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Article ; Online: Optimizing Narrowband UVB Phototherapy: Is It More Challenging for Your Older Patients?

Matthews, Sarah W / Sherman, Karen J / Binick, Stephanie / Chien, Andy J

2022 Volume 110, Issue 2, Page(s) E45–E52

Abstract: Narrowband UVB (NB-UVB) phototherapy remains versatile, safe, and efficacious for multiple dermatologic conditions even with recent pharmacologic treatment advances. Polypharmacy contributes to prescribers pursuing phototherapy as a nonpharmacologic ... ...

Abstract	Narrowband UVB (NB-UVB) phototherapy remains versatile, safe, and efficacious for multiple dermatologic conditions even with recent pharmacologic treatment advances. Polypharmacy contributes to prescribers pursuing phototherapy as a nonpharmacologic treatment, but some wonder if it is as effective and safe for older patients. This study aimed to determine if NB-UVB is equally effective in both older and younger adults treated with the same protocol and to examine the association between photosensitizing medications, clearance, and erythema rates in older vs younger adults.
MeSH term(s)	Adult ; Aged ; Dermatitis, Phototoxic ; Humans ; Phototherapy/methods ; Treatment Outcome ; Ultraviolet Rays ; Ultraviolet Therapy/methods
Language	English
Publishing date	2022-10-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	391840-3
ISSN	2326-6929 ; 0011-4162 ; 0151-9522
ISSN (online)	2326-6929
ISSN	0011-4162 ; 0151-9522
DOI	10.12788/cutis.0617
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Article ; Online: Phototherapy: Safe and Effective for Challenging Skin Conditions in Older Adults.

Matthews, Sarah W / Pike, Kenneth / Chien, Andy J

Cutis

2021 Volume 108, Issue 1, Page(s) E15–E21

Abstract: Identifying safe, effective, and affordable evidence-based dermatologic treatments for older adults can be challenging because of age-related changes. Few studies have examined the effectiveness of phototherapy in older adults. Our retrospective study of ...

Abstract	Identifying safe, effective, and affordable evidence-based dermatologic treatments for older adults can be challenging because of age-related changes. Few studies have examined the effectiveness of phototherapy in older adults. Our retrospective study of patients 65 years and older who were treated with narrowband UVB(NB-UVB) phototherapy aimed to (1) identify the most common dermatologic conditions treated with phototherapy in older adults, (2) examine the effectiveness and safety of phototherapy in older adults, and (3) compare the outcomes to 2 similar studies in the United Kingdom and Turkey.
MeSH term(s)	Aged ; Humans ; Phototherapy ; Retrospective Studies ; Skin Diseases/therapy ; Treatment Outcome ; Turkey ; Ultraviolet Therapy
Language	English
Publishing date	2021-08-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	391840-3
ISSN	2326-6929 ; 0011-4162 ; 0151-9522
ISSN (online)	2326-6929
ISSN	0011-4162 ; 0151-9522
DOI	10.12788/cutis.0307
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Article ; Online: A rare but revealing sign: necrolytic migratory erythema.

Compton, Nicholas L / Chien, Andy J

The American journal of medicine

2013 Volume 126, Issue 5, Page(s) 387–389

MeSH term(s)	Diagnosis, Differential ; Female ; Humans ; Middle Aged ; Necrolytic Migratory Erythema/diagnosis
Language	English
Publishing date	2013-05
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	80015-6
ISSN	1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
ISSN (online)	1555-7162 ; 1873-2178
ISSN	0002-9343 ; 1548-2766
DOI	10.1016/j.amjmed.2013.01.012
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Article ; Online: ASIC3 roles in mechanosensitive elongation of nucleus pulposus cells.

Lim, Jormay / Huang, Shao-Shiang / Nikkhoo, Mohammad / Tai, Wei-Ting / Chu, Ya-Cherng / Chien, Andy / Wang, Jaw-Lin

Journal of biomechanics

2024 Volume 163, Page(s) 111938

Abstract: Morphological changes of the nucleus pulposus (NP) cells occur concomitantly as part of the intervertebral disc (IVD) degeneration and excessive mechanical loading has been speculated as a significant key factor for contributing to such morphological ... ...

