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  1. Article ; Online: Knowledge, attitude, and practices of Filipino adult neurologists on obstructive sleep apnea among stroke patients.

    Diamante, Pearl Angeli / Jocson, Maria Cecilia / Roxas, Artemio

    Sleep medicine: X

    2023  Volume 6, Page(s) 100091

    Abstract: Objectives: This study aimed to describe the knowledge, attitudes, and practices of Filipino adult neurologists in the recognition and treatment of obstructive sleep apnea (OSA) among patients presenting with acute stroke.: Methodology: A prospective ...

    Abstract Objectives: This study aimed to describe the knowledge, attitudes, and practices of Filipino adult neurologists in the recognition and treatment of obstructive sleep apnea (OSA) among patients presenting with acute stroke.
    Methodology: A prospective cross-sectional study was conducted using a web-based survey from April to June 2022 among active locally-practicing adult neurology fellows of the Philippine Neurological Association. The 18-item knowledge statements from the validated "Obstructive Sleep Apnea Knowledge and Attitudes (OSAKA) Questionnaire was used as survey instrument. There were also eight additional items assessing knowledge, six items assessing attitudes, and ten items assessing practices that were included.
    Results: A total of 119 neurologists participated in the survey. Two-thirds of the respondents were females, and 70 % were between 31 and 40 years old. Majority of the respondents are General Neurologists (57.1 %) followed by Neurophysiologists (10 %) and Stroke Specialists (10 %). Forty-seven percent of neurologists got more than or equal to 75 % of the knowledge statements included in the OSAKA questionnaire correctly. Less than half of the respondents correctly answered the questions on (1) uvulopalatopharyngoplasty as curative for majority of patients with OSA (32.8 %), (2) continuous positive airway pressure (CPAP) therapy can cause nasal congestion (42.9 %), (3) laser-assisted uvuloplasty as treatment for severe OSA (16.8 %), and (4) less than 5 apneas is normal in adults (48.7 %). Majority (>80 %) of the respondents were able to correctly answer the statements relating OSA and stroke. Almost all agreed that OSA as a clinical disorder (95 %) is important and that acute stroke patients with possible OSA needs to be identified (94.1 %) and further evaluated (96.6 %). On the other hand, less than half of the respondents feel confident in: identifying patients at-risk for OSA (47.9 %), ability to manage acute stroke patients with OSA (34.5 %), and ability to manage acute stroke patients with OSA on CPAP therapy (21 %). Most neurologists would sometimes screen OSA among their patients with acute stroke (55.5 %). Most respondents would only educate their patients on OSA sometimes (43.7 %). With regards to the diagnosis (42 %), risk factors (42 %), and treatment options for OSA (40.3 %), most would discuss them with their patients.
    Conclusion: Less than half of neurologists were able to get at least 75 % of the knowledge questions. Majority had difficulty with statements pertaining to surgery as cure for OSA, CPAP therapy causing nasal congestion, and OSA severity classification. Almost all has a positive attitude towards the importance of OSA diagnosis and management; however, there is low confidence among them with regards to their practice in identification and handling of these patients.
    Language English
    Publishing date 2023-10-15
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2590-1427
    ISSN (online) 2590-1427
    DOI 10.1016/j.sleepx.2023.100091
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: An

    Roxas, Jillian Dominique P / San Juan, Maria Angela D / Villagracia, Al Rey C / Espiritu, Rafael A

    Journal of biomolecular structure & dynamics

    2024  , Page(s) 1–14

    Abstract: Type 2 diabetes is a medical condition involving elevated blood glucose levels resulting from impaired or improper insulin utilization. As the number of type 2 diabetes cases increases each year, there is an urgent need to develop novel drugs having new ... ...

    Abstract Type 2 diabetes is a medical condition involving elevated blood glucose levels resulting from impaired or improper insulin utilization. As the number of type 2 diabetes cases increases each year, there is an urgent need to develop novel drugs having new targets and/or complementing existing therapeutic protocols. In this regard, marine sponge-derived compounds hold great potential due to their potent biological activity and structural diversity. In this study, a small library of 50 marine sponge-derived compounds were examined for their activity towards type 2 diabetes targets, namely dipeptidyl peptidase-4 (DPP-4) and protein tyrosine phosphatase 1B (PTP1B). The compounds were first subjected to molecular docking on protein models based on their respective co-crystal structures to assess binding free energies (BFE) and conformations. Clustering analysis yielded BFE that ranged from 24.54 kcal/mol to -9.97 kcal/mol for DPP-4, and from -4.98 kcal/mol to -8.67 kcal/mol for PTP1B. Interaction analysis on the top ten compounds with the most negative BFE towards each protein target showed similar intermolecular interactions and key interacting residues as in the previously solved co-crystal structure. These compounds were subjected to absorption, distribution, metabolism, excretion, and toxicity (ADMET) profiling to characterize drug-likeness and combining the results from these analyses, (
    Language English
    Publishing date 2024-01-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2024.2301751
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: The role of enzyme supplementation in digestive disorders.

