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  1. Book ; Online: Medicinal Plants for Cardiovascular and Neurodegenerative Aging-related Diseases: From Bench to Bedside

    Liu, Yue / Echeverria Moran, Valentina / Xu, Youhua / Xu, Youhua

    2020  

    Keywords Science: general issues ; Pharmacology ; medicinal plants ; aging ; age-related diseases ; cardiovascular disease ; neurodegenerative diseases
    Size 1 electronic resource (294 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230427
    ISBN 9782889661602 ; 2889661601
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: The extracellular matrix glycoprotein fibrillin-1 in health and disease.

    Li, Li / Huang, Junxin / Liu, Youhua

    Frontiers in cell and developmental biology

    2024  Volume 11, Page(s) 1302285

    Abstract: Fibrillin-1 (FBN1) is a large, cysteine-rich, calcium binding extracellular matrix glycoprotein encoded ... ...

    Abstract Fibrillin-1 (FBN1) is a large, cysteine-rich, calcium binding extracellular matrix glycoprotein encoded by
    Language English
    Publishing date 2024-01-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2023.1302285
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Commercial genetically modified corn and soybean are poised following pilot planting in China.

    Sun, Mei / Li, Suzhen / Yang, Wenzhu / Zhao, Bowen / Wang, Youhua / Liu, Xiaoqing

    Molecular plant

    2024  

    Language English
    Publishing date 2024-03-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2393618-6
    ISSN 1752-9867 ; 1674-2052
    ISSN (online) 1752-9867
    ISSN 1674-2052
    DOI 10.1016/j.molp.2024.03.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Animal Models of Type 2 Diabetes Complications: A Review.

    Sun, Zhongyan / Liu, Yadi / Zhao, Yonghua / Xu, Youhua

    Endocrine research

    2024  Volume 49, Issue 1, Page(s) 46–58

    Abstract: Diabetes mellitus is a multifactorial metabolic disease, of which type 2 diabetes (T2D) is one of the most common. The complications of diabetes are far more harmful than diabetes itself. Type 2 diabetes complications include diabetic nephropathy (DN), ... ...

    Abstract Diabetes mellitus is a multifactorial metabolic disease, of which type 2 diabetes (T2D) is one of the most common. The complications of diabetes are far more harmful than diabetes itself. Type 2 diabetes complications include diabetic nephropathy (DN), diabetic heart disease, diabetic foot ulcers (DFU), diabetic peripheral neuropathy (DPN), and diabetic retinopathy (DR)
    MeSH term(s) Animals ; Diabetes Mellitus, Type 2/complications ; Diabetic Foot/complications ; Diabetic Nephropathies/etiology ; Diabetic Nephropathies/metabolism ; Diabetic Neuropathies/etiology ; Diabetic Neuropathies/metabolism ; Diabetic Neuropathies/pathology ; Models, Animal ; Risk Factors
    Language English
    Publishing date 2024-01-04
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 605823-1
    ISSN 1532-4206 ; 0743-5800
    ISSN (online) 1532-4206
    ISSN 0743-5800
    DOI 10.1080/07435800.2023.2278049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The extracellular matrix glycoprotein fibrillin-1 in health and disease

    Li Li / Junxin Huang / Youhua Liu

    Frontiers in Cell and Developmental Biology, Vol

    2024  Volume 11

    Abstract: Fibrillin-1 (FBN1) is a large, cysteine-rich, calcium binding extracellular matrix glycoprotein encoded by FBN1 gene. It serves as a structural component of microfibrils and provides force-bearing mechanical support in elastic and nonelastic connective ... ...

    Abstract Fibrillin-1 (FBN1) is a large, cysteine-rich, calcium binding extracellular matrix glycoprotein encoded by FBN1 gene. It serves as a structural component of microfibrils and provides force-bearing mechanical support in elastic and nonelastic connective tissue. As such, mutations in the FBN1 gene can cause a wide variety of genetic diseases such as Marfan syndrome, an autosomal dominant disorder characterized by ocular, skeletal and cardiovascular abnormalities. FBN1 also interacts with numerous microfibril-associated proteins, growth factors and cell membrane receptors, thereby mediating a wide range of biological processes such as cell survival, proliferation, migration and differentiation. Dysregulation of FBN1 is involved in the pathogenesis of many human diseases, such as cancers, cardiovascular disorders and kidney diseases. Paradoxically, both depletion and overexpression of FBN1 upregulate the bioavailability and signal transduction of TGF-β via distinct mechanisms in different settings. In this review, we summarize the structure and expression of FBN1 and present our current understanding of the functional role of FBN1 in various human diseases. This knowledge will allow to develop better strategies for therapeutic intervention of FBN1 related diseases.
    Keywords FBN1 ; extracellular matrix ; marfan syndrome ; TGF-β ; chronic kidney diseases ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Animal Models of Kidney Disease: Challenges and Perspectives.

