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Article ; Online: Hermansky-pudlak syndrome: report of a case and review of the literature.

Hurford, Matthew T / Sebastiano, Christopher

International journal of clinical and experimental pathology

2008 Volume 1, Issue 6, Page(s) 550–554

Abstract: Hermansky-Pudlak syndrome is a rare autosomal recessive disorder characterized by excessive bleeding post surgery. Here we reported such a case and reviewed the clinicopathological features and our current understanding of this rare congenital disorder. ...

Abstract	Hermansky-Pudlak syndrome is a rare autosomal recessive disorder characterized by excessive bleeding post surgery. Here we reported such a case and reviewed the clinicopathological features and our current understanding of this rare congenital disorder.
Language	English
Publishing date	2008-01-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2418306-4
ISSN	1936-2625 ; 1936-2625
ISSN (online)	1936-2625
ISSN	1936-2625
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Article ; Online: Acute promyelocytic leukaemia (APL) in a patient with Crohn's disease and exposure to infliximab: a rare clinical presentation and review of the literature.

Mohammad, Farhan / Vivekanandarajah, Abhirami / Haddad, Housam / Shutty, Christopher M / Hurford, Matthew T / Dai, Qun

BMJ case reports

2014 Volume 2014

Abstract: With the introduction of potent immunosuppressive and chemotherapeutic medications for various diseases, there is an increased incidence of therapy-related myeloid neoplasms. They are the result of mutational rearrangement and historically, have a grave ... ...

Abstract	With the introduction of potent immunosuppressive and chemotherapeutic medications for various diseases, there is an increased incidence of therapy-related myeloid neoplasms. They are the result of mutational rearrangement and historically, have a grave prognosis compared with de novo myeloid neoplasms. We did a short review on various types of myeloid leukaemias reported after therapy with antitumour necrosis factor and also report, to the best of our knowledge, one among the very few cases of therapy-related acute promyelocytic leukaemia in a patient on infliximab therapy for refractory Crohn's disease. The patient responded well to the traditional treatment and is in complete remission for more than 5 years.
MeSH term(s)	Adult ; Antibodies, Monoclonal/adverse effects ; Antibodies, Monoclonal/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Biopsy, Needle ; Bone Marrow Examination ; Crohn Disease/diagnosis ; Crohn Disease/drug therapy ; Female ; Follow-Up Studies ; Humans ; Immunohistochemistry ; Infliximab ; Leukemia, Promyelocytic, Acute/chemically induced ; Leukemia, Promyelocytic, Acute/drug therapy ; Leukemia, Promyelocytic, Acute/pathology ; Risk Assessment ; Severity of Illness Index ; Treatment Outcome
Chemical Substances	Antibodies, Monoclonal ; Infliximab (B72HH48FLU)
Language	English
Publishing date	2014-05-19
Publishing country	England
Document type	Case Reports ; Journal Article ; Review
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2013-203318
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Article ; Online: Glanzmann's thrombasthenia: report of a case and review of the literature.

Sebastiano, Christopher / Bromberg, Michael / Breen, Karen / Hurford, Matthew T

International journal of clinical and experimental pathology

2010 Volume 3, Issue 4, Page(s) 443–447

Abstract: Glanzmann's thrombasthenia is a rare congenital bleeding disorder. Patients usually present with mucocutaneous bleeding and excessive bleeding associated with trauma and/or surgery. Patients have an increased bleeding time and a normal platelet count ... ...

Abstract	Glanzmann's thrombasthenia is a rare congenital bleeding disorder. Patients usually present with mucocutaneous bleeding and excessive bleeding associated with trauma and/or surgery. Patients have an increased bleeding time and a normal platelet count with abnormal platelet function assays. Genetically, Glanzmann's thrombasthenia is associated with mutations in the genes which encode for glycoproteins, GPIIb or GPIIIa. Defects in these genes lead to a lack of or highly reduced expression of the glycoprotein complex (GPIIb/GPIIIa), resulting in platelet dysfunction. Bleeding is managed by platelet transfusions. Bone marrow transplants have been used successfully in rare cases. With proper supportive care Glanzmann's thrombasthenia has a very good prognosis.
MeSH term(s)	Fatal Outcome ; Female ; Humans ; Thrombasthenia/pathology ; Thrombasthenia/physiopathology
Language	English
Publishing date	2010-04-25
Publishing country	United States
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	2418306-4
ISSN	1936-2625 ; 1936-2625
ISSN (online)	1936-2625
ISSN	1936-2625
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Article ; Online: Synchronizing Watches: The Challenge of Aligning Implementation Science and Public Systems.

