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Artikel ; Online: The RL13 Temperance Factor Represses Replication of the Highly Cell Culture-Adapted Towne Strain of Human Cytomegalovirus.

Ourahmane, Amine / Hertel, Laura / McVoy, Michael A

2023 Band 15, Heft 4

Abstract: Human cytomegalovirus (CMV) has evolved to replicate while causing minimal damage, maintain life-long latency, reactivate sub-clinically, and, in spite of robust host immunity, produce and shed infectious virus in order to transmit to new hosts. The CMV ... ...

Abstract	Human cytomegalovirus (CMV) has evolved to replicate while causing minimal damage, maintain life-long latency, reactivate sub-clinically, and, in spite of robust host immunity, produce and shed infectious virus in order to transmit to new hosts. The CMV temperance factor RL13 may contribute to this strategy of coexistence with the host by actively restricting viral replication and spread. Viruses with an intact
Mesh-Begriff(e)	Humans ; Cytomegalovirus/physiology ; Cell Line ; Temperance ; Cell Culture Techniques ; Cytomegalovirus Infections ; Virus Replication
Sprache	Englisch
Erscheinungsdatum	2023-04-21
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15041023
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Reversible conjugation of a CBASS nucleotide cyclase regulates bacterial immune response to phage infection.

Krüger, Larissa / Gaskell-Mew, Laura / Graham, Shirley / Shirran, Sally / Hertel, Robert / White, Malcolm F

Nature microbiology

2024

Abstract: Prokaryotic antiviral defence systems are frequently toxic for host cells and stringent regulation is required to ensure survival and fitness. These systems must be readily available in case of infection but tightly controlled to prevent activation of an ...

Abstract	Prokaryotic antiviral defence systems are frequently toxic for host cells and stringent regulation is required to ensure survival and fitness. These systems must be readily available in case of infection but tightly controlled to prevent activation of an unnecessary cellular response. Here we investigate how the bacterial cyclic oligonucleotide-based antiphage signalling system (CBASS) uses its intrinsic protein modification system to regulate the nucleotide cyclase. By integrating a type II CBASS system from Bacillus cereus into the model organism Bacillus subtilis, we show that the protein-conjugating Cap2 (CBASS associated protein 2) enzyme links the cyclase exclusively to the conserved phage shock protein A (PspA) in the absence of phage. The cyclase-PspA conjugation is reversed by the deconjugating isopeptidase Cap3 (CBASS associated protein 3). We propose a model in which the cyclase is held in an inactive state by conjugation to PspA in the absence of phage, with conjugation released upon infection, priming the cyclase for activation.
Sprache	Englisch
Erscheinungsdatum	2024-04-08
Erscheinungsland	England
Dokumenttyp	Journal Article
ISSN	2058-5276
ISSN (online)	2058-5276
DOI	10.1038/s41564-024-01670-5
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Human cytomegalovirus tropism for mucosal myeloid dendritic cells.

Hertel, Laura

Reviews in medical virology

2014 Band 24, Heft 6, Seite(n) 379–395

Abstract: Human CMV infections are a serious source of morbidity and mortality for immunocompromised patients and for the developing fetus. Because of this, the development of new strategies to prevent CMV acquisition and transmission is a top priority. Myeloid ... ...

Abstract	Human CMV infections are a serious source of morbidity and mortality for immunocompromised patients and for the developing fetus. Because of this, the development of new strategies to prevent CMV acquisition and transmission is a top priority. Myeloid dendritic cells (DC) residing in the oral and nasal mucosae are among the first immune cells to encounter CMV during entry and greatly contribute to virus dissemination, reactivation from latency, and horizontal spread. Albeit affected by the immunoevasive tactics of CMV, mucosal DC remain potent inducers of cellular and humoral immune responses against this virus. Their natural functions could thus be exploited to generate long-lasting protective immunity against CMV by vaccination via the oronasal mucosae. Although related, epithelial Langerhans-type DC and dermal monocyte-derived DC interact with CMV in dramatically different ways. Whereas immature monocyte-derived DC are fully permissive to infection, for instance, immature Langerhans-type DC are completely resistant. Understanding these differences is essential to design innovative vaccines and new antiviral compounds to protect these cells from CMV infection in vivo.
Mesh-Begriff(e)	Animals ; Cytomegalovirus/genetics ; Cytomegalovirus/physiology ; Cytomegalovirus Infections/immunology ; Cytomegalovirus Infections/virology ; Dendritic Cells/virology ; Humans ; Mucous Membrane/immunology ; Mucous Membrane/virology ; Viral Tropism
Sprache	Englisch
Erscheinungsdatum	2014-06-02
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1086043-5
ISSN	1099-1654 ; 1052-9276
ISSN (online)	1099-1654
ISSN	1052-9276
DOI	10.1002/rmv.1797
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Association of preoperative cone biopsy with recurrences after radical hysterectomy.

