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Article ; Online: The true obesity paradox: obese and malnourished?.

Lasocki, Sigismond

2015 Volume 43, Issue 1, Page(s) 240–241

MeSH term(s)	Critical Illness/mortality ; Female ; Humans ; Male ; Nutritional Status ; Obesity/complications
Language	English
Publishing date	2015-01
Publishing country	United States
Document type	Comment ; Editorial
ZDB-ID	197890-1
ISSN	1530-0293 ; 0090-3493
ISSN (online)	1530-0293
ISSN	0090-3493
DOI	10.1097/CCM.0000000000000646
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Article ; Online: Changes in Practices After Implementation of a Patient Blood Management Program in French Surgical Departments: The National Multicenter Observational PERIOPES Study.

Lasocki, Sigismond / Belbachir, Anissa / Mertes, Paul-Michel / Le Pelley, Eric / Bosch, Laetitia / Bezault, Clémence / Belarbia, Samia / Capdevila, Xavier

Anesthesia and analgesia

2024

Abstract: Background: Patient blood management (PBM) is an evidence-based approach recommended to improve patient outcomes. Change in practices is often challenging. We report here data from French surgical departments before and after a standardized ... ...

Abstract	Background: Patient blood management (PBM) is an evidence-based approach recommended to improve patient outcomes. Change in practices is often challenging. We report here data from French surgical departments before and after a standardized implementation of a PBM program. Methods: This was a national, multicenter, observational study in surgical centers ("expert" centers with an already established protocol for preoperative anemia or "pilot" centers). Data from consecutive surgical patients of different specialties were retrieved before and after the implementation of a PBM program. Primary outcome variables (preoperative anemia treatment rates, transfusion rates, and length of hospital stay) before and after the implementation of a PBM program were analyzed with segmented regression adjusted on confounders (American Society of Anesthesiologists [ASA] scores and centers). Results: A total of 1618 patients (ASA physical status III and IV, 38% in the first period and 45% in the second period) were included in expert (N = 454) or pilot (N = 1164) centers during the first period (January 2017-August 2022) and 1542 (N = 440 and N = 1102, respectively) during the second period (January 2020-February 2023). After implementation of the PBM program, the rate of preoperative anemia treatment increased (odds ratio, 2.37; 95% confidence interval [CI], 1.20-4.74; P = .0136) and length of hospital stay in days decreased (estimate, -0.11; 95% CI, -0.21 to -0.02; P = .0186). Transfusion rate significantly decreased only in expert centers (odds ratio, 0.17; 95% CI, 0.03-0.88; P = .0354). Conclusions: PBM practices in various surgical specialties improved significantly after the implementation of a PBM program. However, too many patients with preoperative anemia remained untreated.
Language	English
Publishing date	2024-02-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	80032-6
ISSN	1526-7598 ; 0003-2999
ISSN (online)	1526-7598
ISSN	0003-2999
DOI	10.1213/ANE.0000000000006917
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Article ; Online: Validation of the postoperative Quality of Recovery-15 questionnaire after emergency surgery and association with quality of life at three months.

Le Bescond, Victoria / Petit-Phan, Jonathan / Campfort, Maëva / Nicolleau, Claire / Conté, Mathieu / Bouhours, Guillaume / Rony, Louis / Lasocki, Sigismond / Léger, Maxime

Canadian journal of anaesthesia = Journal canadien d'anesthesie

2024 Volume 71, Issue 5, Page(s) 590–599

Abstract: Purpose: The Quality of Recovery-15 (QoR-15) tool, validated for measuring postoperative recovery following scheduled surgeries, has not been psychometrically assessed in emergency contexts. Moreover, the QoR-15's associations with long-term outcomes ... ...