Rubin, Ronnie M / Hurford, Matthew O / Hadley, Trevor / Matlin, Samantha / Weaver, Shawna / Evans, Arthur C

Administration and policy in mental health

2016 Volume 43, Issue 6, Page(s) 1023–1028

Abstract: This special issue of Administration and Policy in Mental Health explores the complexities of the outer system context in implementation science research. In this commentary, we highlight areas of asynchrony between implementation science research and ... ...

Abstract	This special issue of Administration and Policy in Mental Health explores the complexities of the outer system context in implementation science research. In this commentary, we highlight areas of asynchrony between implementation science research and policy realities of public systems. Timing is a critical factor for many aspects of system-level implementation including when and how evidence-based practice initiatives are launched, short and inconsistent timeframes for funding and support, need for early indicators of success and demonstrating return on investment. Greater consideration for the timing that drives change in public systems will strengthen efforts to implement and sustain EBPs in community settings.
MeSH term(s)	Community Health Planning ; Community Mental Health Services ; Evidence-Based Practice ; Health Policy ; Humans
Language	English
Publishing date	2016
Publishing country	United States
Document type	Journal Article
ZDB-ID	1025319-1
ISSN	1573-3289 ; 0894-587X
ISSN (online)	1573-3289
ISSN	0894-587X
DOI	10.1007/s10488-016-0759-9
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Article ; Online: Kimura disease.

Abuel-Haija, Mohammad / Hurford, Matthew T

Archives of pathology & laboratory medicine

2006 Volume 131, Issue 4, Page(s) 650–651

Abstract: Kimura disease is a benign rare chronic inflammatory disorder of unknown etiology that involves the lymph nodes and subcutaneous tissue of the head and neck regions. Elevated serum immunoglobulin E levels and peripheral blood eosinophilia are also common. ...

Abstract	Kimura disease is a benign rare chronic inflammatory disorder of unknown etiology that involves the lymph nodes and subcutaneous tissue of the head and neck regions. Elevated serum immunoglobulin E levels and peripheral blood eosinophilia are also common. This disease is most common in middle-aged Asian men. Although the etiology is unknown, it most probably represents an aberrant chronic immune response. Treatment for Kimura disease includes surgical resection and regional or systemic steroid therapy. Cytotoxic therapy and radiation have also been utilized. The disease has an excellent prognosis, although it may recur locally.
MeSH term(s)	Angiolymphoid Hyperplasia with Eosinophilia/etiology ; Angiolymphoid Hyperplasia with Eosinophilia/pathology ; Angiolymphoid Hyperplasia with Eosinophilia/therapy ; Diagnosis, Differential ; Female ; Humans ; Male ; Sex Factors
Language	English
Publishing date	2006-01-03
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	194119-7
ISSN	1543-2165 ; 0363-0153 ; 0096-8528 ; 0003-9985
ISSN (online)	1543-2165
ISSN	0363-0153 ; 0096-8528 ; 0003-9985
DOI	10.5858/2007-131-650-KD
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Article ; Online: Appropriate Use of Drug Testing in Clinical Addiction Medicine.

Jarvis, Margaret / Williams, Jessica / Hurford, Matthew / Lindsay, Dawn / Lincoln, Piper / Giles, Leila / Luongo, Peter / Safarian, Taleen

Journal of addiction medicine

2017 Volume 11, Issue 3, Page(s) 163–173

Abstract: Biological drug testing is a tool that provides information about an individual's recent substance use. Like any tool, its value depends on using it correctly; that is, on selecting the right test for the right person at the right time. This document ... ...

Abstract	: Biological drug testing is a tool that provides information about an individual's recent substance use. Like any tool, its value depends on using it correctly; that is, on selecting the right test for the right person at the right time. This document is intended to clarify appropriate clinical use of drug testing in addiction medicine and aid providers in their decisions about drug testing for the identification, diagnosis, treatment, and recovery of patients with, or at risk for, addiction. The RAND Corporation (RAND)/University of California, Los Angeles (UCLA) Appropriateness Method (RAM) process for combining scientific evidence with the collective judgment of experts was used to identify appropriate clinical practices and highlight areas where research is needed. Although consensus panels and expert groups have offered guidance on the use of drug testing for patients with addiction, very few addressed considerations for patients across settings and in different levels of care. This document will focus primarily on patients in addiction treatment and recovery, where drug testing is used to assess patients for a substance use disorder, monitor the effectiveness of a treatment plan, and support recovery. Inasmuch as the scope includes the recognition of addiction, which often occurs in general healthcare settings, selected special populations at risk for addiction visiting these settings are briefly included.
MeSH term(s)	Addiction Medicine/methods ; Clinical Competence ; Humans ; Professional-Patient Relations ; Substance Abuse Detection/methods ; Substance-Related Disorders/diagnosis ; Substance-Related Disorders/therapy
Language	English
Publishing date	2017-05-29
Publishing country	United States
Document type	Consensus Development Conference ; Journal Article ; Practice Guideline
ISSN	1935-3227
ISSN (online)	1935-3227
DOI	10.1097/ADM.0000000000000323
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Article ; Online: System-Level Influences on the Sustainability of a Cognitive Therapy Program in a Community Behavioral Health Network.

