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  1. Article: The effects of the chief technology officer and firm and industry R&D intensity on organizational performance

    Medcof, John W / Lee, Tien

    R & D management Vol. 47, No. 5 , p. 767-781

    2017  Volume 47, Issue 5, Page(s) 767–781

    Author's details John W. Medcof and Tien Lee
    Keywords Technologie ; Führungskräfte ; Forschungskosten ; Organisationsforschung ; Unternehmenserfolg ; Japan
    Language English
    Publisher Wiley-Blackwell
    Publishing place Oxford [u.a.]
    Document type Article
    ZDB-ID 121562-0 ; 2016955-3
    ISSN 1467-9310 ; 0033-6807
    ISSN (online) 1467-9310
    ISSN 0033-6807
    Database ECONomics Information System

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  2. Article ; Online: Laboratory Evolution of Metalloid Reductase Substrate Recognition and Nanoparticle Product Size.

    Hendricks, Alexander R / Cohen, Rachel S / McEwen, Gavin A / Tien, Tony / Guilliams, Bradley F / Alspach, Audrey / Snow, Christopher D / Ackerson, Christopher J

    ACS chemical biology

    2024  Volume 19, Issue 2, Page(s) 289–299

    Abstract: Glutathione reductase-like metalloid reductase (GRLMR) is an enzyme that reduces selenodiglutathione (GS-Se-SG), forming zerovalent Se nanoparticles (SeNPs). Error-prone polymerase chain reaction was used to create a library of ∼10,000 GRLMR variants. ... ...

    Abstract Glutathione reductase-like metalloid reductase (GRLMR) is an enzyme that reduces selenodiglutathione (GS-Se-SG), forming zerovalent Se nanoparticles (SeNPs). Error-prone polymerase chain reaction was used to create a library of ∼10,000 GRLMR variants. The library was expressed in BL21
    MeSH term(s) Oxidoreductases/genetics ; Metalloids ; Nanoparticles ; Selenium/chemistry ; Cystine
    Chemical Substances Oxidoreductases (EC 1.-) ; Metalloids ; Selenium (H6241UJ22B) ; Cystine (48TCX9A1VT)
    Language English
    Publishing date 2024-01-31
    Publishing country United States
    Document type Journal Article
    ISSN 1554-8937
    ISSN (online) 1554-8937
    DOI 10.1021/acschembio.3c00493
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Identification of areas prone to flash-flood phenomena using multiple-criteria decision-making, bivariate statistics, machine learning and their ensembles.

    Costache, Romulus / Tien Bui, Dieu

    The Science of the total environment

    2020  Volume 712, Page(s) 136492

    Abstract: Taking into account the exponential growth of the number of flash-floods events worldwide, the detection of areas prone to these natural hazards is one of the main activities taken in order to mitigate the negative effects of these risk phenomena. In the ...

    Abstract Taking into account the exponential growth of the number of flash-floods events worldwide, the detection of areas prone to these natural hazards is one of the main activities taken in order to mitigate the negative effects of these risk phenomena. In the present paper, new modeling approaches, Alternating Decision Tree (ADT) integrated with IOE (ADT-IOE) and ADT integrated with AHP (ADT-AHP), were proposed for flash-flood susceptibility mapping across the Suha river catchment (Romania). Besides, two stand-alone methods, Index of Entropy (IOE) and Analytical Hierarchy Process (AHP), were also investigated. For this regard, 111 torrential points and 111 non-torrential points along with 8 flash-flood conditioning factors have been involved in the training process of the four models. The quality of the flash-flood models was checked by using the ROC Curve method, classification accuracy (CLA), and Kappa index. The result shows that the two ensemble models, the ADT-IOE (AUC = 0.972, CLC = 86.37%, Kappa statistics = 0.727) and the ADT-AHP (AUC = 0.926, CLA = 87.88%, Kappa statistics = 0.758), have high prediction performance and outperform the other models. Therefore, ADT-IOE and ADT-AHP are new and promising tools for flash-flood susceptibility modeling.
    Language English
    Publishing date 2020-01-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2019.136492
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Surveillance for Diabetes in Hospital-Evaluation of Dashboard Effectiveness.

