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Article ; Online: Linkage Disequilibrium Statistics and Block Visualization.

Marsh, Jacob

Methods in molecular biology (Clifton, N.J.)

2022 Volume 2443, Page(s) 483–496

Abstract: ... the widely applicable population genomics tool PLINK, before plotting linkage blocks generated in R and ...

Abstract	Linkage disequilibrium analysis enables researchers to interrogate the genome for patterns of coinheritance between genetic markers. Visualizing these patterns, and the characteristic haplotype "blocks" of linked variants can be challenging; however, advancements are being made through the development of bioinformatics software. Here, we introduce methods for producing linkage disequilibrium statistics using the widely applicable population genomics tool PLINK, before plotting linkage blocks generated in R and utilizing visualization software LDBlockShow to compare different measures of linkage and definitions of blocks.
MeSH term(s)	Computational Biology ; Genome ; Haplotypes ; Linkage Disequilibrium ; Polymorphism, Single Nucleotide ; Software
Language	English
Publishing date	2022-01-17
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-2067-0_25
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Article ; Online: Phenytoin enzyme induction for management of supratherapeutic tacrolimus levels due to drug-drug interaction with nirmatrelvir/ritonavir: Case series and discussion.

Marsh, Jennifer / Logan, Angela T / Bilgili, Erin P / Bowman, Lyndsey J / Webb, Allyssa R

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists

2024

Abstract: Disclaimer: In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and ...

Abstract	Disclaimer: In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time. Purpose: Nirmatrelvir/ritonavir is one of few options for outpatient treatment of COVID-19, but its use has been limited in transplant recipients due to significant drug interactions with immunosuppressants. Tacrolimus toxicity is possible when the drug is coadministered with nirmatrelvir/ritonavir and may require urgent reduction of tacrolimus levels. This case series describes the use of phenytoin for enzyme induction in 5 adult solid organ transplant recipients with supratherapeutic tacrolimus levels resulting from coadministration with nirmatrelvir/ritonavir. Summary: Solid organ transplant recipients are at high risk for complications related to COVID-19. Outpatient treatment options are limited, and therapeutic drug monitoring is complex in patients requiring quarantine. The 5 solid organ transplant recipients described herein were initiated on nirmatrelvir/ritonavir in the outpatient setting and subsequently presented with supratherapeutic tacrolimus concentrations greater than 59 ng/mL and developed signs and symptoms of tacrolimus toxicity. In all patients, nirmatrelvir/ritonavir and tacrolimus were discontinued, and oral phenytoin (200-400 mg/day) was given for 2 to 4 days. Tacrolimus was resumed once tacrolimus levels decreased to appropriate levels. Conclusion: These observations demonstrate that metabolism induction using phenytoin may be a useful strategy in the setting of supratherapeutic tacrolimus levels resulting from concomitant administration with nirmatrelvir/ritonavir.
Language	English
Publishing date	2024-02-13
Publishing country	England
Document type	Journal Article
ZDB-ID	1224627-x
ISSN	1535-2900 ; 1079-2082
ISSN (online)	1535-2900
ISSN	1079-2082
DOI	10.1093/ajhp/zxae032
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Article: Differential selection of roosts by Eastern Small-footed Myotis (

Moosman, Paul R / Marsh, David M / Pody, Emily K / Brust, Timothy J

Journal of mammalogy

2023 Volume 104, Issue 4, Page(s) 723–738

Abstract: Roost selection by insectivorous bats in temperate regions is presumably influenced by roost microclimates in relation to thermoregulatory strategies, but few studies have included temperature measurements in habitat selection models. Rocky landscape ... ...

Abstract	Roost selection by insectivorous bats in temperate regions is presumably influenced by roost microclimates in relation to thermoregulatory strategies, but few studies have included temperature measurements in habitat selection models. Rocky landscape features are an important source of roosts that provide both shelter from predators and beneficial microclimates for bats. Most information about rock-roosting bats has been derived from western North America. We studied microhabitat selection by the Eastern Small-footed Myotis (
Language	English
Publishing date	2023-04-21
Publishing country	England
Document type	Journal Article
ZDB-ID	218314-6
ISSN	0022-2372
ISSN	0022-2372
DOI	10.1093/jmammal/gyad037
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Article ; Online: Heuristic decision-making across adulthood.

