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  1. Article ; Online: Gut microbiota in women: The secret of psychological and physical well-being.

    Marano, Giuseppe / Traversi, Gianandrea / Gaetani, Eleonora / Gasbarrini, Antonio / Mazza, Marianna

    World journal of gastroenterology

    2023  Volume 29, Issue 45, Page(s) 5945–5952

    Abstract: The gut microbiota works in unison with the host, promoting its health. In particular, it has been shown to exert protective, metabolic and structural functions. Recent evidence has revealed the influence of the gut microbiota on other organs such as the ...

    Abstract The gut microbiota works in unison with the host, promoting its health. In particular, it has been shown to exert protective, metabolic and structural functions. Recent evidence has revealed the influence of the gut microbiota on other organs such as the central nervous system, cardiovascular and the endocrine-metabolic systems and the digestive system. The study of the gut microbiota is outlining new and broader frontiers every day and holds enormous innovation potential for the medical and pharmaceutical fields. Prevention and treatment of specific women's diseases involves the need to deepen the function of the gut as a junction organ where certain positive bacteria can be very beneficial to health. The gut microbiota is unique and dynamic at the same time, subject to external factors that can change it, and is capable of modulating itself at different stages of a woman's life, playing an important role that arises from the intertwining of biological mechanisms between the microbiota and the female genital system. The gut microbiota could play a key role in personalized medicine.
    MeSH term(s) Female ; Humans ; Gastrointestinal Microbiome/physiology ; Microbiota ; Brain ; Central Nervous System
    Language English
    Publishing date 2023-12-20
    Publishing country United States
    Document type Editorial
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v29.i45.5945
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6039: Show issues Location:
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  2. Article: Surgery or No Surgery? Exploring the Dilemma of Epistaxis Management in Patients with HHT.

    Passali, Giulio Cesare / Santantonio, Mariaconsiglia / Vecchioli, Nadia / Sollazzo, Michela / Rolesi, Rolando / Marotta, Ilenia / Corina, Luigi / Riccioni, Maria Elena / Gaetani, Eleonora / Galli, Jacopo

    Journal of clinical medicine

    2024  Volume 13, Issue 6

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2024-03-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13061688
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  3. Article: Treatment of a Patient with a Diagnosis of HHT with a Combined Psychological and Physical Approach.

    Marano, Giuseppe / Mazza, Marianna / Di Martino, Luigi / Agostini, Fabiana / Passali, Giulio Cesare / Sani, Gabriele / Pola, Roberto / Gaetani, Eleonora

    Psychiatria Danubina

    2022  Volume 34, Issue 2, Page(s) 304–305

    Language English
    Publishing date 2022-07-06
    Publishing country Croatia
    Document type Journal Article
    ZDB-ID 1067580-2
    ISSN 0353-5053
    ISSN 0353-5053
    DOI 10.24869/psyd.2022.304
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    Zs.A 3158: Show issues Location:
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  4. Article: Mental Health and Coaching Challenges Facing the COVID-19 Outbreak.

    Marano, Giuseppe / Traversi, Gianandrea / Gesualdi, Amanda / Biffi, Alberto / Gaetani, Eleonora / Sani, Gabriele / Mazza, Marianna

    Psychiatria Danubina

    2021  Volume 33, Issue 1, Page(s) 124–126

    MeSH term(s) COVID-19 ; Disease Outbreaks ; Humans ; Mental Health ; Mentoring ; SARS-CoV-2
    Language English
    Publishing date 2021-04-26
    Publishing country Croatia
    Document type Letter
    ZDB-ID 1067580-2
    ISSN 0353-5053
    ISSN 0353-5053
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  5. Article: Taking Care of Intellectual Disabilities in the Era of COVID-19: Biological Substrates, Personalized Medicine and Counseling.

    Marano, Giuseppe / Traversi, Gianandrea / Gaetani, Eleonora / Pecora, Riccardo Daniele / Paris, Alessandro / Mazza, Salvatore / Mazza, Marianna

    Psychiatria Danubina

    2022  Volume 34, Issue 1, Page(s) 186–187

    MeSH term(s) COVID-19 ; Counseling ; Humans ; Intellectual Disability/epidemiology ; Intellectual Disability/therapy ; Precision Medicine ; Surveys and Questionnaires
    Language English
    Publishing date 2022-04-23
    Publishing country Croatia
    Document type Journal Article
    ZDB-ID 1067580-2
    ISSN 0353-5053
    ISSN 0353-5053
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  6. Article: Alcohol use disorder and liver injury related to the COVID-19 pandemic.

