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  1. Article ; Online: Responsiveness to basement membrane extract as a possible trait for tumorigenicity characterization.

    Murata, Haruhiko / Omeir, Romelda / Tu, Wei / Lanning, Lynda / Phy, Kathryn / Foseh, Gideon / Lewis, Andrew M / Peden, Keith

    Vaccine: X

    2019  Volume 1, Page(s) 100004

    Abstract: Immortalized cell lines used to produce vaccines are expected to be described in terms of their tumorigenicity. However, ... ...

    Abstract Immortalized cell lines used to produce vaccines are expected to be described in terms of their tumorigenicity. However, current
    Language English
    Publishing date 2019-01-03
    Publishing country England
    Document type Journal Article
    ISSN 2590-1362
    ISSN (online) 2590-1362
    DOI 10.1016/j.jvacx.2019.100004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Failure-to-thrive syndrome associated with tumor formation by Madin-Darby canine kidney cells in newborn nude mice.

    Brinster, Lauren R / Omeir, Romelda L / Foseh, Gideon S / Macauley, Juliete N / Snoy, Philip J / Beren, Joel J / Teferedegne, Belete / Peden, Keith / Lewis, Andrew M

    Comparative medicine

    2013  Volume 63, Issue 4, Page(s) 323–330

    Abstract: Tumors that formed in newborn nude mice that were inoculated with 10(7) Madin-Darby canine kidney (MDCK) cells were associated with a failure-to-thrive (FTT) syndrome consisting of growth retardation, lethargy, weakness, and dehydration. Scoliosis ... ...

    Abstract Tumors that formed in newborn nude mice that were inoculated with 10(7) Madin-Darby canine kidney (MDCK) cells were associated with a failure-to-thrive (FTT) syndrome consisting of growth retardation, lethargy, weakness, and dehydration. Scoliosis developed in 41% of affected pups. Pups were symptomatic by week 2; severely affected pups became moribund and required euthanasia within 3 to 4 wk. Mice with FTT were classified into categories of mild, moderate, and severe disease by comparing their weight with that of age-matched normal nude mice. The MDCK-induced tumors were adenocarcinomas that invaded adjacent muscle, connective tissue, and bone; 6 of the 26 pups examined had lung metastases. The induction of FTT did not correlate with cell-line aggressiveness as estimated by histopathology or the efficiency of tumor formation (tumor-forming dose 50% endpoint range = 10(2.8) to 10(7.5)); however, tumor invasion of the paravertebral muscles likely contributed to the scoliosis noted. In contrast to the effect of MDCK cells, tumor formation observed in newborn mice inoculated with highly tumorigenic, human-tumor-derived cell lines was not associated with FTT development. We suggest that tumor formation and FTT are characteristics of these MDCK cell inocula and that FTT represents a new syndrome that may be similar to the cachexia that develops in humans with cancer or other diseases.
    MeSH term(s) Animals ; Animals, Newborn ; Dogs ; Failure to Thrive/pathology ; Failure to Thrive/veterinary ; Madin Darby Canine Kidney Cells ; Mice ; Mice, Nude
    Keywords covid19
    Language English
    Publishing date 2013-10-24
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2006425-1
    ISSN 1532-0820 ; 0023-6764
    ISSN 1532-0820 ; 0023-6764
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article: Heterogeneity of the Tumorigenic Phenotype Expressed by Madin-Darby Canine Kidney Cells

    Omeir, Romelda L / Teferedegne, Belete / Foseh, Gideon S / Beren, Joel J / Snoy, Philip J / Brinster, Lauren R / Cook, James L / Peden, Keith / Lewis, Andrew M. Jr

    Comparative medicine. 2011 June, v. 61, no. 3

    2011  

    Abstract: The mechanisms by which cells spontaneously immortalized in tissue culture develop the capacity to form tumors in vivo likely embody fundamental processes in neoplastic development. The evolution of Madin-Darby canine kidney (MDCK) cells from ... ...

    Abstract The mechanisms by which cells spontaneously immortalized in tissue culture develop the capacity to form tumors in vivo likely embody fundamental processes in neoplastic development. The evolution of Madin-Darby canine kidney (MDCK) cells from presumptively normal kidney cells to immortalized cells that become tumorigenic represents an example of neoplastic development in vitro. Studies of the mechanisms by which spontaneously immortalized cells develop the capacity to form tumors would benefit from quantitative in vivo assays. Most mechanistic correlations are evaluated by using single-dose tumor-induction experiments, which indicate only whether cells are or are not tumorigenic. Here we used quantitative tumorigenicity assays to measure dose-and time-dependent tumor development in nude mice of 3 lots of unmodified MDCK cells. The results revealed lot-to-lot variations in the tumorigenicity of MDCK cells, which were reflected by their tumor-inducing efficiency (threshold cell dose represented by mean tumor-producing dose; log10 50% endpoints of 5.2 for vial 1 and 4.4 for vial 2, and a tumor-producing dose of 5.8 for vial 3) and mean tumor latency (vial 1,6.6 wk; vial 2,2.9 wk; and vial 3,3.8 wk). These studies provide a reference for further characterization of the MDCK cell neoplastic phenotype and may be useful in delineating aspects of neoplastic development in vitro that determine tumor-forming capacity. Such data also are useful when considering MDCK cells as a reagent for vaccine manufacture.
    Keywords carcinogenesis ; dogs ; kidney cells ; kidneys ; mice ; neoplasm cells ; neoplasms ; phenotype ; tissue culture
    Language English
    Size p. 243-250.
    Document type Article
    ISSN 1532-0820
    Database NAL-Catalogue (AGRICOLA)

