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  1. Article ; Online: An Updated Characterization of Childhood Selective Mutism: Exploring Clinical Features, Treatment Utilization, and School Services.

    Boneff-Peng, Kira / Lasutschinkow, Patricia C / Colton, Zachary A / Freedman-Doan, Carol R

    Child psychiatry and human development

    2023  

    Abstract: Selective mutism (SM) is a severe but understudied childhood anxiety disorder. Most epidemiological research on SM was conducted decades ago and is limited by small sample sizes. This study analyzes parent-reported clinical data from 230 children with ... ...

    Abstract Selective mutism (SM) is a severe but understudied childhood anxiety disorder. Most epidemiological research on SM was conducted decades ago and is limited by small sample sizes. This study analyzes parent-reported clinical data from 230 children with diagnosed and suspected SM to provide current information about the presentation of this disorder. Overall, anxiety and social anxiety symptoms were elevated. Gender ratio, comorbidities and family history of psychopathology were generally aligned with previous research. However, age of onset and diagnosis were both earlier than previously reported, with an average delay of 2 years between onset and diagnosis. The majority of children received therapy and school accommodations for their SM, yet there was large variability in types of interventions. This is the largest survey of children with SM conducted primarily within the US and it constitutes the first systematic inquiry into interventions and accommodations received within clinical and school settings.
    Language English
    Publishing date 2023-08-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 223895-0
    ISSN 1573-3327 ; 0009-398X
    ISSN (online) 1573-3327
    ISSN 0009-398X
    DOI 10.1007/s10578-023-01589-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 772: Show issues Location:
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  2. Article ; Online: Patient and caregiver preferences for haemophilia treatments: A discrete-choice experiment.

    Garcia, Viridiana Cano / Mansfield, Carol / Pierce, Anna / Leach, Colton / Smith, Jane Cavanaugh / Afonso, Marion

    Haemophilia : the official journal of the World Federation of Hemophilia

    2024  Volume 30, Issue 2, Page(s) 375–387

    Abstract: Introduction: An evolving haemophilia treatment landscape provides new possibilities for previously unattainable lifestyles.: Aim: We sought to understand how people with haemophilia (PwH) and their caregivers value the potential benefits of novel ... ...

    Abstract Introduction: An evolving haemophilia treatment landscape provides new possibilities for previously unattainable lifestyles.
    Aim: We sought to understand how people with haemophilia (PwH) and their caregivers value the potential benefits of novel prophylactic treatments. We conducted a discrete-choice experiment (DCE) to quantify preferences for features of haemophilia treatments among adults and caregivers of children with haemophilia. A best-worst scaling (BWS) exercise measured the perceived burden of treatment administration features.
    Methods: A cross-sectional, web-based survey was administered to male adults (≥18 years) and caregivers of male children (≤17 years) living with haemophilia in the United States. Respondents evaluated eight pairs of hypothetical haemophilia treatment profiles defined by six attributes in the DCE and 15 features in the BWS.
    Results: In the DCE, both adults with haemophilia (n = 151) and caregivers (n = 151) prioritised avoiding the risk of developing inhibitor/ anti-drug antibodies and treatments that allowed for a more active life. They placed a lower priority on reducing the number of spontaneous bleeding episodes, route and frequency of administration, and avoiding the risk of hospitalisation due to adverse events. The BWS documented the burdensomeness of IV infusions and medications that require mixing and refrigeration.
    Conclusion: PwH and caregivers prefer treatments that enable a more active lifestyle with a lower risk of inhibitor development. Both groups valued the ability to lead an active life over reducing spontaneous bleeding, with caregivers placing the most weight on this attribute. As new treatments expand possibilities, healthcare professionals and PwH should continue to share decision-making, incorporating clinical judgment and individual preferences.
    MeSH term(s) Adult ; Child ; Humans ; Male ; United States ; Hemophilia A/drug therapy ; Caregivers ; Cross-Sectional Studies ; Hemorrhage/prevention & control ; Exercise ; Patient Preference ; Choice Behavior ; Surveys and Questionnaires
    Language English
    Publishing date 2024-01-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 1229713-6
    ISSN 1365-2516 ; 1351-8216 ; 1355-0691
    ISSN (online) 1365-2516
    ISSN 1351-8216 ; 1355-0691
    DOI 10.1111/hae.14928
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    Zs.MO 450: Show issues

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  3. Article ; Online: Alzheimer's Disease Protein Relevance Analysis Using Human and Mouse Model Proteomics Data.

