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Article: Effect of resveratrol and combination of resveratrol and donepezil on the expression of microglial cells and astrocytes in

Rao, Y Lakshmisha / Ganaraja, B / Suresh, Pooja K / Joy, Teresa / Ullal, Sheetal D / Manjrekar, Poornima A / Murlimanju, B V / Sharma, B Gaurav

3 Biotech

2023 Volume 13, Issue 9, Page(s) 319

Abstract: Aim: The goal was to evaluate the effect of resveratrol (RS) and combination therapy of RS and donepezil (DPZ), on the numerical expression of microglial cells and astrocytes, in the frontal cortex, regions of the hippocampus in colchicine-induced ... ...

Abstract	Aim: The goal was to evaluate the effect of resveratrol (RS) and combination therapy of RS and donepezil (DPZ), on the numerical expression of microglial cells and astrocytes, in the frontal cortex, regions of the hippocampus in colchicine-induced Alzheimer's disease (AD) model. Methods: The study involved male albino Results: AD group showed an increase in the number of microglia, and the numbers declined in the treatment groups, RS 10, RS 20, RS10/10 and DPZ + RS ( Conclusion: RS administration has diminished the microglial number and elevated the number of astrocytes. The elevated reactive astrocytes have decreased the microglial population. However, the limitation of our study is utilizing the colchicine for the induction of neurodegeneration. Using the transgenic models of AD may give a better insight into the pathogenesis and effect of RS. Another limitation of this study is the administration of RS and DPZ through different routes. The prospects of this research include studying the probiotic nature of RS and the effect of RS in other neurodegenerative disorders.
Language	English
Publishing date	2023-08-26
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2600522-0
ISSN	2190-5738 ; 2190-572X
ISSN (online)	2190-5738
ISSN	2190-572X
DOI	10.1007/s13205-023-03743-4
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Article ; Online: Stochastic Simulation of Strong Ground Motions From Two M > 5 Uttarakhand Earthquakes

Nitin Sharma / D. Srinagesh / G. Suresh / D. Srinivas

Frontiers in Earth Science, Vol

2021 Volume 9

Abstract: Many studies based on the geodetic data and statistical analysis of seismicity have pointed out that sufficient amount of stress accumulated in the Himalayan plate boundary may host a big earthquake. Consequently, high seismic activities and ... ...

Abstract	Many studies based on the geodetic data and statistical analysis of seismicity have pointed out that sufficient amount of stress accumulated in the Himalayan plate boundary may host a big earthquake. Consequently, high seismic activities and infrastructural developments in the major cities around Himalayan regions are always of major concern. The ground motion parameter estimation plays a vital role in the near real time evaluation of potentially damaged areas and helps in mitigating the seismic hazard. Therefore, keeping in mind the importance of estimation of ground motion parameters, we targeted two moderate-size earthquakes that occurred recently within a gap of 10 months in Uttarakhand region with M > 5.0 on 06/02/2017 and 06/12/2017. The ground motions are simulated by adopting a stochastic modeling technique. The source is assumed as ω−2, a circular point source (Brune’s model). The average value of reported anelastic attenuation from various studies, the quality factor, Qs = 130.4*(f0.996), and stress drop values obtained through iterative procedure are considered for simulations. The stochastic spectra are generated between 0.1 and 10 Hz of frequency range. The site effect is also estimated by using the H/V method in the same frequency range. The synthetic spectra are compared with the observed Fourier amplitude spectra obtained from the recorded waveform data and converted back to the time histories. The stochastic time histories are compared with the observed waveforms and discussed in terms of amplitude (PGA). The simulated and observed response spectra at different structural periods are also discussed. The mismatch between the observed and simulated PGA values along with the GMPE existing for shallow crustal earthquakes is also discussed in the present work.
Keywords	stochastic ; strong ground motion ; earthquake ; site effect ; simulation ; Science ; Q
Subject code	612
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
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Article ; Online: Anthropogenic aerosols in precipitation over the Indo-Gangetic basin

Sharma, Anshumala / Khare, Puja / Nāhara Siṅgha / Tiwari, Suresh / Chate, D. M. / Kumar, Ranjit

Environ Geochem Health. 2023 Mar., v. 45, no. 3 p.961-980

2023

Abstract: This study investigated the concentration of heavy metals in rainwater (RW) at a semi-arid region of the Indo-Gangetic basin to understand the influence of local, regional, or long-range transport of air pollutants during the monsoon and non-monsoonal ... ...

