service at tertiary care center in Riyadh. Patients and methods: We used data from biochemically euthyroid patients who underwent a thyroid Tc-99m pertechnetate scan while having parathyroid scintigraphy for hyperparathyroidism between April 2009 to April 2019. Medical records and biochemical thyroid function tests were reviewed and Tc-99m pertechnetate thyroid uptake values were determined for each patient. Main outcome measures: Thyroid uptake of Tc-99m pertechne-tate in euthyroid patients. Sample size: 167 RESULTS: The mean and median uptake of Tc-99m pertechnetate in euthyroid patients were 0.86% and 1.0%, respectively, and the inter-quartile range was 0.0-1.0%. The normal reference range in the study population was 0.2-2%. Thyroid uptake inversely correlated with age in females (r=-0.37, Conclusion: The range for normal thyroid Tc-99m pertechnetate was lower than the standard 1-4% range. Moreover, uptake decreased with age. Further studies are needed to establish the normal age-adjusted uptake for the thyroid Tc-99m pertechnetate scan. Limitations: Single center and retrospective. Conflict of interest: None.
MeSH term(s)	Cross-Sectional Studies ; Female ; Humans ; Male ; Radiopharmaceuticals ; Reference Values ; Retrospective Studies ; Saudi Arabia ; Sodium Pertechnetate Tc 99m ; Technetium ; Thyroid Gland/diagnostic imaging
Chemical Substances	Radiopharmaceuticals ; Technetium (7440-26-8) ; Sodium Pertechnetate Tc 99m (A0730CX801)
Language	English
Publishing date	2021-04-01
Publishing country	Saudi Arabia
Document type	Journal Article
ZDB-ID	639014-6
ISSN	0975-4466 ; 0256-4947
ISSN (online)	0975-4466
ISSN	0256-4947
DOI	10.5144/0256-4947.2021.86
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 3022: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Hepatitis C Virus Lipoviroparticles Assemble in the Endoplasmic Reticulum (ER) and Bud off from the ER to the Golgi Compartment in COPII Vesicles.

Syed, Gulam H / Khan, Mohsin / Yang, Song / Siddiqui, Aleem

Journal of virology

2017 Volume 91, Issue 15

Abstract: Hepatitis C virus (HCV) exists as a lipoprotein-virus hybrid lipoviroparticle (LVP). ...

Abstract	Hepatitis C virus (HCV) exists as a lipoprotein-virus hybrid lipoviroparticle (LVP).
MeSH term(s)	Biological Transport ; COP-Coated Vesicles/virology ; Endoplasmic Reticulum/virology ; Golgi Apparatus/virology ; Hepacivirus/physiology ; Hepacivirus/ultrastructure ; Humans ; Lipoproteins, VLDL/metabolism ; Microscopy, Immunoelectron ; Virion/metabolism ; Virion/ultrastructure ; Virus Assembly ; Virus Release
Chemical Substances	Lipoproteins, VLDL
Language	English
Publishing date	2017-07-12
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/JVI.00499-17
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 609: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Assessment of normal reference values for thyroid uptake of technetium-99m pertechnetate in a Saudi population

Awad Alshahrani / Gulam M. Syed / Altaf H. Khan / Shah P. Numani / Abdulaziz Alnaim / Faisal Alanazi / Moeber M. Mahzari

Annals of Saudi Medicine, Vol 41, Iss 2, Pp 86-

2021 Volume 90

Abstract: BACKGROUND: Thyrotoxicosis is a common medical problem. Thyroid nuclear imaging with either I123 or technetium-99m (Tc-99m) pertechnetate are used to determine the cause. Although I123 has been the standard technique, Tc-99m pertechnetate is now commonly ...

