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  1. Article: Unusual Hypergranular Myelomatous Plasma Cells.

    D'Arena, Giovanni / Musto, Pellegrino

    Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion

    2017  Volume 33, Issue 4, Page(s) 617–618

    Language English
    Publishing date 2017-01-30
    Publishing country India
    Document type Journal Article
    ZDB-ID 2422370-0
    ISSN 0974-0449 ; 0971-4502
    ISSN (online) 0974-0449
    ISSN 0971-4502
    DOI 10.1007/s12288-017-0786-z
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  2. Article: Measurable residual disease in chronic lymphocytic leukemia.

    Benintende, Giulia / Pozzo, Federico / Innocenti, Idanna / Autore, Francesco / Fresa, Alberto / D'Arena, Giovanni / Gattei, Valter / Lurenti, Luca

    Frontiers in oncology

    2023  Volume 13, Page(s) 1112616

    Abstract: Measurable residual disease (MRD) is defined as the presence of residual cancer cells after treatment in patients with clinically undetectable disease, who would otherwise be considered in complete remission. It is a highly sensitive parameter which ... ...

    Abstract Measurable residual disease (MRD) is defined as the presence of residual cancer cells after treatment in patients with clinically undetectable disease, who would otherwise be considered in complete remission. It is a highly sensitive parameter which indicates the disease burden and predicts survival in this setting of patients. In recent years, MRD has gained a role in many hematological malignancies as a surrogate endpoint for clinical trials: undetectable MRD has been correlated to longer progression free survival (PFS) and overall survival (OS). New drugs and combinations have been developed with the aim to achieve MRD negativity, which would indicate favorable prognosis. Different methods to measure MRD have also been devised, which include flow cytometry, polymerase chain reaction (PCR) and next generation sequencing (NGS), with different sensitivity and accuracy in evaluating deep remission after treatment. In this review, we will analyze the current recommendations for the detection of MRD, with particular focus on its role in Chronic Lymphocytic Leukemia (CLL), as well as the different detection methods. Moreover, we will discuss the results of clinical trials and the role of MRD in new therapeutic schemes with inhibitors and monoclonal antibodies. MRD is not currently used in the clinical practice to evaluate response to treatment, due to technical and economical limitations, but it's gaining more and more interest in trials settings, especially since the introduction of venetoclax. The use of MRD in trials will likely be followed by a broader practical application in the future. The aim of this work is to provide a reader-friendly summary of the state of art in the field, as MRD will soon become an accessible tool to evaluate our patients, predict their survival and guide physician's therapeutic choices and preferences.
    Language English
    Publishing date 2023-02-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1112616
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Thalidomide-induced psoriasis in a patient with multiple myeloma.

    D'Arena, Giovanni / Galdo, Giovanna / Musto, Pellegrino

    Postgraduate medical journal

    2019  Volume 95, Issue 1121, Page(s) 171

    MeSH term(s) Humans ; Immunosuppressive Agents/adverse effects ; Male ; Middle Aged ; Multiple Myeloma/drug therapy ; Psoriasis/chemically induced ; Severity of Illness Index ; Thalidomide/adverse effects
    Chemical Substances Immunosuppressive Agents ; Thalidomide (4Z8R6ORS6L)
    Language English
    Publishing date 2019-02-26
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 80325-x
    ISSN 1469-0756 ; 0032-5473
    ISSN (online) 1469-0756
    ISSN 0032-5473
    DOI 10.1136/postgradmedj-2018-136317
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  4. Article ; Online: Pseudomembranous colitis in acute lymphoblastic leukaemia.

    D'Arena, Giovanni / Pietrantuono, Giuseppe / Musto, Pellegrino

    Postgraduate medical journal

    2018  Volume 94, Issue 1112, Page(s) 361

    Language English
    Publishing date 2018-03-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 80325-x
    ISSN 1469-0756 ; 0032-5473
    ISSN (online) 1469-0756
    ISSN 0032-5473
    DOI 10.1136/postgradmedj-2018-135605
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Preliminary analysis of double-negative T, double-positive T, and natural killer T-like cells in B-cell chronic lymphocytic leukemia.