Abstract	This study investigated the concentration of heavy metals in rainwater (RW) at a semi-arid region of the Indo-Gangetic basin to understand the influence of local, regional, or long-range transport of air pollutants during the monsoon and non-monsoonal rain. The concentration of heavy metals in RW was determined using Atomic Absorption Spectrophotometer with Graphite Furnace, the scavenging ratio was estimated, and source interpretation was carried out using Principle Component Analysis (PCA) and HYSPLIT model. Ca was the highest contributor in RW followed by Na, Fe, Mg, and Al whereas Ba, Cr, Cu, Mn, Ni, Pb, and Zn were found in trace quantity. During the non-monsoon period, the crustal component (Ca) was the highest; however, during the monsoon, sea salt components (Na and Fe) were found higher. The scavenging ratio for metals was estimated and was found many times higher than those reported over European sites. The moderate concentration of heavy metal in RW was found with higher wind from South (S), South-West (SW), and North-West (NW) directions. Air mass back trajectory shows a significant contribution of metals from the Arabian Sea (South-Westerly wind) during active monsoon, whereas, in the non-monsoon season, the air masses mainly originated from the north-west indicating a contribution from wind-blown dust. The correlation analysis has shown the positive correlations between Ca and Mg, Mg and Na, Na and Cu, Al and Zn, Zn and Ba, Ba and Cr, and Cr and Zn. Principal Component Analysis (PCA) indicated loading of Ca, Na, Mg, Cu, Mn, and Ni in the first factor suggesting their crustal origin, whereas the second factor showed high loading of Al, Ba, Zn, Cr, and Ni indicating vehicular exhaust and industrial emission as their major sources, and loading for Ba and Mg in the third factor indicates the mixed contribution from both natural and anthropogenic sources in rainwater during the monsoon and non-monsoon periods. The data of this study can be used in the air pollution transport model. This study will help in source interpretation over the Indo-Gangetic basin and will help in planning for National Clean Air Program (NCAP) and deriving critical load.
Keywords	air ; air pollution ; atomic absorption spectrometry ; basins ; critical load ; dust ; heavy metals ; models ; monsoon season ; principal component analysis ; rain ; semiarid zones ; wind direction ; Arabian Sea
Language	English
Dates of publication	2023-03
Size	p. 961-980.
Publishing place	Springer Netherlands
Document type	Article ; Online
ZDB-ID	52039-1
ISSN	1573-2983 ; 0142-7245 ; 0269-4042
ISSN (online)	1573-2983
ISSN	0142-7245 ; 0269-4042
DOI	10.1007/s10653-022-01236-6
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Article ; Online: In-phase and mixed-phase measure synchronization of camphor rotors.

Jain, Rishabh / Sharma, Jyoti / Tiwari, Ishant / Gadre, Sangeeta D / Kumarasamy, Suresh / Parmananda, P / Prasad, Awadhesh

Physical review. E

2023 Volume 108, Issue 2-1, Page(s) 24217

Abstract: The numerical, analytical, and experimental analyses are presented for synchronizing two rotors under the Yukawa interaction. We report that the rotors exhibit in-phase and mixed-phase measure synchronizations for a pair of coupled rotors. Here, the ... ...