Title translation	Validation du questionnaire sur la qualité de récupération postopératoire-15 après une chirurgie d’urgence et association avec la qualité de vie à trois mois.
Abstract	Purpose: The Quality of Recovery-15 (QoR-15) tool, validated for measuring postoperative recovery following scheduled surgeries, has not been psychometrically assessed in emergency contexts. Moreover, the QoR-15's associations with long-term outcomes remain underexplored. This study aimed to confirm the validity and reliability of the QoR-15 following emergency surgery and assess its association with three-month postoperative quality of life. Methods: We conducted a prospective cohort study (August 2021-April 2022) on adult patients who underwent emergency surgery. The QoR-15 questionnaire was administered before surgery (H0) and at 24 hr (H24) and 48 hr (H48) after surgery. We examined the H24 score's associations with both the three-month quality of life, as assessed by the EQ-5D scale, and the number of days spent at home at 30 (DAH30) and 90 (DAH90) days. Results: Of the 375 included patients, 352 (94%) completed the QoR-15 at H24 and 338 (90%) were followed up at three months. The population represented the following diverse surgical specialties: orthopedic (51%), gastrointestinal (27%), urologic (13%), and others (9%). The QoR-15 questionnaire confirmed all psychometric qualities (internal consistency, reproducibility, responsiveness, acceptability, construct, and convergent validities) in the emergency context. The average minimum clinical difference was 8.0 at H24. There was an association between QoR-15 at H24 and the three-month quality of life (r = 0.24; 95% confidence interval [CI], 0.14 to 0.34; P < 0.001), DAH30 (r = 0.33; 95% CI, 0.23 to 0.41; P < 0.001), and DAH90 (r = 0.31; 95% CI, 0.22 to 0.40; P < 0.001). Conclusion: The QoR-15 score is valid for measuring early postoperative recovery after emergency surgery. The H24 score significantly correlated with both the three-month quality of life and the number of days at home. Study registration: ClinicalTrials.gov (NCT04845763); first submitted 11 April 2021.
MeSH term(s)	Adult ; Humans ; Quality of Life ; Reproducibility of Results ; Anesthesia Recovery Period ; Prospective Studies ; Surveys and Questionnaires
Language	English
Publishing date	2024-03-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	91002-8
ISSN	1496-8975 ; 0832-610X
ISSN (online)	1496-8975
ISSN	0832-610X
DOI	10.1007/s12630-024-02722-4
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Article ; Online: Restrictive transfusion targets the heart now! Insight from the REALITY study.

Lasocki, Sigismond / Bruckert, Vincent / Campfort, Maeva / Leger, Maxime / Rineau, Emmanuel

Anaesthesia, critical care & pain medicine

2021 Volume 40, Issue 2, Page(s) 100854

MeSH term(s)	Blood Transfusion ; Erythrocyte Transfusion ; Hemoglobins ; Humans
Chemical Substances	Hemoglobins
Language	English
Publishing date	2021-03-27
Publishing country	France
Document type	Editorial ; Research Support, Non-U.S. Gov't
ISSN	2352-5568
ISSN (online)	2352-5568
DOI	10.1016/j.accpm.2021.100854
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Article ; Online: Evaluating cognitive aids in hospital management of severe trauma patients: a prospective randomised high-fidelity simulation trial.

Fleury, Maxime J J / Nicolleau, Claire / Bouhours, Guillaume / Conté, Mathieu / Martin, Ludovic / Lasocki, Sigismond / Léger, Maxime

British journal of anaesthesia

2023 Volume 131, Issue 5, Page(s) e150–e152

MeSH term(s)	Humans ; Prospective Studies ; High Fidelity Simulation Training ; Simulation Training ; Cognition ; Hospitals
Language	English
Publishing date	2023-09-22
Publishing country	England
Document type	Randomized Controlled Trial ; Letter
ZDB-ID	80074-0
ISSN	1471-6771 ; 0007-0912
ISSN (online)	1471-6771
ISSN	0007-0912
DOI	10.1016/j.bja.2023.08.028
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Article ; Online: Opioid-free Anesthesia Protocol on the Early Quality of Recovery after Major Surgery (SOFA Trial): A Randomized Clinical Trial.