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  4. Article: Heterogeneity of the tumorigenic phenotype expressed by Madin-Darby canine kidney cells.

    Omeir, Romelda L / Teferedegne, Belete / Foseh, Gideon S / Beren, Joel J / Snoy, Philip J / Brinster, Lauren R / Cook, James L / Peden, Keith / Lewis, Andrew M

    Comparative medicine

    2011  Volume 61, Issue 3, Page(s) 243–250

    Abstract: The mechanisms by which cells spontaneously immortalized in tissue culture develop the capacity to form tumors in vivo likely embody fundamental processes in neoplastic development. The evolution of Madin-Darby canine kidney (MDCK) cells from ... ...

    Abstract The mechanisms by which cells spontaneously immortalized in tissue culture develop the capacity to form tumors in vivo likely embody fundamental processes in neoplastic development. The evolution of Madin-Darby canine kidney (MDCK) cells from presumptively normal kidney cells to immortalized cells that become tumorigenic represents an example of neoplastic development in vitro. Studies of the mechanisms by which spontaneously immortalized cells develop the capacity to form tumors would benefit from quantitative in vivo assays. Most mechanistic correlations are evaluated by using single-dose tumor-induction experiments, which indicate only whether cells are or are not tumorigenic. Here we used quantitative tumorigenicity assays to measure dose-and time-dependent tumor development in nude mice of 3 lots of unmodified MDCK cells. The results revealed lot-to-lot variations in the tumorigenicity of MDCK cells, which were reflected by their tumor-inducing efficiency (threshold cell dose represented by mean tumor-producing dose; log(10) 50% endpoints of 5.2 for vial 1 and 4.4 for vial 2, and a tumor-producing dose of 5.8 for vial 3) and mean tumor latency (vial 1,6.6 wk; vial 2,2.9 wk; and vial 3,3.8 wk). These studies provide a reference for further characterization of the MDCK cell neoplastic phenotype and may be useful in delineating aspects of neoplastic development in vitro that determine tumor-forming capacity. Such data also are useful when considering MDCK cells as a reagent for vaccine manufacture.
    MeSH term(s) Animals ; Carcinogenicity Tests ; Cell Line ; Cell Transformation, Neoplastic ; Dogs ; Mice ; Mice, Nude ; Neoplasms/pathology ; Phenotype
    Language English
    Publishing date 2011-08-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 2006425-1
    ISSN 1532-0820 ; 0023-6764
    ISSN 1532-0820 ; 0023-6764
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 601: Show issues Location:
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  5. Article: Recovery of strains of the polyomavirus SV40 from rhesus monkey kidney cells dating from the 1950s to the early 1960s.

    Peden, Keith / Sheng, Li / Omeir, Romelda / Yacobucci, Maureen / Klutch, Michael / Laassri, Majid / Chumakov, Konstantin / Pal, Achintya / Murata, Haruhiko / Lewis, Andrew M

    Virology

    2008  Volume 370, Issue 1, Page(s) 63–76

    Abstract: From stocks of adenovirus and poliovirus prepared in primary rhesus macaque kidney cells and dating from 1956 to 1961, the time when SV40 contaminated some poliovirus vaccine lots, we have recovered ten isolates of SV40. Of these ten isolates, based on ... ...

    Abstract From stocks of adenovirus and poliovirus prepared in primary rhesus macaque kidney cells and dating from 1956 to 1961, the time when SV40 contaminated some poliovirus vaccine lots, we have recovered ten isolates of SV40. Of these ten isolates, based on the C-terminal region of T antigen, five novel strains of SV40 have been identified. Additionally, three pairs of isolates were found to be the same strain: one pair was strain 777, one pair was strain 776 archetype, and the third pair represented a novel strain. All strains had identical protein sequences for VP2 and VP3. There were two variants of agnoprotein and the small t antigen and three variants of VP1. These results, and those of others, suggest that a limited number of SV40 strains might exist in rhesus macaques in the United States, and thus determining the origin of the SV40 sequences detected in human tumors might be difficult.
    MeSH term(s) Animals ; Antigens, Viral, Tumor/genetics ; Cell Line ; DNA, Viral/analysis ; DNA, Viral/genetics ; DNA, Viral/isolation & purification ; Drug Contamination ; Epithelial Cells/virology ; Genetic Variation ; Humans ; Kidney/cytology ; Kidney/virology ; Macaca mulatta/virology ; Poliovirus Vaccines ; Sequence Analysis, DNA ; Simian virus 40/classification ; Simian virus 40/genetics ; Simian virus 40/isolation & purification ; Time Factors
    Chemical Substances Antigens, Viral, Tumor ; DNA, Viral ; Poliovirus Vaccines
    Language English
    Publishing date 2008-01-05
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 200425-2
    ISSN 1096-0341 ; 0042-6822
    ISSN (online) 1096-0341
    ISSN 0042-6822
    DOI 10.1016/j.virol.2007.06.045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.172: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Heterogeneity of the Tumorigenic Phenotype Expressed by Madin-Darby Canine Kidney Cells