    Hng, Tien-Ming / Kolambkar, Reshma / Luo, Ching / Pryce, David

    Studies in health technology and informatics

    2024  Volume 310, Page(s) 409–413

    Abstract: There is a large burden of diabetes in Western Sydney, and this descriptor is also valid for the inpatient population. Optimizing diabetes care in hospital is important to prevent inpatient morbidity. A surveillance system was developed to address this ... ...

    Abstract There is a large burden of diabetes in Western Sydney, and this descriptor is also valid for the inpatient population. Optimizing diabetes care in hospital is important to prevent inpatient morbidity. A surveillance system was developed to address this need and a diabetes dashboard was developed around a data model built around the patient journey that integrated key data feeds from the pathology, medication, and patient administration systems. This facilitated the rapid identification and triaging of individuals with diabetes. We evaluated this dashboard using high level clinical and financial indicators. This implementation resulted in an improved time to patient review, and a reduction in 28-day readmission rates but the inpatient length of hospital stay was unchanged. (116 words).
    MeSH term(s) Humans ; Diabetes Mellitus/diagnosis ; Diabetes Mellitus/epidemiology ; Diabetes Mellitus/therapy ; Hospitals ; Inpatients ; Length of Stay ; Triage
    Language English
    Publishing date 2024-01-25
    Publishing country Netherlands
    Document type Journal Article
    ISSN 1879-8365
    ISSN (online) 1879-8365
    DOI 10.3233/SHTI230997
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Identification of novel human CC chemokine receptor 8 (CCR8) antagonists via the synthesis of naphthalene amide and sulfonamide isosteres.

    Verhaegen, Yenthel / Liu, Libao / Nguyen, Tien T / Loy, Tom Van / Schols, Dominique / Voet, Arnout R D / Dehaen, Wim / De Jonghe, Steven

    Bioorganic chemistry

    2024  Volume 145, Page(s) 107181

    Abstract: The human CC chemokine receptor 8 (CCR8) has been extensively pursued as target for the treatment of various inflammatory disorders. More recently, the importance of CCR8 in the tumor microenvironment has been demonstrated, spurring the interest in CCR8 ... ...

    Abstract The human CC chemokine receptor 8 (CCR8) has been extensively pursued as target for the treatment of various inflammatory disorders. More recently, the importance of CCR8 in the tumor microenvironment has been demonstrated, spurring the interest in CCR8 antagonism as therapeutic strategy in immuno-oncology. On a previously described naphthalene sulfonamide with CCR8 antagonistic properties, the concept of isosterism was applied, leading to the discovery of novel CCR8 antagonists with IC
    MeSH term(s) Humans ; Chemokines, CC/metabolism ; Chemokine CCL1/metabolism ; Receptors, Chemokine/chemistry ; Receptors, Chemokine/metabolism ; Amides ; Receptors, CCR8 ; Sulfonamides/pharmacology ; Naphthalenes/pharmacology
    Chemical Substances Chemokines, CC ; Chemokine CCL1 ; Receptors, Chemokine ; Amides ; Receptors, CCR8 ; Sulfonamides ; Naphthalenes ; CCR8 protein, human
    Language English
    Publishing date 2024-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 120080-x
    ISSN 1090-2120 ; 0045-2068
    ISSN (online) 1090-2120
    ISSN 0045-2068
    DOI 10.1016/j.bioorg.2024.107181
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Customized designed notch filters and applied effects on glare and contrast sensitivity in patients with dry eye syndrome.

    Tien, Chuen-Lin / Su, Su-Hui / Cheng, Ching-Ying / Su, Kuo-Chen

    International ophthalmology

    2023  Volume 43, Issue 9, Page(s) 3309–3319

    Abstract: ... measurement analysis (R-ANOVA) were utilized by using SPSS 26.0 software.: Results: A dual-wavelength 480 ... _B (3 cpd, F = 0.333, p = 0.771), SWCT_C (6 cpd, F = 1.779, p = 0.159), and SWCT_D (12 cpd, F = 1.447 ...

