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  1. Article ; Online: EDITORIAL COMMENT.

    Ricketts, Christopher J / Linehan, W Marston

    Urology

    2023  Volume 176, Page(s) 113–114

    Language English
    Publishing date 2023-06-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 192062-5
    ISSN 1527-9995 ; 0090-4295
    ISSN (online) 1527-9995
    ISSN 0090-4295
    DOI 10.1016/j.urology.2022.11.054
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  2. Article ; Online: The Warburg effect in hominis: isotope-resolved metabolism in ccRCC.

    Crooks, Daniel R / Linehan, W Marston

    Nature reviews. Urology

    2018  Volume 15, Issue 12, Page(s) 731–732

    Language English
    Publishing date 2018-10-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2493737-X
    ISSN 1759-4820 ; 1759-4812
    ISSN (online) 1759-4820
    ISSN 1759-4812
    DOI 10.1038/s41585-018-0110-1
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  3. Article ; Online: Precision Surgery and Kidney Cancer: Knowledge of Genetic Alterations Influences Surgical Management.

    Gomella, Patrick T. / Linehan, W. Marston / Ball, Mark W.

    Genes

    2021  Volume 12, Issue 2

    Abstract: Renal cell carcinoma is a term that represents multiple different disease processes, each driven by different genetic alterations, with distinct histology, and biological potential which necessitates divergent management strategies. This review discusses ...

    Abstract Renal cell carcinoma is a term that represents multiple different disease processes, each driven by different genetic alterations, with distinct histology, and biological potential which necessitates divergent management strategies. This review discusses the genetic alterations seen in several forms of hereditary kidney cancer and how that knowledge can dictate when and how to intervene with a focus on the surgical management of these tumors.
    MeSH term(s) Carcinoma, Renal Cell/classification ; Carcinoma, Renal Cell/genetics ; Carcinoma, Renal Cell/pathology ; Carcinoma, Renal Cell/surgery ; Humans ; Kidney Neoplasms/classification ; Kidney Neoplasms/genetics ; Kidney Neoplasms/pathology ; Kidney Neoplasms/surgery ; Leiomyomatosis/classification ; Leiomyomatosis/genetics ; Leiomyomatosis/pathology ; Leiomyomatosis/surgery ; Mutation/genetics ; Neoplastic Syndromes, Hereditary/classification ; Neoplastic Syndromes, Hereditary/genetics ; Neoplastic Syndromes, Hereditary/pathology ; Neoplastic Syndromes, Hereditary/surgery ; Skin Neoplasms/classification ; Skin Neoplasms/genetics ; Skin Neoplasms/pathology ; Skin Neoplasms/surgery ; Succinate Dehydrogenase/genetics ; Tumor Suppressor Proteins/genetics ; Ubiquitin Thiolesterase/genetics ; Uterine Neoplasms/classification ; Uterine Neoplasms/genetics ; Uterine Neoplasms/pathology ; Uterine Neoplasms/surgery ; Von Hippel-Lindau Tumor Suppressor Protein/genetics
    Chemical Substances BAP1 protein, human ; Tumor Suppressor Proteins ; Succinate Dehydrogenase (EC 1.3.99.1) ; Von Hippel-Lindau Tumor Suppressor Protein (EC 2.3.2.27) ; Ubiquitin Thiolesterase (EC 3.4.19.12) ; VHL protein, human (EC 6.3.2.-)
    Language English
    Publishing date 2021-02-11
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes12020261
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  4. Article ; Online: The origin, evolution and route to metastasis of clear cell RCC.

    Ricketts, Christopher J / Linehan, W Marston

    Nature reviews. Nephrology

    2018  Volume 14, Issue 9, Page(s) 538–540

    MeSH term(s) Carcinoma, Renal Cell ; Humans ; Kidney ; Kidney Neoplasms
    Language English
    Publishing date 2018-06-06
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2490366-8
    ISSN 1759-507X ; 1759-5061
    ISSN (online) 1759-507X
    ISSN 1759-5061
    DOI 10.1038/s41581-018-0031-5
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  5. Article ; Online: The Cancer Genome Atlas of renal cell carcinoma: findings and clinical implications.

    Linehan, W Marston / Ricketts, Christopher J

    Nature reviews. Urology

    2019  Volume 16, Issue 9, Page(s) 539–552

    Abstract: The Cancer Genome Atlas (TCGA) characterized the somatic genetic and genomic alterations in renal cell carcinoma (RCC) encompassing the major RCC histological subtypes, including clear cell RCC (ccRCC), papillary RCC (pRCC) and chromophobe RCC (chRCC). ... ...

    Abstract The Cancer Genome Atlas (TCGA) characterized the somatic genetic and genomic alterations in renal cell carcinoma (RCC) encompassing the major RCC histological subtypes, including clear cell RCC (ccRCC), papillary RCC (pRCC) and chromophobe RCC (chRCC). Unique distinguishing features were found between the RCC subtypes, including in chromosomal alterations and tumour metabolism, as well as within each RCC subtype, of which some correlated with differences in patient survival. Two new RCC subtypes were defined by distinct epigenetic and metabolic pathway expression patterns, the hypermethylated CpG island methylator phenotype-associated (CIMP) RCCs and metabolically divergent chRCCs, and new biomarkers of poor patient outcome were identified, including PBRM1 mutation in type 1 pRCC and CDKN2A loss in chRCC. Expression of many immune cell gene-specific signatures was increased in ccRCC compared with pRCC and chRCC, and expression of select signatures, including the type 2 T helper cell signature, was increased in CIMP RCC. Increased expression of the type 2 T helper cell signature correlated with poorer survival in ccRCC, pRCC and chRCC. In addition to improving our current understanding of RCC, TCGA RCC studies are an invaluable resource that provides the foundation for the development of improved methods for diagnosis, treatment and prevention of this disease.
    MeSH term(s) Carcinoma, Renal Cell/classification ; Carcinoma, Renal Cell/diagnosis ; Carcinoma, Renal Cell/genetics ; Carcinoma, Renal Cell/therapy ; Epigenomics ; Genome ; Humans ; Kidney Neoplasms/classification ; Kidney Neoplasms/diagnosis ; Kidney Neoplasms/genetics ; Kidney Neoplasms/therapy ; Mutation
    Language English
    Publishing date 2019-07-05
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 2493737-X
    ISSN 1759-4820 ; 1759-4812
    ISSN (online) 1759-4820
    ISSN 1759-4812
    DOI 10.1038/s41585-019-0211-5
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  6. Article ; Online: Multi-regional Sequencing Elucidates the Evolution of Clear Cell Renal Cell Carcinoma.