Taylor, Morgan K / Marsh, Elizabeth J / Samanez-Larkin, Gregory R

Psychology and aging

2023 Volume 38, Issue 6, Page(s) 508–518

Abstract: In general, research on aging and decision-making has grown in recent years. Yet, little work has investigated how reliance on classic heuristics may differ across adulthood. For example, younger adults rely on the availability of information from memory ...

Abstract	In general, research on aging and decision-making has grown in recent years. Yet, little work has investigated how reliance on classic heuristics may differ across adulthood. For example, younger adults rely on the availability of information from memory when judging the relative frequency of plane crashes versus car accidents, but it is unclear if older adults are similarly reliant on this heuristic. In the present study, participants aged 20-90 years old made judgments that could be answered by relying on five different heuristics: anchoring, availability, recognition, representativeness, and sunk-cost bias. We found no evidence of age-related differences in the use of the classic heuristics-younger and older adults employed anchoring, availability, recognition, and representativeness to equal degrees in order to make decisions. However, replicating past work, we found age-related differences in the sunk-cost bias-older adults were more likely to avoid this fallacy compared to younger adults. We explain these different patterns by drawing on the distinctive roles that stored knowledge and personal experience likely play across heuristics. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
MeSH term(s)	Humans ; Aged ; Adult ; Aged, 80 and over ; Decision Making ; Heuristics ; Aging ; Judgment ; Recognition, Psychology
Language	English
Publishing date	2023-02-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	635596-1
ISSN	1939-1498 ; 0882-7974
ISSN (online)	1939-1498
ISSN	0882-7974
DOI	10.1037/pag0000726
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Article ; Online: An age- and sex-specific biokinetic model for radon

Samuels, Caleigh / Marsh, James / Leggett, Rich

Journal of radiological protection : official journal of the Society for Radiological Protection

2023 Volume 43, Issue 4

Abstract: Publication 137 of the International Commission on Radiological Protection (ICRP) describes a biokinetic model for radon used to derive dose coefficients for occupational intake of radon isotopes. The model depicts transfer of inhaled or ingested radon ... ...

Abstract	Publication 137 of the International Commission on Radiological Protection (ICRP) describes a biokinetic model for radon used to derive dose coefficients for occupational intake of radon isotopes. The model depicts transfer of inhaled or ingested radon to blood, exchange of radon between blood and tissues, and gradual loss of radon from the body based on physical laws governing transfer of a non-reactive and soluble gas between materials. This paper describes an age- and sex-specific variation of that model developed for use in an upcoming ICRP series of reports on environmental intake of radionuclides by members of the public titled 'Dose Coefficients for Intakes of Radionuclides by Members of the Public'. The proposed model modifies the model structure and transfer coefficients presented in Publication 137 to allow more realistic dosimetric treatment of bone marrow and breast and expands the model to address pre-adult ages, based on the physical principles used in the development of the model of Publication 137 together with anatomical and physiological changes occurring during human development.
MeSH term(s)	Humans ; Radon/analysis ; Radioisotopes ; Radiometry ; Radiation Dosage
Chemical Substances	Radon (Q74S4N8N1G) ; Radioisotopes
Language	English
Publishing date	2023-10-06
Publishing country	England
Document type	Journal Article
ZDB-ID	639411-5
ISSN	1361-6498 ; 0952-4746
ISSN (online)	1361-6498
ISSN	0952-4746
DOI	10.1088/1361-6498/acfb19
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Conference proceedings ; Online: Tracing Oceanic Sources of Heat Content Available for Atlantic Hurricanes

Harris, E. / Marsh, R. / Grist, J.

XXVIII General Assembly of the International Union of Geodesy and Geophysics (IUGG)

2023

Abstract: In the Main Development Region (MDR) for Atlantic hurricanes, the volume of water warmer than 26.5 ⁰C quantifies the potential source of energy for major storms. Taking a Lagrangian perspective, this warm water is backtracked on seasonal timescales in an ...

