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  1. Book ; Thesis: LH- und Testosteronsekretion beim Mann

    Schepke, Michael

    Physiologie und Beeinflussung durch einen neuartigen GNRH-Antagonisten

    1994  

    Author's details vorgelegt von: Michael Schepke
    Language German
    Size 144 S. : graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Bonn, Univ., Diss., 1994
    HBZ-ID HT006321966
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: The genetic regulation of the gastric transcriptome is associated with metabolic and obesity-related traits and diseases.

    Koebbe, Laura L / Hess, Timo / Giel, Ann-Sophie / Bigge, Jessica / Gehlen, Jan / Schueller, Vitalia / Geppert, Michael / Dumoulin, Franz Ludwig / Heller, Joerg / Schepke, Michael / Plaßmann, Dominik / Vieth, Michael / Venerito, Marino / Schumacher, Johannes / Maj, Carlo

    Physiological genomics

    2024  Volume 56, Issue 5, Page(s) 384–396

    Abstract: Tissue-specific gene expression and gene regulation lead to a better understanding of tissue-specific physiology and pathophysiology. We analyzed the transcriptome and genetic regulatory profiles of two distinct gastric sites, corpus and antrum, to ... ...

    Abstract Tissue-specific gene expression and gene regulation lead to a better understanding of tissue-specific physiology and pathophysiology. We analyzed the transcriptome and genetic regulatory profiles of two distinct gastric sites, corpus and antrum, to identify tissue-specific gene expression and its regulation. Gastric corpus and antrum mucosa biopsies were collected during routine gastroscopies from up to 431 healthy individuals. We obtained genotype and transcriptome data and performed transcriptome profiling and expression quantitative trait locus (eQTL) studies. We further used data from genome-wide association studies (GWAS) of various diseases and traits to partition their heritability and to perform transcriptome-wide association studies (TWAS). The transcriptome data from corpus and antral mucosa highlights the heterogeneity of gene expression in the stomach. We identified enriched pathways revealing distinct and common physiological processes in gastric corpus and antrum. Furthermore, we found an enrichment of the single nucleotide polymorphism (SNP)-based heritability of metabolic, obesity-related, and cardiovascular traits and diseases by considering corpus- and antrum-specifically expressed genes. Particularly, we could prioritize gastric-specific candidate genes for multiple metabolic traits, like
    MeSH term(s) Humans ; Transcriptome/genetics ; Genome-Wide Association Study ; Gene Expression Regulation ; Polymorphism, Single Nucleotide/genetics ; Stomach ; Obesity/genetics ; Genetic Predisposition to Disease
    Language English
    Publishing date 2024-02-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2038823-8
    ISSN 1531-2267 ; 1094-8341
    ISSN (online) 1531-2267
    ISSN 1094-8341
    DOI 10.1152/physiolgenomics.00120.2023
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    Zs.A 5697: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Article ; Online: Drugs, ligation or both for the prevention of variceal rebleeding?

    Schepke, Michael

    Gut

    2009  Volume 58, Issue 8, Page(s) 1045–1046

    MeSH term(s) Adrenergic beta-Antagonists/therapeutic use ; Combined Modality Therapy ; Drug Therapy, Combination ; Esophageal and Gastric Varices/complications ; Gastrointestinal Hemorrhage/prevention & control ; Humans ; Ligation ; Secondary Prevention ; Vasodilator Agents/therapeutic use
    Chemical Substances Adrenergic beta-Antagonists ; Vasodilator Agents
    Language English
    Publishing date 2009-08
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gut.2009.177964
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 160: Show issues Location:
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  4. Article: Hepatorenal syndrome: current diagnostic and therapeutic concepts.

    Schepke, Michael

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2007  Volume 22 Suppl 8, Page(s) viii2–viii4

    MeSH term(s) Clinical Trials as Topic ; Hepatorenal Syndrome/diagnosis ; Hepatorenal Syndrome/epidemiology ; Hepatorenal Syndrome/therapy ; Humans ; Incidence ; Liver Transplantation ; Models, Biological ; Nephrology/methods ; Placebos ; Prognosis ; Research Design ; Treatment Outcome ; Vasoconstrictor Agents/therapeutic use
    Chemical Substances Placebos ; Vasoconstrictor Agents
    Language English
    Publishing date 2007-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfm656
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    Zs.A 2198: Show issues Location:
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    Zs.MO 329: Show issues

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  5. Article: Can we predict hepatocellular carcinoma by endoscopy?

    Schepke, Michael

    Digestion

    2004  Volume 70, Issue 4, Page(s) 231–232

    MeSH term(s) Carcinoma, Hepatocellular/etiology ; Carcinoma, Hepatocellular/pathology ; Endoscopy, Gastrointestinal ; Forecasting ; Hemorrhage ; Humans ; Liver Cirrhosis/complications ; Liver Neoplasms/etiology ; Liver Neoplasms/pathology ; Mass Screening ; Predictive Value of Tests ; Prognosis ; Risk Factors ; Varicose Veins/etiology ; Varicose Veins/pathology
    Language English
    Publishing date 2004
    Publishing country Switzerland
    Document type Comment ; Editorial
    ZDB-ID 1712-7
    ISSN 1421-9867 ; 0012-2823
    ISSN (online) 1421-9867
    ISSN 0012-2823
    DOI 10.1159/000082894
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 572: Show issues Location:
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  6. Article: Can We Predict Hepatocellular Carcinoma by Endoscopy?