    Marano, Giuseppe / Traversi, Gianandrea / Gaetani, Eleonora / Pola, Roberto / Claro, Angelo Emilio / Mazza, Marianna

    World journal of hepatology

    2022  Volume 14, Issue 10, Page(s) 1875–1883

    Abstract: Alcohol use disorder is a complex and heterogeneous phenomenon that can be studied from several points of view by focusing on its different components. Alcohol is a hepatotoxin whose metabolism creates profound alterations within the hepatocyte. The ... ...

    Abstract Alcohol use disorder is a complex and heterogeneous phenomenon that can be studied from several points of view by focusing on its different components. Alcohol is a hepatotoxin whose metabolism creates profound alterations within the hepatocyte. The liver is the central organ in the metabolism of alcohol, a process that also involves other organs and tissues such as the brain, heart and muscles, but the most relevant organ is the liver. The anatomopathological alterations in the liver associated with the prolonged use of alcohol range from the simple accumulation of neutral fats in the hepatocytes, to cirrhosis and hepatocellular carcinoma. Alcohol abuse frequently leads to liver disease such as steatosis, steatohepatitis, fibrosis, cirrhosis, and tumors. Following the spread of coronavirus disease 2019 (COVID-19), there was an increase in alcohol consumption, probably linked to the months of lockdown and smart working. It is known that social isolation leads to a considerable increase in stress, and it is also recognized that high levels of stress can result in an increase in alcohol intake. Cirrhotic patients or subjects with liver cancer are immunocompromised, so they may be more exposed to COVID-19 infection with a worse prognosis. This review focuses on the fact that the COVID-19 pandemic has made the emergence of alcohol-induced liver damage a major medical and social problem.
    Language English
    Publishing date 2022-02-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2573703-X
    ISSN 1948-5182
    ISSN 1948-5182
    DOI 10.4254/wjh.v14.i10.1875
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Evaluation of tolerability and major factors affecting the adherence to probiotic therapy in patients with irritable bowel syndrome: a prospective, observational, real-life study.

    Laterza, Lucrezia / Napoli, Marco / Petito, Valentina / Scaldaferri, Franco / Gaetani, Eleonora / Gasbarrini, Antonio

    Minerva medica

    2021  Volume 114, Issue 2, Page(s) 203–209

    Abstract: Background: Probiotics have been evaluated in multiple clinical trials on irritable bowel syndrome (IBS). However, in real-life long-term compliance could be low. Our study is single-center, observational and prospective, aiming both to evaluate the ... ...

    Abstract Background: Probiotics have been evaluated in multiple clinical trials on irritable bowel syndrome (IBS). However, in real-life long-term compliance could be low. Our study is single-center, observational and prospective, aiming both to evaluate the adherence to prescription of probiotic therapy in real-life and to identify factors able to influence adherence to therapy.
    Methods: Fifty patients diagnosed with IBS according to Rome IV and receiving a clinical prescription of a multistrain probiotic preparation (VSL#3
    Results: Sixty percent of patients took all the prescribed probiotic therapy in real-life setting, with perceived benefits in more than 60% of cases. Among the 20 patients with reduced adherence, 5 took less than 50%, 12 took 50% and 2 took more than 50% but less than 80% of the prescribed doses. Principal reasons of not complete adherence among the 20 patients were: price of the product (8/20), mild adverse events (AEs) (6/20) and poor appreciation of flavour (3/20).
    Conclusions: This study suggested that the adherence to probiotic therapy is affected by different factors in patients with IBS in a real-life setting. The main reason for lack of adherence was the price of the product. Other reasons are mild AEs (mainly bloating) and low palatability.
    MeSH term(s) Humans ; Irritable Bowel Syndrome/diagnosis ; Irritable Bowel Syndrome/drug therapy ; Prospective Studies ; Treatment Outcome ; Probiotics/therapeutic use ; Complementary Therapies
    Language English
    Publishing date 2021-06-11
    Publishing country Italy
    Document type Observational Study ; Journal Article
    ZDB-ID 123586-2
    ISSN 1827-1669 ; 0026-4806
    ISSN (online) 1827-1669
    ISSN 0026-4806
    DOI 10.23736/S0026-4806.21.07015-4
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    Ua VI Zs.132: Show issues Location:
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  8. Article ; Online: The Microbiota-Gut-Brain Axis: Psychoneuroimmunological Insights.