Abstract	Morphological changes of the nucleus pulposus (NP) cells occur concomitantly as part of the intervertebral disc (IVD) degeneration and excessive mechanical loading has been speculated as a significant key factor for contributing to such morphological changes. Therefore, we hypothesize that stress exerted on NP cells can cause a deformity of nucleus in response. The changes of cell morphology is observed in degenerative nucleus pulposus. One of the reasons for degeneration of NP is due to overloading of NP especially in the obese population. So the nucleus deformity caused by stress/force is of our study interest. To delineate the effects and role of mechanical stress, we developed a 3D assay using hydrogel cultures with a circular hole generated with needle indentation to simulate a local stress concentration along the edge of the hole. A stressed zone, encompassing 100 μm of range from the circular edge, is defined based on stress concentration calculation to enable quantitative analysis against the control zone. Our results demonstrated that the circular hole produces stress-induced morphological changes in NP cells. The tangential elongation of NP cells and their nucleus shape changes in the stressed zone are significantly increased compared to the non-stressed control zone. It is proposed that the cell elongation is a direct response to elevated stress within the stressed zone. Subsequently we found the stress induced morphological changes of the NP cells can be significantly reduced by inhibiting ASIC3. This suggests ASIC3 plays an important role of play in mechano-signaling of NP cells.
MeSH term(s)	Humans ; Nucleus Pulposus/physiology ; Intervertebral Disc Degeneration ; Cells, Cultured ; Intervertebral Disc ; Acid Sensing Ion Channels
Chemical Substances	ASIC3 protein, human ; Acid Sensing Ion Channels
Language	English
Publishing date	2024-01-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	218076-5
ISSN	1873-2380 ; 0021-9290
ISSN (online)	1873-2380
ISSN	0021-9290
DOI	10.1016/j.jbiomech.2024.111938
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Article ; Online: Re: Specific targeting of Wnt/β-catenin signaling in human melanoma cells by a dietary triterpene lupeol.

Biechele, Travis L / Chien, Andy J

Carcinogenesis

2011 Volume 32, Issue 1, Page(s) 120; author reply 121

MeSH term(s)	Diet ; Humans ; Melanoma/metabolism ; Pentacyclic Triterpenes/pharmacology ; Prognosis ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Wnt Proteins/metabolism ; beta Catenin/metabolism
Chemical Substances	Pentacyclic Triterpenes ; Wnt Proteins ; beta Catenin ; lupeol (O268W13H3O)
Language	English
Publishing date	2011-01
Publishing country	England
Document type	Comment ; Letter
ZDB-ID	603134-1
ISSN	1460-2180 ; 0143-3334
ISSN (online)	1460-2180
ISSN	0143-3334
DOI	10.1093/carcin/bgq217
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Article: Correction: Identification of a Novel, EBV-based Antibody Risk Stratification Signature for Early Detection of Nasopharyngeal Carcinoma in Taiwan.

Coghill, Anna E / Pfeiffer, Ruth M / Proietti, Carla / Hsu, Wan-Lun / Chien, Yin-Chu / Lekieffre, Lea / Krause, Lutz / Teng, Andy / Pablo, Jocelyn / Yu, Kelly J / Lou, Pei-Jen / Wang, Cheng-Ping / Liu, Zhiwei / Chen, Chien-Jen / Middeldorp, Jaap / Mulvenna, Jason / Bethony, Jeff / Hildesheim, Allan / Doolan, Denise L

Clinical cancer research : an official journal of the American Association for Cancer Research

2020 Volume 26, Issue 13, Page(s) 3496

Language	English
Publishing date	2020-06-29
Publishing country	United States
Document type	Journal Article ; Published Erratum
ZDB-ID	1225457-5
ISSN	1557-3265 ; 1078-0432
ISSN (online)	1557-3265
ISSN	1078-0432
DOI	10.1158/1078-0432.CCR-20-1828
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Zs.A 4223: Show issues

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Article ; Online: Activation of Mechanosensitive Ion Channels by Ultrasound.

