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Article ; Online: Primary rectal squamous cell carcinoma resembling a submucosal tumor.

Hamada, Yasuhiko / Tanaka, Kyosuke / Baba, Youichirou / Horiki, Noriyuki

JGH open : an open access journal of gastroenterology and hepatology

2021 Volume 5, Issue 4, Page(s) 517–519

Abstract: Primary rectal squamous cell carcinoma is an extremely rare tumor and, in most cases, detected at an advanced stage. In our case, the tumor was at an early stage and had a submucosal appearance. Thus, the tumor was difficult to differentiate from other ... ...

Abstract	Primary rectal squamous cell carcinoma is an extremely rare tumor and, in most cases, detected at an advanced stage. In our case, the tumor was at an early stage and had a submucosal appearance. Thus, the tumor was difficult to differentiate from other rectal submucosal tumors and, it was removed by endoscopic submucosal dissection for excisional biopsy.
Language	English
Publishing date	2021-02-26
Publishing country	Australia
Document type	Journal Article
ISSN	2397-9070
ISSN (online)	2397-9070
DOI	10.1002/jgh3.12514
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Solitary rectal metastasis of prostate cancer resembling primary colorectal cancer.

Hamada, Yasuhiko / Ikenoyama, Yohei / Baba, Youichirou / Horiki, Noriyuki / Tanaka, Kyosuke

JGH open : an open access journal of gastroenterology and hepatology

2021 Volume 5, Issue 10, Page(s) 1216–1217

Abstract: Solitary colorectal metastasis of prostate cancer is very rare, but the pathological features can closely resemble a primary colorectal cancer with poorly differentiated adenocarcinoma. Thus, metastasis of prostate cancer should be considered as a ... ...

Abstract	Solitary colorectal metastasis of prostate cancer is very rare, but the pathological features can closely resemble a primary colorectal cancer with poorly differentiated adenocarcinoma. Thus, metastasis of prostate cancer should be considered as a differential diagnosis in male patients with colorectal lesion with poorly differentiated adenocarcinoma.
Language	English
Publishing date	2021-09-02
Publishing country	Australia
Document type	Journal Article
ISSN	2397-9070
ISSN (online)	2397-9070
DOI	10.1002/jgh3.12637
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: CD169

Saito, Yoichi / Fujiwara, Yukio / Miyamoto, Yuji / Ohnishi, Koji / Nakashima, Yuta / Tabata, Yasuhiko / Baba, Hideo / Komohara, Yoshihiro

Cancer medicine

2023 Volume 12, Issue 9, Page(s) 10199–10211

Abstract: Aims: Mismatch-repair deficiency and microsatellite instability-high (dMMR/MSI-H) colorectal cancer (CRC) is treated with programmed death (PD)-1 antibody regardless of PD-ligand (L)1 expression in tumor cells. We previously found that abundant CD169: ...

Abstract	Aims: Mismatch-repair deficiency and microsatellite instability-high (dMMR/MSI-H) colorectal cancer (CRC) is treated with programmed death (PD)-1 antibody regardless of PD-ligand (L)1 expression in tumor cells. We previously found that abundant CD169 Methods and results: We immunostained 83 surgically resected CRC tumors that we previously analyzed for MMR proteins, and identified 9 that were dMMR. The number of CD169 Conclusions: CRC with CD169
MeSH term(s)	Humans ; B7-H1 Antigen/metabolism ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/surgery ; Prognosis ; Colonic Neoplasms/metabolism ; Lymphocytes, Tumor-Infiltrating/pathology ; Lymph Nodes/pathology ; Macrophages ; DNA Mismatch Repair
Chemical Substances	B7-H1 Antigen
Language	English
Publishing date	2023-02-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2659751-2
ISSN	2045-7634 ; 2045-7634
ISSN (online)	2045-7634
ISSN	2045-7634
DOI	10.1002/cam4.5747
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Article ; Online: Solitary Rectal Metastasis from Primary Gastric Cancer.

Hamada, Yasuhiko / Tanaka, Kyosuke / Katsurahara, Masaki / Baba, Youichirou

Internal medicine (Tokyo, Japan)

2018 Volume 58, Issue 7, Page(s) 1037–1038

Language	English
Publishing date	2018-12-18
Publishing country	Japan
Document type	Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.1902-18
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Article ; Online: Colonic histoplasmosis resembling early colon cancer.