    Abstract Purpose: Glare visual acuity and contrast sensitivity are important indicators of visual quality. Studies have shown that the glare visual acuity and contrast sensitivity in dry eye patients tend to degenerate, further affecting their quality of life. The objective of this study was to investigate the effect of notch filters on glare VA and contrast sensitivity in patients with dry eye or with dry eye syndrome.
    Method: 36 subjects in the 20‒65 age group were diagnosed as having dry eye disease or perceived dry eye syndromes themselves who were included after the initial screening with the OSDI questionnaire, and one was subsequently excluded as they had undergone retinal detachment surgery. Finally, 35 subjects (14 male and 21 female) with a mean age of 40.66 ± 15.62 years participated in this study. All subjects wore their habitual prescriptions and four different filter lenses (namely 480, 620, dual 480 & 620 notch filter, and FL-41 tinted lens), and measured the parameters of glare visual acuity and contrast sensitivity using CSV-1000 and sine wave contrast test (SWCT), respectively. Student t-test and Repeated measurement analysis (R-ANOVA) were utilized by using SPSS 26.0 software.
    Results: A dual-wavelength 480 & 620 nm optical notch filter had a significant anti-glare effect decreasing glare disabilities or discomfort, and leading to better visual quality, the same effect was also shown on a 480 nm notch filter lens. All participants showed a significant difference among the baseline, three notch filters (480 nm, 620 nm, dual-wavelength 480 & 620 nm), and FL-41 tinted lens were used on SWCT_A (1.5 cpd, F = 3.054, p = 0.019) and SWCT_E (18 cpd, F = 2.840, p = 0.049); but did not show statistical different on SWCT_B (3 cpd, F = 0.333, p = 0.771), SWCT_C (6 cpd, F = 1.779, p = 0.159), and SWCT_D (12 cpd, F = 1.447, p = 0.228). The baseline showed the best visual performance on CS at a low spatial frequency (SWCT_A, 1.5 cpd), any filter might reduce the contrast sensitivity at low spatial frequencies in the clinical trial, whereas 480 nm notch filter showed the best effectiveness on CS at a high spatial frequency (SWCT_E, 18 cpd), the FL-41 lens that also filters out the 480 nm band does not achieve the same effect. Moreover, patients with dry eye or those older than 40 years old preferred optical multilayer notch filters to FL-41 tinted lenses.
    Conclusion: The 480- & 620-nm dual-wavelength and 480-nm single-wavelength notch filters have the best effect on the glare visual acuity and contrast sensitivity (CS) at high spatial frequencies in dry eye patients. The 620-nm notch filter performs better in CS at low and mid-low spatial frequencies; the FL-41 tinted lens performs poorly for glare VA and CS spatial frequencies examination. Patients with glare disabilities or CS disturbance at high spatial frequencies may choose a 480-nm notch filter lens, and patients who have CS disturbance at low spatial frequencies may consider a 620-nm notch filter for the prescription.
    MeSH term(s) Humans ; Male ; Female ; Adult ; Middle Aged ; Contrast Sensitivity ; Quality of Life ; Visual Acuity ; Glare ; Dry Eye Syndromes/diagnosis
    Language English
    Publishing date 2023-06-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 800087-6
    ISSN 1573-2630 ; 0165-5701
    ISSN (online) 1573-2630
    ISSN 0165-5701
    DOI 10.1007/s10792-023-02735-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Spatial prediction of flood potential using new ensembles of bivariate statistics and artificial intelligence: A case study at the Putna river catchment of Romania.

    Costache, Romulus / Tien Bui, Dieu

    The Science of the total environment

    2019  Volume 691, Page(s) 1098–1118

    Abstract: Flash-flood is considered to be one of the most destructive natural hazards in the world, which is difficult to accurately model and predict. The objective of the present research is to propose new ensembles of bivariate statistics and artificial ... ...

    Abstract Flash-flood is considered to be one of the most destructive natural hazards in the world, which is difficult to accurately model and predict. The objective of the present research is to propose new ensembles of bivariate statistics and artificial intelligences and to introduce a comprehensive methodology for predicting flood susceptibility. The Putna river catchment of Romania is selected as a case study. In this regard, a total of six ensemble models were proposed and verified: Multilayer Perceptron neural network-Frequency Ratio (MLP-FR), Multilayer Perceptron neural network -Weights of Evidence (MLP-WOE), Rotation Forest-Frequency Ratio (RF-FR), Rotation Forest-Weights of Evidence (RF-WOE), Classification and Regression Tree-Frequency Ratio (CART-FR), and Classification and Regression Tree-Weights of Evidence (CART-WOE). In a first step, a geospatial database was created for the study area. This database includes 132 flood locations and 14 conditioning factors (lithology, slope angle, plan curvature, hydrological soil group, topographic wetness index, landuse, convergence index, elevation, distance from river, profile curvature, rainfall, aspect, stream power index, and topographic position index). In the next step, the Information Gain Ratio was used to evaluate the predictive ability of these factors. Subsequently, the database was used to train and validate the six ensemble models. The Receiver operating characteristic (ROC) curve, area under the curve (AUC), and statistical measures were used to evaluate the performance of the models. The results show that the prediction capability of the proposed ensemble models varied from 86.8% (the RF-FR model) to 93.9% (the RF-WOE model). These values indicate a high prediction performance for all the models. Therefore, we can state that the proposed ensemble models are new reliable tools which can be used for flood susceptibility modelling.
    Language English
    Publishing date 2019-07-16
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2019.07.197
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Practitioner Adherence and Competence in MEYA, a Free Online Self-Instruction Program in Modular Psychotherapy and Counseling for Children's Autism-Related Clinical Needs.