Klapdor, Rüdiger / Hertel, Hermann / Delebinski, Laura / Hillemanns, Peter

Archives of gynecology and obstetrics

2021 Band 305, Heft 1, Seite(n) 215–222

Abstract: Objective: To evaluate association of preoperative cone biopsy with the probability of recurrent disease after radical hysterectomy for cervical cancer.: Methods: This is a retrospective single-center study. Patients with cervical cancer stage IA1 ... ...

Abstract	Objective: To evaluate association of preoperative cone biopsy with the probability of recurrent disease after radical hysterectomy for cervical cancer. Methods: This is a retrospective single-center study. Patients with cervical cancer stage IA1 with LVSI to IIA2 and squamous, adenosquamous and adenocarcinoma subtype were included. Patients were analyzed for general characteristics and recurrence-free survival (RFS). Results: In total, of 480 patients with cervical cancer, 183 patients met the inclusion criteria (117 with laparoscopic and 66 with open surgery). The median tumor diameter was 25.0 mm (range 4.6-70.0 mm) with 66 (36.2%) patients having tumors smaller than 2 cm. During median follow-up of 54.0 months (range 0-166.0 months), the RFS for the laparoscopic cohort was 93.2% and 87.5% at 3 and 4.5 years, and 79.3% for the open cohort after 3 and 4.5 years, respectively. In total, 17 (9.3%) patients developed recurrent disease, 9 (7.3%) after laparoscopic, and 8 (12.1%) after open surgery. No preoperative cone biopsy (OR 9.60, 95% CI 2.14-43.09) as well as tumor diameter > 2 cm (OR 5.39, 95% CI 1.20-24.25) were significantly associated with increased risk for recurrence. In multivariate analysis, only missing preoperative cone biopsy was significantly associated with increased risk for recurrence (OR 5.90, 95% CI 1.11-31.29) CONCLUSION: There appears to be a subgroup of patients (preoperative cone biopsy, tumor diameter < 2 cm) with excellent survival and low risk for recurrence after radical hysterectomy which might benefit from the advantages of laparoscopic surgery.
Mesh-Begriff(e)	Conization ; Disease-Free Survival ; Female ; Humans ; Hysterectomy/adverse effects ; Laparoscopy/adverse effects ; Neoplasm Recurrence, Local/pathology ; Neoplasm Staging ; Recurrence ; Retrospective Studies ; Uterine Cervical Neoplasms/pathology
Sprache	Englisch
Erscheinungsdatum	2021-07-21
Erscheinungsland	Germany
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	896455-5
ISSN	1432-0711 ; 0932-0067
ISSN (online)	1432-0711
ISSN	0932-0067
DOI	10.1007/s00404-021-06145-0
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Longitudinal flux balance analyses of a patient with episodic colonic inflammation reveals microbiome metabolic dynamics.

Basile, Arianna / Heinken, Almut / Hertel, Johannes / Smarr, Larry / Li, Weizhong / Treu, Laura / Valle, Giorgio / Campanaro, Stefano / Thiele, Ines

Gut microbes

2023 Band 15, Heft 1, Seite(n) 2226921

Abstract: We report the first use of constraint-based microbial community modeling on a single individual with episodic inflammation of the gastrointestinal tract, who has a well documented set of colonic inflammatory biomarkers, as well as metagenomically- ... ...

Abstract	We report the first use of constraint-based microbial community modeling on a single individual with episodic inflammation of the gastrointestinal tract, who has a well documented set of colonic inflammatory biomarkers, as well as metagenomically-sequenced fecal time series covering seven dates over 16 months. Between the first two time steps the individual was treated with both steroids and antibiotics. Our methodology enabled us to identify numerous time-correlated microbial species and metabolites. We found that the individual's dynamical microbial ecology in the disease state led to time-varying
Mesh-Begriff(e)	Humans ; Male ; Gastrointestinal Microbiome ; Microbiota ; Inflammation ; Liver ; Anti-Bacterial Agents ; Escherichia coli
Chemische Substanzen	Anti-Bacterial Agents
Sprache	Englisch
Erscheinungsdatum	2023-07-12
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2575755-6
ISSN	1949-0984 ; 1949-0984
ISSN (online)	1949-0984
ISSN	1949-0984
DOI	10.1080/19490976.2023.2226921
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Herpesviruses and intermediate filaments: close encounters with the third type.

Hertel, Laura

Viruses

2011 Band 3, Heft 7, Seite(n) 1015–1040

Abstract: Intermediate filaments (IF) are essential to maintain cellular and nuclear integrity and shape, to manage organelle distribution and motility, to control the trafficking and pH of intracellular vesicles, to prevent stress-induced cell death, and to ... ...

