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  1. Article ; Online: Kidney after Liver Transplantation for All: Are You Kidneying Me?

    Kumar, Abhishek / Wadei, Hani M

    Clinical journal of the American Society of Nephrology : CJASN

    2024  Volume 19, Issue 3, Page(s) 289–291

    MeSH term(s) Humans ; Liver Transplantation/adverse effects ; Kidney ; Kidney Transplantation/adverse effects
    Language English
    Publishing date 2024-01-24
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2226665-3
    ISSN 1555-905X ; 1555-9041
    ISSN (online) 1555-905X
    ISSN 1555-9041
    DOI 10.2215/CJN.0000000000000409
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6584: Show issues Location:
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  2. Article: Acute Kidney Injury in Liver Cirrhosis.

    Attieh, Rose Mary / Wadei, Hani M

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 14

    Abstract: Acute kidney injury (AKI) is common in cirrhotic patients affecting almost 20% of these patients. While multiple etiologies can lead to AKI, pre-renal azotemia seems to be the most common cause of AKI. Irrespective of the cause, AKI is associated with ... ...

    Abstract Acute kidney injury (AKI) is common in cirrhotic patients affecting almost 20% of these patients. While multiple etiologies can lead to AKI, pre-renal azotemia seems to be the most common cause of AKI. Irrespective of the cause, AKI is associated with worse survival with the poorest outcomes observed in those with hepatorenal syndrome (HRS) and acute tubular necrosis (ATN). In recent years, new definitions, and classifications of AKI in cirrhosis have emerged. More knowledge has also become available regarding the benefits and drawbacks of albumin and terlipressin use in these patients. Diagnostic tools such as urinary biomarkers and point-of-care ultrasound (POCUS) became available and they will be used in the near future to differentiate between different causes of AKI and direct management of AKI in these patients. In this update, we will review these new classifications, treatment recommendations, and diagnostic tools for AKI in cirrhotic patients.
    Language English
    Publishing date 2023-07-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13142361
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Patients with Hepatorenal Syndrome Should Be Dialyzed? CON.

    Wadei, Hani M

    Kidney360

    2020  Volume 2, Issue 3, Page(s) 410–412

    MeSH term(s) Acute Kidney Injury ; Hepatorenal Syndrome/diagnosis ; Humans ; Liver Cirrhosis/complications
    Language English
    Publishing date 2020-12-16
    Publishing country United States
    Document type Journal Article
    ISSN 2641-7650
    ISSN (online) 2641-7650
    DOI 10.34067/KID.0006872020
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  4. Article ; Online: Kidney after liver transplantation does not have an increased risk of rejection compared to liver alone.

    Ghali, Peter / Ibrahim, Ramez M / Hodge, David / White, Launia / Wadei, Hani M

    Clinical transplantation

    2024  Volume 38, Issue 4, Page(s) e15311

    Abstract: Background: Simultaneous liver kidney (SLK) transplant protects against acute cellular rejection. In 2017, UNOS implemented a "safety net" policy to allow patients with renal recovery to avoid renal transplantation. Whether kidney after liver ... ...

    Abstract Background: Simultaneous liver kidney (SLK) transplant protects against acute cellular rejection. In 2017, UNOS implemented a "safety net" policy to allow patients with renal recovery to avoid renal transplantation. Whether kidney after liver transplantation (KALT) increases the risk of rejection is unknown.
    Methods: We performed a retrospective analysis of the Organ Procurement and Transplantation Network (OPTN) database of adult patients who received liver transplant, SLK or KALT between 2010 and 2020. We examined rejection of the liver within 6 months and 1 year of the liver transplant, as well as rejection of the kidney within 6 months and 1 year of receiving the kidney, as well as patient and graft loss.
    Results: Sixty-six thousand seventy-nine patients were transplanted; 60 168 with liver transplant alone, 5627 with SLK, and 284 with KALT. Acute or chronic liver rejection rates within 6 or 12 months were statistically higher in the KALT group (10.0% and 10.9%) compared to the SLK group (6.1% and 7.5%), but comparable to the LTA group (9.3% and 11.1%). Kidney rejection and graft survival rates were not different. Liver graft survival was worse in KALT than SLK or LTA (Kaplan-Meier estimates .61 vs. .89 and .90), but these patients were more ill at the time of transplantation. KDPI and LDRI scores were notably lower in the SLK than KALT group. Patient survival was not clinically different between the groups.
    Conclusion: KALT does not increase the risk of acute or chronic kidney rejection. SLK has a lower risk of early liver rejection, but this effect diminishes by one year to being not clinically different compared to KALT. Given that KALT is immunologically safe, and potentially avoids unnecessary renal graft use, it should be preferred over SLK.
    Brief summary: Patients undergoing sequential kidney after liver transplant do not have an increased risk of liver or kidney rejection when compared to liver transplant alone or simultaneous liver and kidney transplant.
    MeSH term(s) Adult ; Humans ; Liver Transplantation/adverse effects ; Retrospective Studies ; Liver ; Kidney ; Kidney Transplantation/adverse effects
    Language English
    Publishing date 2024-04-15
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 639001-8
    ISSN 1399-0012 ; 0902-0063
    ISSN (online) 1399-0012
    ISSN 0902-0063
    DOI 10.1111/ctr.15311
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2204: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Disseminated Monkeypox Infection in a Kidney Transplant Recipient: A Case Report.