    Schepke, Michael

    Digestion

    2005  Volume 70, Issue 4, Page(s) 231–232

    Institution Department of Internal Medicine 1, University of Bonn, Bonn, Germany
    Language English
    Publishing date 2005-03-09
    Publisher S. Karger AG
    Publishing place Basel, Switzerland
    Document type Article
    Note Editorial
    ZDB-ID 1712-7
    ISSN 1421-9867 ; 0012-2823
    ISSN (online) 1421-9867
    ISSN 0012-2823
    DOI 10.1159/000082894
    Database Karger publisher's database

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  7. Article ; Online: Standard versus Endocuff versus cap-assisted colonoscopy for adenoma detection: A randomised controlled clinical trial.

    Floer, Martin / Tschaikowski, Laura / Schepke, Michael / Kempinski, Radoslaw / Neubauer, Katarzyna / Poniewierka, Elzbieta / Kunsch, Steffen / Ameis, Detlev / Heinzow, Hauke Sebastian / Auer, Agneta / Schmidt, Hartmut H / Ellenrieder, Volker / Meister, Tobias

    United European gastroenterology journal

    2021  Volume 9, Issue 4, Page(s) 443–450

    Abstract: Background and aims: Adenoma detection rate (ADR) in colon cancer screening is most important for cancer prophylaxis. This work is the first three-armed randomised controlled clinical trial aimed at comparing a head-to-head setting standard colonoscopy ( ...

    Abstract Background and aims: Adenoma detection rate (ADR) in colon cancer screening is most important for cancer prophylaxis. This work is the first three-armed randomised controlled clinical trial aimed at comparing a head-to-head setting standard colonoscopy (SC) with Endocuff-assisted colonoscopy (EC) and cap-assisted colonoscopy (CAC) for improvement of ADR.
    Methods: Patients from Poland and Germany with independent indication for colonoscopy were randomised into three arms of this trial: EC, CAC and SC. Exclusion criteria were age <18 years, active Crohn's disease or ulcerative colitis, known stenosis and post-colonic resection status.
    Results: A total of 585 patients (195 SC, 189 EC and 186 CAC) were enrolled in this study. Indications were not different between the groups (colorectal cancer screening 51%, diagnostic colonoscopy in 31% and post-polypectomy follow-up in 18%; p = 0.94). Withdrawal time was a mean of 7 min in all groups (p = 0.658), and bowel preparation did not differ between the groups. The time to reach the caecum was significantly reduced when using the cap (a mean of 6 min for CAC vs. 7 min for SC; p = 0.0001). There was no significant difference in the primary outcome of the ADR between the groups (EC 32%, CAC 30%, SC 30%; p = 0.815). EC proved to be superior (EC vs. SC) in the sigmoid colon and transverse colon for polyp detection.
    Conclusion: The use of EC increased the total number of polyps seen during colonoscopy. In contrast to recent studies, no significant improvement of the ADR was detected.
    MeSH term(s) Adenoma/diagnosis ; Aged ; Colonic Neoplasms/diagnosis ; Colonic Polyps/diagnosis ; Colonoscopy/adverse effects ; Colonoscopy/instrumentation ; Colonoscopy/methods ; Early Detection of Cancer/instrumentation ; Early Detection of Cancer/methods ; Female ; Humans ; Male ; Middle Aged ; Prospective Studies ; Time Factors
    Language English
    Publishing date 2021-02-16
    Publishing country England
    Document type Comparative Study ; Journal Article ; Multicenter Study ; Randomized Controlled Trial
    ZDB-ID 2728585-6
    ISSN 2050-6414 ; 2050-6406
    ISSN (online) 2050-6414
    ISSN 2050-6406
    DOI 10.1177/2050640620982952
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  8. Article ; Online: Nodular regenerative hyperplasia and portal hypertension in a patient with coeliac disease.

    Biecker, Erwin / Fischer, Hans-Peter / Schepke, Michael

    Case reports in gastrointestinal medicine

    2011  Volume 2011, Page(s) 938580

    Abstract: Nodular regenerative hyperplasia (NRH) of the liver is often associated with rheumatologic or lymphoproliferative disorders and a cause of portal hypertension in some patients. We report the case of a 71-year-old patient with celiac disease and ... ...