Abstract	Intermediate filaments (IF) are essential to maintain cellular and nuclear integrity and shape, to manage organelle distribution and motility, to control the trafficking and pH of intracellular vesicles, to prevent stress-induced cell death, and to support the correct distribution of specific proteins. Because of this, IF are likely to be targeted by a variety of pathogens, and may act in favor or against infection progress. As many IF functions remain to be identified, however, little is currently known about these interactions. Herpesviruses can infect a wide variety of cell types, and are thus bound to encounter the different types of IF expressed in each tissue. The analysis of these interrelationships can yield precious insights into how IF proteins work, and into how viruses have evolved to exploit these functions. These interactions, either known or potential, will be the focus of this review.
Mesh-Begriff(e)	Animals ; Herpesviridae/physiology ; Herpesviridae Infections/virology ; Humans ; Intermediate Filament Proteins/physiology ; Intermediate Filaments/physiology ; Intermediate Filaments/ultrastructure
Chemische Substanzen	Intermediate Filament Proteins
Sprache	Englisch
Erscheinungsdatum	2011-07-04
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article ; Review
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v3071015
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Biodegradation of selected aminophosphonates by the bacterial isolate Ochrobactrum sp. BTU1.

Riedel, Ramona / Commichau, Fabian M / Benndorf, Dirk / Hertel, Robert / Holzer, Katharina / Hoelzle, Ludwig E / Mardoukhi, Mohammad Saba Yousef / Noack, Laura Emelie / Martienssen, Marion

Microbiological research

2024 Band 280, Seite(n) 127600

Abstract: Aminophosphonates, like glyphosate (GS) or metal chelators such as ethylenediaminetetra(methylenephosphonic acid) (EDTMP), are released on a large scale worldwide. Here, we have characterized a bacterial strain capable of degrading synthetic ... ...

Abstract	Aminophosphonates, like glyphosate (GS) or metal chelators such as ethylenediaminetetra(methylenephosphonic acid) (EDTMP), are released on a large scale worldwide. Here, we have characterized a bacterial strain capable of degrading synthetic aminophosphonates. The strain was isolated from LC/MS standard solution. Genome sequencing indicated that the strain belongs to the genus Ochrobactrum. Whole-genome classification using pyANI software to compute a pairwise ANI and other metrics between Brucella assemblies and Ochrobactrum contigs revealed that the bacterial strain is designated as Ochrobactrum sp. BTU1. Degradation batch tests with Ochrobactrum sp. BTU1 and the selected aminophosphonates GS, EDTMP, aminomethylphosphonic acid (AMPA), iminodi(methylene-phosphonic) (IDMP) and ethylaminobis(methylenephosphonic) acid (EABMP) showed that the strain can use all phosphonates as sole phosphorus source during phosphorus starvation. The highest growth rate was achieved with AMPA, while EDTMP and GS were least supportive for growth. Proteome analysis revealed that GS degradation is promoted by C-P lyase via the sarcosine pathway, i.e., initial cleavage at the C-P bond. We also identified C-P lyase to be responsible for degradation of EDTMP, EABMP, IDMP and AMPA. However, the identification of the metabolite ethylenediaminetri(methylenephosphonic acid) via LC/MS analysis in the test medium during EDTMP degradation indicates a different initial cleavage step as compared to GS. For EDTMP, it is evident that the initial cleavage occurs at the C-N bond. The detection of different key enzymes at regulated levels, form the bacterial proteoms during EDTMP exposure, further supports this finding. This study illustrates that widely used and structurally more complex aminophosphonates can be degraded by Ochrobactrum sp. BTU1 via the well-known degradation pathways but with different initial cleavage strategy compared to GS.
Mesh-Begriff(e)	Ochrobactrum/genetics ; Ochrobactrum/metabolism ; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/metabolism ; Biodegradation, Environmental ; Glyphosate ; Organophosphonates/metabolism ; Phosphorus/metabolism ; Phentermine/analogs & derivatives
Chemische Substanzen	N,N-dimethyl-4-iodophentermine (108731-71-1) ; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (77521-29-0) ; Glyphosate (4632WW1X5A) ; aminomethylphosphonic acid (AMPA) (90825O5C1U) ; Organophosphonates ; Phosphorus (27YLU75U4W) ; Phentermine (C045TQL4WP)
Sprache	Englisch
Erscheinungsdatum	2024-01-08
Erscheinungsland	Germany
Dokumenttyp	Journal Article
ZDB-ID	1189614-0
ISSN	1618-0623 ; 0944-5013
ISSN (online)	1618-0623
ISSN	0944-5013
DOI	10.1016/j.micres.2024.127600
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Future Time Perspective in Occupational Teams: Do Older Workers Prefer More Familiar Teams?

