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Article: Before it becomes completely random.

Abda, Assil / Leduc, Jean-Michel / Benoit, Geneviève / Hervouet-Zeiber, Catherine

2022 Volume 13, Issue 4, Page(s) 117–118

Language	English
Publishing date	2022-08-26
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2689512-2
ISSN	1923-1202
ISSN	1923-1202
DOI	10.36834/cmej.75318
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Before it becomes completely random

Assil Abda / Jean-Michel Leduc / Geneviève Benoit / Catherine Hervouet-Zeiber

Canadian Medical Education Journal (2022)

2022

Keywords	Education (General) ; L7-991 ; Medicine (General) ; R5-920
Language	English
Publishing date	2022-07-01T00:00:00Z
Publisher	Canadian Medical Education Journal
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Prevalence and determinants of hypertension in the adult Inuit population of Nunavik (northern Quebec, Canada).

Allaire, Janie / Lévesque, Benoît / Poirier, Paul / Gagnon, Claudia / Auclair, Geneviève / Lemire, Mélanie / Ayotte, Pierre

Canadian journal of public health = Revue canadienne de sante publique

2023 Volume 115, Issue Suppl 1, Page(s) 168–179

Abstract: Objectives: To assess the prevalence of arterial hypertension among Inuit adults living in Nunavik (northern Quebec, Canada) in 2017 and identify its sociodemographic and lifestyle determinants.: Methods: We used data obtained from 1177 Inuit adults ... ...

Abstract	Objectives: To assess the prevalence of arterial hypertension among Inuit adults living in Nunavik (northern Quebec, Canada) in 2017 and identify its sociodemographic and lifestyle determinants. Methods: We used data obtained from 1177 Inuit adults aged ≥ 18 years who participated in the cross-sectional Qanuilirpitaa? Nunavik Inuit Health Survey during late summer-early fall of 2017. Resting blood pressure (BP) and anthropometric characteristics were measured during a clinical session, while sociodemographic characteristics and lifestyle habits were documented using validated questionnaires. Information on current medication was retrieved from medical files. Sex-stratified population-weighted log-binomial regressions were conducted to identify determinants of hypertension, adjusting for potential confounders. Results: Hypertension (systolic BP ≥ 140 mm Hg or diastolic BP ≥ 90 mmHg or taking antihypertensive medication) was present in 23% of the adult population and was more frequent in men than women (29% vs. 18%). About a third of hypertensive individuals (34%) were taking antihypertensive medication. These estimates are prone to biases due to the relatively low participation rate (37%). As expected, the prevalence of hypertension increased with age, but values were surprisingly elevated in 18 to 29-year-old men and women (18% and 8%, respectively) compared with 20 to 39-year-old adults of the general Canadian population (3% in both sexes, according to data from the Canadian Health Measures Survey, 2012-2015). Hypertension was associated with obesity and alcohol consumption in both men and women, and with higher socioeconomic status among men. Conclusion: This survey revealed a high prevalence of hypertension among young Nunavimmiut adults in 2017 and the need to improve hypertension diagnosis and treatment in the region. Curbing obesity and alcohol consumption, two actionable determinants of hypertension, will require improving food security and addressing the consequences of historical trauma linked to colonization.
MeSH term(s)	Adolescent ; Adult ; Female ; Humans ; Male ; Young Adult ; Antihypertensive Agents ; Canada ; Cross-Sectional Studies ; Hypertension/epidemiology ; Inuit ; Obesity/epidemiology ; Prevalence ; Quebec/epidemiology ; Social Determinants of Health
Chemical Substances	Antihypertensive Agents
Language	English
Publishing date	2023-05-08
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	417262-0
ISSN	1920-7476 ; 0008-4263
ISSN (online)	1920-7476
ISSN	0008-4263
DOI	10.17269/s41997-023-00774-5
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Article ; Online: The 37TrillionCells initiative for improving global healthcare via cell-based interception and precision medicine: focus on neurodegenerative diseases.

Coulombe, Benoit / Durcan, Thomas M / Bernard, Geneviève / Moursli, Asmae / Poitras, Christian / Faubert, Denis / Pinard, Maxime

Molecular brain

2024 Volume 17, Issue 1, Page(s) 18

Abstract: One of the main burdens in the treatment of diseases is imputable to the delay between the appearance of molecular dysfunctions in the first affected disease cells and their presence in sufficient number for detection in specific tissues or organs. This ... ...