Hamada, Yasuhiko / Tanaka, Kyosuke / Horiki, Noriyuki / Baba, Youichirou / Takei, Yoshiyuki

Gastrointestinal endoscopy

2019 Volume 91, Issue 4, Page(s) 951–952

MeSH term(s)	Colon ; Colonic Diseases/diagnosis ; Colonic Neoplasms/diagnosis ; Histoplasmosis/diagnosis ; Humans
Language	English
Publishing date	2019-11-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	391583-9
ISSN	1097-6779 ; 0016-5107
ISSN (online)	1097-6779
ISSN	0016-5107
DOI	10.1016/j.gie.2019.11.003
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Article: Immune checkpoint inhibitors in patients with lung cancer having chronic interstitial pneumonia.

Isobe, Kazutoshi / Nakamura, Yasuhiko / Sakamoto, Susumu / Tomii, Keisuke / Takimoto, Takayuki / Miyazaki, Yasunari / Matsumoto, Masaru / Sugino, Keishi / Ichikado, Kazuya / Moriguchi, Shuhei / Yamaguchi, Kakuhiro / Baba, Tomohisa / Ozasa, Hiroaki / Igata, Fumiyasu / Anabuki, Kazuki / Homma, Sakae / Date, Hiroshi / Suda, Takafumi / Kishi, Kazuma

ERJ open research

2024 Volume 10, Issue 2

Abstract: Background: In interstitial pneumonia (IP)-associated lung cancer, immune checkpoint inhibitor pneumonitis (ICIP) is common with immune checkpoint inhibitor (ICI) treatment. The purpose of the present study was to clarify the safety and efficacy of ICI ... ...

Abstract	Background: In interstitial pneumonia (IP)-associated lung cancer, immune checkpoint inhibitor pneumonitis (ICIP) is common with immune checkpoint inhibitor (ICI) treatment. The purpose of the present study was to clarify the safety and efficacy of ICI treatment for patients with lung cancer with IP. Methods: This multicentre retrospective observational study was conducted from June 2016 to December 2020 in patients with primary lung cancer with IP who received ICI treatment. Results: A total of 200 patients (median age 70 years; male/female, 176/24) were enrolled from 27 institutions. ICIP occurred in 61 patients (30.5%), pneumonitis grades 3-5 in 32 patients (15.5%) and death in nine patients (4.5%). The common computed tomography pattern of ICIP was organising pneumonia in 29 patients (47.5%). Subsequently, diffuse alveolar damage (DAD) pattern was observed in 19 patients (31.1%) who had a significantly worse prognosis than those with a non-DAD pattern (median progression-free survival (PFS) 115 days Conclusions: Although ICI treatment was effective for patients with lung cancer with IP, ICIP developed in approximately 30% of patients. Patients with irAEs had a significantly better PFS and OS than those without irAEs.
Language	English
Publishing date	2024-03-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2827830-6
ISSN	2312-0541
ISSN	2312-0541
DOI	10.1183/23120541.00981-2023
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Article ; Online: Therapeutic effects and adaptive limits of an acellular technique by ultrapurified alginate (UPAL) gel implantation in canine osteochondral defect models.

Onodera, Tomohiro / Baba, Rikiya / Kasahara, Yasuhiko / Tsuda, Toshihiko / Iwasaki, Norimasa

Regenerative therapy

2020 Volume 14, Page(s) 154–159

Abstract: Background: The aim of this study was to clarify the objective therapeutic effects of an acellular technique by ultrapurified alginate (UPAL) gel implantation in canine osteochondral defect models.: Methods: Two osteochondral defects (diameters: 3.0 ... ...