    Wood, Jeffrey J / Wood, Karen S / Rosenau, Kashia A / Cho, An Chuen / Johnson, Amanda R / Muscatello, Virginia S / Tien, Ingrid S / Straus, Jolie / Wolpe, Samara / Zeldin, Ari / Kazlauskas, Kristofer / McLeod, Bryce D

    Journal of autism and developmental disorders

    2024  

    Abstract: The quality of care in public schools and other community settings for school-aged youths on the autism spectrum is variable and often not evidence-based. Training practitioners in these settings to deliver evidence-based practices (EBPs) may improve the ...

    Abstract The quality of care in public schools and other community settings for school-aged youths on the autism spectrum is variable and often not evidence-based. Training practitioners in these settings to deliver evidence-based practices (EBPs) may improve the quality of care. We developed a free internet-based training and clinical guidance system synthesizing multiple EBPs for youth on the autism spectrum addressing a range of mental health needs and autism-related behaviors, entitled Modular EBPs for Youth on the Autism Spectrum (MEYA; meya.ucla.edu). A multiple baseline study was conducted with seven practitioners recruited from mental health practice settings across the United States who were providing services to children on the autism spectrum (aged 6 to 17 years). Practitioners were randomly assigned to undergo baseline conditions of 2 to 8 weeks. Once online training in MEYA commenced, practitioners engaged in algorithm-guided self-instruction in EBPs for autism. Participants video-recorded sessions. Independent coders used the MEYA Fidelity Scale (MEYA-FS) to rate adherence and competence in EBPs for autism. Practitioners also completed measures pertaining to implementation outcomes and parents rated youth outcomes on personalized target behaviors. Five of seven practitioners increased their adherence to MEYA practices (i.e., MEYA-FS scores) following MEYA training. Findings for competence were similar, though somewhat less robust. Practitioners generally viewed MEYA as feasible, understandable, and acceptable. Most youth outcomes improved during MEYA. A randomized, controlled trial of MEYA would be helpful in characterizing its effectiveness for supporting practitioner EBP implementation and youth outcomes in school and community service settings.
    Language English
    Publishing date 2024-01-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391999-7
    ISSN 1573-3432 ; 0162-3257
    ISSN (online) 1573-3432
    ISSN 0162-3257
    DOI 10.1007/s10803-023-06226-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Optimising the Geospatial Configuration of a Future Lithium Ion Battery Recycling Industry in the Transition to Electric Vehicles and a Circular Economy

    Nguyen-Tien, Viet / Dai, Qiang / D. J. Harper, Gavin / Anderson, Paul A. / Elliott, Robert J.R.

    Applied energy. 2022 Apr. 30,

    2022  

    Abstract: Rapid electrification of the transport system will generate substantial volumes of Lithium-ion-battery (LiB) waste as batteries reach their end-of-life. Much attention focuses on the recycling processes, neglecting a broader systemic view that considers ... ...