    Attieh, Rose Mary / Brumble, Lisa / Elwasila, Sammer M / Wadei, Hani M

    Transplantation proceedings

    2023  Volume 55, Issue 3, Page(s) 667–671

    Abstract: Monkeypox is a rapidly spreading infection worldwide and is a public health concern, especially with newly reported fatality cases. The characteristics and disease course of monkeypox infection in transplant recipients remain elusive because no case ... ...

    Abstract Monkeypox is a rapidly spreading infection worldwide and is a public health concern, especially with newly reported fatality cases. The characteristics and disease course of monkeypox infection in transplant recipients remain elusive because no case reports have been published detailing its clinical presentation and outcome in this population. We report a case of a kidney transplant recipient who developed end-stage renal disease secondary to HIV-associated nephropathy and manifested monkeypox infection after kidney transplantation. The patient had severe clinical manifestations, including disseminated vesicular skin rash, diffuse mucosal involvement, urine retention, proctitis, and bowel obstruction. We also highlight several clinical considerations regarding the use of tecovirimat, a novel antiviral therapy with activity against orthopoxviruses that has been used in the United States to treat monkeypox infection.
    MeSH term(s) Humans ; Mpox (monkeypox) ; Transplant Recipients ; Kidney Transplantation/adverse effects ; Antiviral Agents ; Benzamides
    Chemical Substances Antiviral Agents ; Benzamides
    Language English
    Publishing date 2023-03-21
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 82046-5
    ISSN 1873-2623 ; 0041-1345
    ISSN (online) 1873-2623
    ISSN 0041-1345
    DOI 10.1016/j.transproceed.2023.02.031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 835: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Timing of Everolimus Conversion After Liver Transplantation: Ever Early and Never Late.

    Wadei, Hani M / Keaveny, Andrew P

    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

    2020  Volume 26, Issue 11, Page(s) 1395–1397

    MeSH term(s) Calcineurin Inhibitors ; Everolimus/adverse effects ; Humans ; Immunosuppressive Agents/adverse effects ; Liver Transplantation/adverse effects ; Registries
    Chemical Substances Calcineurin Inhibitors ; Immunosuppressive Agents ; Everolimus (9HW64Q8G6G)
    Language English
    Publishing date 2020-10-01
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2006866-9
    ISSN 1527-6473 ; 1527-6465
    ISSN (online) 1527-6473
    ISSN 1527-6465
    DOI 10.1002/lt.25881
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4702: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  7. Article ; Online: Essentials of Liver Transplantation in the Setting of Acute Kidney Injury and Chronic Kidney Disease.

    Gonzalez, Stevan A / Farfan Ruiz, Ana Cecilia / Ibrahim, Ramez M / Wadei, Hani M

    Advances in kidney disease and health

    2023  Volume 30, Issue 4, Page(s) 356–367

    Abstract: Kidney dysfunction is common among liver transplant candidates with decompensated cirrhosis and has a major impact on pre- and post-liver transplant survival. Updated definitions of acute kidney injury and criteria for the diagnosis of hepatorenal ... ...

    Abstract Kidney dysfunction is common among liver transplant candidates with decompensated cirrhosis and has a major impact on pre- and post-liver transplant survival. Updated definitions of acute kidney injury and criteria for the diagnosis of hepatorenal syndrome allow for early recognition and intervention, including early initiation of vasoconstrictor therapy for hepatorenal syndrome. The rise of the metabolic syndrome and nonalcoholic fatty liver disease as a cause of cirrhosis has coincided with an increase in intrinsic chronic kidney disease recognized in transplant candidates and recipients. Ultimately, the ability to accurately assess kidney function and associated risk is essential to decision-making in the context of transplantation, including selection of candidates for simultaneous liver and kidney transplantation.
    MeSH term(s) Humans ; Liver Transplantation ; Hepatorenal Syndrome/diagnosis ; Acute Kidney Injury/diagnosis ; Renal Insufficiency, Chronic/complications
    Language English
    Publishing date 2023-07-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 3156601-7
    ISSN 2949-8139
    ISSN (online) 2949-8139
    DOI 10.1053/j.akdh.2023.06.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4627: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Improving Outcomes in Hepatorenal Syndrome-Acute Kidney Injury With Early Diagnoses and Implementation of Approved Treatment Regimens.

