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  1. Book: Principles of molecular diagnostics and personalized cancer medicine

    Tan, Dongfeng / Lynch, Henry T.

    2013  

    Author's details ed. Dongfeng Tan ; Henry T. Lynch
    Keywords Neoplasms / diagnosis ; Neoplasms / therapy ; Individualized Medicine / methods ; Medical Oncology / methods ; Molecular Diagnostic Techniques ; Molecular Targeted Therapy
    Language English
    Size XXIII, 968 S. : Ill., graph. Darst.
    Publisher Wolters Kluwer Lippincott Williams & Wilkins
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    Note Includes bibliographical references
    Accompanying material Zugang zur Internetausgabe über Code
    HBZ-ID HT017541337
    ISBN 978-1-4511-3197-0 ; 1-4511-3197-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2012 A 5180 order for loan Magazin
    Zugang zur Internetausgabe über Code aus lizenzrechtlichen Gründen nicht verfügbar

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  2. Book ; Conference proceedings: American Cancer Society Second National Conference on Cancer Genetics

    Lynch, Henry T.

    San Francisco, California, June 26 - 28, 1998

    (Cancer ; 86,8, Suppl.)

    1999  

    Institution American Cancer Society
    Event/congress National Conference on Cancer Genetics (2, 1998, SanFranciscoCalif.)
    Author's details Co-Chairpersons Henry T. Lynch ... American Cancer Society
    Series title Cancer ; 86,8, Suppl.
    Collection
    Language English
    Size S. 1629 - 1768 : Ill., graph. Darst.
    Publisher Wiley
    Publishing place New York, NY
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT011127804
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Uh III Zs 146 -86- verfügbar in Königswinter Königswinter

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  3. Article ; Online: Gene and pathway based burden analyses in familial lymphoid cancer cases: Rare variants in immune pathway genes.

    Ralli, Sneha / Jones, Samantha J / Leach, Stephen / Lynch, Henry T / Brooks-Wilson, Angela R

    PloS one

    2023  Volume 18, Issue 6, Page(s) e0287602

    Abstract: Genome-wide association studies have revealed common genetic variants with small effect sizes associated with diverse lymphoid cancers. Family studies have uncovered rare variants with high effect sizes. However, these variants explain only a portion of ... ...

    Abstract Genome-wide association studies have revealed common genetic variants with small effect sizes associated with diverse lymphoid cancers. Family studies have uncovered rare variants with high effect sizes. However, these variants explain only a portion of the heritability of these cancers. Some of the missing heritability may be attributable to rare variants with small effect sizes. We aim to identify rare germline variants associated with familial lymphoid cancers using exome sequencing. One case per family was selected from 39 lymphoid cancer families based on early onset of disease or rarity of subtype. Control data was from Non-Finnish Europeans in gnomAD exomes (N = 56,885) or ExAC (N = 33,370). Gene and pathway-based burden tests for rare variants were performed using TRAPD. Five putatively pathogenic germline variants were found in four genes: INTU, PEX7, EHHADH, and ASXL1. Pathway-based association tests identified the innate and adaptive immune systems, peroxisomal pathway and olfactory receptor pathway as associated with lymphoid cancers in familial cases. Our results suggest that rare inherited defects in the genes involved in immune system and peroxisomal pathway may predispose individuals to lymphoid cancers.
    MeSH term(s) Humans ; Genome-Wide Association Study ; Genetic Predisposition to Disease ; Neoplasms ; Germ-Line Mutation ; Exome Sequencing
    Language English
    Publishing date 2023-06-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0287602
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: Hereditary aspects of common cancers

    Lynch, Henry T.

    (Surgical oncology clinics of North America ; 3,3)

    1994  

    Author's details Henry T. Lynch ..., guest. ed
    Series title Surgical oncology clinics of North America ; 3,3
    Collection
    Keywords Neoplasms / genetics ; Krebs ; Erbkrankheit
    Subject Genetische Krankheit ; Heredopathie ; Genetisch bedingte Krankheit ; Genetisches Syndrom ; Erbkrankheiten ; Carcinom ; Malignom ; Maligner Tumor ; Neoplasma ; Karzinom ; Bösartiger Tumor ; Krebserkrankung
    Language English
    Size XVI S., S. 419 - 635 : Ill., graph. Darst.
    Publisher Saunders
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT006361499
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 1339 -3,3- verfügbar in Königswinter Königswinter

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  5. Article ; Online: Gene and pathway based burden analyses in familial lymphoid cancer cases

    Sneha Ralli / Samantha J Jones / Stephen Leach / Henry T Lynch / Angela R Brooks-Wilson

    PLoS ONE, Vol 18, Iss 6, p e

    Rare variants in immune pathway genes.