    Valvano, Luciana / Nozza, Filomena / D'Arena, Giovanni / D'Auria, Fiorella / De Luca, Luciana / Pietrantuono, Giuseppe / Mansueto, Giovanna / Villani, Oreste / D'Agostino, Simona / Lamorte, Daniela / Calice, Giovanni / Statuto, Teodora

    Cancer medicine

    2023  Volume 12, Issue 12, Page(s) 13241–13255

    Abstract: Background: B-cell chronic lymphocytic leukemia (B-CLL) is characterized by the expansion of CD5: Methods: A detailed immunophenotypic analysis of the peripheral blood T-cell compartment of 50 patients with B-CLL (classified in three prognostic ... ...

    Abstract Background: B-cell chronic lymphocytic leukemia (B-CLL) is characterized by the expansion of CD5
    Methods: A detailed immunophenotypic analysis of the peripheral blood T-cell compartment of 50 patients with B-CLL (classified in three prognostic groups) and 38 healthy donors (as controls) matched for age was performed. The samples were analyzed by flow cytometry using a stain-lyse-no wash technique and a comprehensive six-color antibody panels.
    Results: Our data confirmed a reduction in percentage values and an increase in absolute values of T lymphocytes in patients with B-CLL, as already reported. In particular, DNT, DPT, and NKT-like percentages were significantly lower than in the controls, except for NKT-like in the low-risk prognostic group. Moreover, a significant rise in the absolute counts of DNT cells in each prognostic group and in the low-risk prognostic group of NKT-like cells was found. A significant correlation of the absolute values of NKT-like cells in the intermediate-risk prognostic group versus B cells was observed. Furthermore, we analyzed whether the increase in T cells was related to the subpopulations of interest. Only DNT cells were positively correlated with the increase in CD3
    Conclusion: These early results supported that DNT, DPT, and NKT-like subsets may be related to disease progression and should encourage further studies aimed at identifying the potential immune surveillance role of these minority T subpopulations.
    MeSH term(s) Humans ; Leukemia, Lymphocytic, Chronic, B-Cell ; T-Lymphocyte Subsets ; B-Lymphocytes/pathology ; Natural Killer T-Cells/pathology ; Killer Cells, Natural ; Flow Cytometry
    Language English
    Publishing date 2023-05-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2659751-2
    ISSN 2045-7634 ; 2045-7634
    ISSN (online) 2045-7634
    ISSN 2045-7634
    DOI 10.1002/cam4.6015
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  6. Article: What Does Atypical Chronic Lymphocytic Leukemia Really Mean? A Retrospective Morphological and Immunophenotypic Study.

    D'Arena, Giovanni / Vitale, Candida / Pietrantuono, Giuseppe / Villani, Oreste / Mansueto, Giovanna / D'Auria, Fiorella / Statuto, Teodora / D'Agostino, Simona / Sabetta, Rosalaura / Tarasco, Angela / Innocenti, Idanna / Autore, Francesco / Fresa, Alberto / Valvano, Luciana / Tomasso, Annamaria / Cafaro, Lorenzo / Lamorte, Daniela / Laurenti, Luca

    Cancers

    2024  Volume 16, Issue 2

    Abstract: Atypical chronic lymphocytic leukemia (CLL) is still defined according to morphological criteria. However, deviance from the typical surface immunological profile suggests an atypical immunological-based CLL. A large cohort of patients with CLL was ... ...

