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  1. Article ; Online: Corrigendum to 'Draft genome sequence of a multidrug-resistant Pseudomonas aeruginosa producing blaSIM metallo-β-lactamase: London, UK' [Journal of Global Antimicrobial Resistance 29 (2022) 222-224].

    Bean, David C / Wareham, David W

    Journal of global antimicrobial resistance

    2022  Volume 30, Page(s) 490

    Language English
    Publishing date 2022-07-25
    Publishing country Netherlands
    Document type Published Erratum
    ZDB-ID 2710046-7
    ISSN 2213-7173 ; 2213-7173
    ISSN (online) 2213-7173
    ISSN 2213-7173
    DOI 10.1016/j.jgar.2022.07.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Draft genome sequence of a multidrug-resistant Pseudomonas aeruginosa producing bla

    Bean, David C / Wareham, David W

    Journal of global antimicrobial resistance

    2022  Volume 29, Page(s) 222–224

    Abstract: Objectives: We report the draft genome sequence of a multidrug-resistant Pseudomonas aeruginosa isolate (PA3) producing SIM carbapenemase from a patient in the United Kingdom.: Methods: Isolation, identification and antimicrobial susceptibility ... ...

    Abstract Objectives: We report the draft genome sequence of a multidrug-resistant Pseudomonas aeruginosa isolate (PA3) producing SIM carbapenemase from a patient in the United Kingdom.
    Methods: Isolation, identification and antimicrobial susceptibility testing were performed according to local routine microbiology protocols. Whole genomic DNA was sequenced using an Illumina HiSeq platform. The generated reads were de novo assembled using SPAdes version 3.7.1. Annotation was performed by the NCBI Prokaryote Genome Annotation Pipeline version 4.6. Sequence type, antimicrobial resistance and virulence-related genes were predicted from the sequence.
    Results: P. aeruginosa PA3 was resistant to most antipseudomonal β-lactams, aminoglycosides and quinolones but susceptible to colistin. The assembly comprised 100 contigs (>1000 bp) with a total length of 7 485 621 bp, and a total of 7190 coding sequences. The isolate belonged to sequence type (ST) 446, serotype O11 and contained bla
    Conclusion: We report a bla
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Drug Resistance, Multiple, Bacterial/genetics ; Genome, Bacterial ; Humans ; London ; Pseudomonas aeruginosa ; beta-Lactamases/genetics
    Chemical Substances Anti-Bacterial Agents ; beta-Lactamases (EC 3.5.2.6)
    Language English
    Publishing date 2022-04-10
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2710046-7
    ISSN 2213-7173 ; 2213-7173
    ISSN (online) 2213-7173
    ISSN 2213-7173
    DOI 10.1016/j.jgar.2022.03.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Intravenous cefiderocol for neurosurgical meningitis from an extensively drug-resistant New-Delhi metallo-β-lactamase-producing Pseudomonas aeruginosa strain.

    Stevenson, Daniel R / Cherian, Benny P / Kinzig, Martina / Sörgel, Fritz / Wareham, David W

    Journal of global antimicrobial resistance

    2022  Volume 32, Page(s) 29–30

    MeSH term(s) Pseudomonas aeruginosa ; Cephalosporins/pharmacology ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; beta-Lactamases/genetics ; Cefiderocol
    Chemical Substances Cephalosporins ; Anti-Bacterial Agents ; beta-Lactamases (EC 3.5.2.6)
    Language English
    Publishing date 2022-12-25
    Publishing country Netherlands
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2710046-7
    ISSN 2213-7173 ; 2213-7173
    ISSN (online) 2213-7173
    ISSN 2213-7173
    DOI 10.1016/j.jgar.2022.11.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Effects of In vivo Emergent Tigecycline Resistance on the Pathogenic Potential of Acinetobacter baumannii.

    Hornsey, Michael / Wareham, David W

    Scientific reports

    2018  Volume 8, Issue 1, Page(s) 4234

    Abstract: Multidrug-resistant lineages of Acinetobacter baumannii (MDRAB) are important nosocomial pathogens. As tigecycline remains active against most MDRAB we sought to investigate whether tigecycline resistance impacts biological fitness. The effects of ... ...