Stirman, Shannon Wiltsey / Matza, Alexis / Gamarra, Jennifer / Toder, Katherine / Xhezo, Regina / Evans, Arthur C / Hurford, Matthew / Beck, Aaron T / Crits-Christoph, Paul / Creed, Torrey

Psychiatric services (Washington, D.C.)

2015 Volume 66, Issue 7, Page(s) 734–742

Abstract: Objective: The purpose of this study was to examine influences on the sustainability of a program to implement an evidence-based psychotherapy in a mental health system.: Methods: Interviews with program administrators, training consultants, agency ... ...

Abstract	Objective: The purpose of this study was to examine influences on the sustainability of a program to implement an evidence-based psychotherapy in a mental health system. Methods: Interviews with program administrators, training consultants, agency administrators, and supervisors (N=24), along with summaries of program evaluation data and program documentation, were analyzed with a directed content-analytic approach. Results: Findings suggested a number of interconnected and interacting influences on sustainability, including alignment with emerging sociopolitical influences and system and organizational priorities; program-level adaptation and evolution; intervention flexibility; strong communication, collaboration, planning, and support; and perceived benefit. These individual factors appeared to mutually influence one another and contribute to the degree of program sustainability achieved at the system level. Although most influences were positive, financial planning and support emerged as potentially both facilitator and barrier, and evaluation of benefits at the patient level remained a challenge. Conclusions: Several factors appeared to contribute to the sustainability of a psychosocial intervention in a large urban mental health system and warrant further investigation. Understanding interconnections between multiple individual facilitators and barriers appears critical to advancing understanding of sustainability in dynamic systems and adds to emerging recommendations for other implementation efforts. In particular, implications of the findings include the importance of implementation strategies, such as long-term planning, coalition building, clarifying roles and expectations, planned adaptation, evaluation, diversification of financing strategies, and incentivizing implementation.
MeSH term(s)	Cognitive Therapy/economics ; Community Networks ; Cooperative Behavior ; Evidence-Based Medicine ; Female ; Health Personnel ; Humans ; Interviews as Topic ; Male ; Pennsylvania ; Program Evaluation/economics
Language	English
Publishing date	2015-07
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1220173-x
ISSN	1557-9700 ; 1075-2730
ISSN (online)	1557-9700
ISSN	1075-2730
DOI	10.1176/appi.ps.201400147
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Article: Unique pattern of nuclear TdT immunofluorescence distinguishes normal precursor B cells (Hematogones) from lymphoblasts of precursor B-lymphoblastic leukemia.

Hurford, Matthew T / Altman, Arnold J / DiGiuseppe, Joseph A / Sherburne, Bradford J / Rezuke, William N

American journal of clinical pathology

2008 Volume 129, Issue 5, Page(s) 700–705

Abstract: Normal precursor B cells or hematogones share morphologic and immunophenotypic similarities with lymphoblasts of precursor B-lymphoblastic leukemia. The numbers are often increased and difficult to distinguish in many patients following chemotherapy for ... ...

Abstract	Normal precursor B cells or hematogones share morphologic and immunophenotypic similarities with lymphoblasts of precursor B-lymphoblastic leukemia. The numbers are often increased and difficult to distinguish in many patients following chemotherapy for precursor B-lymphoblastic leukemia. The purpose of this study was to establish a unique method for differentiating hematogones from lymphoblasts by evaluating the immunofluorescence pattern of nuclear terminal deoxynucleotidyl transferase (TdT) staining in 29 cases of TdT+ acute leukemia and 20 cases with increased numbers of hematogones. All 29 cases of TdT+ acute leukemia demonstrated a finely granular pattern of TdT immunofluorescence that was uniformly distributed in the nucleus, whereas all 20 cases with increased hematogones demonstrated a coarsely granular or speckled pattern of TdT immunofluorescence, which often intensely aligns the nuclear membrane. The nuclear pattern of immunofluorescence using antibodies to TdT is an effective method for distinguishing hematogones from leukemic blasts.
MeSH term(s)	Adolescent ; Adult ; Aged ; B-Lymphocytes/metabolism ; B-Lymphocytes/pathology ; Cell Nucleus/metabolism ; Child ; Child, Preschool ; DNA Nucleotidylexotransferase/metabolism ; Female ; Flow Cytometry ; Fluorescent Antibody Technique ; Humans ; Infant ; Male ; Middle Aged ; Neoplastic Stem Cells/metabolism ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/diagnosis ; Stem Cells/metabolism ; Stem Cells/pathology
Chemical Substances	DNA Nucleotidylexotransferase (EC 2.7.7.31)
Language	English
Publishing date	2008-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2944-0
ISSN	1943-7722 ; 0002-9173
ISSN (online)	1943-7722
ISSN	0002-9173
DOI	10.1309/ANERT51H38TUEC45
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Article ; Online: Lessons learned from implementing a pilot RCT of transitional care model for individuals with serious mental illness.

