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  1. Book ; Online ; E-Book: Beatmung

    Larsen, Reinhard / Mathes, Alexander

    Indikationen - Techniken - Krankheitsbilder

    2023  

    Abstract: ... Intensivmedizin an den Universitätskliniken des Saarlandes, Homburg/Saar Prof. Dr. med. Alexander Mathes, DESA, LL ... M. ist leitender Oberarzt an der Klinik für Anästhesiologie und Operative Intensivmedizin ...

    Author's details Reinhard Larsen, Alexander Mathes
    Abstract Gewusst wie und warum! Mit diesem Buch lernen Sie die Prinzipien der Beatmungstherapie grundlegend kennen: Vom richtigen Zeitpunkt der Indikation über die Wahl des Beatmungsverfahrens bis hin zur Entwöhnung. Umfassend überarbeitet und aktualisiert finden Ärzte und Pflegekräfte auf Intensivstationen und im OP Antworten auf praxisrelevante Fragen. Der übersichtliche Aufbau, die klare Sprache und konkrete Hinweise auf die klinische Praxis zeichnen dieses Nachschlagewerk besonders aus. Einstiegsfragen zu den Grundlagenkapiteln erleichtern die Vertiefung von anatomischen, physiologischen und pathophysiologischen Themen. Aus dem Inhalt Formen der respiratorischen Insuffizienz und indikationsgerechter Beginn der Beatmung Nicht-invasive Beatmung, moderne Grund- und Spezialverfahren der Beatmung und ihre Alternativen Entwöhnung, intra- und postoperative Beatmung sowie Beatmung bei speziellen Krankheitsbildern Extrakorporale Lungenunterstützung, Beatmung am Lebensende Neu: Beatmung bei virusbedingten Pneumonien (incl. Covid-19), Beatmung bei Kapazitätsengpässen Dieses Standardwerk der Beatmungsmedizin bereitet Sie umfassend auf den klinischen Alltag vor! Die Autoren Prof. Dr. med. Reinhard Larsen ist ehemaliger Direktor der Klinik für Anästhesiologie und Intensivmedizin an den Universitätskliniken des Saarlandes, Homburg/Saar Prof. Dr. med. Alexander Mathes, DESA, LL.M. ist leitender Oberarzt an der Klinik für Anästhesiologie und Operative Intensivmedizin am Universitätsklinikum Köln sowie Magister der Rechte für Medizinrecht.
    Keywords Critical care medicine ; Anesthesiology ; Nursing ; Neurology ; Internal medicine
    Language German
    Size 1 Online-Ressource (XIII, 614 Seiten), Illustrationen, Diagramme
    Edition 7. Auflage
    Publisher Springer
    Publishing place Berlin
    Publishing country Germany
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT030026183
    ISBN 978-3-662-64536-9 ; 9783662645352 ; 3-662-64536-X ; 3662645351
    DOI 10.1007/978-3-662-64536-9
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; E-Book: Pocket Guide Beatmung

    Larsen, Reinhard / Mathes, Alexander

    2021  

    Author's details Reinhard Larsen, Alexander Mathes
    Language German
    Size 1 Online-Ressource (XII, 345 Seiten), Illustrationen, Diagramme
    Edition 4., überarbeitete Auflage
    Publisher Springer
    Publishing place Berlin
    Publishing country Germany
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021206317
    ISBN 978-3-662-63440-0 ; 9783662634394 ; 3-662-63440-6 ; 3662634392
    DOI 10.1007/978-3-662-63440-0
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online ; Thesis: Erweiterte Evaluation der Effektivität eines proaktiven forcierten Oszillationstechnik-basierten Auto-CPAP-Algorithmus

    Herkenrath, Simon Dominik / Randerath, Winfried J. / Mathes, Alexander

    2020  

    Institution Universitätsklinikum Köln / Klinik und Poliklinik für Kardiologie, Pneumologie, Angiologie und Internistische Intensivmedizin
    Author's details vorgelegt von Simon Dominik Herkenrath ; 1. Gutachter: Professor Dr. med. W. Randerath, 2. Gutachter: Professor Dr. med. A. Mathes ; aus dem Zentrum für Innere Medizin der Universität zu Köln, Klinik und Poliklinik für Innere Medizin III Kardiologie
    Subject code 610
    Language German ; English
    Size 1 Online-Ressource (74 Seiten), Illustrationen, Diagramme
    Publishing place Köln
    Publishing country Germany
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität zu Köln, 2020
    Note Enthält Reprint aus Zeitschrift in englischer Sprache ; Open Access
    HBZ-ID HT020572625
    DOI 10.4126/FRL01-006422926
    Database Repository for Life Sciences

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  4. Book ; Thesis: Erweiterte Evaluation der Effektivität eines proaktiven forcierten Oszillationstechnik-basierten Auto-CPAP-Algorithmus

    Herkenrath, Simon Dominik / Randerath, Winfried J. / Mathes, Alexander

    2020  

    Institution Universitätsklinikum Köln / Klinik und Poliklinik für Kardiologie, Pneumologie, Angiologie und Internistische Intensivmedizin
    Author's details vorgelegt von Simon Dominik Herkenrath ; 1. Gutachter: Professor Dr. med. W. Randerath, 2. Gutachter: Professor Dr. med. A. Mathes ; aus dem Zentrum für Innere Medizin der Universität zu Köln, Klinik und Poliklinik für Innere Medizin III Kardiologie
    Subject code 610
    Language German ; English
    Size 78 Seiten, Illustrationen, Diagramme
    Publishing place Köln
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität zu Köln, 2020
    Note Enthält Reprint aus Zeitschrift in englischer Sprache
    HBZ-ID HT020659280
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2020 D 843 order for loan Magazin

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  5. Book ; Online ; E-Book: Beatmung

    Larsen, Reinhard / Ziegenfuß, Thomas / Mathes, Alexander

    Indikationen - Techniken - Krankheitsbilder

    2018  

    Abstract: Klar strukturiert, verständlich geschrieben und einprägsam bebildert, vermittelt der Band Grundlagen und Praxis der Beatmung: von der Physiologie der Atmung, Formen der respiratorischen Insuffizienz, Indikationen und Kontraindikationen bis zu modernen ... ...

    Author's details Reinhard Larsen, Thomas Ziegenfuß, Alexander Mathes
    Abstract Klar strukturiert, verständlich geschrieben und einprägsam bebildert, vermittelt der Band Grundlagen und Praxis der Beatmung: von der Physiologie der Atmung, Formen der respiratorischen Insuffizienz, Indikationen und Kontraindikationen bis zu modernen Beatmungsverfahren. Alle Informationen sind so ausführlich wie nötig und so stringent wie möglich dargestellt, so dass Ärzte und Pflegende rasch Antworten auf klinische Fragestellungen finden. Für die 5. Auflage wurden alle Kapitel überarbeitet und um Fragen zur Überprüfung des Fachwissens ergänzt.
    Language German
    Size 1 Online-Ressource (IX, 525 Seiten), 125 Illustrationen, Diagramme
    Edition 6., vollständig überarbeitete und aktualisierte Auflage
    Publisher Springer
    Publishing place Berlin
    Publishing country Germany
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019521700
    ISBN 978-3-662-54853-0 ; 9783662548523 ; 3-662-54853-4 ; 3662548526
    DOI 10.1007/978-3-662-54853-0
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  6. Article ; Online: Hepatoprotective actions of melatonin: possible mediation by melatonin receptors.

    Mathes, Alexander M

    World journal of gastroenterology

    2010  Volume 16, Issue 48, Page(s) 6087–6097

    Abstract: Melatonin, the hormone of darkness and messenger of the photoperiod, is also well known to exhibit strong direct and indirect antioxidant properties. Melatonin has previously been demonstrated to be a powerful organ protective substance in numerous ... ...

    Abstract Melatonin, the hormone of darkness and messenger of the photoperiod, is also well known to exhibit strong direct and indirect antioxidant properties. Melatonin has previously been demonstrated to be a powerful organ protective substance in numerous models of injury; these beneficial effects have been attributed to the hormone's intense radical scavenging capacity. The present report reviews the hepatoprotective potential of the pineal hormone in various models of oxidative stress in vivo, and summarizes the extensive literature showing that melatonin may be a suitable experimental substance to reduce liver damage after sepsis, hemorrhagic shock, ischemia/reperfusion, and in numerous models of toxic liver injury. Melatonin's influence on hepatic antioxidant enzymes and other potentially relevant pathways, such as nitric oxide signaling, hepatic cytokine and heat shock protein expression, are evaluated. Based on recent literature demonstrating the functional relevance of melatonin receptor activation for hepatic organ protection, this article finally suggests that melatonin receptors could mediate the hepatoprotective actions of melatonin therapy.
    MeSH term(s) Animals ; Antioxidants/metabolism ; Cytokines/metabolism ; Disease Models, Animal ; Humans ; Liver/metabolism ; Melatonin/metabolism ; Oxidative Stress ; Receptors, Melatonin/metabolism ; Shock, Hemorrhagic/pathology ; Shock, Hemorrhagic/physiopathology ; Signal Transduction/physiology
    Chemical Substances Antioxidants ; Cytokines ; Receptors, Melatonin ; Melatonin (JL5DK93RCL)
    Language English
    Publishing date 2010-12-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v16.i48.6087
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6039: Show issues Location:
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  7. Article ; Online: Intravenous propofol, ketamine (ketofol) and rocuronium after sevoflurane induction provides long lasting anesthesia in ventilated rats.

    Kiefer, Daniel / Müller-Wirtz, Lukas M / Maurer, Felix / Hüppe, Tobias / Mathes, Alexander M / Volk, Thomas / Kreuer, Sascha / Fink, Tobias

    Experimental animals

    2021  Volume 71, Issue 2, Page(s) 231–239

    Abstract: Rats are commonly used animals for laboratory experiments and many experiments require general anesthesia. However, the lack of published and reproducible intravenous anesthesia protocols for rats results in unnecessary animal use to establish new ... ...

    Abstract Rats are commonly used animals for laboratory experiments and many experiments require general anesthesia. However, the lack of published and reproducible intravenous anesthesia protocols for rats results in unnecessary animal use to establish new anesthesia techniques across institutions. We therefore developed an anesthesia protocol with propofol, ketamine, and rocuronium for mechanically ventilated rats, and evaluated vital parameters and plasma concentrations. 15 male Sprague-Dawley rats underwent inhalation induction with sevoflurane and tracheal, venous and arterial cannulation. After established venous access, sevoflurane was substituted by propofol and ketamine (ketofol). Rocuronium was added under mechanical ventilation for 7 h. Drug dosages were stepwise reduced to prevent accumulation. All animals survived the observation period and showed adequate depth of anesthesia. Mean arterial pressure and heart rate remained within normal ranges. Median propofol plasma concentrations remained stable: 1, 4, 7 h: 2.0 (interquartile range (IQR): 1.8-2.2), 2.1 (1.8-2.2), 1.8 (1.6-2.1) µg/ml, whereas median ketamine concentrations slightly differed after 7 h compared to 1 h: 1, 4, 7 h: 3.7 (IQR: 3.5-4.5), 3.8 (3.3-4.1), 3.8 (3.0-4.1) µg/ml. Median rocuronium plasma concentrations were lower after 4 and 7 h compared to 1 h: 1, 4, 7 h: 3.9 (IQR: 3.5-4.9), 3.2 (2.7-3.3), 3.0 (2.4-3.4) µg/ml. Our anesthesia protocol provides stable and reliable anesthesia in mechanically ventilated rats for several hours.
    MeSH term(s) Anesthesia, General ; Anesthesia, Intravenous ; Anesthetics, Inhalation/pharmacology ; Anesthetics, Intravenous/pharmacology ; Animals ; Ketamine ; Male ; Methyl Ethers/pharmacology ; Propofol/pharmacology ; Rats ; Rats, Sprague-Dawley ; Rocuronium ; Sevoflurane
    Chemical Substances Anesthetics, Inhalation ; Anesthetics, Intravenous ; Methyl Ethers ; Sevoflurane (38LVP0K73A) ; Ketamine (690G0D6V8H) ; Rocuronium (WRE554RFEZ) ; Propofol (YI7VU623SF)
    Language English
    Publishing date 2021-12-08
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2088228-2
    ISSN 1881-7122 ; 1341-1357 ; 0007-5124
    ISSN (online) 1881-7122
    ISSN 1341-1357 ; 0007-5124
    DOI 10.1538/expanim.21-0147
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 1653: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Influence of Short and Long Hyperglycemia on Cardioprotection by Remote Ischemic Preconditioning-A Translational Approach.

    Feige, Katharina / Roth, Sebastian / M'Pembele, René / Galow, Anna / Koenig, Sarah / Stroethoff, Martin / Raupach, Annika / Lurati Buse, Giovanna / Mathes, Alexander M / Hollmann, Markus W / Huhn, Ragnar / Torregroza, Carolin

    International journal of molecular sciences

    2022  Volume 23, Issue 23

    Abstract: The adverse impact of common diseases like diabetes mellitus and acute hyperglycemia on morbidity and mortality from myocardial infarction (MI) has been well documented over the past years of research. In the clinical setting, the relationship between ... ...

