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Article ; Online: Nucleotide analysis and prevalence of Escherichia coli isolated from feces of some captive avian species

Nimra khalid / Syed Mohsin Bukhari / Mohammad Y. Alshahrani / Khalil Ur Rehman / Shahbaz Ahmad / Shahla Andleeb / Arshad Javid / Sheikh Muhammad Azam

Journal of King Saud University: Science, Vol 35, Iss 1, Pp 102375- (2023)

1480

Abstract: The aim of the study was to check the prevalence of Escherichia coli in some captive avian species, seasonal effect on the E.coli prevalence and analysis of nucleotide sequences of E.coli. A total of 132 samples, 33 from Turkey (Meleagris gallopavo), 33 ... ...

Abstract	The aim of the study was to check the prevalence of Escherichia coli in some captive avian species, seasonal effect on the E.coli prevalence and analysis of nucleotide sequences of E.coli. A total of 132 samples, 33 from Turkey (Meleagris gallopavo), 33 form Pheasant (Phasianus colchicus), 33 from Budgerigar (Melopsittacus undulates) and 33 from Chukar partridge (Alectoris chukar) were collected from Conservation and Research Center, UVAS, Ravi Campus, Pattoki. Colony forming units was quantified for each sample. E. coli confirmation was done by biochemical and molecular characterization. 16S rRNA was amplified and sequenced. 16S rRNA sequence was submitted to NCBI under the accession number MN841017, MN841018 and MN841019.Descriptive statistics showed the mean ± SEM value for E. coli CFU/ml of fecal sample from Turkey 1.91 × 108 ± 4.4 × 107, for Pheasants, the mean ± SEM was 1.55 × 108 ± 5.2 × 107 CFU/ml of fecal sample. The mean ± SEM of the fecal sample for Budgerigars and Chukar were 2.12 × 108 ± 3.3 × 107 CFU/ml and 1.6 × 108 ± 4.5 × 107 CFU/ml respectively. Inferential statistics showed that regardless of the bird species, there was almost a similar frequency of E. coli CFU/ml of fecal sample (p = 0.74). However, the incidence of E. coli fluctuates significantly depending on the season in the case of turkey and pheasants, and the impact was statistically significant (p < 0.0005). E.coli was most prevalent in Turkey during rainy summer and in Pheasants during cool dry winter. These findings show that accidental or direct contact with feces of these captive birds have possible risk of gastric illness to humans and animals. Furthermore, understanding the mechanisms driving the seasonality of this important zoonotic pathogen will allow for the execution of effective control strategies when it is most prevalent.
Keywords	Captive avian species ; Escherichia coli ; Prevalence ; Fecal sample ; 16S rRNA gene ; Science (General) ; Q1-390
Subject code	630
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Targeting Autophagy, Apoptosis, and SIRT1/Nrf2 Axis with Topiramate Underlies Its Neuroprotective Effect against Cadmium-Evoked Cognitive Deficits in Rats.

Arab, Hany H / Eid, Ahmed H / Yahia, Rania / Alsufyani, Shuruq E / Ashour, Ahmed M / El-Sheikh, Azza A K / Darwish, Hany W / Saad, Muhammed A / Al-Shorbagy, Muhammad Y / Masoud, Marwa A

Pharmaceuticals (Basel, Switzerland)

2023 Volume 16, Issue 9

Abstract: ... molecular changes in the hippocampal area were explored. Herein, Morris water maze, Y-maze, and novel object ...

Abstract	Cadmium is an environmental toxicant that instigates cognitive deficits with excessive glutamate excitatory neuroactivity in the brain. Topiramate, a glutamate receptor antagonist, has displayed favorable neuroprotection against epilepsy, cerebral ischemia, and Huntington's disease; however, its effect on cadmium neurotoxicity remains to be investigated. In this study, topiramate was tested for its potential to combat the cognitive deficits induced by cadmium in rats with an emphasis on hippocampal oxidative insult, apoptosis, and autophagy. After topiramate intake (50 mg/kg/day; p.o.) for 8 weeks, behavioral disturbances and molecular changes in the hippocampal area were explored. Herein, Morris water maze, Y-maze, and novel object recognition test revealed that topiramate rescued cadmium-induced memory/learning deficits. Moreover, topiramate significantly lowered hippocampal histopathological damage scores. Mechanistically, topiramate significantly replenished hippocampal GLP-1 and dampened Aβ42 and p-tau neurotoxic cues. Notably, it significantly diminished hippocampal glutamate content and enhanced acetylcholine and GABA neurotransmitters. The behavioral recovery was prompted by hippocampal suppression of the pro-oxidant events with notable activation of SIRT1/Nrf2/HO-1 axis. Moreover, topiramate inactivated GSK-3β and dampened the hippocampal apoptotic changes. In tandem, stimulation of hippocampal pro-autophagy events, including Beclin 1 upregulation, was triggered by topiramate that also activated AMPK/mTOR pathway. Together, the pro-autophagic, antioxidant, and anti-apoptotic features of topiramate contributed to its neuroprotective properties in rats intoxicated with cadmium. Therefore, it may be useful to mitigate cadmium-induced cognitive deficits.
Language	English
Publishing date	2023-08-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2193542-7
ISSN	1424-8247
ISSN	1424-8247
DOI	10.3390/ph16091214
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Article ; Online: DenseHillNet: a lightweight CNN for accurate classification of natural images.

Saqib, Sheikh Muhammad / Zubair Asghar, Muhammad / Iqbal, Muhammad / Al-Rasheed, Amal / Amir Khan, Muhammad / Ghadi, Yazeed / Mazhar, Tehseen

PeerJ. Computer science

2024 Volume 10, Page(s) e1995

Abstract: The detection of natural images, such as glaciers and mountains, holds practical applications in transportation automation and outdoor activities. Convolutional neural networks (CNNs) have been widely employed for image recognition and classification ... ...

Abstract	The detection of natural images, such as glaciers and mountains, holds practical applications in transportation automation and outdoor activities. Convolutional neural networks (CNNs) have been widely employed for image recognition and classification tasks. While previous studies have focused on fruits, land sliding, and medical images, there is a need for further research on the detection of natural images, particularly glaciers and mountains. To address the limitations of traditional CNNs, such as vanishing gradients and the need for many layers, the proposed work introduces a novel model called DenseHillNet. The model utilizes a DenseHillNet architecture, a type of CNN with densely connected layers, to accurately classify images as glaciers or mountains. The model contributes to the development of automation technologies in transportation and outdoor activities. The dataset used in this study comprises 3,096 images of each of the "glacier" and "mountain" categories. Rigorous methodology was employed for dataset preparation and model training, ensuring the validity of the results. A comparison with a previous work revealed that the proposed DenseHillNet model, trained on both glacier and mountain images, achieved higher accuracy (86%) compared to a CNN model that only utilized glacier images (72%). Researchers and graduate students are the audience of our article.
Language	English
Publishing date	2024-04-22
Publishing country	United States
Document type	Journal Article
ISSN	2376-5992
ISSN (online)	2376-5992
DOI	10.7717/peerj-cs.1995
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Article: Stimulation of Autophagy by Dapagliflozin Mitigates Cadmium-Induced Testicular Dysfunction in Rats: The Role of AMPK/mTOR and SIRT1/Nrf2/HO-1 Pathways.

Arab, Hany H / Fikry, Ebtehal Mohammad / Alsufyani, Shuruq E / Ashour, Ahmed M / El-Sheikh, Azza A K / Darwish, Hany W / Al-Hossaini, Abdullah M / Saad, Muhammed A / Al-Shorbagy, Muhammad Y / Eid, Ahmed H

Pharmaceuticals (Basel, Switzerland)

2023 Volume 16, Issue 7

Abstract: Cadmium (Cd) is a widespread environmental pollutant that triggers testicular dysfunction. Dapagliflozin is a selective sodium-glucose co-transporter-2 inhibitor with notable antioxidant and anti-apoptotic features. It has shown marked cardio-, reno-, ... ...

Abstract	Cadmium (Cd) is a widespread environmental pollutant that triggers testicular dysfunction. Dapagliflozin is a selective sodium-glucose co-transporter-2 inhibitor with notable antioxidant and anti-apoptotic features. It has shown marked cardio-, reno-, hepato-, and neuroprotective effects. Yet, its effect on Cd-evoked testicular impairment has not been examined. Hence, the goal of the current study was to investigate the potential positive effect of dapagliflozin against Cd-induced testicular dysfunction in rats, with an emphasis on autophagy, apoptosis, and oxidative insult. Dapagliflozin (1 mg/kg/day) was given by oral gavage, and testicular dysfunction, impaired spermatogenesis, and biomolecular events were studied via immunohistochemistry, histopathology, and ELISA. The current findings demonstrated that dapagliflozin improved relative testicular weight, serum testosterone, and sperm count/motility and reduced sperm abnormalities, signifying mitigation of testicular impairment and spermatogenesis disruption. Moreover, dapagliflozin attenuated Cd-induced histological abnormalities and preserved testicular structure. The testicular function recovery was prompted by stimulating the cytoprotective SIRT1/Nrf2/HO-1 axis, lowering the testicular oxidative changes, and augmenting cellular antioxidants. As regards apoptosis, dapagliflozin counteracted the apoptotic machinery by downregulating the pro-apoptotic signals together with Bcl-2 upregulation. Meanwhile, dapagliflozin reactivated the impaired autophagy, as seen by a lowered accumulation of SQSTM-1/p62 and Beclin 1 upregulation. In the same context, the testicular AMPK/mTOR pathway was stimulated as evidenced by the increased p-AMPK (Ser487)/total AMPK ratio alongside the lowered p-mTOR (Ser2448)/total mTOR ratio. Together, the favorable mitigation of Cd-induced testicular impairment/disrupted spermatogenesis was driven by the antioxidant, anti-apoptotic, and pro-autophagic actions of dapagliflozin. Thus, it could serve as a tool for the management of Cd-evoked testicular dysfunction.
Language	English
Publishing date	2023-07-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2193542-7
ISSN	1424-8247
ISSN	1424-8247
DOI	10.3390/ph16071006
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Article ; Online: Synthesis, Molecular Docking Study, and Cytotoxicity Evaluation of Some Novel 1,3,4-Thiadiazole as Well as 1,3-Thiazole Derivatives Bearing a Pyridine Moiety.

Abouzied, Amr S / Al-Humaidi, Jehan Y / Bazaid, Abdulrahman S / Qanash, Husam / Binsaleh, Naif K / Alamri, Abdulwahab / Ibrahim, Sheikh Muhammad / Gomha, Sobhi M

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 19

Abstract: Pyridine, 1,3,4-thiadiazole, and 1,3-thiazole derivatives have various biological activities, such as antimicrobial, analgesic, anticonvulsant, and antitubercular, as well as other anticipated biological properties, including anticancer activity. The ... ...

Abstract	Pyridine, 1,3,4-thiadiazole, and 1,3-thiazole derivatives have various biological activities, such as antimicrobial, analgesic, anticonvulsant, and antitubercular, as well as other anticipated biological properties, including anticancer activity. The starting 1-(3-cyano-4,6-dimethyl-2-oxopyridin-1(2
MeSH term(s)	Anticonvulsants ; Antineoplastic Agents/chemistry ; Drug Screening Assays, Antitumor ; ErbB Receptors ; Harmine ; Humans ; Molecular Docking Simulation ; Molecular Structure ; Phenylthiourea ; Pyridines/pharmacology ; Structure-Activity Relationship ; Thiadiazoles/chemistry ; Thiazoles/chemistry
Chemical Substances	Anticonvulsants ; Antineoplastic Agents ; Pyridines ; Thiadiazoles ; Thiazoles ; 1,3,4-thiadiazole (14IAC3GH7G) ; Harmine (4FHH5G48T7) ; Phenylthiourea (6F82C6Q54C) ; ErbB Receptors (EC 2.7.10.1)
Language	English
Publishing date	2022-09-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27196368
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Article ; Online: Targeting Autophagy, Apoptosis, and SIRT1/Nrf2 Axis with Topiramate Underlies Its Neuroprotective Effect against Cadmium-Evoked Cognitive Deficits in Rats