    Abstract Atypical chronic lymphocytic leukemia (CLL) is still defined according to morphological criteria. However, deviance from the typical surface immunological profile suggests an atypical immunological-based CLL. A large cohort of patients with CLL was retrospectively evaluated aiming at assessing morphological (FAB criteria), immunophenotypical (two or more discordances from the typical profile), and clinical-biological features of atypical CLL. Compared to typical cases, morphologically atypical CLL showed a greater percentage of unmutated IgVH and CD38 positivity, and a higher expression of CD20. Immunophenotypically atypical CLL was characterized by more advanced clinical stages, higher expression of CD20, higher rate of FMC7, CD79b and CD49d positivity, and by an intermediate-high expression of membrane surface immunoglobulin, compared to typical cases. When patients were categorized based on immunophenotypic and morphologic concordance or discordance, no difference emerged. Finally, morphological features better discriminated patients' prognosis in terms of time-to-first treatment, while concordant atypical cases showed overall a worse prognosis. Discordant cases by immunophenotype and/or morphology did not identify specific prognostic groups. Whether-in the era of molecular markers used as prognostic indicators-it does make sense to focus on morphology and immunophenotype features in CLL is still matter of debate needing further research.
    Language English
    Publishing date 2024-01-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16020469
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  7. Article ; Online: Potential Mechanisms by which Glucocorticoids Induce Breast Carcinogenesis through Nrf2 Inhibition.

    Giudice, Aldo / Aliberti, Silvana Mirella / Barbieri, Antonio / Pentangelo, Paola / Bisogno, Ilaria / D'Arena, Giovanni / Cianciola, Emidio / Caraglia, Michele / Capunzo, Mario

    Frontiers in bioscience (Landmark edition)

    2022  Volume 27, Issue 7, Page(s) 223

    Abstract: Breast cancer is the most common malignancy among women worldwide. Several studies indicate that, in addition to established risk factors for breast cancer, other factors such as cortisol release related to psychological stress and drug treatment with ... ...

    Abstract Breast cancer is the most common malignancy among women worldwide. Several studies indicate that, in addition to established risk factors for breast cancer, other factors such as cortisol release related to psychological stress and drug treatment with high levels of glucocorticoids may also contribute significantly to the initiation of breast cancer. There are several possible mechanisms by which glucocorticoids might promote neoplastic transformation of breast tissue. Among these, the least known and studied is the inhibition of the nuclear erythroid factor 2-related (Nrf2)-antioxidant/electrophile response element (ARE/EpRE) pathway by high levels of glucocorticoids. Specifically, Nrf2 is a potent transcriptional activator that plays a central role in the basal and inducible expression of many cytoprotective genes that effectively protect mammalian cells from various forms of stress and reduce the propensity of tissues and organisms to develop disease or malignancy including breast cancer. Consequently, a loss of Nrf2 in response to high levels of gluco-corticoids may lead to a decrease in cellular defense against oxidative stress, which plays an important role in the initiation of human mammary carcinogenesis. In the present review, we provide a comprehensive overview of the current state of knowledge of the cellular mechanisms by which both glucocorticoid pharmacotherapy and endogenous GCs (cortisol in humans and corticosterone in rodents) may contribute to breast cancer development through inhibition of the Nrf2-ARE/EpRE pathway and the protective role of melatonin against glucocorticoid-induced apoptosis in the immune system.
    MeSH term(s) Antioxidants/pharmacology ; Breast Neoplasms/chemically induced ; Carcinogenesis/chemically induced ; Female ; Glucocorticoids/adverse effects ; Humans ; Hydrocortisone ; NF-E2-Related Factor 2/antagonists & inhibitors ; NF-E2-Related Factor 2/genetics ; Oxidative Stress
    Chemical Substances Antioxidants ; Glucocorticoids ; NF-E2-Related Factor 2 ; Hydrocortisone (WI4X0X7BPJ)
    Language English
    Publishing date 2022-07-21
    Publishing country Singapore
    Document type Journal Article ; Review
    ZDB-ID 2704569-9
    ISSN 2768-6698 ; 2768-6698
    ISSN (online) 2768-6698
    ISSN 2768-6698
    DOI 10.31083/j.fbl2707223
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  8. Article ; Online: NFKBIE mutations are selected by the tumor microenvironment and contribute to immune escape in chronic lymphocytic leukemia.