Abstract	The numerical, analytical, and experimental analyses are presented for synchronizing two rotors under the Yukawa interaction. We report that the rotors exhibit in-phase and mixed-phase measure synchronizations for a pair of coupled rotors. Here, the analytical condition for synchronization is derived, tested numerically, and confirmed experimentally using coupled camphor infused rotors as a test bed. Moreover, the concept of measure synchronization is discussed. We report that, in conservative systems, not only the critical coupling parameter but initial conditions also play an essential role for estimating the measure synchronization region.
Language	English
Publishing date	2023-09-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2844562-4
ISSN	2470-0053 ; 2470-0045
ISSN (online)	2470-0053
ISSN	2470-0045
DOI	10.1103/PhysRevE.108.024217
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Article ; Online: Hepatitis C virus 1b viral factors (core, NS3, and NS5A) and increased risk of hepatocellular carcinoma.

Sharma, Suresh D

Hepatology (Baltimore, Md.)

2013 Volume 58, Issue 2, Page(s) 491–493

MeSH term(s)	Carcinoma, Hepatocellular/virology ; Female ; Hepacivirus/genetics ; Hepatitis C, Chronic/virology ; Humans ; Liver Neoplasms/virology ; Male ; Viral Core Proteins/genetics ; Viral Nonstructural Proteins/genetics
Chemical Substances	NS3 protein, hepatitis C virus ; Viral Core Proteins ; Viral Nonstructural Proteins ; nucleocapsid protein, Hepatitis C virus ; NS-5 protein, hepatitis C virus (EC 2.7.7.48)
Language	English
Publishing date	2013-06-25
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	604603-4
ISSN	1527-3350 ; 0270-9139
ISSN (online)	1527-3350
ISSN	0270-9139
DOI	10.1002/hep.26362
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Article ; Online: Anthropogenic aerosols in precipitation over the Indo-Gangetic basin.

Sharma, Anshumala / Khare, Puja / Singh, Nahar / Tiwari, Suresh / Chate, D M / Kumar, Ranjit

Environmental geochemistry and health

2022 Volume 45, Issue 3, Page(s) 961–980

Abstract	This study investigated the concentration of heavy metals in rainwater (RW) at a semi-arid region of the Indo-Gangetic basin to understand the influence of local, regional, or long-range transport of air pollutants during the monsoon and non-monsoonal rain. The concentration of heavy metals in RW was determined using Atomic Absorption Spectrophotometer with Graphite Furnace, the scavenging ratio was estimated, and source interpretation was carried out using Principle Component Analysis (PCA) and HYSPLIT model. Ca was the highest contributor in RW followed by Na, Fe, Mg, and Al whereas Ba, Cr, Cu, Mn, Ni, Pb, and Zn were found in trace quantity. During the non-monsoon period, the crustal component (Ca) was the highest; however, during the monsoon, sea salt components (Na and Fe) were found higher. The scavenging ratio for metals was estimated and was found many times higher than those reported over European sites. The moderate concentration of heavy metal in RW was found with higher wind from South (S), South-West (SW), and North-West (NW) directions. Air mass back trajectory shows a significant contribution of metals from the Arabian Sea (South-Westerly wind) during active monsoon, whereas, in the non-monsoon season, the air masses mainly originated from the north-west indicating a contribution from wind-blown dust. The correlation analysis has shown the positive correlations between Ca and Mg, Mg and Na, Na and Cu, Al and Zn, Zn and Ba, Ba and Cr, and Cr and Zn. Principal Component Analysis (PCA) indicated loading of Ca, Na, Mg, Cu, Mn, and Ni in the first factor suggesting their crustal origin, whereas the second factor showed high loading of Al, Ba, Zn, Cr, and Ni indicating vehicular exhaust and industrial emission as their major sources, and loading for Ba and Mg in the third factor indicates the mixed contribution from both natural and anthropogenic sources in rainwater during the monsoon and non-monsoon periods. The data of this study can be used in the air pollution transport model. This study will help in source interpretation over the Indo-Gangetic basin and will help in planning for National Clean Air Program (NCAP) and deriving critical load.
MeSH term(s)	Environmental Monitoring ; Metals, Heavy/analysis ; Air Pollutants/analysis ; Rain ; Aerosols/analysis
Chemical Substances	Metals, Heavy ; Air Pollutants ; Aerosols
Language	English
Publishing date	2022-04-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	52039-1
ISSN	1573-2983 ; 0142-7245 ; 0269-4042
ISSN (online)	1573-2983
ISSN	0142-7245 ; 0269-4042
DOI	10.1007/s10653-022-01236-6
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Article ; Online: Epidrugs: alternative chemotherapy targeting