Abstract	BACKGROUND: Thyrotoxicosis is a common medical problem. Thyroid nuclear imaging with either I123 or technetium-99m (Tc-99m) pertechnetate are used to determine the cause. Although I123 has been the standard technique, Tc-99m pertechnetate is now commonly used, acceptable and easier to perform. The commonly used normal value of Tc-99m pertechnetate is 1–4%, but lower normal values have been reported in different populations. OBJECTIVE: Determine normal reference range of Tc-99m pertechne-tate thyroid uptake for thyroid scintigraphy in Saudi Arabia. DESIGN: Retrospective, cross-sectional. SETTING: Nuclear medicine service at tertiary care center in Riyadh. PATIENTS AND METHODS: We used data from biochemically euthyroid patients who underwent a thyroid Tc-99m pertechnetate scan while having parathyroid scintigraphy for hyperparathyroidism between April 2009 to April 2019. Medical records and biochemical thyroid function tests were reviewed and Tc-99m pertechnetate thyroid uptake values were determined for each patient. MAIN OUTCOME MEASURES: Thyroid uptake of Tc-99m pertechne-tate in euthyroid patients. SAMPLE SIZE: 167 RESULTS: The mean and median uptake of Tc-99m pertechnetate in euthyroid patients were 0.86% and 1.0%, respectively, and the inter-quartile range was 0.0–1.0%. The normal reference range in the study population was 0.2-2%. Thyroid uptake inversely correlated with age in females (r=−0.37, P<.001), males (r=−0.46, P=.001), and for all patients (r=−0.39, P<.0001). CONCLUSION: The range for normal thyroid Tc-99m pertechnetate was lower than the standard 1-4% range. Moreover, uptake decreased with age. Further studies are needed to establish the normal age-adjusted uptake for the thyroid Tc-99m pertechnetate scan. LIMITATIONS: Single center and retrospective. CONFLICT OF INTEREST: None.
Keywords	Medicine ; R
Subject code	610
Language	English
Publishing date	2021-04-01T00:00:00Z
Publisher	King Faisal Specialist Hospital and Research Centre
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Transgenic mouse models support a protective role of type I IFN response in SARS-CoV-2 infection-related lung immunopathology and neuroinvasion.

Cell reports

2023 Volume 42, Issue 11, Page(s) 113275

Abstract: Type I interferon (IFN-I) response is the first line of host defense against invading viruses. In the absence of definite mouse models, the role of IFN-I in SARS-CoV-2 infection remains perplexing. Here, we develop two mouse models, one with ... ...

Abstract	Type I interferon (IFN-I) response is the first line of host defense against invading viruses. In the absence of definite mouse models, the role of IFN-I in SARS-CoV-2 infection remains perplexing. Here, we develop two mouse models, one with constitutively high IFN-I response (hACE2; Irgm1
MeSH term(s)	Mice ; Animals ; Mice, Transgenic ; COVID-19 ; SARS-CoV-2 ; Interferon Type I ; Mice, Knockout ; Antibodies ; Disease Models, Animal ; Lung
Chemical Substances	Interferon Type I ; Antibodies
Language	English
Publishing date	2023-10-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2023.113275
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: The essential role of mitochondrial dynamics in antiviral immunity.

Kim, Seong-Jun / Ahn, Dae-Gyun / Syed, Gulam H / Siddiqui, Aleem

Mitochondrion

2017 Volume 41, Page(s) 21–27

Abstract: Viruses alter cellular physiology and function to establish cellular environment conducive for viral proliferation. Viral immune evasion is an essential aspect of viral persistence and proliferation. The multifaceted mitochondria play a central role in ... ...

Abstract	Viruses alter cellular physiology and function to establish cellular environment conducive for viral proliferation. Viral immune evasion is an essential aspect of viral persistence and proliferation. The multifaceted mitochondria play a central role in many cellular events such as metabolism, bioenergetics, cell death, and innate immune signaling. Recent findings accentuate that viruses regulate mitochondrial function and dynamics to facilitate viral proliferation. In this review, we will discuss how viruses exploit mitochondrial dynamics to modulate mitochondria-mediated antiviral innate immune response during infection. This review will provide new insight to understanding the virus-mediated alteration of mitochondrial dynamics and functions to perturb host antiviral immune signaling.
MeSH term(s)	Animals ; Antiviral Agents/pharmacology ; Host-Pathogen Interactions/immunology ; Humans ; Immune Evasion/drug effects ; Immune Evasion/immunology ; Immunity, Innate/immunology ; Mitochondria/immunology ; Mitochondria/pathology ; Mitochondria/virology ; Mitochondrial Dynamics ; Signal Transduction ; Viruses/immunology
Chemical Substances	Antiviral Agents
Keywords	covid19
Language	English
Publishing date	2017-12-05
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2056923-3
ISSN	1872-8278 ; 1567-7249
ISSN (online)	1872-8278
ISSN	1567-7249
DOI	10.1016/j.mito.2017.11.007
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito