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Article ; Online: NKNK: a New Essential Motif in the C-Terminal Domain of HIV-1 Group M Integrases.

Kanja, Marine / Cappy, Pierre / Levy, Nicolas / Oladosu, Oyndamola / Schmidt, Sylvie / Rossolillo, Paola / Winter, Flore / Gasser, Romain / Moog, Christiane / Ruff, Marc / Negroni, Matteo / Lener, Daniela

Journal of virology

2020 Volume 94, Issue 20

Abstract: ... related isolates, one from the main group M and the other from the minor group O of HIV-1, we identify ...

Abstract	Using coevolution network interference based on comparison of two phylogenetically distantly related isolates, one from the main group M and the other from the minor group O of HIV-1, we identify, in the C-terminal domain (CTD) of integrase, a new functional motif constituted by four noncontiguous amino acids (N
MeSH term(s)	Amino Acid Motifs ; Cell Line, Tumor ; HEK293 Cells ; HIV Integrase/chemistry ; HIV Integrase/genetics ; HIV-1/chemistry ; HIV-1/genetics ; Humans ; Protein Domains
Chemical Substances	HIV Integrase (EC 2.7.7.-)
Language	English
Publishing date	2020-09-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/JVI.01035-20
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Zs.A 609: Show issues

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Article ; Online: Ronald M. Burde (1938–2015).

Levy, Marc H / Slamovits, Thomas L

Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society

2016 Volume 35, Issue 4, Page(s) 333–334

MeSH term(s)	Aged ; History, 20th Century ; History, 21st Century ; Humans ; Male ; Neurology/history ; Ophthalmology/history
Language	English
Publishing date	2016-02-18
Publishing country	United States
Document type	Biography ; Historical Article ; Journal Article ; Portrait
ZDB-ID	1189901-3
ISSN	1536-5166 ; 1070-8022
ISSN (online)	1536-5166
ISSN	1070-8022
DOI	10.1097/wno.0000000000000320
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Zs.A 1670: Show issues

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Article ; Online: Response to Letter to the Editor from Justin M. Gregory: "Age and Hospitalization Risk in People With Type 1 Diabetes and COVID-19: Data From the T1D Exchange Surveillance Study".

Demeterco-Berggren, Carla / Ebekozien, Osagie / Levy, Carol J / Maahs, David M

The Journal of clinical endocrinology and metabolism

2021 Volume 107, Issue 4, Page(s) e1769–e1770

MeSH term(s)	COVID-19 ; Diabetes Mellitus, Type 1/epidemiology ; Diabetes Mellitus, Type 1/therapy ; Hospitalization ; Humans ; SARS-CoV-2
Language	English
Publishing date	2021-12-06
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/clinem/dgab872
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Uh III Zs.134: Show issues

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Article ; Online: Carfilzomib weekly 20/56 mg/m

Richez, Valentine / Gruchet, Cecile / Guidez, Stephanie / Fouquet, Guillemette / Azais, Isabelle / Durand, Geraldine / Javaugue, Vincent / Brigaud, Antoine / Plasse, Florent / Diolez, Jéremie / Machet, Antoine / Moya, Niels / Gardeney, Helene / Franques, Paul / Bobin, Arthur / Levy, Anthony / Sabirou, Florence / Bonnin, Anthony / Dieval, Celine /

Primault, Sylvain / Barrier, Jocelyn / Fleck, Emmanuel / Bouyier, Sabrina / Daras, Claire / Princet, Isabelle / Bauwens, Delphine / Legros, Laurence / Fuzibet, Jean-Gabriel / Gil, Angela / Bridoux, Frank / Avet-Loiseau, Hervé / Leleu, Xavier

American journal of hematology

2018 Volume 94, Issue 1, Page(s) E17–E20

MeSH term(s)	Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Dexamethasone/administration & dosage ; Drug Administration Schedule ; Female ; Humans ; Kaplan-Meier Estimate ; Lenalidomide/administration & dosage ; Male ; Middle Aged ; Multiple Myeloma/drug therapy ; Oligopeptides/administration & dosage ; Progression-Free Survival ; Recurrence ; Salvage Therapy
Chemical Substances	Oligopeptides ; carfilzomib (72X6E3J5AR) ; Dexamethasone (7S5I7G3JQL) ; Lenalidomide (F0P408N6V4)
Language	English
Publishing date	2018-11-25
Publishing country	United States
Document type	Letter
ZDB-ID	196767-8
ISSN	1096-8652 ; 0361-8609
ISSN (online)	1096-8652
ISSN	0361-8609
DOI	10.1002/ajh.25327
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Zs.A 1251: Show issues

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Article ; Online: The interplays between Crimean-Congo hemorrhagic fever virus (CCHFV) M segment-encoded accessory proteins and structural proteins promote virus assembly and infectivity.