    Abstract Multidrug-resistant lineages of Acinetobacter baumannii (MDRAB) are important nosocomial pathogens. As tigecycline remains active against most MDRAB we sought to investigate whether tigecycline resistance impacts biological fitness. The effects of treatment-emergent tigecycline resistance were investigated in vitro and in vivo using two pre- (AB210; W6976) and post-therapy (AB211; W7282) clinical pairs, recovered from individual patients, where tigecycline resistance was associated with up-regulated efflux activity. All isolates belonged to the same epidemic UK lineage. Significant differences were observed in end-point survival proportions between AB210 and AB211, but not between W6976 and W7282, using the Galleria mellonella infection model. Isolate AB211 outcompeted AB210 in vivo, in contrast to isolate W7282, which was outcompeted by its pre-therapy counterpart, W6972. Whole-genome sequencing of isolates W6976 and W7282 revealed a mutation in the adeABC regulatory gene, adeS in W7282; resulting in a Ser-8 → Arg substitution. Previous whole-genome comparison of AB210 and AB211 also identified a non-synonymous mutation in adeS, among several other lesions in genes involved in biofilm formation and DNA mismatch repair; consistent with the phenotypic differences described here. In conclusion, the differing effects on the wider phenotype were not predictable from the antibiograms or clonal lineage, despite a common mechanism of tigecycline resistance.
    MeSH term(s) Acinetobacter baumannii/drug effects ; Acinetobacter baumannii/physiology ; Biofilms/drug effects ; Drug Resistance, Bacterial ; Drug Resistance, Multiple ; Microbial Sensitivity Tests ; Tigecycline/pharmacology
    Chemical Substances Tigecycline (70JE2N95KR)
    Language English
    Publishing date 2018-03-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-018-22549-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Draft Genome Sequence of

    Bean, David C / Wigmore, Sarah M / Wareham, David W

    Genome announcements

    2017  Volume 5, Issue 7

    Abstract: Staphylococcus ... ...

    Abstract Staphylococcus cohnii
    Language English
    Publishing date 2017-02-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2704277-7
    ISSN 2169-8287
    ISSN 2169-8287
    DOI 10.1128/genomeA.01628-16
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Cefiderocol in the treatment of systemic carbapenemase-producing multidrug-resistant Klebsiella pneumoniae infection.

    Lampejo, Temi / Cherian, Benny P / Tan, Mei Gie Meiqi / Wareham, David W

    Journal of global antimicrobial resistance

    2020  Volume 23, Page(s) 338–339

    MeSH term(s) Bacterial Proteins ; Cephalosporins/pharmacology ; Cephalosporins/therapeutic use ; Klebsiella pneumoniae ; beta-Lactamases/genetics ; Cefiderocol
    Chemical Substances Bacterial Proteins ; Cephalosporins ; beta-Lactamases (EC 3.5.2.6) ; carbapenemase (EC 3.5.2.6)
    Language English
    Publishing date 2020-10-30
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2710046-7
    ISSN 2213-7173 ; 2213-7173
    ISSN (online) 2213-7173
    ISSN 2213-7173
    DOI 10.1016/j.jgar.2020.10.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Draft Genome Sequence of a Canine Isolate of Methicillin-Resistant

    Bean, David C / Wigmore, Sarah M / Wareham, David W

    Genome announcements

    2017  Volume 5, Issue 14

    Abstract: Staphylococcus ... ...

    Abstract Staphylococcus haemolyticus
    Language English
    Publishing date 2017-04-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2704277-7
    ISSN 2169-8287
    ISSN 2169-8287
    DOI 10.1128/genomeA.00146-17
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Recurrent spontaneous

    Amulele, Anne V / Ong'ayo, Gerald / Arara, Alfred M / Machanja, Edwin W / Etyang, Anthony / Aliyan, Nadia A / Wareham, David W / Berkley, James A / Gordon, Nicola C

    JAC-antimicrobial resistance

    2023  Volume 5, Issue 2, Page(s) dlad029

    Abstract: Objectives: The aim of this study was to characterize an unusual case of spontaneous, community-acquired : Patient and methods: An adult presented to a hospital in Kenya with meningitis symptoms. : Results: The : Conclusions: Though less fit ... ...