Solomon, Phyllis / Hanrahan, Nancy P / Hurford, Matthew / DeCesaris, Marissa / Josey, LaKeetra

Archives of psychiatric nursing

2014 Volume 28, Issue 4, Page(s) 250–255

Abstract: ... An advisory group (AG) of community stakeholders assessed barriers and facilitators of a 90-day T-Care ...

Abstract	We adapted an evidence-based transitional care model for older adults being released from acute care hospitals for patients with serious mental illness and medical co-morbidities being discharged from two psychiatric units of an acute care hospital (TCare) and evaluated implementation issues. An advisory group (AG) of community stakeholders assessed barriers and facilitators of a 90-day T-Care intervention delivered by a psychiatric nurse practitioner (NP) in the context of conducting a pilot randomized controlled trial. Minutes of AG and case narratives by NP of 20 intervention participants were content analyzed. Patients with immediate and pressing physical health problems were most receptive and actively utilized the service. Provider barriers consisted of communication and privacy issues making it difficult to contact patients in mental health facilities. In contrast, the NP was accepted and valued in the physical health arena. Psychosocial needs and relationship issues were demanding, and we recommend a team approach for TCare with the addition of a social worker, peer provider, and consulting psychiatrist for severely mentally ill patients being released from an acute physical health hospitalization.
MeSH term(s)	Adult ; Aftercare ; Combined Modality Therapy ; Comorbidity ; Cooperative Behavior ; Evidence-Based Nursing ; Female ; Health Plan Implementation ; Humans ; Interdisciplinary Communication ; Male ; Mental Disorders/diagnosis ; Mental Disorders/nursing ; Mental Disorders/psychology ; Middle Aged ; Models, Nursing ; Needs Assessment ; Nurse Practitioners ; Patient Discharge ; Pilot Projects ; Psychotropic Drugs/therapeutic use ; Transitional Care
Chemical Substances	Psychotropic Drugs
Language	English
Publishing date	2014-08
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	639197-7
ISSN	1532-8228 ; 0883-9417
ISSN (online)	1532-8228
ISSN	0883-9417
DOI	10.1016/j.apnu.2014.03.005
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Article ; Online: Implementing an E-prescribing system in outpatient mental health programs.

Rothbard, Aileen B / Noll, Elizabeth / Kuno, Eri / Zubritsky, Cynthia / Hurford, Matthew O / Holzer, Cordula / Hadley, Trevor

Administration and policy in mental health

2013 Volume 40, Issue 3, Page(s) 168–178

Abstract: This study describes the implementation and evaluation of an electronic prescription ordering system and feedback report in three community-based mental health outpatient agencies and the usefulness of the system in improving psychiatrists' prescribing ... ...

Abstract	This study describes the implementation and evaluation of an electronic prescription ordering system and feedback report in three community-based mental health outpatient agencies and the usefulness of the system in improving psychiatrists' prescribing behavior. Using the e-prescribing system as a data collection tool, feedback on evidence based prescribing practices for patients diagnosed with schizophrenia spectrum disorder or major affective disorder was provided to agency directors and prescribers via a monthly report. The results of the project were that e-prescribing tools can be installed at a reasonable cost with a short start up period. Although the feedback intervention did not show a significant reduction in questionable prescribing patterns, we should continue to investigate how to best use HIT to improve safety, reduce costs, and enhance the quality of healthcare. A better understanding of what prescribers find useful and the reasons why they are prescribing non-evidenced based medications is needed if interventions of this type are to be effective. Given the availability of administrative claims data and electronic prescribing technology, considerable potential exists to provide useful information for monitoring and clinical decision making in public mental health systems.
MeSH term(s)	Antipsychotic Agents/therapeutic use ; Decision Support Systems, Clinical ; Depressive Disorder, Major/drug therapy ; Diffusion of Innovation ; Electronic Prescribing ; Evidence-Based Practice ; Feedback ; Focus Groups ; Humans ; Mental Health Services ; Outpatients ; Schizophrenia/drug therapy ; United States
Chemical Substances	Antipsychotic Agents
Language	English
Publishing date	2013-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	1025319-1
ISSN	1573-3289 ; 0894-587X
ISSN (online)	1573-3289
ISSN	0894-587X
DOI	10.1007/s10488-011-0392-6
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