    Abstract The adverse impact of common diseases like diabetes mellitus and acute hyperglycemia on morbidity and mortality from myocardial infarction (MI) has been well documented over the past years of research. In the clinical setting, the relationship between blood glucose and mortality appears linear, with amplifying risk associated with increasing blood glucose levels. Further, this seems to be independent of a diagnosis of diabetes. In the experimental setting, various comorbidities seem to impact ischemic and pharmacological conditioning strategies, protecting the heart against ischemia and reperfusion injury. In this translational experimental approach from bedside to bench, we set out to determine whether acute and/or prolonged hyperglycemia have an influence on the protective effect of transferred human RIPC-plasma and, therefore, might obstruct translation into the clinical setting. Control and RIPC plasma of young healthy men were transferred to isolated hearts of young male Wistar rats in vitro. Plasma was administered before global ischemia under either short hyperglycemic (HGs Con, HGs RIPC) conditions, prolonged hyperglycemia (HGl Con, HGl RIPC), or under normoglycemia (Con, RIPC). Infarct sizes were determined by TTC staining. Control hearts showed an infarct size of 55 ± 7%. Preconditioning with transferred RIPC plasma under normoglycemia significantly reduced infarct size to 25 ± 4% (p < 0.05 vs. Con). Under acute hyperglycemia, control hearts showed an infarct size of 63 ± 5%. Applying RIPC plasma under short hyperglycemic conditions led to a significant infarct size reduction of 41 ± 4% (p < 0.05 vs. HGs Con). However, the cardioprotective effect of RIPC plasma under normoglycemia was significantly stronger compared with acute hyperglycemic conditions (RIPC vs. HGs RIPC; p < 0.05). Prolonged hyperglycemia (HGl RIPC) completely abolished the cardioprotective effect of RIPC plasma (infarct size 60 ± 7%; p < 0.05 vs. HGl Con; HGl Con 59 ± 5%).
    MeSH term(s) Rats ; Animals ; Male ; Humans ; Myocardial Reperfusion Injury/prevention & control ; Blood Glucose ; Rats, Wistar ; Ischemic Preconditioning ; Myocardial Infarction/prevention & control ; Hyperglycemia/complications ; Ischemic Preconditioning, Myocardial
    Chemical Substances Blood Glucose
    Language English
    Publishing date 2022-11-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms232314557
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  9. Article: Depth of Neuromuscular Block Is Not Associated with Abdominal Wall Distention or Surgical Conditions during Gynecologic Laparoscopic Operations. A Prospective Trial.

    Soltesz, Stefan / Mathes, Alexander / Anapolski, Michael / Noé, Karl Guenter

    Journal of clinical medicine

    2020  Volume 9, Issue 4

    Abstract: The influence of the degree of a neuromuscular block (NMB) on surgical operating conditions during laparoscopic surgery is debated controversially. The extent of abdominal distension during the time course of the NMB was assessed as a new measurement ... ...

    Abstract The influence of the degree of a neuromuscular block (NMB) on surgical operating conditions during laparoscopic surgery is debated controversially. The extent of abdominal distension during the time course of the NMB was assessed as a new measurement tool. In 60 patients scheduled for gynecologic laparoscopic surgery, the increase of the abdominal wall length induced by the capnoperitoneum was measured at 5 degrees of the NMB: intense NMB-post-tetanic count (PTC) = 0; deep NMB-train-of-four count (TOF) = 0 and PTC = 1-5; medium NMB-PTC > 5 and TOF = 0-1; shallow NMB-TOF > 1; full recovery-train-of-four ratio TOFR > 90%. Simultaneously, the quality of operating conditions was assessed with a standardized rating scale (SRS) reaching from 1 (extremely poor conditions) to 5 (excellent conditions). Fifty patients could be included in the analysis. The abdominal wall length increased by 10-13 mm induced by the capnoperitoneum. SRS was higher during intense NMB (4.7 ± 0.5) vs. full recovery (4.5 ± 0.5) (mean ± SD;
    Language English
    Publishing date 2020-04-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm9041078
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  10. Article: Endogenous and Exogenous Melatonin Exposure Attenuates Hepatic MT

    Mathes, Alexander M / Heymann, Paul / Ruf, Christian / Huhn, Ragnar / Hinkelbein, Jochen / Volk, Thomas / Fink, Tobias

    Antioxidants (Basel, Switzerland)

    2019  Volume 8, Issue 9

    Abstract: Melatonin receptors are highly relevant for the hepatoprotective effects of the pineal hormone melatonin after experimental hemorrhagic shock in rats. In this study, we sought to determine the spatial expression pattern and a putative regulation of two ... ...

    Abstract Melatonin receptors are highly relevant for the hepatoprotective effects of the pineal hormone melatonin after experimental hemorrhagic shock in rats. In this study, we sought to determine the spatial expression pattern and a putative regulation of two melatonin receptors, membrane bound type 1 and 2 (MT
    Language English
    Publishing date 2019-09-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox8090408
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