Hany H. Arab / Ahmed H. Eid / Rania Yahia / Shuruq E. Alsufyani / Ahmed M. Ashour / Azza A. K. El-Sheikh / Hany W. Darwish / Muhammed A. Saad / Muhammad Y. Al-Shorbagy / Marwa A. Masoud

Pharmaceuticals, Vol 16, Iss 1214, p

2023 Volume 1214

Abstract: ... molecular changes in the hippocampal area were explored. Herein, Morris water maze, Y-maze, and novel object ...

Abstract	Cadmium is an environmental toxicant that instigates cognitive deficits with excessive glutamate excitatory neuroactivity in the brain. Topiramate, a glutamate receptor antagonist, has displayed favorable neuroprotection against epilepsy, cerebral ischemia, and Huntington’s disease; however, its effect on cadmium neurotoxicity remains to be investigated. In this study, topiramate was tested for its potential to combat the cognitive deficits induced by cadmium in rats with an emphasis on hippocampal oxidative insult, apoptosis, and autophagy. After topiramate intake (50 mg/kg/day; p.o.) for 8 weeks, behavioral disturbances and molecular changes in the hippocampal area were explored. Herein, Morris water maze, Y-maze, and novel object recognition test revealed that topiramate rescued cadmium-induced memory/learning deficits. Moreover, topiramate significantly lowered hippocampal histopathological damage scores. Mechanistically, topiramate significantly replenished hippocampal GLP-1 and dampened Aβ42 and p-tau neurotoxic cues. Notably, it significantly diminished hippocampal glutamate content and enhanced acetylcholine and GABA neurotransmitters. The behavioral recovery was prompted by hippocampal suppression of the pro-oxidant events with notable activation of SIRT1/Nrf2/HO-1 axis. Moreover, topiramate inactivated GSK-3β and dampened the hippocampal apoptotic changes. In tandem, stimulation of hippocampal pro-autophagy events, including Beclin 1 upregulation, was triggered by topiramate that also activated AMPK/mTOR pathway. Together, the pro-autophagic, antioxidant, and anti-apoptotic features of topiramate contributed to its neuroprotective properties in rats intoxicated with cadmium. Therefore, it may be useful to mitigate cadmium-induced cognitive deficits.
Keywords	topiramate ; cadmium ; Alzheimer ; autophagy ; apoptosis ; glutamate ; Medicine ; R ; Pharmacy and materia medica ; RS1-441
Subject code	150
Language	English
Publishing date	2023-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Activation of CD8

American journal of respiratory and critical care medicine

2023 Volume 208, Issue 11, Page(s) 1177–1195

Abstract: Rationale: ...

Abstract	Rationale:
MeSH term(s)	Humans ; Animals ; Mice ; CD8-Positive T-Lymphocytes ; Disease Models, Animal ; Proteomics ; Lung/metabolism ; Pulmonary Disease, Chronic Obstructive ; Inflammation ; Receptors, Antigen, T-Cell
Chemical Substances	Receptors, Antigen, T-Cell
Language	English
Publishing date	2023-09-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	1180953-x
ISSN	1535-4970 ; 0003-0805 ; 1073-449X
ISSN (online)	1535-4970
ISSN	0003-0805 ; 1073-449X
DOI	10.1164/rccm.202305-0924OC
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Article: Proactive Personality and Innovative Work Behavior: Through the Juxtapose of Schumpeter's Theory of Innovation and Broaden-And-Build Theory.

Li, Weizheng / Gill, Shabeeb Ahmad / Wang, Yang / Safdar, Muhammad Adeel / Sheikh, Muhammad Ramzan

Frontiers in psychology

2022 Volume 13, Page(s) 927458

Abstract: This study aimed to unfold the implicit interplay of open innovation (OI) and perceived insider status (PIS) between the relationship of proactive personality (PP) and innovative work behavior (IWB). The phenomenon studied the moderated mediation of OI ... ...