Kamble, Sonam / Singh, Sakshi / Suresh, Akash / Singothu, Siva / Dandesena, Debabrata / Bhandari, Vasundhra / Sharma, Paresh

Microbiology spectrum

2024 Volume 12, Issue 4, Page(s) e0325823

Abstract: The growing emergence of resistance to current anti-theilerial agents necessitates the exploration of alternative approaches to drug discovery. This study evaluated the antiparasitic efficacy of 148 compounds derived from an epigenetic inhibitor library ... ...

Abstract	The growing emergence of resistance to current anti-theilerial agents necessitates the exploration of alternative approaches to drug discovery. This study evaluated the antiparasitic efficacy of 148 compounds derived from an epigenetic inhibitor library against the schizont stage of a
MeSH term(s)	Humans ; Animals ; Cattle ; Theileria annulata/chemistry ; Theileria annulata/genetics ; Theileria annulata/metabolism ; Theileriasis/drug therapy ; Theileriasis/parasitology ; Parasites ; Molecular Docking Simulation ; Schizonts/chemistry ; Cattle Diseases/prevention & control ; Hydroxamic Acids ; Naphthalenes ; Naphthoquinones
Chemical Substances	methylstat ; plumbagin (YAS4TBQ4OQ) ; trichostatin A (3X2S926L3Z) ; Hydroxamic Acids ; Naphthalenes ; Naphthoquinones
Language	English
Publishing date	2024-02-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.03258-23
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Article ; Online: Beyond Maternal Mortality: A Systematic Review of Evidences on Mistreatment and Disrespect During Childbirth in Health Facilities in India.

Jungari, Suresh / Sharma, Baby / Wagh, Dhananjay

Trauma, violence & abuse

2019 Volume 22, Issue 4, Page(s) 739–751

Abstract: ... of disrespect and abuse (D&A), mistreatment and practices of respectful maternity care of women during ... and Hill landscape analytical framework for D&A of women during childbirth. Eleven studies are ... The frequency of reported D&A was high, ranging from 10% to 77.3%. These behaviors were influenced by lack ...

Abstract	The aim of this systematic review is to examine current evidence on the nature and extent of disrespect and abuse (D&A), mistreatment and practices of respectful maternity care of women during childbirth in India. Electronic databases were searched for published studies relevant to the topic. The search was conducted from May to September 2018. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used to conduct the review. A results synthesis was done using the Bowser and Hill landscape analytical framework for D&A of women during childbirth. Eleven studies are included in this review of which six were cross-sectional, four were qualitative, and one used a mixed-method approach. The type of abuse most frequently reported was the lack of respect and dignity (nondignified care) experienced by the women, usually in the form of negative and unfriendly attitudes of the providers. The least frequent form of mistreatment was physical abuse and detention in the facilities. The frequency of reported D&A was high, ranging from 10% to 77.3%. These behaviors were influenced by lack of education and empowerment of the women, their low socioeconomic status, poor training of providers and supervision, and a lack of accountability. Overall, disrespectful and abusive behavior had adverse impact on the utilization of health facilities for childbirth. It created a psychological distance between women and health providers. To our knowledge, this is the first systematic literature review to be conducted on respectful maternity care in India.
MeSH term(s)	Attitude of Health Personnel ; Female ; Health Facilities ; Humans ; Maternal Health Services ; Maternal Mortality ; Parturition ; Pregnancy ; Professional-Patient Relations
Language	English
Publishing date	2019-10-20
Publishing country	United States
Document type	Journal Article ; Systematic Review
ZDB-ID	2070884-1
ISSN	1552-8324 ; 1524-8380
ISSN (online)	1552-8324
ISSN	1524-8380
DOI	10.1177/1524838019881719
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Article ; Online: Innate functions of natural products: A promising path for the identification of novel therapeutics.