    Shi, Cathy / Gottschalk, W Kirby / Colton, Carol A / Mukherjee, Sayan / Lutz, Michael W

    Frontiers in systems biology

    2023  Volume 3

    Abstract: The principles governing genotype-phenotype relationships are still emerging(1-3), and detailed translational as well as transcriptomic information is required to understand complex phenotypes, such as the pathogenesis of Alzheimer's disease. For this ... ...

    Abstract The principles governing genotype-phenotype relationships are still emerging(1-3), and detailed translational as well as transcriptomic information is required to understand complex phenotypes, such as the pathogenesis of Alzheimer's disease. For this reason, the proteomics of Alzheimer disease (AD) continues to be studied extensively. Although comparisons between data obtained from humans and mouse models have been reported, approaches that specifically address the between-species statistical comparisons are understudied. Our study investigated the performance of two statistical methods for identification of proteins and biological pathways associated with Alzheimer's disease for cross-species comparisons, taking specific data analysis challenges into account, including collinearity, dimensionality reduction and cross-species protein matching. We used a human dataset from a well-characterized cohort followed for over 22 years with proteomic data available. For the mouse model, we generated proteomic data from whole brains of CVN-AD and matching control mouse models. We used these analyses to determine the reliability of a mouse model to forecast significant proteomic-based pathological changes in the brain that may mimic pathology in human Alzheimer's disease. Compared with LASSO regression, partial least squares discriminant analysis provided better statistical performance for the proteomics analysis. The major biological finding of the study was that extracellular matrix proteins and integrin-related pathways were dysregulated in both the human and mouse data. This approach may help inform the development of mouse models that are more relevant to the study of human late-onset Alzheimer's disease.
    Language English
    Publishing date 2023-07-13
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2674-0702
    ISSN (online) 2674-0702
    DOI 10.3389/fsysb.2023.1085577
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  4. Article ; Online: Microglial-neuronal interactions during neurodegenerative diseases.

    Colton, Carol A

    Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology

    2013  Volume 8, Issue 1, Page(s) 4–6

    Abstract: The impact of the brain's immune response to disease is no longer relegated to a secondary event of limited interest. Multiple types of brain and spinal cord injuries and diseases show varying immune phenotypes over the time course of the disease. The ... ...

    Abstract The impact of the brain's immune response to disease is no longer relegated to a secondary event of limited interest. Multiple types of brain and spinal cord injuries and diseases show varying immune phenotypes over the time course of the disease. The collection of articles illustrates the wide reach of brain immunity and provides research papers and reviews that illustrate this point. These articles have added both new information and new directions to consider, and I would like to thank all of the participants for their insightful contributions to the field.
    MeSH term(s) Animals ; Brain/immunology ; Brain/pathology ; Brain Chemistry ; Chemokines/physiology ; Humans ; Lipid Metabolism ; Microglia/immunology ; Microglia/physiology ; Neurodegenerative Diseases/immunology ; Neurodegenerative Diseases/pathology ; Neurons/immunology ; Neurons/physiology
    Chemical Substances Chemokines
    Language English
    Publishing date 2013-02-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2227405-4
    ISSN 1557-1904 ; 1557-1890
    ISSN (online) 1557-1904
    ISSN 1557-1890
    DOI 10.1007/s11481-013-9437-9
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  5. Article ; Online: Immune heterogeneity in neuroinflammation: dendritic cells in the brain.

    Colton, Carol A

    Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology

    2012  Volume 8, Issue 1, Page(s) 145–162

    Abstract: Dendritic cells (DC) are critical to an integrated immune response and serve as the key link between the innate and adaptive arms of the immune system. Under steady state conditions, brain DC's act as sentinels, continually sampling their local ... ...

    Abstract Dendritic cells (DC) are critical to an integrated immune response and serve as the key link between the innate and adaptive arms of the immune system. Under steady state conditions, brain DC's act as sentinels, continually sampling their local environment. They share this function with macrophages derived from the same basic hemopoietic (bone marrow-derived) precursor and with parenchymal microglia that arise from a unique non-hemopoietic origin. While multiple cells may serve as antigen presenting cells (APCs), dendritic cells present both foreign and self-proteins to naïve T cells that, in turn, carry out effector functions that serve to protect or destroy. The resulting activation of the adaptive response is a critical step to resolution of injury or infection and is key to survival. In this review we will explore the critical roles that DCs play in the brain's response to neuroinflammatory disease with emphasis on how the brain's microenvironment impacts these actions.
    MeSH term(s) Animals ; Brain/immunology ; Brain/pathology ; Dendritic Cells/immunology ; Dendritic Cells/pathology ; Encephalitis/immunology ; Encephalitis/pathology ; Humans ; Immune Tolerance ; Macrophages/immunology ; Macrophages/physiology ; Microglia/physiology ; Monocytes/immunology ; Monocytes/physiology ; Neuritis/immunology ; Neuritis/pathology
    Keywords covid19
    Language English
    Publishing date 2012-11-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2227405-4
    ISSN 1557-1904 ; 1557-1890
    ISSN (online) 1557-1904
    ISSN 1557-1890
    DOI 10.1007/s11481-012-9414-8
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  6. Article ; Online: CVN-AD Alzheimer's mice show premature reduction in neurovascular coupling in response to spreading depression and anoxia compared to aged controls.