    Abstract Objectives: The aim of this study was to characterize an unusual case of spontaneous, community-acquired
    Patient and methods: An adult presented to a hospital in Kenya with meningitis symptoms.
    Results: The
    Conclusions: Though less fit and virulent
    Language English
    Publishing date 2023-03-28
    Publishing country England
    Document type Journal Article
    ISSN 2632-1823
    ISSN (online) 2632-1823
    DOI 10.1093/jacamr/dlad029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Effects of In vivo Emergent Tigecycline Resistance on the Pathogenic Potential of Acinetobacter baumannii

    Michael Hornsey / David W. Wareham

    Scientific Reports, Vol 8, Iss 1, Pp 1-

    2018  Volume 8

    Abstract: Abstract Multidrug-resistant lineages of Acinetobacter baumannii (MDRAB) are important nosocomial pathogens. As tigecycline remains active against most MDRAB we sought to investigate whether tigecycline resistance impacts biological fitness. The effects ... ...

    Abstract Abstract Multidrug-resistant lineages of Acinetobacter baumannii (MDRAB) are important nosocomial pathogens. As tigecycline remains active against most MDRAB we sought to investigate whether tigecycline resistance impacts biological fitness. The effects of treatment-emergent tigecycline resistance were investigated in vitro and in vivo using two pre- (AB210; W6976) and post-therapy (AB211; W7282) clinical pairs, recovered from individual patients, where tigecycline resistance was associated with up-regulated efflux activity. All isolates belonged to the same epidemic UK lineage. Significant differences were observed in end-point survival proportions between AB210 and AB211, but not between W6976 and W7282, using the Galleria mellonella infection model. Isolate AB211 outcompeted AB210 in vivo, in contrast to isolate W7282, which was outcompeted by its pre-therapy counterpart, W6972. Whole-genome sequencing of isolates W6976 and W7282 revealed a mutation in the adeABC regulatory gene, adeS in W7282; resulting in a Ser-8 → Arg substitution. Previous whole-genome comparison of AB210 and AB211 also identified a non-synonymous mutation in adeS, among several other lesions in genes involved in biofilm formation and DNA mismatch repair; consistent with the phenotypic differences described here. In conclusion, the differing effects on the wider phenotype were not predictable from the antibiograms or clonal lineage, despite a common mechanism of tigecycline resistance.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2018-03-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Compassionate use of cefiderocol for carbapenem-resistant

    Mabayoje, Diana A / NicFhogartaigh, Caoimhe / Cherian, Benny P / Tan, Mei Gie Meiqi / Wareham, David W

    JAC-antimicrobial resistance

    2021  Volume 3, Issue Suppl 1, Page(s) i21–i24

    Abstract: Background: Cefiderocol is a recently licensed novel siderophore-conjugated cephalosporin stable to hydrolysis by serine and MBLs. It has been successfully used to treat Enterobacterales infections and is approved for the treatment of infections due to ... ...

    Abstract Background: Cefiderocol is a recently licensed novel siderophore-conjugated cephalosporin stable to hydrolysis by serine and MBLs. It has been successfully used to treat Enterobacterales infections and is approved for the treatment of infections due to aerobic Gram-negative organisms in adults with limited treatment options.
    Objectives: To describe the compassionate use of cefiderocol and clinical outcome in a case of prosthetic joint infection due to MDR
    Patients and methods: This case study follows a 66-year-old woman who sustained an open fracture of the left distal humerus in Pakistan. She underwent open reduction and internal fixation and on return to the UK presented to hospital with a discharging surgical wound.
    Results: Debridement of her wound cultured NDM carbapenemase-producing
    Conclusions: Cefiderocol's novel mode of cell entry is effective against MDR Gram-negative bacteria with reduced toxicity compared with other last line antibiotics. Our case demonstrates that cefiderocol may be useful as therapy for patients with limited treatment options due to antimicrobial resistance.
    Language English
    Publishing date 2021-06-15
    Publishing country England
    Document type Journal Article
    ISSN 2632-1823
    ISSN (online) 2632-1823
    DOI 10.1093/jacamr/dlab055
    Database MEDical Literature Analysis and Retrieval System OnLINE

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