    Omeir, Romelda L. / Teferedegne, Belete / Foseh, Gideon S. / Beren, Joel J. / Snoy, Philip J. / Brinster, Lauren R. / Cook, James L. / Peden, Keith / Lewis, Andrew M. Jr.

    Comparative medicine

    Volume v. 61,, Issue no. 3

    Abstract: The mechanisms by which cells spontaneously immortalized in tissue culture develop the capacity to form tumors in vivo likely embody fundamental processes in neoplastic development. The evolution of Madin-Darby canine kidney (MDCK) cells from ... ...

    Abstract The mechanisms by which cells spontaneously immortalized in tissue culture develop the capacity to form tumors in vivo likely embody fundamental processes in neoplastic development. The evolution of Madin-Darby canine kidney (MDCK) cells from presumptively normal kidney cells to immortalized cells that become tumorigenic represents an example of neoplastic development in vitro. Studies of the mechanisms by which spontaneously immortalized cells develop the capacity to form tumors would benefit from quantitative in vivo assays. Most mechanistic correlations are evaluated by using single-dose tumor-induction experiments, which indicate only whether cells are or are not tumorigenic. Here we used quantitative tumorigenicity assays to measure dose-and time-dependent tumor development in nude mice of 3 lots of unmodified MDCK cells. The results revealed lot-to-lot variations in the tumorigenicity of MDCK cells, which were reflected by their tumor-inducing efficiency (threshold cell dose represented by mean tumor-producing dose; log10 50% endpoints of 5.2 for vial 1 and 4.4 for vial 2, and a tumor-producing dose of 5.8 for vial 3) and mean tumor latency (vial 1,6.6 wk; vial 2,2.9 wk; and vial 3,3.8 wk). These studies provide a reference for further characterization of the MDCK cell neoplastic phenotype and may be useful in delineating aspects of neoplastic development in vitro that determine tumor-forming capacity. Such data also are useful when considering MDCK cells as a reagent for vaccine manufacture.
    Keywords mice ; kidneys ; dogs ; carcinogenesis ; kidney cells ; neoplasms ; phenotype ; neoplasm cells ; tissue culture
    Language English
    Document type Article
    ISSN 1532-0820
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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  7. Article: Failure-to-Thrive Syndrome Associated with Tumor Formation by Madin–Darby Canine Kidney Cells in Newborn Nude Mice

    Brinster, Lauren R / Omeir, Romelda L / Foseh, Gideon S / Macauley, Juliete N / Snoy, Philip J / Beren, Joel J / Teferedegne, Belete / Peden, Keith / Lewis, Andrew M

    Abstract: Tumors that formed in newborn nude mice that were inoculated with 10(7) Madin–Darby canine kidney (MDCK) cells were associated with a failure-to-thrive (FTT) syndrome consisting of growth retardation, lethargy, weakness, and dehydration. Scoliosis ... ...

    Abstract Tumors that formed in newborn nude mice that were inoculated with 10(7) Madin–Darby canine kidney (MDCK) cells were associated with a failure-to-thrive (FTT) syndrome consisting of growth retardation, lethargy, weakness, and dehydration. Scoliosis developed in 41% of affected pups. Pups were symptomatic by week 2; severely affected pups became moribund and required euthanasia within 3 to 4 wk. Mice with FTT were classified into categories of mild, moderate, and severe disease by comparing their weight with that of age-matched normal nude mice. The MDCK-induced tumors were adenocarcinomas that invaded adjacent muscle, connective tissue, and bone; 6 of the 26 pups examined had lung metastases. The induction of FTT did not correlate with cell-line aggressiveness as estimated by histopathology or the efficiency of tumor formation (tumor-forming dose 50% endpoint range = 10(2.8) to 10(7.5)); however, tumor invasion of the paravertebral muscles likely contributed to the scoliosis noted. In contrast to the effect of MDCK cells, tumor formation observed in newborn mice inoculated with highly tumorigenic, human-tumor–derived cell lines was not associated with FTT development. We suggest that tumor formation and FTT are characteristics of these MDCK cell inocula and that FTT represents a new syndrome that may be similar to the cachexia that develops in humans with cancer or other diseases.
    Keywords covid19
    Publisher PMC
    Document type Article
    Database COVID19

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