LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 86

Search options

  1. Article ; Online: Potentiating mitochondrial aldehyde dehydrogenase 2 to treat post-infarction heart failure.

    Yavari, Arash / Ashrafian, Houman

    Cardiovascular research

    2014  Volume 103, Issue 4, Page(s) 429–431

    MeSH term(s) Aldehyde Dehydrogenase/metabolism ; Aldehyde Dehydrogenase, Mitochondrial ; Animals ; Heart Failure/enzymology ; Male ; Mitochondria/enzymology ; Mitochondrial Proteins/metabolism ; Ventricular Remodeling/physiology
    Chemical Substances Mitochondrial Proteins ; Aldehyde Dehydrogenase (EC 1.2.1.3) ; Aldehyde Dehydrogenase, Mitochondrial (EC 1.2.1.3) ; Aldh2 protein, rat (EC 1.2.1.3)
    Language English
    Publishing date 2014-09-01
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvu175
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 565: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Metabolic profiling of aortic stenosis and hypertrophic cardiomyopathy identifies mechanistic contrasts in substrate utilization.

    Pal, Nikhil / Acharjee, Animesh / Ament, Zsuzsanna / Dent, Tim / Yavari, Arash / Mahmod, Masliza / Ariga, Rina / West, James / Steeples, Violetta / Cassar, Mark / Howell, Neil J / Lockstone, Helen / Elliott, Kate / Yavari, Parisa / Briggs, William / Frenneaux, Michael / Prendergast, Bernard / Dwight, Jeremy S / Kharbanda, Rajesh /
    Watkins, Hugh / Ashrafian, Houman / Griffin, Julian L

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

    2024  Volume 38, Issue 6, Page(s) e23505

    Abstract: Aortic stenosis (AS) and hypertrophic cardiomyopathy (HCM) are distinct disorders leading to left ventricular hypertrophy (LVH), but whether cardiac metabolism substantially differs between these in humans remains to be elucidated. We undertook an ... ...

    Abstract Aortic stenosis (AS) and hypertrophic cardiomyopathy (HCM) are distinct disorders leading to left ventricular hypertrophy (LVH), but whether cardiac metabolism substantially differs between these in humans remains to be elucidated. We undertook an invasive (aortic root, coronary sinus) metabolic profiling in patients with severe AS and HCM in comparison with non-LVH controls to investigate cardiac fuel selection and metabolic remodeling. These patients were assessed under different physiological states (at rest, during stress induced by pacing). The identified changes in the metabolome were further validated by metabolomic and orthogonal transcriptomic analysis, in separately recruited patient cohorts. We identified a highly discriminant metabolomic signature in severe AS in all samples, regardless of sampling site, characterized by striking accumulation of long-chain acylcarnitines, intermediates of fatty acid transport across the inner mitochondrial membrane, and validated this in a separate cohort. Mechanistically, we identify a downregulation in the PPAR-α transcriptional network, including expression of genes regulating fatty acid oxidation (FAO). In silico modeling of β-oxidation demonstrated that flux could be inhibited by both the accumulation of fatty acids as a substrate for mitochondria and the accumulation of medium-chain carnitines which induce competitive inhibition of the acyl-CoA dehydrogenases. We present a comprehensive analysis of changes in the metabolic pathways (transcriptome to metabolome) in severe AS, and its comparison to HCM. Our results demonstrate a progressive impairment of β-oxidation from HCM to AS, particularly for FAO of long-chain fatty acids, and that the PPAR-α signaling network may be a specific metabolic therapeutic target in AS.
    MeSH term(s) Humans ; Peroxisome Proliferator-Activated Receptors ; Cardiomyopathy, Hypertrophic/genetics ; Hypertrophy, Left Ventricular/genetics ; Aortic Valve Stenosis/genetics ; Fatty Acids/metabolism
    Chemical Substances Peroxisome Proliferator-Activated Receptors ; Fatty Acids
    Language English
    Publishing date 2024-03-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639186-2
    ISSN 1530-6860 ; 0892-6638
    ISSN (online) 1530-6860
    ISSN 0892-6638
    DOI 10.1096/fj.202301710RR
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2266: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 296: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Cancer's sweet tooth: the Janus effect of glucose metabolism in tumorigenesis.

    Ashrafian, Houman

    Lancet (London, England)

    2006  Volume 367, Issue 9510, Page(s) 618–621

    Abstract: Despite Otto Warburg's 1931 Nobel Prize for his work affirming the role of metabolism in carcinogenesis, there has been little further interest in this association between metabolism and cancer. Disinterest has, in part, been attributable to the notion ... ...