    Liang, Jianqing / Liu, Youhua

    Kidney360

    2023  Volume 4, Issue 10, Page(s) 1479–1493

    Abstract: Kidney disease is highly prevalent and affects approximately 850 million people worldwide. It is also associated with high morbidity and mortality, and current therapies are incurable and often ineffective. Animal models are indispensable for ... ...

    Abstract Kidney disease is highly prevalent and affects approximately 850 million people worldwide. It is also associated with high morbidity and mortality, and current therapies are incurable and often ineffective. Animal models are indispensable for understanding the pathophysiology of various kidney diseases and for preclinically testing novel remedies. In the last two decades, rodents continue to be the most used models for imitating human kidney diseases, largely because of the increasing availability of many unique genetically modified mice. Despite many limitations and pitfalls, animal models play an essential and irreplaceable role in gaining novel insights into the mechanisms, pathologies, and therapeutic targets of kidney disease. In this review, we highlight commonly used animal models of kidney diseases by focusing on experimental AKI, CKD, and diabetic kidney disease. We briefly summarize the pathological characteristics, advantages, and drawbacks of some widely used models. Emerging animal models such as mini pig, salamander, zebrafish, and drosophila, as well as human-derived kidney organoids and kidney-on-a-chip are also discussed. Undoubtedly, careful selection and utilization of appropriate animal models is of vital importance in deciphering the mechanisms underlying nephropathies and evaluating the efficacy of new treatment options. Such studies will provide a solid foundation for future diagnosis, prevention, and treatment of human kidney diseases.
    MeSH term(s) Swine ; Animals ; Mice ; Humans ; Zebrafish ; Swine, Miniature ; Kidney/pathology ; Models, Animal ; Diabetic Nephropathies ; Rodentia ; Drosophila
    Language English
    Publishing date 2023-08-01
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2641-7650
    ISSN (online) 2641-7650
    DOI 10.34067/KID.0000000000000227
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Klotho-derived peptide KP1 ameliorates SARS-CoV-2-associated acute kidney injury.

    Xu, Jie / Lin, Enqing / Hong, Xue / Li, Li / Gu, Jun / Zhao, Jinghong / Liu, Youhua

    Frontiers in pharmacology

    2024  Volume 14, Page(s) 1333389

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2024-01-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1333389
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Matrix Metalloproteinase-10 in Kidney Injury Repair and Disease

    Xiaoli Sun / Youhua Liu

    International Journal of Molecular Sciences, Vol 23, Iss 2131, p

    2022  Volume 2131

    Abstract: Matrix metalloproteinase-10 (MMP-10) is a zinc-dependent endopeptidase with the ability to degrade a broad spectrum of extracellular matrices and other protein substrates. The expression of MMP-10 is induced in acute kidney injury (AKI) and chronic ... ...

    Abstract Matrix metalloproteinase-10 (MMP-10) is a zinc-dependent endopeptidase with the ability to degrade a broad spectrum of extracellular matrices and other protein substrates. The expression of MMP-10 is induced in acute kidney injury (AKI) and chronic kidney disease (CKD), as well as in renal cell carcinoma (RCC). During the different stages of kidney injury, MMP-10 may exert distinct functions by cleaving various bioactive substrates including heparin-binding epidermal growth factor (HB-EGF), zonula occludens-1 (ZO-1), and pro-MMP-1, -7, -8, -9, -10, -13. Functionally, MMP-10 is reno-protective in AKI by promoting HB-EGF-mediated tubular repair and regeneration, whereas it aggravates podocyte dysfunction and proteinuria by disrupting glomerular filtration integrity via degrading ZO-1. MMP-10 is also involved in cancerous invasion and emerges as a promising therapeutic target in patients with RCC. As a secreted protein, MMP-10 could be detected in the circulation and presents an inverse correlation with renal function. Due to the structural similarities between MMP-10 and the other MMPs, development of specific inhibitors targeting MMP-10 is challenging. In this review, we summarize our current understanding of the role of MMP-10 in kidney diseases and discuss the potential mechanisms of its actions.
    Keywords MMP-10 ; acute kidney injury ; chronic kidney disease ; renal fibrosis ; proteinuria ; HB-EGF ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 616
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Cell-cell communication in kidney fibrosis.