    2023  Volume 0287602

    Abstract: Genome-wide association studies have revealed common genetic variants with small effect sizes associated with diverse lymphoid cancers. Family studies have uncovered rare variants with high effect sizes. However, these variants explain only a portion of ... ...

    Abstract Genome-wide association studies have revealed common genetic variants with small effect sizes associated with diverse lymphoid cancers. Family studies have uncovered rare variants with high effect sizes. However, these variants explain only a portion of the heritability of these cancers. Some of the missing heritability may be attributable to rare variants with small effect sizes. We aim to identify rare germline variants associated with familial lymphoid cancers using exome sequencing. One case per family was selected from 39 lymphoid cancer families based on early onset of disease or rarity of subtype. Control data was from Non-Finnish Europeans in gnomAD exomes (N = 56,885) or ExAC (N = 33,370). Gene and pathway-based burden tests for rare variants were performed using TRAPD. Five putatively pathogenic germline variants were found in four genes: INTU, PEX7, EHHADH, and ASXL1. Pathway-based association tests identified the innate and adaptive immune systems, peroxisomal pathway and olfactory receptor pathway as associated with lymphoid cancers in familial cases. Our results suggest that rare inherited defects in the genes involved in immune system and peroxisomal pathway may predispose individuals to lymphoid cancers.
    Keywords Medicine ; R ; Science ; Q
    Subject code 616
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  6. Book: Hereditary malignant melanoma

    Lynch, Henry T.

    1991  

    Author's details ed. Henry T. Lynch
    Keywords Dysplastic Nevus Syndrome ; Melanoma / genetics ; Melanom ; Erbkrankheit ; Erblichkeit ; Vererblichkeit
    Subject Vererbbarkeit ; Malignes Melanom ; Melanocytoblastom ; Melanozytoblastom ; Melanosarkom ; Melanoma maligna ; Heredität ; Genetische Krankheit ; Heredopathie ; Genetisch bedingte Krankheit ; Genetisches Syndrom ; Erbkrankheiten
    Size 114 S. : Ill., graph. Darst., Kt.
    Publisher CRC Pr
    Publishing place Boca Raton u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT003861082
    ISBN 0-8493-6051-X ; 978-0-8493-6051-0
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1991 A 3732 order for loan Magazin

    Order via subito

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  7. Book: Recent progress in the genetic epidemiology of cancer

    Lynch, Henry T.

    1991  

    Title variant Genetic epidemiology of cancer
    Author's details Henry T. Lynch ... (eds.)
    Keywords Neoplasms / epidemiology ; Neoplasms / genetics ; Krebs ; Erbkrankheit ; Epidemiologie
    Subject Krankheitsverbreitung ; Genetische Krankheit ; Heredopathie ; Genetisch bedingte Krankheit ; Genetisches Syndrom ; Erbkrankheiten ; Carcinom ; Malignom ; Maligner Tumor ; Neoplasma ; Karzinom ; Bösartiger Tumor ; Krebserkrankung
    Language English
    Size X, 162 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Berlin u.a.
    Document type Book
    HBZ-ID HT003785372
    ISBN 3-540-53022-3 ; 0-387-53022-3 ; 978-3-540-53022-0 ; 978-0-387-53022-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1991 A 2465 order for loan Magazin

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  8. Article ; Online: Family Chronicles of Missed Opportunities.

    Flugelman, Anath A / Lynch, Henry T

    JAMA oncology

    2016  Volume 2, Issue 5, Page(s) 573–574

    Language English
    Publishing date 2016-04-08
    Publishing country United States
    Document type Journal Article
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2016.0110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Introduction to special issue of Familial Cancer.