    Turner, Dennis A / Degan, Simone / Hoffmann, Ulrike / Galeffi, Francesca / Colton, Carol A

    Alzheimer's & dementia : the journal of the Alzheimer's Association

    2021  Volume 17, Issue 7, Page(s) 1109–1120

    Abstract: We compared the efficacy of neurovascular coupling and substrate supply in cerebral cortex during severe metabolic challenges in transgenic Alzheimer's [CVN-AD] and control [C57Bl/6] mice, to evaluate the hypothesis that metabolic insufficiency is a ... ...

    Abstract We compared the efficacy of neurovascular coupling and substrate supply in cerebral cortex during severe metabolic challenges in transgenic Alzheimer's [CVN-AD] and control [C57Bl/6] mice, to evaluate the hypothesis that metabolic insufficiency is a critical component of degeneration leading to dementia. We analyzed cerebral blood flow and metabolic responses to spreading depression (induced by K
    MeSH term(s) Aging ; Alzheimer Disease/pathology ; Animals ; Cerebrovascular Circulation/physiology ; Depression/physiopathology ; Disease Models, Animal ; Female ; Hemodynamics/physiology ; Humans ; Hypoxia/physiopathology ; Male ; Mice ; Mice, Inbred C57BL ; Neurovascular Coupling
    Language English
    Publishing date 2021-03-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2211627-8
    ISSN 1552-5279 ; 1552-5260
    ISSN (online) 1552-5279
    ISSN 1552-5260
    DOI 10.1002/alz.12289
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6316: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 540: Show issues

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  7. Article ; Online: Metabolism-Based Gene Differences in Neurons Expressing Hyperphosphorylated AT8- Positive (AT8+) Tau in Alzheimer's Disease.

    York, Audra / Everhart, Angela / Vitek, Michael P / Gottschalk, Kirby W / Colton, Carol A

    ASN neuro

    2021  Volume 13, Page(s) 17590914211019443

    Abstract: Metabolic adaptations in the brain are critical to the establishment and maintenance of normal cellular functions and to the pathological responses to disease processes. Here, we have focused on specific metabolic pathways that are involved in immune- ... ...

    Abstract Metabolic adaptations in the brain are critical to the establishment and maintenance of normal cellular functions and to the pathological responses to disease processes. Here, we have focused on specific metabolic pathways that are involved in immune-mediated neuronal processes in brain using isolated neurons derived from human autopsy brain sections of normal individuals and individuals diagnosed as Alzheimer's disease (AD). Laser capture microscopy was used to select specific cell types in immune-stained thin brain sections followed by NanoString technology to identify and quantify differences in mRNA levels between age-matched control and AD neuronal samples. Comparisons were also made between neurons isolated from AD brain sections expressing pathogenic hyperphosphorylated AT8- positive (AT8+) tau and non-AT8+ AD neurons using double labeling techniques. The mRNA expression data showed unique patterns of metabolic pathway expression between the subtypes of captured neurons that involved membrane based solute transporters, redox factors, and arginine and methionine metabolic pathways. We also identified the expression levels of a novel metabolic gene, Radical-S-Adenosyl Domain1 (
    MeSH term(s) Alzheimer Disease/genetics ; Apolipoprotein E4 ; Female ; Humans ; Male ; Neurons/metabolism ; Phosphorylation ; tau Proteins/genetics ; tau Proteins/metabolism
    Chemical Substances Apolipoprotein E4 ; tau Proteins
    Language English
    Publishing date 2021-06-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2485467-0
    ISSN 1759-0914 ; 1759-0914
    ISSN (online) 1759-0914
    ISSN 1759-0914
    DOI 10.1177/17590914211019443
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book: Reactive oxygen species in biological systems

    Gilbert, Daniel L. / Colton, Carol A.

    an interdisciplinary approach

    1999  

    Author's details Daniel L. Gilbert and Carol A. Colton
    Language English
    Size XXV, 707 S. : Ill., graph. Darst.
    Publisher Kluwer u.a.
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT010736941
    ISBN 0-306-45756-3 ; 978-0-306-45756-2
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1999 A 4267 order for loan Magazin

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  9. Article ; Online: Differential effects in young and aged rats' navigational accuracy following instantaneous rotation of environmental cues.