Léger, Maxime / Perrault, Tristan / Pessiot-Royer, Solène / Parot-Schinkel, Elsa / Costerousse, Fabienne / Rineau, Emmanuel / Lasocki, Sigismond

Anesthesiology

2023 Volume 140, Issue 4, Page(s) 679–689

MeSH term(s)	Humans ; Male ; Female ; Adult ; Middle Aged ; Analgesics, Opioid/therapeutic use ; Quality of Life ; Pain, Postoperative/epidemiology ; Lidocaine/adverse effects ; Anesthesia, General/adverse effects ; Randomized Controlled Trials as Topic
Chemical Substances	Analgesics, Opioid ; Lidocaine (98PI200987)
Language	English
Publishing date	2023-11-17
Publishing country	United States
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	269-0
ISSN	1528-1175 ; 0003-3022
ISSN (online)	1528-1175
ISSN	0003-3022
DOI	10.1097/ALN.0000000000004840
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Zs.MO 199: Show issues

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Article ; Online: Evaluation of Anemia and Iron Deficiency in French Surgical Departments: The National Multicenter Observational PERIOPES Study.

Lasocki, Sigismond / Belbachir, Anissa / Mertes, Paul-Michel / Pelley, Eric Le / Capdevila, Xavier

Anesthesia and analgesia

2023 Volume 137, Issue 1, Page(s) 182–190

Abstract: Background: Assessment of anemia and iron deficiency before surgery is pivotal for patient blood management (PBM), but few data on current practices are available in the French context. The objective of this study was to describe anemia and iron ... ...

Abstract	Background: Assessment of anemia and iron deficiency before surgery is pivotal for patient blood management (PBM), but few data on current practices are available in the French context. The objective of this study was to describe anemia and iron deficiency management and blood transfusion use in surgical departments in France. Methods: This was a national multicenter cross-sectional study in 13 public hospitals and 3 private ones (all with an interest for PBM). Data of consecutive surgical patients from different specialties were retrieved from their chart between July 30, 2019, and December 31, 2021. Data included hemoglobin, iron workup, treatment with oral/intravenous iron or erythropoiesis-stimulating agent, and transfusions. Results: Data from 2345 patients (median age, 68 years; women, 50.9%; American Society of Anesthesiologists [ASA] physical status III-IV, 35.4%) were obtained. Only 5 centers had a formalized PBM program. At preoperative anesthesia visit, hemoglobin (Hb) level was assessed in 2112 (90.1%) patients and anemia diagnosed in 722 of them (34.2%). Complete iron workup was performed in 715 (30.5%) of the 2345 patients. Iron deficiency anemia was present in 219 (30.3%) of the 722 anemic patients. Among patients with anemia, only 217 (30.1%) of them were treated. A total of 479 perioperative blood transfusions were reported in 315 patients. Restrictive transfusion was not applied in 50% of transfusion episodes, and the single-unit red blood cell transfusion was also not frequent (37.2%). Conclusions: Our observational study showed that preoperative anemia was frequent, but iron deficiency was often not assessed and few patients were treated. There is an urgent need for PBM implementation in these centers.
MeSH term(s)	Humans ; Female ; Aged ; Cross-Sectional Studies ; Anemia/diagnosis ; Anemia/epidemiology ; Anemia/therapy ; Iron ; Hemoglobins/analysis ; Iron Deficiencies
Chemical Substances	Iron (E1UOL152H7) ; Hemoglobins
Language	English
Publishing date	2023-06-16
Publishing country	United States
Document type	Observational Study ; Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80032-6
ISSN	1526-7598 ; 0003-2999
ISSN (online)	1526-7598
ISSN	0003-2999
DOI	10.1213/ANE.0000000000006362
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Zs.MO 149: Show issues

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Article ; Online: Early quality of recovery according to QoR-15 score is associated with one-month postoperative complications after elective surgery.

Campfort, Maëva / Cayla, Cléor / Lasocki, Sigismond / Rineau, Emmanuel / Léger, Maxime

Journal of clinical anesthesia

2022 Volume 78, Page(s) 110638

Abstract: Study objective: The QoR-15 scale is a validated tool to assess the quality of postoperative recovery (QoR). Our objective was to assess the association between the early QoR-15 values and the occurrence of one-month postoperative complications.: ... ...