    Abstract Despite Otto Warburg's 1931 Nobel Prize for his work affirming the role of metabolism in carcinogenesis, there has been little further interest in this association between metabolism and cancer. Disinterest has, in part, been attributable to the notion that Warburg's description of a relation between a shift to glycolysis in carcinogenesis may be an epiphenomenon rather than a mechanistic determinant. By studying the critical cellular energy sensor AMP-activated protein kinase (AMPK), I postulate that the association between intermediary metabolism and tumours varies over time. Through accumulation of carbohydrates and pan-inhibition of AMPK, premalignant tumours may gain a replicative advantage through the repression of senescence. Conversely, malignant tumours, with a defective tumour suppressor contingent, undergo a "glycolytic switch", in part by tolerating a degree of AMPK activation, to mitigate substrate limitation. I contend that this Janus-faced relation with intermediary metabolism contributes to carcinogenesis; if proven, this finding would have important implications for public health, in that it would lend support to the idea that prevention of obesity, and caloric restriction and exercise could reduce the predisposition to cancer.
    MeSH term(s) AMP-Activated Protein Kinases ; Glucose/metabolism ; Humans ; Multienzyme Complexes/antagonists & inhibitors ; Multienzyme Complexes/metabolism ; Multienzyme Complexes/physiology ; Neoplasms/etiology ; Neoplasms/prevention & control ; Protein-Serine-Threonine Kinases/antagonists & inhibitors ; Protein-Serine-Threonine Kinases/metabolism ; Protein-Serine-Threonine Kinases/physiology
    Chemical Substances Multienzyme Complexes ; Protein-Serine-Threonine Kinases (EC 2.7.11.1) ; AMP-Activated Protein Kinases (EC 2.7.11.31) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2006-02-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(06)68228-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.5: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 94: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: Hepcidin: the missing link between hemochromatosis and infections.

    Ashrafian, Houman

    Infection and immunity

    2003  Volume 71, Issue 12, Page(s) 6693–6700

    MeSH term(s) Antimicrobial Cationic Peptides/metabolism ; Antimicrobial Cationic Peptides/pharmacology ; Bacteria/drug effects ; Bacteria/pathogenicity ; Bacterial Infections/complications ; Bacterial Infections/microbiology ; Hemochromatosis/complications ; Hemochromatosis/pathology ; Hepcidins ; Humans ; Iron/metabolism ; Vibrio Infections/complications ; Vibrio Infections/pathology ; Vibrio vulnificus/drug effects ; Vibrio vulnificus/pathogenicity
    Chemical Substances Antimicrobial Cationic Peptides ; HAMP protein, human ; Hepcidins ; Iron (E1UOL152H7)
    Language English
    Publishing date 2003-11-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 218698-6
    ISSN 1098-5522 ; 0019-9567
    ISSN (online) 1098-5522
    ISSN 0019-9567
    DOI 10.1128/IAI.71.12.6693-6700.2003
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 684: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: Aggressive restenosis after percutaneous intervention in two coronary loci in a patient with human immunodeficiency virus infection.

    Alkhalil, Mohammad / Conlon, Christopher P / Ashrafian, Houman / Choudhury, Robin P

    World journal of clinical cases

    2017  Volume 5, Issue 2, Page(s) 40–45

    Abstract: A 54-year-old black African woman, 22 years human immunodeficiency virus (HIV)-positive, presented with an acute coronary syndrome. She was taking two nucleoside reverse transcriptase inhibitors and two protease inhibitors. Viral load and CD4 count were ... ...

    Abstract A 54-year-old black African woman, 22 years human immunodeficiency virus (HIV)-positive, presented with an acute coronary syndrome. She was taking two nucleoside reverse transcriptase inhibitors and two protease inhibitors. Viral load and CD4 count were stable. Angiography revealed a right coronary artery lesion, which was treated with everolimus eluting stent. She also underwent balloon angioplasty to the first diagonal. She re-presented on three different occasions and technically successful coronary intervention was performed. The patient has reported satisfactory compliance with dual anti platelet therapy throughout. She was successfully treated with surgical revascularisation. The patient did not experience any clinical recurrence on follow up. This case demonstrates exceptionally aggressive multifocal and recurrent instent restenosis in a patient treated for HIV infection, raising the possibility of an association with HIV infection or potentially components of retro viral therapy.
    Language English
    Publishing date 2017-02-17
    Publishing country United States
    Document type Case Reports
    ISSN 2307-8960
    ISSN 2307-8960
    DOI 10.12998/wjcc.v5.i2.40
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: Cardiac energetics in congestive heart failure.