Freitas, Natalia / Enguehard, Margot / Denolly, Solène / Levy, Camille / Neveu, Gregory / Lerolle, Solène / Devignot, Stephanie / Weber, Friedemann / Bergeron, Eric / Legros, Vincent / Cosset, François-Loïc

PLoS pathogens

2020 Volume 16, Issue 9, Page(s) e1008850

Abstract: ... a serious threat to the public health. CCHFV has a single-stranded, tripartite RNA genome composed of L, M ... and S segments. Cleavage of the M polyprotein precursor generates the two envelope glycoproteins (GPs ... we examined the relevance of each M-segment non-structural proteins in virus assembly, egress and infectivity ...

Abstract	Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne orthonairovirus that has become a serious threat to the public health. CCHFV has a single-stranded, tripartite RNA genome composed of L, M, and S segments. Cleavage of the M polyprotein precursor generates the two envelope glycoproteins (GPs) as well as three secreted nonstructural proteins GP38 and GP85 or GP160, representing GP38 only or GP38 linked to a mucin-like protein (MLD), and a double-membrane-spanning protein called NSm. Here, we examined the relevance of each M-segment non-structural proteins in virus assembly, egress and infectivity using a well-established CCHFV virus-like-particle system (tc-VLP). Deletion of MLD protein had no impact on infectivity although it reduced by 60% incorporation of GPs into particles. Additional deletion of GP38 abolished production of infectious tc-VLPs. The loss of infectivity was associated with impaired Gc maturation and exclusion from the Golgi, showing that Gn is not sufficient to target CCHFV GPs to the site of assembly. Consistent with this, efficient complementation was achieved in cells expressing MLD-GP38 in trans with increased levels of preGc to Gc conversion, co-targeting to the Golgi, resulting in particle incorporation and restored infectivity. Contrastingly, a MLD-GP38 variant retained in the ER allowed preGc cleavage but failed to rescue miss-localization or infectivity. NSm deletion, conversely, did not affect trafficking of Gc but interfered with Gc processing, particle formation and secretion. NSm expression affected N-glycosylation of different viral proteins most likely due to increased speed of trafficking through the secretory pathway. This highlights a potential role of NSm in overcoming Golgi retention and facilitating CCHFV egress. Thus, deletions of GP38 or NSm demonstrate their important role on CCHFV particle production and infectivity. GP85 is an essential viral factor for preGc cleavage, trafficking and Gc incorporation into particles, whereas NSm protein is involved in CCHFV assembly and virion secretion.
MeSH term(s)	Cell Line, Tumor ; Gene Deletion ; Hemorrhagic Fever Virus, Crimean-Congo/physiology ; Humans ; Viral Structural Proteins/genetics ; Viral Structural Proteins/metabolism ; Virus Assembly
Chemical Substances	Viral Structural Proteins
Language	English
Publishing date	2020-09-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2205412-1
ISSN	1553-7374 ; 1553-7366
ISSN (online)	1553-7374
ISSN	1553-7366
DOI	10.1371/journal.ppat.1008850
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Article ; Online: Normative Left Ventricular M-Mode Echocardiographic Values in Preterm Infants up to 2 kg.

Choudhry, Swati / Salter, Amber / Cunningham, Tyler W / Levy, Philip T / Nguyen, Hoang H / Wallendorf, Michael / Singh, Gautam K / Johnson, Mark C

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography

2017 Volume 30, Issue 8, Page(s) 781–789.e4

Abstract: ... The objectives of this study were to (1) derive left ventricular (LV) M-mode reference values and (2) compare ... In this retrospective study, LV M-mode echocardiographic measurements of end-diastolic interventricular septal thickness, end ... From this large cohort of preterm infants, LV M-mode dimension and LVM centile curves indexed to weight were ...