Chu, Ya-Cherng / Lim, Jormay / Chien, Andy / Chen, Chih-Cheng / Wang, Jaw-Lin

Ultrasound in medicine & biology

2022 Volume 48, Issue 10, Page(s) 1981–1994

Abstract: Mechanosensitive channels (MSCs) play an important role in how cells transduce mechanical stimuli into electrical or chemical signals, which provides an interventional possibility through the manipulation of ion channel activation using different ... ...

Abstract	Mechanosensitive channels (MSCs) play an important role in how cells transduce mechanical stimuli into electrical or chemical signals, which provides an interventional possibility through the manipulation of ion channel activation using different mechanical stimulation conditions. With good spatial resolution and depth of penetration, ultrasound is often proposed as the tool of choice for such therapeutic applications. Despite the identification of many ion channels as mechanosensitive in recent years, only a limited number of MSCs have been reported to be activated by ultrasound with substantial evidence. Furthermore, although many therapeutic implications using ultrasound have been explored, few offered insights into the molecular basis and the biological effects induced by ultrasound in relieving pain and accelerate tissue healing. In this review, we examined the literature, in particular studies that provided evidence of cellular responses to ultrasound, with and without the target ion channels. The ultrasound activation conditions were then summarized for these ion channels, and these conditions were related to their mode of activation based on the current biological concepts. The overall goal is to bridge the results relating to the activation of MSCs that is specific for ultrasound with the current knowledge in molecular structure and the available physiological evidence that may have facilitated such phenomena. We discussed how collating the information revealed by available scientific investigations helps in the design of a more effective stimulus device for the proposed translational purposes. Traditionally, studies on the effects of ultrasound have focused largely on its mechanical and physical interaction with the targeted tissue through thermal-based therapies as well as non-thermal mechanisms including ultrasonic cavitation; gas body activation; the direct action of the compressional, tensile and shear stresses; radiation force; and acoustic streaming. However, the current review explores and attempts to establish whether the application of low-intensity ultrasound may be associated with the activation of specific MSCs, which in turn triggers relevant cell signaling as its molecular mechanism in achieving the desired therapeutic effects. Non-invasive brain stimulation has recently become an area of intense research interest for rehabilitation, and the implication of low-intensity ultrasound is particularly critical given the need to minimize heat generation to preserve tissue integrity for such applications.
MeSH term(s)	Cell Communication ; Ion Channels ; Mechanotransduction, Cellular ; Signal Transduction ; Ultrasonography
Chemical Substances	Ion Channels
Language	English
Publishing date	2022-08-06
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	186150-5
ISSN	1879-291X ; 0301-5629
ISSN (online)	1879-291X
ISSN	0301-5629
DOI	10.1016/j.ultrasmedbio.2022.06.008
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Zs.A 963: Show issues

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Article ; Online: Association between Lithium Use and Melanoma Risk and Mortality: A Population-Based Study.

Asgari, Maryam M / Chien, Andy J / Tsai, Ai Lin / Fireman, Bruce / Quesenberry, Charles P

The Journal of investigative dermatology

2017 Volume 137, Issue 10, Page(s) 2087–2091

Abstract: Laboratory studies show that lithium, an activator of the Wnt/ß-catenin signaling pathway, slows melanoma progression, but to our knowledge no published epidemiologic studies have explored this association. We conducted a retrospective cohort study of ... ...