    Roxas, Mario

    Alternative medicine review : a journal of clinical therapeutic

    2008  Volume 13, Issue 4, Page(s) 307–314

    Abstract: This article reviews various forms of enzyme supplementation used clinically in digestive and absorption disorders. Enzyme supplementation plays an integral role in the management of various digestive disorders, particularly with regard to exocrine ... ...

    Abstract This article reviews various forms of enzyme supplementation used clinically in digestive and absorption disorders. Enzyme supplementation plays an integral role in the management of various digestive disorders, particularly with regard to exocrine pancreatic insufficiency. However, application of enzymes may also be beneficial for other conditions associated with poor digestion including lactose intolerance. Historically, porcine and bovine pancreatic enzymes have been the preferred form of supplementation for exocrine pancreatic insufficiency. Use of microbe-derived lipase has shown promise with studies indicating benefit similar to pancreatic enzymes, but at a lower dosage concentration and with a broader pH range. Safety and efficacy of enzymes derived from microbial species in the treatment of conditions such as malabsorption and lactose intolerance is promising. Plant-based enzymes, such as bromelain from pineapple, serve as effective digestive aids in the breakdown of proteins. Synergistic effects have been observed using a combination of animal-based enzymes and microbe-derived enzymes or bromelain.
    MeSH term(s) Celiac Disease/drug therapy ; Exocrine Pancreatic Insufficiency/complications ; Exocrine Pancreatic Insufficiency/drug therapy ; Fungi/enzymology ; Gastrointestinal Agents/therapeutic use ; Humans ; Lactose Intolerance/drug therapy ; Malabsorption Syndromes/drug therapy ; Pancreas/enzymology ; Phytotherapy/methods
    Chemical Substances Gastrointestinal Agents
    Language English
    Publishing date 2008-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1465535-4
    ISSN 1089-5159
    ISSN 1089-5159
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A machine learning-based SNP-set analysis approach for identifying disease-associated susceptibility loci.

    Silva, Princess P / Gaudillo, Joverlyn D / Vilela, Julianne A / Roxas-Villanueva, Ranzivelle Marianne L / Tiangco, Beatrice J / Domingo, Mario R / Albia, Jason R

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 15817

    Abstract: Identifying disease-associated susceptibility loci is one of the most pressing and crucial challenges in modeling complex diseases. Existing approaches to biomarker discovery are subject to several limitations including underpowered detection, neglect ... ...

    Abstract Identifying disease-associated susceptibility loci is one of the most pressing and crucial challenges in modeling complex diseases. Existing approaches to biomarker discovery are subject to several limitations including underpowered detection, neglect for variant interactions, and restrictive dependence on prior biological knowledge. Addressing these challenges necessitates more ingenious ways of approaching the "missing heritability" problem. This study aims to discover disease-associated susceptibility loci by augmenting previous genome-wide association study (GWAS) using the integration of random forest and cluster analysis. The proposed integrated framework is applied to a hepatitis B virus surface antigen (HBsAg) seroclearance GWAS data. Multiple cluster analyses were performed on (1) single nucleotide polymorphisms (SNPs) considered significant by GWAS and (2) SNPs with the highest feature importance scores obtained using random forest. The resulting SNP-sets from the cluster analyses were subsequently tested for trait-association. Three susceptibility loci possibly associated with HBsAg seroclearance were identified: (1) SNP rs2399971, (2) gene LINC00578, and (3) locus 11p15. SNP rs2399971 is a biomarker reported in the literature to be significantly associated with HBsAg seroclearance in patients who had received antiviral treatment. The latter two loci are linked with diseases influenced by the presence of hepatitis B virus infection. These findings demonstrate the potential of the proposed integrated framework in identifying disease-associated susceptibility loci. With further validation, results herein could aid in better understanding complex disease etiologies and provide inputs for a more advanced disease risk assessment for patients.
    MeSH term(s) Antigens, Surface ; Antiviral Agents ; Biomarkers ; Genetic Predisposition to Disease ; Genome-Wide Association Study/methods ; Genotype ; Hepatitis B Surface Antigens/genetics ; Humans ; Machine Learning ; Polymorphism, Single Nucleotide
    Chemical Substances Antigens, Surface ; Antiviral Agents ; Biomarkers ; Hepatitis B Surface Antigens
    Language English
    Publishing date 2022-09-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-19708-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Herpes zoster and postherpetic neuralgia: diagnosis and therapeutic considerations.