    He, Meizhi / Liu, Zhao / Li, Li / Liu, Youhua

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2023  

    Abstract: Kidney fibrosis is a common outcome of a wide variety of chronic kidney diseases, in which virtually all kinds of renal resident and infiltrating cells are involved. As such, well-orchestrated intercellular communication is of vital importance in ... ...

    Abstract Kidney fibrosis is a common outcome of a wide variety of chronic kidney diseases, in which virtually all kinds of renal resident and infiltrating cells are involved. As such, well-orchestrated intercellular communication is of vital importance in coordinating complex actions during renal fibrogenesis. Cell-cell communication in multicellular organisms is traditionally assumed to be mediated by direct cell contact or soluble factors, including growth factors, cytokines and chemokines, through autocrine, paracrine, endocrine and juxtacrine signaling mechanisms. Growing evidence also demonstrates that extracellular vesicles, naturally released lipid bilayer-encircled particles from almost all types of cells, can act as a vehicle to transfer a diverse array of biomolecules including proteins, mRNA, miRNA and lipids to mediate cell-cell communication. We recently described a new mode of intercellular communication via building a special extracellular niche by insoluble matricellular proteins. Kidney cells, upon injury, produce and secrete different matricellular proteins, which incorporate into local extracellular matrix network, and regulate the behavior, trajectory and fate of neighboring cells in a spatially confined fashion. This extracellular niche-mediated cell-cell communication is unique in that it restrains the crosstalk between cells within a particular locality. Detailed delineation of this unique manner of intercellular communication will help to elucidate the mechanism of kidney fibrosis and could offer novel insights in developing therapeutic intervention.
    Language English
    Publishing date 2023-12-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfad257
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Matrix Metalloproteinase-10 in Kidney Injury Repair and Disease.

    Sun, Xiaoli / Liu, Youhua

    International journal of molecular sciences

    2022  Volume 23, Issue 4

    Abstract: Matrix metalloproteinase-10 (MMP-10) is a zinc-dependent endopeptidase with the ability to degrade a broad spectrum of extracellular matrices and other protein substrates. The expression of MMP-10 is induced in acute kidney injury (AKI) and chronic ... ...

    Abstract Matrix metalloproteinase-10 (MMP-10) is a zinc-dependent endopeptidase with the ability to degrade a broad spectrum of extracellular matrices and other protein substrates. The expression of MMP-10 is induced in acute kidney injury (AKI) and chronic kidney disease (CKD), as well as in renal cell carcinoma (RCC). During the different stages of kidney injury, MMP-10 may exert distinct functions by cleaving various bioactive substrates including heparin-binding epidermal growth factor (HB-EGF), zonula occludens-1 (ZO-1), and pro-MMP-1, -7, -8, -9, -10, -13. Functionally, MMP-10 is reno-protective in AKI by promoting HB-EGF-mediated tubular repair and regeneration, whereas it aggravates podocyte dysfunction and proteinuria by disrupting glomerular filtration integrity via degrading ZO-1. MMP-10 is also involved in cancerous invasion and emerges as a promising therapeutic target in patients with RCC. As a secreted protein, MMP-10 could be detected in the circulation and presents an inverse correlation with renal function. Due to the structural similarities between MMP-10 and the other MMPs, development of specific inhibitors targeting MMP-10 is challenging. In this review, we summarize our current understanding of the role of MMP-10 in kidney diseases and discuss the potential mechanisms of its actions.
    MeSH term(s) Acute Kidney Injury/metabolism ; Animals ; Humans ; Kidney/metabolism ; Matrix Metalloproteinase 10/metabolism ; Renal Insufficiency, Chronic/metabolism
    Chemical Substances Matrix Metalloproteinase 10 (EC 3.4.24.22)
    Language English
    Publishing date 2022-02-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23042131
    Database MEDical Literature Analysis and Retrieval System OnLINE

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