Abstract	One of the main burdens in the treatment of diseases is imputable to the delay between the appearance of molecular dysfunctions in the first affected disease cells and their presence in sufficient number for detection in specific tissues or organs. This delay obviously plays in favor of disease progression to an extent that makes efficient treatments difficult, as they arrive too late. The development of a novel medical strategy, termed cell-based interception and precision medicine, seeks to identify dysfunctional cells early, when tissue damages are not apparent and symptoms not yet present, and develop therapies to treat diseases early. Central to this strategy is the use of single-cell technologies that allow detection of molecular changes in cells at the time of phenotypical bifurcation from health to disease. In this article we describe a general procedure to support such an approach applied to neurodegenerative disorders. This procedure combines four components directed towards highly complementary objectives: 1) a high-performance single-cell proteomics (SCP) method (Detect), 2) the development of disease experimental cell models and predictive computational models of cell trajectories (Understand), 3) the discovery of specific targets and personalized therapies (Cure), and 4) the creation of a community of collaborating laboratories to accelerate the development of this novel medical paradigm (Collaborate). A global initiative named 37TrillionCells (37TC) was launched to advance the development of cell-based interception and precision medicine.
MeSH term(s)	Humans ; Neurodegenerative Diseases/therapy ; Precision Medicine/methods ; Delivery of Health Care ; Proteomics/methods
Language	English
Publishing date	2024-04-11
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2436057-0
ISSN	1756-6606 ; 1756-6606
ISSN (online)	1756-6606
ISSN	1756-6606
DOI	10.1186/s13041-024-01088-4
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Article ; Online: Development of a machine learning detector for North Atlantic humpback whale song.

Kather, Vincent / Seipel, Fabian / Berges, Benoit / Davis, Genevieve / Gibson, Catherine / Harvey, Matt / Henry, Lea-Anne / Stevenson, Andrew / Risch, Denise

The Journal of the Acoustical Society of America

2024 Volume 155, Issue 3, Page(s) 2050–2064

Abstract: The study of humpback whale song using passive acoustic monitoring devices requires bioacousticians to manually review hours of audio recordings to annotate the signals. To vastly reduce the time of manual annotation through automation, a machine ... ...

Abstract	The study of humpback whale song using passive acoustic monitoring devices requires bioacousticians to manually review hours of audio recordings to annotate the signals. To vastly reduce the time of manual annotation through automation, a machine learning model was developed. Convolutional neural networks have made major advances in the previous decade, leading to a wide range of applications, including the detection of frequency modulated vocalizations by cetaceans. A large dataset of over 60 000 audio segments of 4 s length is collected from the North Atlantic and used to fine-tune an existing model for humpback whale song detection in the North Pacific (see Allen, Harvey, Harrell, Jansen, Merkens, Wall, Cattiau, and Oleson (2021). Front. Mar. Sci. 8, 607321). Furthermore, different data augmentation techniques (time-shift, noise augmentation, and masking) are used to artificially increase the variability within the training set. Retraining and augmentation yield F-score values of 0.88 on context window basis and 0.89 on hourly basis with false positive rates of 0.05 on context window basis and 0.01 on hourly basis. If necessary, usage and retraining of the existing model is made convenient by a framework (AcoDet, acoustic detector) built during this project. Combining the tools provided by this framework could save researchers hours of manual annotation time and, thus, accelerate their research.
MeSH term(s)	Animals ; Humpback Whale ; Vocalization, Animal ; Sound Spectrography ; Time Factors ; Seasons ; Acoustics
Language	English
Publishing date	2024-03-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	219231-7
ISSN	1520-8524 ; 0001-4966
ISSN (online)	1520-8524
ISSN	0001-4966
DOI	10.1121/10.0025275
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Article ; Online: Influence of Deep Serratus Anterior Plane Block on Chronic Pain at 3 Months After Breast-Conserving Surgery: Prospective, Cohort Study.

Fuzier, Régis / Salvignol, Geneviève / Gilbert, Olivier / Bremaud, Marc / Bataille, Benoît / Izard, Philippe

The Clinical journal of pain

2022 Volume 38, Issue 6, Page(s) 418–423

Abstract: Objectives: In 2015, we evaluated our practices regarding pain after breast-conserving surgery. Thereafter, we have adapted our practices by performing a systematic deep serratus plane block before the surgical incision. In 2019, we assessed the impact ... ...