    Abstract Nodular regenerative hyperplasia (NRH) of the liver is often associated with rheumatologic or lymphoproliferative disorders and a cause of portal hypertension in some patients. We report the case of a 71-year-old patient with celiac disease and unexplained portal hypertension. Biopsy of the liver revealed NRH as the underlying cause. The patient did not suffer from an autoimmune, rheumatologic or lymphoproliferative disease. A thrombophilic disorder that might cause NRH was ruled out. Celiac disease is often associated with mild elevation of liver enzymes and steatosis of the liver, but the association with NRH was described in only a few patients. We discuss the possible relationship of celiac disease and NRH.
    Language English
    Publishing date 2011-08-28
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2627636-7
    ISSN 2090-6536 ; 2090-6528
    ISSN (online) 2090-6536
    ISSN 2090-6528
    DOI 10.1155/2011/938580
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  9. Article: Fulminant sepsis after liver biopsy: A long forgotten complication?

    Claudi, Corinna / Henschel, Martin / Vogel, Jürgen / Schepke, Michael / Biecker, Erwin

    World journal of clinical cases

    2013  Volume 1, Issue 1, Page(s) 41–43

    Abstract: We report on a 74-year-old patient with recurrent cholangitis and a large juxtapapillary duodenal diverticulum. Despite drainage of the common bile duct by an endoscopically placed stent, the elevated liver enzymes normalized only partially. To rule out ... ...

    Abstract We report on a 74-year-old patient with recurrent cholangitis and a large juxtapapillary duodenal diverticulum. Despite drainage of the common bile duct by an endoscopically placed stent, the elevated liver enzymes normalized only partially. To rule out other possible causes of liver injury, a percutaneous liver biopsy was done. After the liver biopsy the patient developed fulminant septic shock and died within 24 h. We discuss the possible causes of the septic shock following percutaneous liver biopsy in our patient and give a concise overview of the literature.
    Language English
    Publishing date 2013-11-18
    Publishing country United States
    Document type Case Reports
    ISSN 2307-8960
    ISSN 2307-8960
    DOI 10.12998/wjcc.v1.i1.41
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  10. Article ; Online: Improving primary prophylaxis of variceal bleeding by adapting therapy to the clinical stage of cirrhosis. A competing-risk meta-analysis of individual participant data.

    Villanueva, Càndid / Sapena, Victor / Lo, Gin-Ho / Seo, Yeon Seok / Shah, Hasnain Ali / Singh, Virendra / Tripathi, Dhiraj / Schepke, Michael / Gheorghe, Cristian / Bonilha, Daniell Q / Jutabha, Rome / Wang, Huay-Min / Rodrigues, Susana G / Brujats, Anna / Lee, Han Ah / Azam, Zahid / Kumar, Pramod / Hayes, Peter C / Sauerbruch, Tilman /
    Chen, Wen-Chi / Iacob, Speranta / Libera, Ermelindo D / Jensen, Dennis M / Alvarado, Edilmar / Torres, Ferran / Bosch, Jaume

    Alimentary pharmacology & therapeutics

    2023  Volume 59, Issue 3, Page(s) 306–321

    Abstract: Background & aims: Non-selective β-blockers (NSBBs) and endoscopic variceal-ligation (EVL) have similar efficacy preventing first variceal bleeding. Compensated and decompensated cirrhosis are markedly different stages, which may impact treatment ... ...

    Abstract Background & aims: Non-selective β-blockers (NSBBs) and endoscopic variceal-ligation (EVL) have similar efficacy preventing first variceal bleeding. Compensated and decompensated cirrhosis are markedly different stages, which may impact treatment outcomes. We aimed to assess the efficacy of NSBBs vs EVL on survival in patients with high-risk varices without previous bleeding, stratifying risk according to compensated/decompensated stage of cirrhosis.
    Methods: By systematic review, we identified RCTs comparing NSBBs vs EVL, in monotherapy or combined, for primary bleeding prevention. We performed a competing-risk, time-to-event meta-analysis, using individual patient data (IPD) obtained from principal investigators of RCTs. Analyses were stratified according to previous decompensation of cirrhosis.
    Results: Of 25 RCTs eligible, 14 failed to provide IPD and 11 were included, comprising 1400 patients (656 compensated, 744 decompensated), treated with NSBBs (N = 625), EVL (N = 546) or NSBB+EVL (N = 229). Baseline characteristics were similar between groups. Overall, mortality risk was similar with EVL vs. NSBBs (subdistribution hazard-ratio (sHR) = 1.05, 95% CI = 0.75-1.49) and with EVL + NSBBs vs either monotherapy, with low heterogeneity (I
    Conclusions: In patients with compensated cirrhosis and high-risk varices on primary prophylaxis, NSBBs significantly improved survival vs EVL, with no additional benefit noted adding EVL to NSBBs. In decompensated patients, survival was similar with both therapies. The study suggests that NSBBs are preferable when advising preventive therapy in compensated patients.
    MeSH term(s) Humans ; Esophageal and Gastric Varices/drug therapy ; Esophageal and Gastric Varices/prevention & control ; Gastrointestinal Hemorrhage ; Ligation ; Adrenergic beta-Antagonists/therapeutic use ; Liver Cirrhosis/complications ; Liver Cirrhosis/drug therapy ; Varicose Veins/drug therapy
    Chemical Substances Adrenergic beta-Antagonists
    Language English
    Publishing date 2023-12-18
    Publishing country England
    Document type Meta-Analysis ; Journal Article ; Review
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.17824
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