    Roxas, Mario

    Alternative medicine review : a journal of clinical therapeutic

    2006  Volume 11, Issue 2, Page(s) 102–113

    Abstract: Herpes zoster (HZ), also known as shingles, is a painful vesicular rash resulting from reactivation of the virus that also causes chickenpox - Varicella zoster virus (VZV). Typically, the rash runs its course in a matter of 4-5 weeks. The pain, however, ... ...

    Abstract Herpes zoster (HZ), also known as shingles, is a painful vesicular rash resulting from reactivation of the virus that also causes chickenpox - Varicella zoster virus (VZV). Typically, the rash runs its course in a matter of 4-5 weeks. The pain, however, may persist months, even years, after the skin heals. This phenomenon is known as postherpetic neuralgia (PHN). Often described as an intense burning, itching sensation, this pain can be significant to the point of being debilitating, and as such can greatly affect quality of life. Although shingles is generally regarded as a self-limited condition, the fact it can take several weeks to resolve and has the potential for development of complications such as PHN presents a challenge to clinicians. Many treatment options are available, each offering variable levels of efficacy. Conventional therapies include prescription antivirals, corticosteroids, and analgesics, both oral and topical. Other considerations include use of over-the-counter anti-inflammatory agents, physiotherapy, and nerve block injections. This article reviews herpes zoster and postherpetic neuralgia, and presents the most effective conventional treatment options currently available, as well as select botanical, nutritional, and other considerations that may be beneficial in the management of this condition.
    MeSH term(s) Complementary Therapies/methods ; Herpes Zoster/complications ; Humans ; Neuralgia, Postherpetic/diagnosis ; Neuralgia, Postherpetic/therapy ; Neuralgia, Postherpetic/virology
    Language English
    Publishing date 2006-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1465535-4
    ISSN 1089-5159
    ISSN 1089-5159
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Plantar fasciitis: diagnosis and therapeutic considerations.

    Roxas, Mario

    Alternative medicine review : a journal of clinical therapeutic

    2005  Volume 10, Issue 2, Page(s) 83–93

    Abstract: Plantar fasciitis is the most common cause of inferior heel pain. The pain and discomfort associated with this condition can have a dramatic impact on physical mobility. The etiology of this condition is not clearly understood and is probably multi- ... ...

    Abstract Plantar fasciitis is the most common cause of inferior heel pain. The pain and discomfort associated with this condition can have a dramatic impact on physical mobility. The etiology of this condition is not clearly understood and is probably multi-factorial in nature. Weight gain, occupation-related activity, anatomical variations, poor biomechanics, overexertion, and inadequate footwear are contributing factors. Although plantar fasciitis is generally regarded as a self-limited condition, it can take months to years to resolve, presenting a challenge for clinicians. Many treatment options are available that demonstrate variable levels of efficacy. Conservative therapies include rest and avoidance of potentially aggravating activities, stretching and strengthening exercises, orthotics, arch supports, and night splinting. Other considerations include use of anti-inflammatory agents, ultrasonic shockwave therapy, and, in the most extreme cases, surgery. This article reviews plantar fasciitis, presents the most effective treatment options currently available, and proposes nutritional considerations that may be beneficial in the management of this condition.
    MeSH term(s) Dietary Supplements ; Fasciitis, Plantar/diagnosis ; Fasciitis, Plantar/etiology ; Fasciitis, Plantar/therapy ; Humans ; Nutritional Physiological Phenomena ; Orthotic Devices ; Physical Therapy Modalities ; Risk Factors ; Shoes ; Ultrasonic Therapy
    Language English
    Publishing date 2005-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1465535-4
    ISSN 1089-5159
    ISSN 1089-5159
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Knowledge, attitude, and practices of Filipino adult neurologists on obstructive sleep apnea among stroke patients

    Pearl Angeli Diamante / Maria Cecilia Jocson / Artemio Roxas, Jr.

    Sleep Medicine: X, Vol 6, Iss , Pp 100091- (2023)

    2023  

    Abstract: Objectives: This study aimed to describe the knowledge, attitudes, and practices of Filipino adult neurologists in the recognition and treatment of obstructive sleep apnea (OSA) among patients presenting with acute stroke. Methodology: A prospective ... ...