Abstract	Study objective: The QoR-15 scale is a validated tool to assess the quality of postoperative recovery (QoR). Our objective was to assess the association between the early QoR-15 values and the occurrence of one-month postoperative complications. Design: We used the data from a prospective single-centre cohort study conducted in the Angers University Hospital from July 2019 to February 2020 that validated the French version of the QoR-15 (FQoR-15). Setting: Preoperative room, ward, and home. Patients: 363 French-speaking adult patients, undergoing elective surgery, were enrolled (217 (59,8%) men, median age 60 (range 44 to 71) years old), including 139 (38.3%) ambulatory surgeries. Intervention: Patients completed the QoR-15 scale the day before, at 24 and 48 h after surgery. Measurements: Postoperative complications were recorded according to the PostOperative Morbidity Survey (POMS) classification till 30 days after surgery. The QoR was classified as excellent (QoR-15 > 135), good (122 ≤ QoR-15 ≤ 135), moderate (90 ≤ QoR-15 ≤ 121) or poor (QoR-15 < 90). Days alive and out of hospital up to 30 days after surgery was also recorded. Main results: According to the POMS classification, 176 (48.5%) patients had at least one complication up to 30 days after surgery. Among the 69 (19.0%) patients with a poor recovery at H24, 58 (84.1%) had at least one complication up to 30 days after surgery compared to 10 (23.8%) among the 42 (11.6%) in the excellent recovery group (p < 0.0001). The QoR-15 score at H24 allowed suitable discrimination of the occurrence of at least one complication up to 30 days after surgery (AUC 0.732 (95% CI 0.680 to 0.784)). Conclusion: The early QoR-15 scale after surgery is moderately associated with the occurrence of postoperative complications up to 30 days after elective surgeries (i.e. it has predictive validity).
MeSH term(s)	Adult ; Aged ; Anesthesia Recovery Period ; Cohort Studies ; Elective Surgical Procedures/adverse effects ; Humans ; Male ; Middle Aged ; Postoperative Complications/diagnosis ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Prospective Studies ; Surveys and Questionnaires
Language	English
Publishing date	2022-01-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	1011618-7
ISSN	1873-4529 ; 0952-8180
ISSN (online)	1873-4529
ISSN	0952-8180
DOI	10.1016/j.jclinane.2021.110638
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Article ; Online: Postoperative quality of recovery measurements as endpoints in comparative anaesthesia studies: a systematic review.

Léger, Maxime / Campfort, Maëva / Cayla, Cléor / Lasocki, Sigismond / Rineau, Emmanuel

British journal of anaesthesia

2021 Volume 126, Issue 6, Page(s) e210–e212

MeSH term(s)	Anesthesia/adverse effects ; Anesthesia Recovery Period ; Endpoint Determination ; Humans ; Patient Outcome Assessment ; Recovery of Function ; Research Design ; Surgical Procedures, Operative/adverse effects ; Time Factors ; Treatment Outcome
Language	English
Publishing date	2021-04-21
Publishing country	England
Document type	Letter ; Systematic Review
ZDB-ID	80074-0
ISSN	1471-6771 ; 0007-0912
ISSN (online)	1471-6771
ISSN	0007-0912
DOI	10.1016/j.bja.2021.03.008
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Article ; Online: Treating critically ill anaemic patients with erythropoietin: why not?

Lasocki, Sigismond / Kimmoun, Antoine / Chanques, Gerald / Velly, Lionel / Pène, Frédéric

Intensive care medicine

2020 Volume 46, Issue 9, Page(s) 1794–1795

MeSH term(s)	Adult ; Anemia/drug therapy ; Anemia/etiology ; Critical Care ; Critical Illness ; Erythropoietin ; Humans ; Medicine
Chemical Substances	Erythropoietin (11096-26-7)
Language	English
Publishing date	2020-07-16
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	80387-x
ISSN	1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
ISSN (online)	1432-1238
ISSN	0340-0964 ; 0342-4642 ; 0935-1701
DOI	10.1007/s00134-020-06175-3
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