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  1. Article ; Online: The Current and Future State of Microbiome Therapeutics in Liver Disease.

    Bloom, Patricia P / Bajaj, Jasmohan S

    The American journal of gastroenterology

    2023  Volume 119, Issue 1S, Page(s) S36–S41

    MeSH term(s) Humans ; Microbiota ; Liver Diseases/therapy ; Digestive System Diseases
    Language English
    Publishing date 2023-12-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.14309/ajg.0000000000002581
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Weight to go!-Glucagon-like peptide 1 receptor agonists in liver transplant recipients.

    Shenoy, Abhishek / Bloom, Patricia P

    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

    2023  Volume 30, Issue 2, Page(s) 124–126

    MeSH term(s) Humans ; Liver Transplantation/adverse effects ; Diabetes Mellitus, Type 2 ; Glucagon-Like Peptide 1 ; Hypoglycemic Agents
    Chemical Substances Glucagon-Like Peptide 1 (89750-14-1) ; Hypoglycemic Agents
    Language English
    Publishing date 2023-10-30
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2006866-9
    ISSN 1527-6473 ; 1527-6465
    ISSN (online) 1527-6473
    ISSN 1527-6465
    DOI 10.1097/LVT.0000000000000291
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Lactulose in cirrhosis: Current understanding of efficacy, mechanism, and practical considerations.

    Bloom, Patricia P / Tapper, Elliot B

    Hepatology communications

    2023  Volume 7, Issue 11

    Abstract: HE is a complication of cirrhosis characterized by neuropsychiatric and motor dysfunction, and results in decreased quality of life and increased mortality. Lactulose is a synthetic disaccharide used to treat HE since 1966, though many questions about ... ...

    Abstract HE is a complication of cirrhosis characterized by neuropsychiatric and motor dysfunction, and results in decreased quality of life and increased mortality. Lactulose is a synthetic disaccharide used to treat HE since 1966, though many questions about its use remain unanswered. Lactulose reverses minimal HE, prevents overt HE, improves quality of life, increases the rate of recovery from overt HE, and improves survival rates. Lactulose's clinical effect appears to be derived from its impact on intestinal microbes, likely a result of its enteric acidifying effect, positive pressure on beneficial taxa, and improvement of gut barrier function. There are several practical considerations with lactulose including (1) a need to avoid excessive bowel movements and subsequent dehydration, (2) treatment titration protocols need further investigation, (3) baseline or treatment-induced gastrointestinal side effects limit adherence in some cases, and (4) the utility of monitoring stool consistency or pH remains unknown. Further research is needed to optimize our use of this effective treatment for HE.
    MeSH term(s) Humans ; Lactulose/therapeutic use ; Gastrointestinal Agents/adverse effects ; Hepatic Encephalopathy/drug therapy ; Quality of Life ; Liver Cirrhosis/complications
    Chemical Substances Lactulose (4618-18-2) ; Gastrointestinal Agents
    Language English
    Publishing date 2023-10-12
    Publishing country United States
    Document type Journal Article
    ISSN 2471-254X
    ISSN (online) 2471-254X
    DOI 10.1097/HC9.0000000000000295
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A Call to Action: Novel Ways that Hepatologists Can Contribute to Patient Care During the COVID-19 Pandemic.

    Bloom, Patricia P

    Digestive diseases and sciences

    2020  Volume 65, Issue 6, Page(s) 1557–1558

    MeSH term(s) COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/epidemiology ; Coronavirus Infections/therapy ; Gastroenterologists ; Humans ; Liver/metabolism ; Liver Transplantation ; Pandemics ; Patient Care ; Pneumonia, Viral/complications ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/therapy
    Keywords covid19
    Language English
    Publishing date 2020-04-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-020-06251-0
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  5. Article ; Online: Microbiome therapeutics for the treatment of recurrent

    Bloom, Patricia P / Young, Vincent B

    Expert opinion on biological therapy

    2022  Volume 23, Issue 1, Page(s) 89–101

    Abstract: Introduction: The gut microbiome is implicated in : Areas covered: This review covers the mechanisms by which microbiome therapeutics treat rCDI, their efficacy and safety, and clinical trial design considerations for future research.: Expert ... ...