Gärtner, Laura U A / Hertel, Guido

Frontiers in psychology

2017 Band 8, Seite(n) 1639

Abstract: Working in teams is quite popular across different industries and cultures. While some of these teams exist for longer time periods, other teams collaborate only for short periods and members switch into new teams after goals are accomplished. However, ... ...

Abstract	Working in teams is quite popular across different industries and cultures. While some of these teams exist for longer time periods, other teams collaborate only for short periods and members switch into new teams after goals are accomplished. However, workers' preferences for joining a new team might vary in different ways. Based on Carstensen's socioemotional selectivity theory, we predict that emotionally meaningful teams are prioritized when occupational future time perspective (OFTP) is perceived as limited. Building and expanding on studies outside of the work context, we expected that older as compared to younger workers prefer more familiar teams, and that this effect is mediated by workers' OFTP. Moreover, we assumed that experimentally manipulated OFTP can change such team preferences. The hypotheses were tested in an online scenario study using three experimental conditions (within-person design). Four hundred and fifty-four workers (57% female, age
Sprache	Englisch
Erscheinungsdatum	2017-09-26
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2017.01639
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Herpesviruses and Intermediate Filaments

Laura Hertel

Viruses, Vol 3, Iss 7, Pp 1015-

Close Encounters with the Third Type

2011 Band 1040

Abstract	Intermediate filaments (IF) are essential to maintain cellular and nuclear integrity and shape, to manage organelle distribution and motility, to control the trafficking and pH of intracellular vesicles, to prevent stress-induced cell death, and to support the correct distribution of specific proteins. Because of this, IF are likely to be targeted by a variety of pathogens, and may act in favor or against infection progress. As many IF functions remain to be identified, however, little is currently known about these interactions. Herpesviruses can infect a wide variety of cell types, and are thus bound to encounter the different types of IF expressed in each tissue. The analysis of these interrelationships can yield precious insights into how IF proteins work, and into how viruses have evolved to exploit these functions. These interactions, either known or potential, will be the focus of this review.
Schlagwörter	intermediate filament ; herpesvirus ; herpes simplex virus ; varicella zoster virus ; cytomegalovirus ; Epstein-Barr virus ; Kaposi’s sarcoma associated herpesvirus ; cytoskeleton ; infection ; Microbiology ; QR1-502 ; Science ; Q ; DOAJ:Microbiology ; DOAJ:Biology ; DOAJ:Biology and Life Sciences
Thema/Rubrik (Code)	612
Sprache	Englisch
Erscheinungsdatum	2011-07-01T00:00:00Z
Verlag	Molecular Diversity Preservation International
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel ; Online: Tackling policy leakage and targeting hotspots could be key to addressing the ‘Wicked’ challenge of nutrient pollution from corn production in the U.S.

Jing Liu / Laura Bowling / Christopher Kucharik / Sadia Jame / Uris Baldos / Larissa Jarvis / Navin Ramankutty / Thomas Hertel

Environmental Research Letters, Vol 18, Iss 10, p

2023 Band 105002

Abstract: Reducing nutrient loss from agriculture to improve water quality requires a combination of management practices. However, it has been unclear what pattern of mitigation is likely to emerge from different policies, individually and combined, and the ... ...

Abstract	Reducing nutrient loss from agriculture to improve water quality requires a combination of management practices. However, it has been unclear what pattern of mitigation is likely to emerge from different policies, individually and combined, and the consequences for local and national land use and farm returns. We address this research gap by constructing an integrated multi-scale framework for evaluating alternative nitrogen loss management policies for corn production in the US. This approach combines site- and practice-specific agro-ecosystem processes with a grid-resolving economic model to identify locations that can be prioritized to increase the economic efficiency of the policies. We find that regional measures, albeit effective in reducing local nitrogen loss, can displace corn production to the area where nitrogen fertilizer productivity is low and nutrient loss rate is high, thereby offsetting the overall effectiveness of the nutrient management strategy. This spatial spillover effect can be suppressed by implementing the partial measures in tandem with nationwide policies. Wetland restoration combined with split fertilizer application, along with a nitrogen loss tax could reduce nitrate nitrogen loss to the Mississippi River by 30% while only increasing corn prices by less than 2%.
Schlagwörter	multi-scale analysis ; N loss management ; conservation practices ; spatial spillover effect ; Environmental technology. Sanitary engineering ; TD1-1066 ; Environmental sciences ; GE1-350 ; Science ; Q ; Physics ; QC1-999
Thema/Rubrik (Code)	333
Sprache	Englisch
Erscheinungsdatum	2023-01-01T00:00:00Z
Verlag	IOP Publishing
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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