    Lester, Adam W / Jordan, Gianna A / Blum, Colton J / Philpot, Zachary P / Barnes, Carol A

    Behavioral neuroscience

    2022  Volume 136, Issue 6, Page(s) 561–574

    Abstract: Successful navigation depends critically upon two broad categories of spatial navigation strategies that include allocentric and egocentric reference frames, relying on external or internal spatial information, respectively. As with older adults, aged ... ...

    Abstract Successful navigation depends critically upon two broad categories of spatial navigation strategies that include allocentric and egocentric reference frames, relying on external or internal spatial information, respectively. As with older adults, aged rats show robust impairments on a number of different spatial navigation tasks. There is some evidence that these navigation impairments are accompanied by a bias toward relying on egocentric over allocentric navigation strategies. To test the degree to which young and aged animals utilize these two navigation approaches, a novel behavioral arena was used in which rats are trained to traverse a circular track and to stop at a learned goal location that is fixed with respect to a panorama of visual cues projected onto the surrounding walls. By instantaneously rotating the cues, allocentric and egocentric reference frames were put in direct and immediate conflict and goal navigation performance was assessed with respect to how accurately young and aged animals were able to utilize the rotated cues. Behavioral data collected from nine young and eight aged animals revealed that both age groups were able to update their navigation performance following cue rotation. Contrary to what was expected, however, aged animals showed more accurate overall goal navigation performance, stronger allocentric strategy use, and more evident changes in behavior in response to cue rotation compared to younger animals. The young rats appeared to mix egocentric and allocentric strategies for ICR task solution. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
    MeSH term(s) Animals ; Rats ; Cues ; Maze Learning/physiology ; Spatial Navigation/physiology ; Behavior, Animal
    Language English
    Publishing date 2022-11-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 230159-3
    ISSN 1939-0084 ; 0735-7044
    ISSN (online) 1939-0084
    ISSN 0735-7044
    DOI 10.1037/bne0000536
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1837: Show issues Location:
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  10. Article: Patients' Preferences for Adjunctive Parkinson's Disease Treatments: A Discrete-Choice Experiment.

    Serbin, Michael / Marras, Connie / Mansfield, Carol / Leach, Colton / Yonan, Charles / Sheehan, Margaret / Donnelly, Anne / Klepitskaya, Olga

    Patient preference and adherence

    2023  Volume 17, Page(s) 2263–2277

    Abstract: Background: Several adjunctive medications are available to reduce OFF time between levodopa/carbidopa (LD/CD) doses for people with Parkinson's disease (PD).: Objective: To explore how individuals with PD balance benefits and burdens when ... ...

    Abstract Background: Several adjunctive medications are available to reduce OFF time between levodopa/carbidopa (LD/CD) doses for people with Parkinson's disease (PD).
    Objective: To explore how individuals with PD balance benefits and burdens when considering adjunctive medications.
    Methods: US adults (30-83 years) with self-reported PD, currently treated with LD/CD, who experienced OFF episodes were recruited through the Fox Insight study to complete a discrete-choice experiment survey. Respondents selected among experimentally designed profiles for hypothetical adjunctive PD treatments that varied in efficacy (additional ON time), potential adverse effects (troublesome dyskinesia, risk of diarrhea, risk of change in bodily fluid color), and dosing frequency or the option "No additional medicine". Data were analyzed with random-parameters logit models.
    Results: Respondents (N=480) would require ≥60 additional minutes of daily ON time to accept either a 40% risk of change in bodily fluid color or 10 additional minutes with troublesome dyskinesia daily. Respondents would require 40 additional minutes of daily ON time to accept a 10% risk of diarrhea and 22 additional minutes of daily ON time to switch from 1 additional pill each day to 1 pill with each LD/CD dose. On average, respondents preferred adjunctive PD medication over no additional medication. Results predicted that 59.1% of respondents would select a hypothetical treatment profile similar to opicapone, followed by no additional medication (27.5%) and a hypothetical treatment profile similar to entacapone (13.4%).
    Limitations: The data collected were based on responses to hypothetical choice profiles in the survey questions. The attributes and levels selected for this study were intended to reflect the characteristics of opicapone and entacapone; attributes associated with other adjunctive therapies were not evaluated.
    Conclusion: Patients with PD expressed interest in adjunctive treatment to increase ON time and would accept reduced ON time to avoid adverse effects.
    Language English
    Publishing date 2023-09-13
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2455848-5
    ISSN 1177-889X
    ISSN 1177-889X
    DOI 10.2147/PPA.S420051
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