    Pyrsopoulos, Nikolaos T / Bernstein, David / Kugelmas, Marcelo / Owen, Emily J / Reddy, K Rajender / Reau, Nancy / Saab, Sammy / Wadei, Hani M

    Gastroenterology & hepatology

    2024  Volume 19, Issue 12 Suppl 7, Page(s) 3–13

    Abstract: Decompensated cirrhosis, defined by the overt manifestations of liver failure and portal hypertension (eg, ascites, hepatic encephalopathy, variceal bleeding), is the inflection point associated with increased morbidity and mortality in chronic liver ... ...

    Abstract Decompensated cirrhosis, defined by the overt manifestations of liver failure and portal hypertension (eg, ascites, hepatic encephalopathy, variceal bleeding), is the inflection point associated with increased morbidity and mortality in chronic liver disease. Acute kidney injury in the setting of cirrhosis (hepatorenal syndrome-acute kidney injury [HRS-AKI]) is a severe and often fatal complication. The goals of treatment of HRS-AKI are to reverse renal failure and prolong survival in these critically ill patients or perhaps to allow the transplant team to complete the pretransplant evaluation and bridge the patient to transplant. Historically, in the United States, standard-of-care treatments for HRS-AKI were chosen by default despite lack of data, off-label use, and suboptimal results. Terlipressin represents the first drug in the United States indicated for the treatment of HRS-AKI. This review provides an up-to-date overview of HRS-AKI, discusses terlipressin and how to incorporate this new treatment into patient care and streamline society guidelines on HRS diagnosis and treatment in a practical way for clinical use, and concludes with a sample order set that highlights the recommendations discussed throughout the supplement.
    Language English
    Publishing date 2024-02-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2386402-3
    ISSN 1554-7914
    ISSN 1554-7914
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6543: Show issues Location:
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    Zs.MO 517: Show issues

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  9. Article ; Online: The impact of cold ischemia time at the higher end of the KDPI spectrum: what is the risk?

    Lee, David D / Wadei, Hani M

    Transplant international : official journal of the European Society for Organ Transplantation

    2018  Volume 31, Issue 7, Page(s) 706–707

    MeSH term(s) Cold Ischemia ; Cold Temperature ; Donor Selection ; Humans ; Ischemia ; Tissue Donors
    Language English
    Publishing date 2018-02-03
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 639435-8
    ISSN 1432-2277 ; 0934-0874
    ISSN (online) 1432-2277
    ISSN 0934-0874
    DOI 10.1111/tri.13135
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    Zs.A 2358: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  10. Article ; Online: Delayed renal transplant failure secondary to renal vein thrombosis in a patient with a permanent IVC filter.

    Lewis, Kristyn L / Patel, Payal / Wadei, Hani M / Guru, Pramod K

    BMJ case reports

    2021  Volume 14, Issue 3

    Abstract: Renal vein thrombosis is a rare, but potentially serious complication in patients with renal transplantation as it can lead to non-reversible graft injury and failure. Often this clinical entity is found in the early transplantation period, and the ... ...

    Abstract Renal vein thrombosis is a rare, but potentially serious complication in patients with renal transplantation as it can lead to non-reversible graft injury and failure. Often this clinical entity is found in the early transplantation period, and the available management strategies are associated with favourable patient outcomes. The incidence, pathophysiology and outcomes for the delayed occurrence of renal vein thrombosis are unknown. The case here describes a unique situation with an excellent clinical outcome related to early diagnosis and appropriate care.
    MeSH term(s) Humans ; Kidney ; Kidney Transplantation/adverse effects ; Renal Insufficiency ; Renal Veins/diagnostic imaging ; Treatment Outcome ; Venous Thrombosis/diagnostic imaging ; Venous Thrombosis/etiology
    Language English
    Publishing date 2021-03-29
    Publishing country England
    Document type Journal Article ; Case Reports
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2020-236619
    Database MEDical Literature Analysis and Retrieval System OnLINE

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