Abstract	Objectives: In 2015, we evaluated our practices regarding pain after breast-conserving surgery. Thereafter, we have adapted our practices by performing a systematic deep serratus plane block before the surgical incision. In 2019, we assessed the impact of these changes in terms of chronic pain. The main objective of this study was to evaluate the prevalence of chronic pain 3 months after this type of surgery. Materials and methods: All patients treated with breast-conserving surgery as outpatients were included in this prospective study between April and July 2019. After inducing general anesthesia, 20 mL of ropivacaine 3.75 mg/mL were injected under the serratus muscle. Morphine titration was performed in the recovery room according to pain scores. A pain and quality of life questionnaire was sent 3 months after surgery. A backward logistic regression model was applied to calculate the adjusted odds ratios. Results: The final analysis involved 137 patients. Three months after surgery, 43 patients (31%) reported persistent pain related to the surgery. Maximum pain in the last 24 hours was moderate to severe in 60% of cases, 16 patients (35%) took painkillers. Morphine titration in the recovery room was required in 25 patients (18%). Younger age and the use of lidocaine to prevent after injection of propofol during general anesthesia induction appeared to be protective factors for the risk of pain at 3 months (secondary endpoints). Discussion: No persistent pain at 3 months was reported in 69% of cases. Furthermore, the use of a deep serratus anterior plane block before the surgical incision has limited the need for morphine titration in the recovery room to <1 patient in 5. These evaluations of professional practices should be encouraged.
MeSH term(s)	Chronic Pain/drug therapy ; Chronic Pain/epidemiology ; Chronic Pain/etiology ; Cohort Studies ; Humans ; Mastectomy/adverse effects ; Mastectomy, Segmental/adverse effects ; Morphine/therapeutic use ; Pain, Postoperative/epidemiology ; Prospective Studies ; Quality of Life ; Surgical Wound
Chemical Substances	Morphine (76I7G6D29C)
Language	English
Publishing date	2022-06-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	632582-8
ISSN	1536-5409 ; 0749-8047
ISSN (online)	1536-5409
ISSN	0749-8047
DOI	10.1097/AJP.0000000000001035
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Article ; Online: Iron Oxide/Polymer Core–Shell Nanomaterials with Star-like Behavior

Virginie Vergnat / Benoît Heinrich / Michel Rawiso / René Muller / Geneviève Pourroy / Patrick Masson

Nanomaterials, Vol 11, Iss 2453, p

2021 Volume 2453

Abstract: Embedding nanoparticles (NPs) with organic shells is a way to control their aggregation behavior. Using polymers allows reaching relatively high shell thicknesses but suffers from the difficulty of obtaining regular hybrid objects at gram scale. Here, we ...

Abstract	Embedding nanoparticles (NPs) with organic shells is a way to control their aggregation behavior. Using polymers allows reaching relatively high shell thicknesses but suffers from the difficulty of obtaining regular hybrid objects at gram scale. Here, we describe a three-step synthesis in which multi-gram NP batches are first obtained by thermal decomposition, prior to their covalent grafting by an atom transfer radical polymerization (ATRP) initiator and to the controlled growing of the polymer shell. Specifically, non-aggregated iron oxide NPs with a core principally composed of γ-Fe 2 O 3 (maghemite) and either polystyrene (PS) or polymethyl methacrylate (PMMA) shell were elaborated. The oxide cores of about 13 nm diameter were characterized by dynamic light scattering (DLS), transmission electron microscopy (TEM), and small-angle X-ray scattering (SAXS). After the polymerization, the overall diameter reached 60 nm, as shown by small-angle neutron scattering (SANS). The behavior in solution as well as rheological properties in the molten state of the polymeric shell resemble those of star polymers. Strategies to further improve the screening of NP cores with the polymer shells are discussed.
Keywords	hybrid materials ; non-aggregated nanoparticles ; grafting from method ; X-ray scattering ; neutron scattering ; star polymers ; Chemistry ; QD1-999
Subject code	540
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book: Mozambique

Dagobert, Benoît / Vilnet, Geneviève

littératures et sociétés contemporaines

2013

Author's details	sous la direction de Geneviève Vilnet. Avec la participation de Benoît Dagobert
Language	French
Size	193 S, 21 cm
Publisher	Indigo et Côté-Femmes
Publishing place	Paris
Document type	Book
Note	Collected essays
ISBN	2352600936 ; 9782352600930
Database	Former special subject collection: coastal and deep sea fishing

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Article ; Online: Télétravail en contexte de pandémie : stratégies mises en place par les télétravailleurs.

Lépine Lopez, Anaïs / Fecteau, Geneviève / Desgroseillers, Benoit / Pinard, Isabelle / Hurtubise, Anick / Tanguay, Pascal / Corbière, Marc

Sante mentale au Quebec

2023 Volume 48, Issue 1, Page(s) 17–47

Abstract: Objectives Since the 2000s, telework became common practice with the advent of telecommunication technologies. In the lockdown context linked to the COVID-19 pandemic, telework became the norm. The literature indicates that telework can have positive ... ...