Abstract	In the Main Development Region (MDR) for Atlantic hurricanes, the volume of water warmer than 26.5 ⁰C quantifies the potential source of energy for major storms. Taking a Lagrangian perspective, this warm water is backtracked on seasonal timescales in an eddy-resolving ocean model hindcast spanning 1988-2010. Being confined near the surface and assuming a mixed layer depth of 50 m, net heat fluxes into or out of water parcels advected towards the MDR are inferred from along-trajectory temperature tendencies. To first order, these heat fluxes match surface net heat fluxes during the months over which water advects into the region. Contributions to this warm water in the preceding 6 months include water resident in the MDR (20-40%), arriving via the North Brazil Current (NBC, 5-15%), or via Ekman drift across 10 ⁰S. In relative terms, decreased contributions from the NBC and Ekman drift and more in situ warming within the MDR lead to warmer, more active hurricane seasons.
Subject code	551
Language	English
Publishing date	2023-07-11
Publishing country	de
Document type	Conference proceedings ; Online
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Article: Comparison between ozone column depths and methane lifetimes computed by one- and three-dimensional models at different atmospheric O

Ji, A / Kasting, J F / Cooke, G J / Marsh, D R / Tsigaridis, K

Royal Society open science

2023 Volume 10, Issue 5, Page(s) 230056

Abstract: Recently, ... ...

Abstract	Recently, Cooke
Language	English
Publishing date	2023-05-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2787755-3
ISSN	2054-5703
ISSN	2054-5703
DOI	10.1098/rsos.230056
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Conference proceedings ; Online: Impacts of a weakening subpolar North Atlantic influence on the European Slope Current, North Sea inflow and primary production

Clark, M. / Marsh, R. / Harle, J.

XXVIII General Assembly of the International Union of Geodesy and Geophysics (IUGG)

2023

Abstract: The subpolar North Atlantic provides a strong geostrophic eastward inflow to the European shelf seas, which varies across timescales with basin-scale warming and cooling. Lagrangian particle back-tracking experiments have suggested that this is a main ... ...

Abstract	The subpolar North Atlantic provides a strong geostrophic eastward inflow to the European shelf seas, which varies across timescales with basin-scale warming and cooling. Lagrangian particle back-tracking experiments have suggested that this is a main contributor to the northward flow of the European Slope Current. As the subpolar North Atlantic has warmed by approximately 2°C over the past 4 decades, geostrophic inflow to the European shelf edge and shelf seas has decreased in strength by up to 10 Sv (nearly 50%) due to weakened meridional density gradients across subpolar latitudes. There has been a corresponding 2-3 Sv (50-70%) drop in northward along-slope Slope Current transport. Atlantic inflow to the Slope Current has become more subtropical in provenance, slower, warmer and shallower, since 1997. The North Sea is consequently freshening with decreasing Atlantic inflow, being more influenced by Baltic outflow and riverine inputs. Using a 1D physics-biology coupled model, prescribing surface nutrient supply in proportion to Slope Current transport and shelf edge exchange, we present evidence of decreasing primary production over 1988-2010. Largest changes are associated with reduced productivity during the autumn bloom, after spring bloom exhaustion of surface nutrients that are subsequently reset during winter mixing. These findings have implications for seasonality of the North Sea ecosystem, particularly fisheries, and may explain some recently observed ecological shifts.
Subject code	551
Language	English
Publishing country	de
Document type	Conference proceedings ; Online
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Article ; Online: Correction: Marsh et al. Peptidic Connexin43 Therapeutics in Cardiac Reparative Medicine.

Marsh, Spencer R / Williams, Zachary J / Pridham, Kevin J / Gourdie, Robert G

Journal of cardiovascular development and disease

2022 Volume 9, Issue 4

Abstract: The authors would like to make corrections to the reference citations in the original article [ ... ]. ...