Abstract	Background: There is a paucity of normative echocardiographic data in preterm infants. The objectives of this study were to (1) derive left ventricular (LV) M-mode reference values and (2) compare the performance of alternative methods of indexing LV dimensions and LV mass (LVM) in preterm infants. The authors propose that indexing LV measures to weight in preterm infants is a practical approach given the variability associated with tape-measure length measurement in infants. Methods: In this retrospective study, LV M-mode echocardiographic measurements of end-diastolic interventricular septal thickness, end-diastolic LV posterior wall thickness, LV end-diastolic and end-systolic dimensions, LVM, and relative wall thickness were remeasured in 503 hospitalized preterm infants ≤2 kg (372 from a retrospective sample and 131 prospectively enrolled). Measures for all variables did not differ between retrospective and prospective samples, so results were pooled. LV dimensions and LVM indexed for weight, length, and body surface area sex-specific centile curves and corresponding Z scores were generated using Cole's lambda-mu-sigma method. Threshold limits (10th and 80th percentiles) were used to generate the normative range for relative wall thickness. Results: Sex-specific centile curves using LVM, end-diastolic interventricular septal thickness, end-diastolic LV posterior wall thickness, LV end-diastolic dimension, and LV end-systolic dimension indexed to weight were similar to the curves generated using length and body surface area. The mean normal range for relative wall thickness was 0.33 (10th percentile, 0.26; 80th percentile, 0.38). Conclusions: From this large cohort of preterm infants, LV M-mode dimension and LVM centile curves indexed to weight were developed as a practical method to assess LV morphology in preterm infants.
MeSH term(s)	Echocardiography/methods ; Female ; Follow-Up Studies ; Gestational Age ; Heart Defects, Congenital/diagnosis ; Heart Defects, Congenital/physiopathology ; Heart Ventricles/diagnostic imaging ; Humans ; Infant, Low Birth Weight ; Infant, Newborn ; Infant, Premature ; Male ; Prospective Studies ; Reference Values ; Retrospective Studies ; Ventricular Function, Left/physiology
Language	English
Publishing date	2017-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	1035622-8
ISSN	1097-6795 ; 0894-7317
ISSN (online)	1097-6795
ISSN	0894-7317
DOI	10.1016/j.echo.2017.04.010
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Zs.A 2638: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 55: Show issues

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Article ; Online: Independent Host Factors and Bacterial Genetic Determinants of the Emergence and Dominance of Escherichia coli Sequence Type 131 CTX-M-27 in a Community Pediatric Cohort Study.

Birgy, André / Levy, Corinne / Nicolas-Chanoine, Marie-Hélène / Cointe, Aurélie / Hobson, Claire A / Magnan, Mélanie / Bechet, Stéphane / Bidet, Philippe / Cohen, Robert / Bonacorsi, Stéphane

Antimicrobial agents and chemotherapy

2019 Volume 63, Issue 7

Abstract: The recent emergence and diffusion in the community ... ...

Abstract	The recent emergence and diffusion in the community of
MeSH term(s)	Adhesins, Escherichia coli/genetics ; Bacteriocins/genetics ; Child, Preschool ; Cohort Studies ; Drug Resistance, Bacterial/genetics ; Escherichia coli/drug effects ; Escherichia coli/genetics ; Escherichia coli/isolation & purification ; Escherichia coli Infections/microbiology ; Escherichia coli Proteins/genetics ; Feces/microbiology ; Fimbriae Proteins/genetics ; France ; Host-Pathogen Interactions/genetics ; Humans ; Infant ; Life Style ; Phylogeny ; Plasmids/genetics ; Virulence Factors/genetics ; Whole Genome Sequencing ; beta-Lactamases/genetics
Chemical Substances	Adhesins, Escherichia coli ; Bacteriocins ; Escherichia coli Proteins ; Virulence Factors ; fimH protein, E coli ; Fimbriae Proteins (147680-16-8) ; CTX-M-27, E coli (EC 3.5.2.-) ; beta-Lactamases (EC 3.5.2.6)
Language	English
Publishing date	2019-06-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	217602-6
ISSN	1098-6596 ; 0066-4804
ISSN (online)	1098-6596
ISSN	0066-4804
DOI	10.1128/AAC.00382-19
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Zs.A 809: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Einzelsignatur: Show issues

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Article ; Online: Is Exercise the Best Medicine during a COVID-19 Pandemic? Comment on Constandt, B.; Thibaut, E.; De Bosscher, V.; Scheerder, J.; Ricour, M.; Willem, A. Exercising in Times of Lockdown: An Analysis of the Impact of COVID-19 on Levels and Patterns of Exercise among Adults in Belgium.

Hew-Butler, Tamara / Smith-Hale, Valerie / Van Sumeren, Matthew / Sabourin, Jordan / Levy, Phillip

International journal of environmental research and public health

2020 Volume 17, Issue 16

Abstract: From Constandt et al.'s survey of 13,515 Belgium respondents, regular physical activity can be successfully initiated and sustained during a lockdown, with appropriate social distancing measures. Documentation that 77% of highly active people and 58% of ... ...