Title translation	Telework in a pandemic context: Strategies implemented by teleworkers.
Abstract	Objectives Since the 2000s, telework became common practice with the advent of telecommunication technologies. In the lockdown context linked to the COVID-19 pandemic, telework became the norm. The literature indicates that telework can have positive effects (e.g., reduction of commuting) but can also create challenges in terms of work-life balance, productivity at work and relationships within the work collective. Few studies focused on the elements that allow teleworkers to accomplish their work tasks optimally in the pandemic context. This study aimed to identify workers' best practices in telework by bringing forward the strategies they put into practice. More precisely, this study aimed at surveying teleworkers on their winning strategies in telework in order to 1) promote their work-life balance (and vice-versa) and their productivity in telework; and 2) promote their relationship with their immediate supervisor and their colleagues. Method This study allowed us to survey, using LimeSurvey, 318 teleworks in the general population and 405 teleworkers in a large health centre in Québec. We analysed these strategies using thematic analysis with inter judge agreement. Results Our results generated 72 winning strategies used by many teleworkers, to keep a balance between their professional life and their personal life (and vice versa), and promote their productivity at work. These strategies were grouped into 12 large categories. The questions regarding relationships with the work collective generated 41 strategies grouped into five large categories. Strategies mentioned the most frequently touched on notions of structure/routine, organisation of activities, clear separation between personal life and professional life, physical space dedicated to work, familiarity with communication technologies, and holding regular work meetings. Conclusion This study presents an extensive range of winning strategies used by teleworkers. Results highlight the importance of having guidance and support from colleagues and the immediate supervisor. Also, having access to an adequate home workspace, and the presence of a regular work schedule and a routine allows teleworkers to ensure their productivity and keep a good work-life balance. Telework seems to be a noteworthy work mode and deserves a better structural ground to assure workers' wellbeing and success.
MeSH term(s)	Humans ; Employment ; Teleworking ; Pandemics/prevention & control ; Personnel Staffing and Scheduling ; Quebec
Language	French
Publishing date	2023-10-20
Publishing country	Canada
Document type	English Abstract ; Journal Article
ZDB-ID	1147902-4
ISSN	1708-3923 ; 0383-6320
ISSN (online)	1708-3923
ISSN	0383-6320
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Article ; Online: Riluzole partially restores RNA polymerase III complex assembly in cells expressing the leukodystrophy-causative variant POLR3B R103H.

Pinard, Maxime / Dastpeyman, Samaneh / Poitras, Christian / Bernard, Geneviève / Gauthier, Marie-Soleil / Coulombe, Benoit

Molecular brain

2022 Volume 15, Issue 1, Page(s) 98

Abstract: The mechanism of assembly of RNA polymerase III (Pol III), the 17-subunit enzyme that synthesizes tRNAs, 5 S rRNA, and other small-nuclear (sn) RNAs in eukaryotes, is not clearly understood. The recent discovery of the HSP90 co-chaperone PAQosome ( ... ...

Abstract	The mechanism of assembly of RNA polymerase III (Pol III), the 17-subunit enzyme that synthesizes tRNAs, 5 S rRNA, and other small-nuclear (sn) RNAs in eukaryotes, is not clearly understood. The recent discovery of the HSP90 co-chaperone PAQosome (Particle for Arrangement of Quaternary structure) revealed a function for this machinery in the biogenesis of nuclear RNA polymerases. However, the connection between Pol III subunits and the PAQosome during the assembly process remains unexplored. Here, we report the development of a mass spectrometry-based assay that allows the characterization of Pol III assembly. This assay was used to dissect the stages of Pol III assembly, to start defining the function of the PAQosome in this process, to dissect the assembly defects driven by the leukodystrophy-causative R103H substitution in POLR3B, and to discover that riluzole, an FDA-approved drug for alleviation of ALS symptoms, partly corrects these assembly defects. Together, these results shed new light on the mechanism and regulation of human nuclear Pol III biogenesis.
MeSH term(s)	Humans ; RNA Polymerase III/genetics ; Riluzole ; DNA-Directed RNA Polymerases ; Neurodegenerative Diseases ; Mutation, Missense
Chemical Substances	RNA Polymerase III (EC 2.7.7.6) ; Riluzole (7LJ087RS6F) ; DNA-Directed RNA Polymerases (EC 2.7.7.6) ; POLR3B protein, human (EC 2.7.7.6)
Language	English
Publishing date	2022-11-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2436057-0
ISSN	1756-6606 ; 1756-6606
ISSN (online)	1756-6606
ISSN	1756-6606
DOI	10.1186/s13041-022-00974-z
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