Abstract	The authors would like to make corrections to the reference citations in the original article [...].
Language	English
Publishing date	2022-04-16
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2777082-5
ISSN	2308-3425 ; 2308-3425
ISSN (online)	2308-3425
ISSN	2308-3425
DOI	10.3390/jcdd9040121
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Article ; Online: UV damage to hair and the effect of antioxidants and metal chelators.

Millington, K R / Marsh, J M

International journal of cosmetic science

2020 Volume 42, Issue 2, Page(s) 174–184

Abstract: Objective: To study the effects of addition of a redox metal, copper, antioxidants and metal chelators on the formation of free radicals in natural white Caucasian hair subsequently exposed to UV light. Three different methods, electron paramagnetic ... ...

Abstract	Objective: To study the effects of addition of a redox metal, copper, antioxidants and metal chelators on the formation of free radicals in natural white Caucasian hair subsequently exposed to UV light. Three different methods, electron paramagnetic resonance (EPR), a fluorescent probe for hydroxyl radical formation (terephthalate) and free radical photoyellowing, were used. These methods utilized different UV sources and reaction conditions, and so can give insights into the different mechanisms of action occurring during UV oxidation of hair. In addition, this study demonstrates how antioxidants and chelators can be screened to determine whether they can protect hair from UV damage. Results: The three methods gave somewhat different results, illustrating the importance of reaction conditions and wavelength on the photochemical mechanisms, and the efficacy of additives to influence these reactions. EPR results showed that N-acetylcysteine (NAC) pre-treatment eliminated the intensity of the signal because of sulphur and carbon free radicals in white hair both before and after exposure to UVB radiation. Doping the hair with copper ions had no effect on the intensity of the EPR signal under dry conditions. Terephthalate fluorescent probe data showed that under wet conditions, irradiation of white hair with UVA produced significant amounts of hydroxyl radicals. Pre-treatment of hair with NAC reduced the number of •OH radicals produced by natural white hair compared to an untreated control. In contrast to the EPR result, white hair doped with copper ions produced significantly higher levels of •OH radicals under wet conditions. It appears that the ability of copper ions to catalyse the photogeneration free radicals in hair is highly dependent on water content. Photoyellowing data showed a benefit for oxalic acid but no difference for NAC and an increase in yellowing for EDTA. Conclusion: The micro-EPR and terephthalate fluorescent probe methods are both effective techniques to study production of free radicals by hair exposed to UV light under wet and dry conditions, respectively. Both assays are simple methods for determining the effectiveness of potential protective hair treatments against UV damage, but because they assess free radical damage under dry vs wet conditions, the chemistry created on UV exposure is different. This gives insights into mechanism of action, but results may not be consistent between the two methods for actives added for reduction of UV damage. NAC pre-treatment did reduce free radical generation in UV-exposed hair under both wet and dry conditions. Photoyellowing data are more complicated as it is a less direct measure of UV damage and is highly dependent on irradiation source. Using UVB irradiation is experimentally convenient but may not be appropriate, because UVB wavelengths comprise only 0.3% of terrestrial sunlight. The photochemistry of hair exposed to sunlight involves concurrent photobleaching and photoyellowing processes and is far more complex. Under UVB irradiation conditions, oxalic acid showed a yellowing benefit.
MeSH term(s)	Acetylcysteine/pharmacology ; Antioxidants/pharmacology ; Chelating Agents/pharmacology ; Electron Spin Resonance Spectroscopy ; Fluorescent Dyes/chemistry ; Free Radicals/chemistry ; Hair/drug effects ; Hair/radiation effects ; Hair Color ; Humans ; Metals/chemistry ; Ultraviolet Rays
Chemical Substances	Antioxidants ; Chelating Agents ; Fluorescent Dyes ; Free Radicals ; Metals ; Acetylcysteine (WYQ7N0BPYC)
Language	English
Publishing date	2020-03-11
Publishing country	England
Document type	Journal Article
ZDB-ID	198917-0
ISSN	1468-2494 ; 0142-5463
ISSN (online)	1468-2494
ISSN	0142-5463
DOI	10.1111/ics.12601
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