Abstract	Background: The aim of this study was to clarify the objective therapeutic effects of an acellular technique by ultrapurified alginate (UPAL) gel implantation in canine osteochondral defect models. Methods: Two osteochondral defects (diameters: 3.0 and 5.0 mm) were created on each patellar groove in both knees of 10 dogs. Defects were divided into four groups (n = 10 each): Group 1, untreated 3.0-mm defect; Group 2, 3.0-mm defect with UPAL gel; Group 3, untreated 5.0-mm defect; and Group 4, 5.0-mm defect with UPAL gel. All surgical procedures were performed by individuals unfamiliar with the technique at an independent institution. Articular surfaces were evaluated grossly and histologically at 27 weeks after operation. Results: UPAL gel-treated osteochondral defects showed significantly improved gross appearance in Group 4 and histological appearance in Groups 2 and 4. Reparative tissues in the 3.0-mm defect with UPAL gel were replaced by hyaline-like cartilage tissue. The 5.0-mm defects with UPAL gel were mostly covered with fibrocartilaginous tissue, whereas UPAL gel-untreated defects mostly remained uncovered by any tissue. Conclusions: Although an acellular technique using UPAL gel implantation significantly enhanced osteochondral repair in canines, reparative tissues of the large defect with alginate gel comprised of fibrocartilaginous tissue. This surgical technique is effective, especially for small cartilage injuries. Further improvements are required before clinical application in cases of severe osteochondral defects in humans.
Language	English
Publishing date	2020-02-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2835333-X
ISSN	2352-3204 ; 2352-3204
ISSN (online)	2352-3204
ISSN	2352-3204
DOI	10.1016/j.reth.2020.01.001
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Article ; Online: Therapeutic effects and adaptive limits of an acellular technique by ultrapurified alginate (UPAL) gel implantation in canine osteochondral defect models

Tomohiro Onodera / Rikiya Baba / Yasuhiko Kasahara / Toshihiko Tsuda / Norimasa Iwasaki

Regenerative Therapy, Vol 14, Iss , Pp 154-

2020 Volume 159

Abstract: Background: The aim of this study was to clarify the objective therapeutic effects of an acellular technique by ultrapurified alginate (UPAL) gel implantation in canine osteochondral defect models. Methods: Two osteochondral defects (diameters: 3.0 and 5. ...

Abstract	Background: The aim of this study was to clarify the objective therapeutic effects of an acellular technique by ultrapurified alginate (UPAL) gel implantation in canine osteochondral defect models. Methods: Two osteochondral defects (diameters: 3.0 and 5.0 mm) were created on each patellar groove in both knees of 10 dogs. Defects were divided into four groups (n = 10 each): Group 1, untreated 3.0-mm defect; Group 2, 3.0-mm defect with UPAL gel; Group 3, untreated 5.0-mm defect; and Group 4, 5.0-mm defect with UPAL gel. All surgical procedures were performed by individuals unfamiliar with the technique at an independent institution. Articular surfaces were evaluated grossly and histologically at 27 weeks after operation. Results: UPAL gel-treated osteochondral defects showed significantly improved gross appearance in Group 4 and histological appearance in Groups 2 and 4. Reparative tissues in the 3.0-mm defect with UPAL gel were replaced by hyaline-like cartilage tissue. The 5.0-mm defects with UPAL gel were mostly covered with fibrocartilaginous tissue, whereas UPAL gel-untreated defects mostly remained uncovered by any tissue. Conclusions: Although an acellular technique using UPAL gel implantation significantly enhanced osteochondral repair in canines, reparative tissues of the large defect with alginate gel comprised of fibrocartilaginous tissue. This surgical technique is effective, especially for small cartilage injuries. Further improvements are required before clinical application in cases of severe osteochondral defects in humans.
Keywords	Cartilage ; Alginate ; Acellular technique ; Animal model ; Medicine (General) ; R5-920 ; Cytology ; QH573-671
Language	English
Publishing date	2020-06-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: In Vivo Multimodal Imaging of Stem Cells Using Nanohybrid Particles Incorporating Quantum Dots and Magnetic Nanoparticles.

Yamada, Shota / Yukawa, Hiroshi / Yamada, Kaori / Murata, Yuki / Jo, Jun-Ichiro / Yamamoto, Masaya / Sugawara-Narutaki, Ayae / Tabata, Yasuhiko / Baba, Yoshinobu

Sensors (Basel, Switzerland)

2022 Volume 22, Issue 15

Abstract: The diagnosis of the dynamics, accumulation, and engraftment of transplanted stem cells in vivo is essential for ensuring the safety and the maximum therapeutic effect of regenerative medicine. However, in vivo imaging technologies for detecting ... ...