    Bonato, Alice / Chakraborty, Supriya / Bomben, Riccardo / Canarutto, Giulia / Felician, Giulia / Martines, Claudio / Zucchetto, Antonella / Pozzo, Federico / Vujovikj, Marija / Polesel, Jerry / Chiarenza, Annalisa / Del Principe, Maria Ilaria / Del Poeta, Giovanni / D'Arena, Giovanni / Marasca, Roberto / Tafuri, Agostino / Laurenti, Luca / Piazza, Silvano / Dimovski, Aleksandar J /
    Gattei, Valter / Efremov, Dimitar G

    Leukemia

    2024  

    Abstract: Loss-of-function mutations in NFKBIE, which encodes for the NF-κB inhibitor IκBε, are frequent in chronic lymphocytic leukemia (CLL) and certain other B-cell malignancies and have been associated with accelerated disease progression and inferior ... ...

    Abstract Loss-of-function mutations in NFKBIE, which encodes for the NF-κB inhibitor IκBε, are frequent in chronic lymphocytic leukemia (CLL) and certain other B-cell malignancies and have been associated with accelerated disease progression and inferior responses to chemotherapy. Using in vitro and in vivo murine models and primary patient samples, we now show that NFKBIE-mutated CLL cells are selected by microenvironmental signals that activate the NF-κB pathway and induce alterations within the tumor microenvironment that can allow for immune escape, including expansion of CD8+ T-cells with an exhausted phenotype and increased PD-L1 expression on the malignant B-cells. Consistent with the latter observations, we find increased expression of exhaustion markers on T-cells from patients with NFKBIE-mutated CLL. In addition, we show that NFKBIE-mutated murine CLL cells display selective resistance to ibrutinib and report inferior outcomes to ibrutinib treatment in NFKBIE-mutated CLL patients. These findings suggest that NFKBIE mutations can contribute to CLL progression through multiple mechanisms, including a bidirectional crosstalk with the microenvironment and reduced sensitivity to BTK inhibitor treatment.
    Language English
    Publishing date 2024-03-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 807030-1
    ISSN 1476-5551 ; 0887-6924
    ISSN (online) 1476-5551
    ISSN 0887-6924
    DOI 10.1038/s41375-024-02224-8
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  9. Article ; Online: Alemtuzumab and treatment of chronic lymphocytic leukemia and its immune-related disorders: one player on two tables.

    D'Arena, Giovanni / Laurenti, Luca

    Acta haematologica

    2014  Volume 132, Issue 2, Page(s) 237–239

    MeSH term(s) Alemtuzumab ; Antibodies, Monoclonal, Humanized/therapeutic use ; Guillain-Barre Syndrome/drug therapy ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/complications ; Male
    Chemical Substances Antibodies, Monoclonal, Humanized ; Alemtuzumab (3A189DH42V)
    Language English
    Publishing date 2014
    Publishing country Switzerland
    Document type Editorial ; Comment
    ZDB-ID 80008-9
    ISSN 1421-9662 ; 0001-5792
    ISSN (online) 1421-9662
    ISSN 0001-5792
    DOI 10.1159/000359949
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  10. Article: SARS-COV2 Infection in Vaccinated Patients: Look for Clinical History and Test Humoral Immunity.

    D'Arena, Giovanni / La Penna, Augusto / Crocamo, Antonino / Ametrano, Marcello / Di Palma, Anna / Avino, Daniela / Pietrantuono, Giuseppe / Gambardella, Michele

    Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion

    2021  Volume 38, Issue 1, Page(s) 207–209

    Language English
    Publishing date 2021-10-11
    Publishing country India
    Document type Journal Article
    ZDB-ID 2422370-0
    ISSN 0974-0449 ; 0971-4502
    ISSN (online) 0974-0449
    ISSN 0971-4502
    DOI 10.1007/s12288-021-01499-6
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