    Ricketts, Christopher J / Linehan, W Marston

    Cell

    2018  Volume 173, Issue 3, Page(s) 540–542

    Abstract: Extensive multi-regional whole-genome and -exome sequencing performed in tumors from patients with localized, as well as metastatic, clear cell renal cell carcinoma provides a comprehensive description of the tumor origin, intratumoral heterogeneity, ... ...

    Abstract Extensive multi-regional whole-genome and -exome sequencing performed in tumors from patients with localized, as well as metastatic, clear cell renal cell carcinoma provides a comprehensive description of the tumor origin, intratumoral heterogeneity, evolution, and route to metastasis, laying the foundation for the development of precision clinical management.
    MeSH term(s) Carcinoma, Renal Cell ; Humans ; Kidney Neoplasms ; Mutation
    Language English
    Publishing date 2018-04-18
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2018.03.077
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  7. Article ; Online: A mouse model of renal cell carcinoma.

    Schmidt, Laura S / Linehan, W Marston

    Nature medicine

    2017  Volume 23, Issue 7, Page(s) 802–803

    MeSH term(s) Animals ; Carcinoma, Renal Cell/genetics ; Disease Models, Animal ; Kidney Neoplasms/genetics ; Mice ; Mutation
    Language English
    Publishing date 2017-07-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/nm.4366
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  8. Article ; Online: TEMPOL inhibits SARS-CoV-2 replication and development of lung disease in the Syrian hamster model.

    Maio, Nunziata / Cherry, Sara / Schultz, David C / Hurst, Brett L / Linehan, W Marston / Rouault, Tracey A

    iScience

    2022  Volume 25, Issue 10, Page(s) 105074

    Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a worldwide outbreak, known as coronavirus disease 2019 (COVID-19). Alongside vaccines, antiviral therapeutics is an important part of the healthcare response to COVID-19. We ... ...

    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a worldwide outbreak, known as coronavirus disease 2019 (COVID-19). Alongside vaccines, antiviral therapeutics is an important part of the healthcare response to COVID-19. We previously reported that TEMPOL, a small molecule stable nitroxide, inactivated the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 by causing the oxidative degradation of its iron-sulfur cofactors. Here, we demonstrate that TEMPOL is effective
    Language English
    Publishing date 2022-09-06
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2022.105074
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  9. Article: Evaluation and screening for hereditary renal cell cancers.

    Linehan, W Marston

    Canadian Urological Association journal = Journal de l'Association des urologues du Canada

    2013  Volume 7, Issue 9-10, Page(s) 324–325

    Language English
    Publishing date 2013-11-23
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2431403-1
    ISSN 1911-6470
    ISSN 1911-6470
    DOI 10.5489/cuaj.1685
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  10. Article ; Online: Resolving Enantiomers of 2-Hydroxy Acids by Nuclear Magnetic Resonance.

    Lin, Penghui / Crooks, Daniel R / Linehan, W Marston / Fan, Teresa W-M / Lane, Andrew N

    Analytical chemistry

    2022  Volume 94, Issue 36, Page(s) 12286–12291

    Abstract: Biologically important 2-hydroxy carboxylates such as lactate, malate, and 2-hydroxyglutarate exist in two enantiomeric forms that cannot be distinguished under achiral conditions. The D and L (or R, S) enantiomers have different biological origins and ... ...

    Abstract Biologically important 2-hydroxy carboxylates such as lactate, malate, and 2-hydroxyglutarate exist in two enantiomeric forms that cannot be distinguished under achiral conditions. The D and L (or R, S) enantiomers have different biological origins and functions, and therefore, there is a need for a simple method for resolving, identifying, and quantifying these enantiomers. We have adapted and improved a chiral derivatization technique for nuclear magnetic resonance (NMR), which needs no chromatography for enantiomer resolution, with greater than 90% overall recovery. This method was developed for 2-hydroxyglutarate (2HG) to produce diastereomers resolvable by column chromatography. We have applied the method to lactate, malate, and 2HG. The limit of quantification was determined to be about 1 nmol for 2HG with coefficients of variation of less than 5%. We also demonstrated the method on an extract of a renal carcinoma bearing an isocitrate dehydrogenase-2 (IDH2) variant that produces copious quantities of 2HG and showed that it is the D enantiomer that was exclusively produced. We also demonstrated in the same experiment that the lactate produced in the same sample was the L enantiomer.
    MeSH term(s) Humans ; Hydroxy Acids ; Isocitrate Dehydrogenase ; Kidney Neoplasms ; Lactates ; Magnetic Resonance Spectroscopy ; Malates
    Chemical Substances Hydroxy Acids ; Lactates ; Malates ; Isocitrate Dehydrogenase (EC 1.1.1.41)
    Language English
    Publishing date 2022-08-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.2c00490
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