    Lynch, Henry T / Snyder, Carrie L

    Familial cancer

    2016  Volume 15, Issue 3, Page(s) 357–358

    Language English
    Publishing date 2016-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1502496-9
    ISSN 1573-7292 ; 1389-9600
    ISSN (online) 1573-7292
    ISSN 1389-9600
    DOI 10.1007/s10689-016-9909-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6099: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: The role of surgical disconnection for posterior fossa pial arteriovenous fistulas and dural fistulas with pial supply: an illustrative case series.

    Golub, Danielle / Lynch, Daniel G / Mehta, Shyle H / Donaldson, Hayley / Shah, Kevin A / White, Timothy G / Quach, Eric T / Papadimitriou, Kyriakos / Kuffer, Alexander F / Woo, Henry H / Link, Thomas W / Patsalides, Athos / Dehdashti, Amir R

    Neurosurgical review

    2024  Volume 47, Issue 1, Page(s) 189

    Abstract: Background: Pial arteriovenous fistulas (pAVFs) are rare vascular malformations characterized by high-flow arteriovenous shunting involving a cortical arterial supply directly connecting to venous drainage without an intermediate nidus. Dural ... ...

    Abstract Background: Pial arteriovenous fistulas (pAVFs) are rare vascular malformations characterized by high-flow arteriovenous shunting involving a cortical arterial supply directly connecting to venous drainage without an intermediate nidus. Dural arteriovenous fistulas (dAVFs) can infrequently involve additional pial feeders which can introduce higher flow shunting and increase the associated treatment risk. In the posterior fossa, arteriovenous fistula (AVF) angioarchitecture tends to be particularly complex, involving either multiple arterial feeders-sometimes from both dural and pial origins-or small caliber vessels that are difficult to catheterize and tend to be intimately involved with functionally critical brainstem or upper cervical cord structures. Given their rarity, published experience on microsurgical or endovascular treatment strategies for posterior fossa pAVFs and dAVFs with pial supply remains limited.
    Methods: Retrospective chart review from 2019-2023 at a high-volume center identified six adult patients with posterior fossa pAVFs that were unable to be fully treated endovascularly and required microsurgical disconnection. These cases are individually presented with a technical emphasis and supported by comprehensive angiographic and intraoperative images.
    Results: One vermian (Case 1), three cerebellopontine angle (Cases 2-4) and two craniovertebral junction (Cases 5-6) posterior fossa pAVFs or dAVFs with pial supply are presented. Three cases involved mixed dural and pial arterial supply (Cases 1, 4, and 6), and one case involved a concomitant microAVM (Case 2). Endovascular embolization was attempted in four cases (Cases 1-4): The small caliber and tortuosity of the main arterial feeder prevented catheterization in two cases (Cases 1 and 3). Partial embolization was achieved in Cases 2 and 4. In Cases 5 and 6, involvement of the lateral spinal artery or anterior spinal artery created a prohibitive risk for endovascular embolization, and surgical clip ligation was pursued as primary management. In all cases, microsurgical disconnection resulted in complete fistula obliteration without evidence of recurrence on follow-up imaging (mean follow-up 27.1 months). Two patients experienced persistent post-treatment sensory deficits without significant functional limitation.
    Conclusions: This illustrative case series highlights the technical difficulties and anatomical limitations of endovascular management for posterior fossa pAVFs and dAVFs with pial supply and emphasizes the relative safety and utility of microsurgical disconnection in this context. A combined approach involving partial preoperative embolization-when the angioarchitecture is permissive-can potentially decrease surgical morbidity. Larger studies are warranted to better define the role for multimodal intervention and to assess associated long-term AVF obliteration rates in the setting of pial arterial involvement.
    MeSH term(s) Humans ; Male ; Female ; Middle Aged ; Central Nervous System Vascular Malformations/surgery ; Aged ; Pia Mater/blood supply ; Pia Mater/surgery ; Retrospective Studies ; Adult ; Arteriovenous Fistula/surgery ; Cranial Fossa, Posterior/surgery ; Neurosurgical Procedures/methods ; Embolization, Therapeutic/methods ; Intracranial Arteriovenous Malformations/surgery
    Language English
    Publishing date 2024-04-25
    Publishing country Germany
    Document type Journal Article ; Case Reports
    ZDB-ID 6907-3
    ISSN 1437-2320 ; 0344-5607
    ISSN (online) 1437-2320
    ISSN 0344-5607
    DOI 10.1007/s10143-024-02407-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1445: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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