    Marano, Giuseppe / Mazza, Marianna / Lisci, Francesco Maria / Ciliberto, Michele / Traversi, Gianandrea / Kotzalidis, Georgios Demetrios / De Berardis, Domenico / Laterza, Lucrezia / Sani, Gabriele / Gasbarrini, Antonio / Gaetani, Eleonora

    Nutrients

    2023  Volume 15, Issue 6

    Abstract: There is growing interest in the role that the intestinal microbiota and the related autoimmune processes may have in the genesis and presentation of some psychiatric diseases. An alteration in the communication of the microbiota-gut-brain axis, which ... ...

    Abstract There is growing interest in the role that the intestinal microbiota and the related autoimmune processes may have in the genesis and presentation of some psychiatric diseases. An alteration in the communication of the microbiota-gut-brain axis, which constitutes a communicative model between the central nervous system (CNS) and the gastro-enteric tract, has been identified as one of the possible causes of some psychiatric diseases. The purpose of this narrative review is to describe evidence supporting a role of the gut microbiota in psychiatric diseases and the impact of diet on microbiota and mental health. Change in the composition of the gut microbiota could determine an increase in the permeability of the intestinal barrier, leading to a cytokine storm. This could trigger a systemic inflammatory activation and immune response: this series of events could have repercussions on the release of some neurotransmitters, altering the activity of the hypothalamic-pituitary-adrenal axis, and reducing the presence of trophic brain factors. Although gut microbiota and psychiatric disorders seem to be connected, more effort is needed to understand the potential causative mechanisms underlying the interactions between these systems.
    MeSH term(s) Humans ; Brain-Gut Axis ; Hypothalamo-Hypophyseal System ; Pituitary-Adrenal System ; Brain/physiology ; Central Nervous System
    Language English
    Publishing date 2023-03-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15061496
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Hereditary haemorrhagic telangiectasia: A disease not to be forgotten during the COVID-19 pandemic.

    Gaetani, Eleonora / Passali, Giulio Cesare / Riccioni, Maria E / Tortora, Annalisa / Pola, Roberto / Costamagna, Guido / Gasbarrini, Antonio

    Journal of thrombosis and haemostasis : JTH

    2020  Volume 18, Issue 7, Page(s) 1799–1801

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Outcome Assessment, Health Care ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Telangiectasia, Hereditary Hemorrhagic ; Vascular Diseases
    Keywords covid19
    Language English
    Publishing date 2020-04-29
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1111/jth.14885
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    Zs.MO 295: Show issues

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  10. Article ; Online: The Hedgehog Signaling Pathway in Ischemic Tissues.

    Giarretta, Igor / Gaetani, Eleonora / Bigossi, Margherita / Tondi, Paolo / Asahara, Takayuki / Pola, Roberto

    International journal of molecular sciences

    2019  Volume 20, Issue 21

    Abstract: Hedgehog (Hh) proteins are prototypical morphogens known to regulate epithelial/mesenchymal interactions during embryonic development. In addition to its pivotal role in embryogenesis, the Hh signaling pathway may be recapitulated in post-natal life in a ...

    Abstract Hedgehog (Hh) proteins are prototypical morphogens known to regulate epithelial/mesenchymal interactions during embryonic development. In addition to its pivotal role in embryogenesis, the Hh signaling pathway may be recapitulated in post-natal life in a number of physiological and pathological conditions, including ischemia. This review highlights the involvement of Hh signaling in ischemic tissue regeneration and angiogenesis, with particular attention to the heart, the brain, and the skeletal muscle. Updated information on the potential role of the Hh pathway as a therapeutic target in the ischemic condition is also presented.
    MeSH term(s) Animals ; Brain/metabolism ; Hedgehog Proteins/metabolism ; Humans ; Ischemia/metabolism ; Ischemia/pathology ; Muscle, Skeletal/metabolism ; Myocardium/metabolism ; Signal Transduction
    Chemical Substances Hedgehog Proteins
    Language English
    Publishing date 2019-10-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms20215270
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