Abstract	Laboratory studies show that lithium, an activator of the Wnt/ß-catenin signaling pathway, slows melanoma progression, but to our knowledge no published epidemiologic studies have explored this association. We conducted a retrospective cohort study of adult white Kaiser Permanente Northern California members (n = 2,213,848) from 1997-2012 to examine the association between lithium use and melanoma risk. Lithium exposure (n = 11,317) was assessed from pharmacy databases, serum lithium levels were obtained from electronic laboratory databases, and incident cutaneous melanomas (n = 14,056) were identified from an established cancer registry. In addition to examining melanoma incidence, melanoma hazard ratios and 95% confidence intervals for lithium exposure were estimated using Cox proportional hazards models, adjusted for potential confounders. Melanoma incidence per 100,000 person-years among lithium-exposed individuals was 67.4, compared with 92.5 in unexposed individuals (P = 0.027). Lithium-exposed individuals had a 32% lower risk of melanoma (hazard ratio = 0.68, 95% confidence interval = 0.51-0.90) in unadjusted analysis, but the estimate was attenuated and nonsignificant in adjusted analysis (adjusted hazard ratio = 0.77, 95% confidence interval = 0.58-1.02). No lithium-exposed individuals presented with thick (>4 mm) or advanced-stage melanoma at diagnosis. Among melanoma patients, lithium-exposed individuals were less likely to suffer melanoma-associated mortality (rate = 4.68/1,000 person-years) compared with the unexposed (rate = 7.21/1,000 person-years). Our findings suggest that lithium may reduce melanoma risk and associated mortality.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; California/epidemiology ; Cause of Death/trends ; Disease Progression ; Female ; Follow-Up Studies ; Humans ; Incidence ; Lithium/adverse effects ; Lithium/pharmacokinetics ; Male ; Melanoma/blood ; Melanoma/chemically induced ; Melanoma/epidemiology ; Middle Aged ; Retrospective Studies ; Risk Assessment/methods ; Risk Factors ; SEER Program ; Skin Neoplasms/blood ; Skin Neoplasms/chemically induced ; Skin Neoplasms/epidemiology ; Survival Rate/trends ; Young Adult ; Melanoma, Cutaneous Malignant
Chemical Substances	Lithium (9FN79X2M3F)
Language	English
Publishing date	2017-06-17
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural
ZDB-ID	80136-7
ISSN	1523-1747 ; 0022-202X
ISSN (online)	1523-1747
ISSN	0022-202X
DOI	10.1016/j.jid.2017.06.002
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Book ; Online: Generative Expressive Robot Behaviors using Large Language Models

Mahadevan, Karthik / Chien, Jonathan / Brown, Noah / Xu, Zhuo / Parada, Carolina / Xia, Fei / Zeng, Andy / Takayama, Leila / Sadigh, Dorsa

2024

Abstract: People employ expressive behaviors to effectively communicate and coordinate their actions with others, such as nodding to acknowledge a person glancing at them or saying "excuse me" to pass people in a busy corridor. We would like robots to also ... ...

Abstract	People employ expressive behaviors to effectively communicate and coordinate their actions with others, such as nodding to acknowledge a person glancing at them or saying "excuse me" to pass people in a busy corridor. We would like robots to also demonstrate expressive behaviors in human-robot interaction. Prior work proposes rule-based methods that struggle to scale to new communication modalities or social situations, while data-driven methods require specialized datasets for each social situation the robot is used in. We propose to leverage the rich social context available from large language models (LLMs) and their ability to generate motion based on instructions or user preferences, to generate expressive robot motion that is adaptable and composable, building upon each other. Our approach utilizes few-shot chain-of-thought prompting to translate human language instructions into parametrized control code using the robot's available and learned skills. Through user studies and simulation experiments, we demonstrate that our approach produces behaviors that users found to be competent and easy to understand. Supplementary material can be found at https://generative-expressive-motion.github.io/.
Keywords	Computer Science - Robotics
Subject code	629
Publishing date	2024-01-26
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Why do so many clinicians believe that recurrent zoster is common?

Chien, Andy J / Olerud, John E

Dermatology online journal

2007 Volume 13, Issue 2, Page(s) 2

MeSH term(s)	Aged ; Female ; Herpes Zoster/diagnosis ; Herpes Zoster/epidemiology ; Herpes Zoster/immunology ; Humans ; Immunocompetence ; Incidence ; Male ; Middle Aged ; Prognosis ; Recurrence ; Risk Assessment ; Severity of Illness Index
Language	English
Publishing date	2007
Publishing country	United States
Document type	Journal Article
ISSN	1087-2108
ISSN (online)	1087-2108
Database	MEDical Literature Analysis and Retrieval System OnLINE

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