    Ashrafian, Houman

    Circulation

    2002  Volume 105, Issue 6, Page(s) e44–5

    MeSH term(s) Animals ; Carbohydrate Metabolism ; Disease Models, Animal ; Energy Metabolism ; Glycolysis ; Heart Failure/metabolism ; Humans ; Lactic Acid/metabolism ; Lipid Metabolism ; Monocarboxylic Acid Transporters/metabolism ; Rats ; Research Design ; Symporters/metabolism ; Up-Regulation
    Chemical Substances Monocarboxylic Acid Transporters ; Symporters ; monocarboxylate transport protein 1 ; Lactic Acid (33X04XA5AT)
    Language English
    Publishing date 2002-02-12
    Publishing country United States
    Document type Letter
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ui IV Zs.60: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Metabolic modulation in heart failure: high time for a definitive clinical trial.

    Ashrafian, Houman / Neubauer, Stefan

    Heart (British Cardiac Society)

    2011  Volume 97, Issue 4, Page(s) 267–268

    MeSH term(s) Acetyl-CoA C-Acyltransferase/antagonists & inhibitors ; Chronic Disease ; Enzyme Inhibitors/therapeutic use ; Heart Failure/drug therapy ; Heart Failure/metabolism ; Heart Failure/mortality ; Humans ; Meta-Analysis as Topic ; Treatment Outcome ; Trimetazidine/therapeutic use ; Vasodilator Agents/therapeutic use
    Chemical Substances Enzyme Inhibitors ; Vasodilator Agents ; Acetyl-CoA C-Acyltransferase (EC 2.3.1.16) ; Trimetazidine (N9A0A0R9S8)
    Language English
    Publishing date 2011-02
    Publishing country England
    Document type Comment ; Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1303417-0
    ISSN 1468-201X ; 1355-6037
    ISSN (online) 1468-201X
    ISSN 1355-6037
    DOI 10.1136/hrt.2010.214932
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ui IV Zs.40: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 112: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Metabolomic profiling of cardiac substrate utilization: fanning the flames of systems biology?

    Ashrafian, Houman / Neubauer, Stefan

    Circulation

    2009  Volume 119, Issue 13, Page(s) 1700–1702

    MeSH term(s) Heart/physiology ; Heart Diseases/metabolism ; Heart Diseases/surgery ; Humans ; Metabolome/physiology ; Myocardium/metabolism ; Systems Biology
    Language English
    Publishing date 2009-04-07
    Publishing country United States
    Document type Comment ; Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.109.849919
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ui IV Zs.60: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Citric acid cycle intermediates in cardioprotection.

    Czibik, Gabor / Steeples, Violetta / Yavari, Arash / Ashrafian, Houman

    Circulation. Cardiovascular genetics

    2014  Volume 7, Issue 5, Page(s) 711–719

    Abstract: Over the last decade, there has been a concerted clinical effort to deliver on the laboratory promise that a variety of maneuvers can profoundly increase cardiac tolerance to ischemia and/or reduce additional damage consequent upon reperfusion. Here we ... ...

    Abstract Over the last decade, there has been a concerted clinical effort to deliver on the laboratory promise that a variety of maneuvers can profoundly increase cardiac tolerance to ischemia and/or reduce additional damage consequent upon reperfusion. Here we will review the proximity of the metabolic approach to clinical practice. Specifically, we will focus on how the citric acid cycle is involved in cardioprotection. Inspired by cross-fertilization between fundamental cancer biology and cardiovascular medicine, a set of metabolic observations have identified novel metabolic pathways, easily manipulable in man, which can harness metabolism to robustly combat ischemia-reperfusion injury.
    MeSH term(s) Animals ; Citric Acid Cycle/physiology ; Coronary Artery Disease/metabolism ; Coronary Artery Disease/prevention & control ; Heart/physiopathology ; Humans ; Myocardial Ischemia/metabolism ; Myocardial Ischemia/prevention & control ; Myocardium/metabolism
    Language English
    Publishing date 2014-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2477394-3
    ISSN 1942-3268 ; 1942-325X
    ISSN (online) 1942-3268
    ISSN 1942-325X
    DOI 10.1161/CIRCGENETICS.114.000220
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6731: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Inherited cardiomyopathies.

    Watkins, Hugh / Ashrafian, Houman / Redwood, Charles

    The New England journal of medicine

    2011  Volume 364, Issue 17, Page(s) 1643–1656

    MeSH term(s) Cardiomyopathies/classification ; Cardiomyopathies/etiology ; Cardiomyopathies/genetics ; Cardiomyopathies/pathology ; Cardiomyopathy, Dilated ; Cardiomyopathy, Hypertrophic ; Desmosomes ; Diabetic Cardiomyopathies ; Humans ; Mutation ; Myocardium/pathology ; Penetrance ; Phenotype ; Sarcomeres
    Language English
    Publishing date 2011-04-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMra0902923
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.34: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top