    Abstract Rapid electrification of the transport system will generate substantial volumes of Lithium-ion-battery (LiB) waste as batteries reach their end-of-life. Much attention focuses on the recycling processes, neglecting a broader systemic view that considers the concentration of the costs and impacts associated with logistics and transportation. This paper provides an economic, environmental and geospatial analysis of a future LiB recycling industry in the UK. Hitherto, state-of-the-art assessment methods have evaluated life cycle impacts and costs but have not considered the geographical layer of the problem. This paper develops a GSC derived supply chain model for the UK electric vehicle and battery end-of-life vehicle industry. Considering both pyrometallurgical and hydrometallurgical recycling technologies, the optimisation process takes into account anticipated EV volumes, and, based on anticipated near-term technological evolution of LiBs, the evolution of the mix of battery cathodes in production, and presents a number of scenarios to show where LiB recycling facilities should ideally be geographically located. An economic and environmental assessment based on a customised Everbatt model is provided.
    Keywords circular economy ; electric vehicles ; energy ; environmental assessment ; industry ; lithium batteries ; supply chain
    Language English
    Dates of publication 2022-0430
    Publishing place Elsevier Ltd
    Document type Article
    Note Pre-press version
    ZDB-ID 2000772-3
    ISSN 0306-2619
    ISSN 0306-2619
    DOI 10.1016/j.apenergy.2022.119230
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Radiographic characteristics of rifampicin-resistant tuberculosis in the STREAM stage 1 trial and their influence on time to culture conversion in the short regimen.

    Chiang, Chen-Yuan / Bern, Henry / Goodall, Ruth / Chien, Shun-Tien / Rusen, I D / Nunn, Andrew

    BMC infectious diseases

    2024  Volume 24, Issue 1, Page(s) 144

    Abstract: Background: Stage 1 of the STREAM trial demonstrated that the 9 month (Short) regimen developed in Bangladesh was non-inferior to the 20 month (Long) 2011 World Health Organization recommended regimen. We assess the association between HIV infection and ...

    Abstract Background: Stage 1 of the STREAM trial demonstrated that the 9 month (Short) regimen developed in Bangladesh was non-inferior to the 20 month (Long) 2011 World Health Organization recommended regimen. We assess the association between HIV infection and radiographic manifestations of tuberculosis and factors associated with time to culture conversion in Stage 1 of the STREAM trial.
    Methods: Reading of chest radiographs was undertaken independently by two clinicians, and films with discordant reading were read by a third reader. Recording of abnormal opacity of the lung parenchyma included location (right upper, right lower, left upper, and left lower) and extent of disease (minimal, moderately-advanced, and far advanced). Time to culture conversion was defined as the number of days from initiation of treatment to the first of two consecutive negative culture results, and compared using the log-rank test, stratified by country. Cox proportional hazards models, stratified by country and adjusted for HIV status, were used to identify factors associated with culture conversion.
    Results: Of the 364 participants, all but one had an abnormal chest X-ray: 347 (95%) had opacities over upper lung fields, 318 (87%) had opacities over lower lung fields, 124 (34%) had far advanced pulmonary involvement, and 281 (77%) had cavitation. There was no significant association between HIV and locations of lung parenchymal opacities, extent of opacities, the presence of cavitation, and location of cavitation. Participants infected with HIV were significantly less likely to have the highest positivity grade (3+) of sputum culture (p = 0.035) as compared to participants not infected with HIV. Cavitation was significantly associated with high smear positivity grades (p < 0.001) and high culture positivity grades (p = 0.004) among all participants. Co-infection with HIV was associated with a shorter time to culture conversion (hazard ratio 1.59, 95% CI 1.05-2.40).
    Conclusions: Radiographic manifestations of tuberculosis among the HIV-infected in the era of anti-retroviral therapy may not differ from that among those who were not infected with HIV. Radiographic manifestations were not consistently associated with time to culture conversion, perhaps indicating that the Short regimen is sufficiently powerful in achieving sputum conversion across the spectrum of radiographic pulmonary involvements.
    Trial registration: ISRCTN ISRCTN78372190. Registered 14/10/2010. The date of first registration 10/02/2016.
    MeSH term(s) Humans ; Antitubercular Agents/therapeutic use ; HIV Infections/complications ; HIV Infections/drug therapy ; Myocardial Infarction ; Rifampin/therapeutic use ; Sputum ; Tuberculosis, Multidrug-Resistant/drug therapy ; Tuberculosis, Pulmonary/diagnostic imaging ; Tuberculosis, Pulmonary/drug therapy
    Chemical Substances Antitubercular Agents ; Rifampin (VJT6J7R4TR)
    Language English
    Publishing date 2024-01-30
    Publishing country England
    Document type Clinical Trial ; Journal Article
    ZDB-ID 2041550-3
    ISSN 1471-2334 ; 1471-2334
    ISSN (online) 1471-2334
    ISSN 1471-2334
    DOI 10.1186/s12879-024-09039-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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