    Abstract Objectives: This study aimed to describe the knowledge, attitudes, and practices of Filipino adult neurologists in the recognition and treatment of obstructive sleep apnea (OSA) among patients presenting with acute stroke. Methodology: A prospective cross-sectional study was conducted using a web-based survey from April to June 2022 among active locally-practicing adult neurology fellows of the Philippine Neurological Association. The 18-item knowledge statements from the validated “Obstructive Sleep Apnea Knowledge and Attitudes (OSAKA) Questionnaire was used as survey instrument. There were also eight additional items assessing knowledge, six items assessing attitudes, and ten items assessing practices that were included. Results: A total of 119 neurologists participated in the survey. Two-thirds of the respondents were females, and 70 % were between 31 and 40 years old. Majority of the respondents are General Neurologists (57.1 %) followed by Neurophysiologists (10 %) and Stroke Specialists (10 %). Forty-seven percent of neurologists got more than or equal to 75 % of the knowledge statements included in the OSAKA questionnaire correctly. Less than half of the respondents correctly answered the questions on (1) uvulopalatopharyngoplasty as curative for majority of patients with OSA (32.8 %), (2) continuous positive airway pressure (CPAP) therapy can cause nasal congestion (42.9 %), (3) laser-assisted uvuloplasty as treatment for severe OSA (16.8 %), and (4) less than 5 apneas is normal in adults (48.7 %). Majority (>80 %) of the respondents were able to correctly answer the statements relating OSA and stroke. Almost all agreed that OSA as a clinical disorder (95 %) is important and that acute stroke patients with possible OSA needs to be identified (94.1 %) and further evaluated (96.6 %). On the other hand, less than half of the respondents feel confident in: identifying patients at-risk for OSA (47.9 %), ability to manage acute stroke patients with OSA (34.5 %), and ability to manage acute stroke patients ...
    Keywords Knowledge ; attitude ; and practice (KAP) ; Neurologists ; Obstructive sleep apnea (OSA) ; Stroke ; Specialties of internal medicine ; RC581-951
    Subject code 610
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Bodies-in-waiting as infrastructure: Assembling the Philippine Government's disciplinary quarantine response to COVID-19.

    Canoy, Nico A / Robles, Augil Marie Q / Roxas, Gilana Kim T

    Social science & medicine (1982)

    2021  Volume 294, Page(s) 114695

    Abstract: The purpose of this article is to advance the concept of bodies-in-waiting as an everyday infrastructure to explain the shifting nature of 'pandemic cities' in response to the changing dynamics of infection control in urban spaces. While previous ... ...

    Abstract The purpose of this article is to advance the concept of bodies-in-waiting as an everyday infrastructure to explain the shifting nature of 'pandemic cities' in response to the changing dynamics of infection control in urban spaces. While previous literatures have been 'sanitized' to emphasize the importance of managing optimal physiological health and safety, we would like to argue that keener attention is needed to rethink the constitutive role of bodies in co-producing a city's sociopolitical ecologies at this time of crisis. The main body is divided into three sections. The first section introduces the political dimensions of pandemic response by various governments with an emphasis to experiences of middle to low income countries. Our intention is to show how these studies bring into light the role of local politics of pandemic response within countries, and that actual governance mechanisms in cities are shaped and contested by shifting power blocs and emergent affinities. The second section forwards an embodied urban political approach that conceptualizes bodies-in-waiting as infrastructure. In this view, bodies-in-waiting is produced and reproduced by complex social-material flows and transformation rooted in variegated matrices of power through which urban spaces are (re)assembled. The last section demonstrates a sample case that shows how bodies-in-waiting as infrastructure are understood using Twitter-sourced data associated with the Philippine government's disciplinary quarantine measures which started March 12, 2020 in the NCR. At its core, bodies-in-waiting as infrastructures populate a politically affirmative urban imaginary of bodies living on despite the existence of an accelerated and mutating virus in slower moving cities.
    MeSH term(s) COVID-19 ; Government ; Humans ; Philippines ; Quarantine ; SARS-CoV-2
    Language English
    Publishing date 2021-12-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 4766-1
    ISSN 1873-5347 ; 0037-7856 ; 0277-9536
    ISSN (online) 1873-5347
    ISSN 0037-7856 ; 0277-9536
    DOI 10.1016/j.socscimed.2021.114695
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A Qualitative Study on the Implementation of the Workplace TB Program in the Philippines: Challenges and Way Forward.