Abstract	This study aimed to unfold the implicit interplay of open innovation (OI) and perceived insider status (PIS) between the relationship of proactive personality (PP) and innovative work behavior (IWB). The phenomenon studied the moderated mediation of OI and PIS through the combined optic of the theory of innovation and the broaden-and-build theory. The nature of this study was post-positivist. The two-step approach of structural equation modeling was implemented. First, quantitative data were collected through an online questionnaire from the employees of IT industries in China. The study sample consisted of 460 responses used for data analysis in SPSS and AMOS version 26. This study was based on mediated moderation, which was statistically similar to Model 15 of the process macro. There were six hypotheses based on the theoretical framework. The result of H6 was rejected, which demonstrated that the conditional direct effect of OI and PIS mediated moderation on PP and IWB. The results comprehensively testified to the theoretical framework.
Language	English
Publishing date	2022-06-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2022.927458
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Article: Renal endometriosis: A benign disease with malignant presentation.

Nawaz, Muhammad Mubashir / Masood, Yasir / Usmani, Afshan Saeed / Basheer, Muhammad Irfan / Sheikh, Umer Nisar / Mir, Khurram

Urology case reports

2022 Volume 43, Page(s) 102110

Abstract: Endometriosis is a common gynecological disorder in which endometrial tissue is located outside the uterine cavity. Urinary tract involvement by endometriosis is uncommon. Renal endometriosis is a rare disorder and is not evident on imaging. It may be ... ...

Abstract	Endometriosis is a common gynecological disorder in which endometrial tissue is located outside the uterine cavity. Urinary tract involvement by endometriosis is uncommon. Renal endometriosis is a rare disorder and is not evident on imaging. It may be misdiagnosed as malignant disease and patients may undergo invasive procedures for it. We report a case of a young lady who presented with symptoms typical for renal mass, and was diagnosed as a tumor on imaging. Patient underwent radical surgery and histology revealed renal endometriosis.
Language	English
Publishing date	2022-05-07
Publishing country	United States
Document type	Case Reports
ZDB-ID	2745459-9
ISSN	2214-4420
ISSN	2214-4420
DOI	10.1016/j.eucr.2022.102110
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Article ; Online: Single-cell transcriptomics reveal a hyperacute cytokine and immune checkpoint axis after cardiac arrest in patients with poor neurological outcome.

Med (New York, N.Y.)

2023 Volume 4, Issue 7, Page(s) 432–456.e6

Abstract: Background: Most patients hospitalized after cardiac arrest (CA) die because of neurological injury. The systemic inflammatory response after CA is associated with neurological injury and mortality but remains poorly defined.: Methods: We determine ... ...

Abstract	Background: Most patients hospitalized after cardiac arrest (CA) die because of neurological injury. The systemic inflammatory response after CA is associated with neurological injury and mortality but remains poorly defined. Methods: We determine the innate immune network induced by clinical CA at single-cell resolution. Findings: Immune cell states diverge as early as 6 h post-CA between patients with good or poor neurological outcomes 30 days after CA. Nectin-2 Conclusions: The initial hours after CA may represent a window for therapeutic intervention in the resolution of inflammation via immune checkpoints. Funding: This work was supported by funding from the American Heart Association, Brigham and Women's Hospital Department of Medicine, the Evergreen Innovation Fund, and the National Institutes of Health.
MeSH term(s)	United States ; Humans ; Female ; Cytokines/pharmacology ; Nectins/genetics ; Transcriptome ; Killer Cells, Natural ; Inflammation
Chemical Substances	Cytokines ; Nectins
Language	English
Publishing date	2023-05-30
Publishing country	United States
Document type	Journal Article
ISSN	2666-6340
ISSN (online)	2666-6340
DOI	10.1016/j.medj.2023.05.003
Database	MEDical Literature Analysis and Retrieval System OnLINE

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