Suresh, Patil Shivprasad / Kumari, Surekha / Sahal, Dinkar / Sharma, Upendra

European journal of medicinal chemistry

2023 Volume 260, Page(s) 115748

Abstract: In the course of evolution, living organisms have become well equipped with diverse natural products that serve important functions, including defence from biotic and abiotic stress, growth regulation, reproduction, metabolism, and epigenetic regulation. ...

Abstract	In the course of evolution, living organisms have become well equipped with diverse natural products that serve important functions, including defence from biotic and abiotic stress, growth regulation, reproduction, metabolism, and epigenetic regulation. It seems to be the organism's ecological niche that influences the natural product's structural and functional diversity. Indeed, natural products constitute the nuts and bolts of molecular co-evolution and ecological relationships among different life forms. Since natural products in the form of specialized secondary metabolites exhibit biological functions via interactions with specific target proteins, they can provide a simultaneous glimpse of both new therapeutics and therapeutic targets in humans as well. In this review, we have discussed the innate role of natural products in the ecosystem and how this intrinsic role provides a futuristic opportunity to identify new drugs and therapeutic targets rapidly.
MeSH term(s)	Humans ; Ecosystem ; Epigenesis, Genetic ; Biological Products/pharmacology
Chemical Substances	Biological Products
Language	English
Publishing date	2023-08-19
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	188597-2
ISSN	1768-3254 ; 0009-4374 ; 0223-5234
ISSN (online)	1768-3254
ISSN	0009-4374 ; 0223-5234
DOI	10.1016/j.ejmech.2023.115748
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Article ; Online: Generation of aperiodic motion due to sporadic collisions of camphor ribbons.

Jain, Rishabh / Sharma, Jyoti / Tiwari, Ishant / Gadre, Sangeeta D / Kumarasamy, Suresh / Parmananda, P / Prasad, Awadhesh

Physical review. E

2022 Volume 106, Issue 2-1, Page(s) 24201

Abstract: We present numerical and experimental results for the generation of aperiodic motion in coupled active rotators. The numerical analysis is presented for two point particles constrained to move on a unit circle under the Yukawa-like interaction. ... ...

Abstract	We present numerical and experimental results for the generation of aperiodic motion in coupled active rotators. The numerical analysis is presented for two point particles constrained to move on a unit circle under the Yukawa-like interaction. Simulations exhibit that the collision among the rotors results in chaotic motion of the rotating point particles. Furthermore, the numerical model predicts a route to chaotic motion. Subsequently, we explore the effect of separation between the rotors on their chaotic dynamics. The numerically calculated fraction of initial conditions which led to chaotic motion shed light on the observed effects. We reproduce a subset of the numerical observations with two self-propelled ribbons rotating at the air-water interface. A pinned camphor rotor moves at the interface due to the Marangoni forces generated by surface tension imbalance around it. The camphor layer present at the common water surface acts as chemical coupling between two ribbons. The separation distance of ribbons (L) determines the nature of coupled dynamics. Below a critical distance (L_{T}), rotors can potentially, by virtue of collisions, exhibit aperiodic oscillations characterized via a mixture of co- and counterrotating oscillations. These aperiodic dynamics qualitatively matched the chaotic motion observed in the numerical model.
Language	English
Publishing date	2022-09-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2844562-4
ISSN	2470-0053 ; 2470-0045
ISSN (online)	2470-0053
ISSN	2470-0045
DOI	10.1103/PhysRevE.106.024201
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