    Roxas, Evalyn A / Fadrilan-Camacho, Vivien Fe F / Lota, Maria Margarita M / Hernandez, Paul Michael R / Agravante, Adrian Paul M / Loterio, Loisse Mikaela M / Arevalo, Micaela J / Maglalang, Richelle Liza F / Lumangaya, Carlo R / Belizario, Vicente Y

    Tropical medicine and infectious disease

    2023  Volume 8, Issue 2

    Abstract: Tuberculosis (TB) is a chronic infectious disease that remains to be a primary health concern globally. The Philippines is among the top TB-burdened countries. Workplace TB prevention and control programs are essential to ensure the health and safety of ... ...

    Abstract Tuberculosis (TB) is a chronic infectious disease that remains to be a primary health concern globally. The Philippines is among the top TB-burdened countries. Workplace TB prevention and control programs are essential to ensure the health and safety of workers and economic security. There remains a knowledge gap regarding the Philippine workplace TB prevention and control program implementation. This qualitative study involving key informant interviews reviewed the implementation of the workplace TB program in selected companies in a high TB burden region in Eastern Philippines. Results were presented under four themes in accordance with the components of the workplace TB policy: preventive strategies, medical management, data recording and reporting, and social policy. Various good practices, opportunities, and challenges in the implementation of the workplace TB program were identified. There is a need to strengthen the enforcement of policy across different components. Compliance with guidelines on preventive strategies and recording and reporting schemes needs to be intensified. Coordination across different levels and agencies may also be enhanced to allow more efficient implementation. Increased awareness of corporate decision-makers may improve company ownership of the program leading to improved implementation while increased awareness of employees on their rights and entitlements may likewise enhance compliance.
    Language English
    Publishing date 2023-01-30
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2414-6366
    ISSN (online) 2414-6366
    DOI 10.3390/tropicalmed8020093
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Colds and influenza: a review of diagnosis and conventional, botanical, and nutritional considerations.

    Roxas, Mario / Jurenka, Julie

    Alternative medicine review : a journal of clinical therapeutic

    2007  Volume 12, Issue 1, Page(s) 25–48

    Abstract: The common cold is the leading cause of doctor visits in the United States and annually results in 189 million lost school days. In the course of one year the U.S. population contracts approximately 1 billion colds. Influenza infection is still a leading ...

    Abstract The common cold is the leading cause of doctor visits in the United States and annually results in 189 million lost school days. In the course of one year the U.S. population contracts approximately 1 billion colds. Influenza infection is still a leading cause of morbidity and mortality, accounting for 20-25 million doctor visits and 36,000 deaths per year in the United States. Conventional therapies for colds and flu focus primarily on temporary symptom relief and include over-the-counter antipyretics, anti-inflammatories, and decongestants. Treatment for influenza also includes prescription antiviral agents and vaccines for prevention. This article reviews the common cold and influenza viruses, presents the conventional treatment options, and highlights select botanicals (Echinacea spp., Sambucus nigra, larch arabinogalactan, Astragalus membranaceous, Baptisia tinctoria, Allium sativa, Panax quinquefolium, Eleutherococcus senticosus, Andrographis paniculata, olive leaf extract, and Isatis tinctoria) and nutritional considerations (vitamins A and C, zinc, high lactoferrin whey protein, N-acetylcysteine, and DHEA) that may help in the prevention and treatment of these conditions.
    MeSH term(s) Acetylcysteine/therapeutic use ; Antiviral Agents/therapeutic use ; Common Cold/complications ; Common Cold/therapy ; Common Cold/virology ; Dehydroepiandrosterone/therapeutic use ; Humans ; Influenza Vaccines/therapeutic use ; Influenza, Human/complications ; Influenza, Human/therapy ; Influenza, Human/virology ; Lactoferrin/therapeutic use ; Nonprescription Drugs/therapeutic use ; Phytotherapy/methods ; Zinc/therapeutic use
    Chemical Substances Antiviral Agents ; Influenza Vaccines ; Nonprescription Drugs ; Dehydroepiandrosterone (459AG36T1B) ; Lactoferrin (EC 3.4.21.-) ; Zinc (J41CSQ7QDS) ; Acetylcysteine (WYQ7N0BPYC)
    Keywords covid19
    Language English
    Publishing date 2007-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1465535-4
    ISSN 1089-5159
    ISSN 1089-5159
    Database MEDical Literature Analysis and Retrieval System OnLINE

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