Abstract	The diagnosis of the dynamics, accumulation, and engraftment of transplanted stem cells in vivo is essential for ensuring the safety and the maximum therapeutic effect of regenerative medicine. However, in vivo imaging technologies for detecting transplanted stem cells are not sufficient at present. We developed nanohybrid particles composed of dendron-baring lipids having two unsaturated bonds (DLU2) molecules, quantum dots (QDs), and magnetic nanoparticles in order to diagnose the dynamics, accumulation, and engraftment of transplanted stem cells, and then addressed the labeling and in vivo fluorescence and magnetic resonance (MR) imaging of stem cells using the nanohybrid particles (DLU2-NPs). Five kinds of DLU2-NPs (DLU2-NPs-1-5) composed of different concentrations of DLU2 molecules, QDs525, QDs605, QDs705, and ATDM were prepared. Adipose tissue-derived stem cells (ASCs) were labeled with DLU2-NPs for 4 h incubation, no cytotoxicity or marked effect on the proliferation ability was observed in ASCs labeled with DLU2-NPs (640- or 320-fold diluted). ASCs labeled with DLU2-NPs (640-fold diluted) were transplanted subcutaneously onto the backs of mice, and the labeled ASCs could be imaged with good contrast using in vivo fluorescence and an MR imaging system. DLU2-NPs may be useful for in vivo multimodal imaging of transplanted stem cells.
MeSH term(s)	Animals ; Magnetic Resonance Imaging ; Magnetite Nanoparticles/toxicity ; Mice ; Multimodal Imaging ; Quantum Dots/chemistry ; Stem Cells
Chemical Substances	Magnetite Nanoparticles
Language	English
Publishing date	2022-07-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s22155705
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Article ; Online: Takotsubo cardiomyopathy in Guillain-Barré syndrome.

Terayama, Atsushi / Kuwahara, Motoi / Yoshikawa, Keisuke / Yamagishi, Yuko / Samukawa, Makoto / Yamashita, Shoko / Onishi, Kyohei / Nagano, Tomoya / Tatsumi, Chikao / Ishii, Junko / Kawamoto, Michi / Tokashiki, Takashi / Deguchi, Shoko / Deguchi, Kentaro / Ishida, Atsushi / Baba, Yasuhiko / Yamaguchi, Shigeki / Kusunoki, Susumu / Nagai, Yoshitaka

Journal of neurology

2024

Abstract: Background and purpose: Takotsubo cardiomyopathy (TCM) is a serious autonomic complication of Guillain-Barré syndrome (GBS). However, the association between TCM and GBS has not been investigated in detail. We investigated the characteristics of GBS ... ...

Abstract	Background and purpose: Takotsubo cardiomyopathy (TCM) is a serious autonomic complication of Guillain-Barré syndrome (GBS). However, the association between TCM and GBS has not been investigated in detail. We investigated the characteristics of GBS patients with TCM (GBS-TCM). Methods: Clinical features and anti-ganglioside antibody between the GBS-TCM patients and 62 classical GBS patients without TCM as control patients were compared. Results: Eight GBS-TCM patients were identified, in whom TCM was diagnosed at a mean of 6.5 [range 3-42] days after the onset of GBS. The age at onset of GBS was elder in the GBS-TCM patients than in the control GBS patients (76.5 [56-87] vs. 52 [20-88] years, p < 0.01). Notably, cranial nerve deficits, particularly in the lower cranial nerves, were observed in all GBS-TCM patients (100% vs. 41.9%, p < 0.01). Additionally, the GBS-TCM patients showed a higher GBS disability score at nadir (5 [4-5] vs. 4 [1-5], p < 0.01), and lower Medical Research Council sum scores at admission and nadir (37 [30-44] vs. 48 [12-60] at admission, p < 0.05, and 20 [12-44] vs. 40 [0-60] at nadir, p < 0.05, respectively). Mechanical ventilation was more frequently required in the GBS-TCM patients (62.5% vs. 11.3%, p < 0.01). Three GBS-TCM patients were positive for anti-ganglioside antibodies. Conclusions: TCM occurred at a relatively early phase of GBS. The characteristics of GBS-TCM were the elder, lower cranial nerve involvements, severe limb weakness, and respiratory failure.
Language	English
Publishing date	2024-04-04
Publishing country	Germany
Document type	Journal Article
ZDB-ID	187050-6
ISSN	1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
ISSN (online)	1432-1459
ISSN	0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
DOI	10.1007/s00415-024-12295-3
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