    Abstract Introduction: The gut microbiome is implicated in
    Areas covered: This review covers the mechanisms by which microbiome therapeutics treat rCDI, their efficacy and safety, and clinical trial design considerations for future research.
    Expert opinion: Altering the chemical environment of the gut and reconstituting colonization resistance is a promising strategy for preventing and treating rCDI. Fecal microbiota transplant (FMT) is safe and effective for the treatment of rCDI. However, limitations of FMT have prompted investigation into alternative microbiome therapeutics. These alternative microbiome therapies require further evaluation, and adaptive trial designs should be strongly considered to more rapidly discern variables including the need for bowel preparation, timing and selection of pre-treatment antibiotics, and dose and duration of microbiome therapeutics. A broad range of adverse events must be prospectively evaluated in these controlled trials, as microbiome therapeutics have the potential for numerous effects. Future studies will lead to a greater understanding of the mechanisms by which microbiome therapies can break the cycle of rCDI, which should ultimately yield a personalized approach to rCDI treatment that restores an individual's specific deficit(s) in colonization resistance to
    MeSH term(s) Humans ; Clostridioides difficile ; Fecal Microbiota Transplantation/adverse effects ; Clostridium Infections/drug therapy ; Microbiota ; Anti-Bacterial Agents/adverse effects ; Treatment Outcome ; Recurrence
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2022-12-19
    Publishing country England
    Document type Review ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2052501-1
    ISSN 1744-7682 ; 1471-2598
    ISSN (online) 1744-7682
    ISSN 1471-2598
    DOI 10.1080/14712598.2022.2154600
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  6. Article: Incidental Hepatocellular Carcinoma Bony Metastasis in a Patient Listed for Liver Transplant.

    Levine, Jake W / Hawa, Fadi / Bloom, Patricia P

    ACG case reports journal

    2023  Volume 10, Issue 1, Page(s) e00967

    Abstract: A 67-year-old man with a history of alcohol and hepatitis C-associated cirrhosis is diagnosed with incidental metastatic liver cancer during hospitalization for hepatic encephalopathy. He had 2 LI-RADS-3 (indeterminant) lesions on liver magnetic ... ...

    Abstract A 67-year-old man with a history of alcohol and hepatitis C-associated cirrhosis is diagnosed with incidental metastatic liver cancer during hospitalization for hepatic encephalopathy. He had 2 LI-RADS-3 (indeterminant) lesions on liver magnetic resonance imaging 3 months prior but had no history of hepatocellular carcinoma and was listed for liver transplant. During inpatient paracentesis, the ascites fluid was bloody, so the abdominal and pelvic computed tomography was performed showing a lytic lesion in the left posterior inferior pubic rami. Alpha fetoprotein was within normal limits. His liver was imaged on several occasions without definite evidence of malignancy. Bone biopsy revealed metastatic hepatocellular carcinoma. On return to baseline mental status, patient endorsed no bony pain.
    Language English
    Publishing date 2023-01-27
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2814825-3
    ISSN 2326-3253
    ISSN 2326-3253
    DOI 10.14309/crj.0000000000000967
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: With Alcohol as the Fuel, COVID Is the Match: Liver Transplantation for Alcohol-Associated Liver Disease Is Increasing in the United States.

    Bloom, Patricia P / Fontana, Robert J

    Hepatology (Baltimore, Md.)

    2021  Volume 74, Issue 6, Page(s) 2948–2951

    MeSH term(s) COVID-19 ; Ethanol ; Humans ; Liver Diseases, Alcoholic ; Liver Transplantation ; SARS-CoV-2 ; United States
    Chemical Substances Ethanol (3K9958V90M)
    Language English
    Publishing date 2021-10-23
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1002/hep.32141
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  9. Article ; Online: A Call to Action

    Bloom, Patricia P.

    Digestive Diseases and Sciences

    Novel Ways that Hepatologists Can Contribute to Patient Care During the COVID-19 Pandemic

    2020  Volume 65, Issue 6, Page(s) 1557–1558

    Keywords Gastroenterology ; Physiology ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-020-06251-0
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  10. Article ; Online: Reply.

    Bloom, Patricia P / Chung, Raymond T

    Hepatology (Baltimore, Md.)

    2020  Volume 73, Issue 2, Page(s) 875–876

    Keywords covid19
    Language English
    Publishing date 2020-07-21
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1002/hep.31510
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