Abstract	From Constandt et al.'s survey of 13,515 Belgium respondents, regular physical activity can be successfully initiated and sustained during a lockdown, with appropriate social distancing measures. Documentation that 77% of highly active people and 58% of low active people exercised as much or more following the institution of a nationwide lockdown was impressive, given that the cases of COVID-19 were accelerating at that time. The Belgian government's central promotion of exercise, to boost both the mental and physical health of the population, likely contributed to the health, tolerance, and ultimate success of lockdown. In this commentary, we wish to pose a follow-up query which highlights the potential detrimental effects of intense exercise (competition) performed without social distancing measures. The proposed graphical abstract elucidates these possible risks, in contrast to the favorable results outlined in Constandt et al.'s study.
MeSH term(s)	Adult ; Belgium ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Humans ; Pandemics ; Pneumonia, Viral ; Public Health ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-08-08
Publishing country	Switzerland
Document type	Journal Article ; Comment
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph17165730
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Article ; Online: Genomic analysis of a Kpi (pilus system)-positive and CTX-M-15-producing Klebsiella pneumoniae belonging to the high-risk clone ST15 isolated from an impacted river in Brazil.

Cardoso, Brenda / Esposito, Fernanda / Fontana, Herrison / Fuga, Bruna / Moura, Quézia / Sano, Elder / Sato, Maria I Z / Brandão, Carlos J / Oliveira, Flavio A / Levy, Carlos E / Lincopan, Nilton

Genomics

2021 Volume 114, Issue 1, Page(s) 378–383

Abstract: ... worldwide. A multidrug-resistant CTX-M-15-producing K. pneumoniae (TIES-4900 strain) was isolated ...

Abstract	Convergence of resistance and virulence in Klebsiella pneumoniae is a critical public health issue worldwide. A multidrug-resistant CTX-M-15-producing K. pneumoniae (TIES-4900 strain) was isolated from a highly impacted urban river, in Brazil. The genome was sequenced by MiSeq Illumina platform and de novo assembled using Unicycler. In silico prediction was accomplished by bioinformatics tools. The size of the genome is 5.4 Mb with 5145 protein-coding genes. TIES-4900 strain belonged to the sequence type ST15, yersiniabactin sequence type YbST10, ICEKp4, KL24 (wzi-24) and O1v1 locus. Phylogenomics confirmed genomic relatedness with ST15 clones from human and animal hosts. Convergence of broad resistome (antibiotics, heavy-metals and biocides) and virulome, including the Kpi pilus system involved in host-pathogen interaction and persistence of ST15 clone to hospital environments, were predicted. Virulent behavior was confirmed in the Galleria mellonella infection model. This study may give genomic insights on the spread of critical-priority WHO pathogens beyond hospital settings.
MeSH term(s)	Animals ; Anti-Bacterial Agents/pharmacology ; Brazil ; Clone Cells ; Drug Resistance, Multiple, Bacterial/genetics ; Genomics ; Klebsiella Infections ; Klebsiella pneumoniae ; Rivers ; beta-Lactamases/genetics
Chemical Substances	Anti-Bacterial Agents ; beta-Lactamases (EC 3.5.2.6)
Language	English
Publishing date	2021-12-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	356334-0
ISSN	1089-8646 ; 0888-7543
ISSN (online)	1089-8646
ISSN	0888-7543
DOI	10.1016/j.ygeno.2021.12.007
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Zs.A 2367: Show issues

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Article: Mutations in the H, F, or M Proteins Can Facilitate Resistance of Measles Virus to Neutralizing Human Anti-MV Sera.

Kweder, Hasan / Ainouze, Michelle / Cosby, Sara Louise / Muller, Claude P / Lévy, Camille / Verhoeyen, Els / Cosset, François-Loïc / Manet, Evelyne / Buckland, Robin

Advances in virology

2014 Volume 2014, Page(s) 205617

Abstract: ... and M proteins. Cytometric analysis of cells expressing viral escape mutants possessing minimal ... mutations and their plasmid-expressed H, F, and M proteins indicates that immune resistance is due ...

Abstract	Although there is currently no evidence of emerging strains of measles virus (MV) that can resist neutralization by the anti-MV antibodies present in vaccinees, certain mutations in circulating wt MV strains appear to reduce the efficacy of these antibodies. Moreover, it has been hypothesized that resistance to neutralization by such antibodies could allow MV to persist. In this study, we use a novel in vitro system to determine the molecular basis of MV's resistance to neutralization. We find that both wild-type and laboratory strain MV variants that escape neutralization by anti-MV polyclonal sera possess multiple mutations in their H, F, and M proteins. Cytometric analysis of cells expressing viral escape mutants possessing minimal mutations and their plasmid-expressed H, F, and M proteins indicates that immune resistance is due to particular mutations that can occur in any of these three proteins that affect at distance, rather than directly, the native conformation of the MV-H globular head and hence its epitopes. A high percentage of the escape mutants contain mutations found in cases of Subacute Sclerosing Panencephalitis (SSPE) and our results could potentially shed light on the pathogenesis of this rare fatal disease.
Language	English
Publishing date	2014-02-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2625776-2
ISSN	1687-8647 ; 1687-8639
ISSN (online)	1687-8647
ISSN	1687-8639
DOI	10.1155/2014/205617
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