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Article ; Online: Molecular insights into PCB neurotoxicity: Comparing transcriptomic responses across dopaminergic neurons, population blood cells, and Parkinson's disease pathology.

Krauskopf, Julian / Eggermont, Kristel / Caiment, Florian / Verfaillie, Catherine / de Kok, Theo M

2024 Volume 186, Page(s) 108642

Abstract: Parkinson's disease (PD) is a complex neurodegenerative disorder influenced by genetic factors and environmental exposures. Polychlorinated biphenyls (PCBs), a group of synthetic organic compounds, have been identified as potential environmental risk ... ...

Abstract	Parkinson's disease (PD) is a complex neurodegenerative disorder influenced by genetic factors and environmental exposures. Polychlorinated biphenyls (PCBs), a group of synthetic organic compounds, have been identified as potential environmental risk factors for neurodegenerative diseases, including PD. We explored PCB-induced neurotoxicity mechanisms using iPSC-derived dopaminergic neurons and assessed their transcriptomic responses to varying PCB concentrations (0.01 μM, 0.5 μM, and 10 μM). Specifically, we focused on PCB-180, a congener known for its accumulation in human brains. The exposure durations were 24 h and 74 h, allowing us to capture both short-term and more prolonged effects on gene expression patterns. We observed that PCB exposure led to the suppression of oxidative phosphorylation, synaptic function, and neurotransmitter release, implicating these pathways in PCB-induced neurotoxicity. In our comparative analysis, we noted similarities in PCB-induced changes with other PD-related compounds like MPP+ and rotenone. Our findings also aligned with gene expression changes in human blood derived from a population exposed to PCBs, highlighting broader inflammatory responses. Additionally, molecular patterns seen in iPSC-derived neurons were confirmed in postmortem PD brain tissues, validating our in vitro results. In conclusion, our study offers novel insights into the multifaceted impacts of PCB-induced perturbations on various cellular contexts relevant to PD. The use of iPSC-derived dopaminergic neurons allowed us to decipher intricate transcriptomic alterations, bridging the gap between in vitro and in vivo findings. This work underscores the potential role of PCB exposure in neurodegenerative diseases like PD, emphasizing the need to consider both systemic and cell specific effects.
MeSH term(s)	Polychlorinated Biphenyls/toxicity ; Parkinson Disease ; Dopaminergic Neurons/drug effects ; Humans ; Transcriptome/drug effects ; Blood Cells/drug effects ; Induced Pluripotent Stem Cells/drug effects ; Induced Pluripotent Stem Cells/metabolism ; Environmental Pollutants/toxicity
Chemical Substances	Polychlorinated Biphenyls (DFC2HB4I0K) ; Environmental Pollutants
Language	English
Publishing date	2024-04-10
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	554791-x
ISSN	1873-6750 ; 0160-4120
ISSN (online)	1873-6750
ISSN	0160-4120
DOI	10.1016/j.envint.2024.108642
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Zs.A 3131: Show issues

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Article ; Online: Evaluations of the radial peripapillary, macular and choriocapillaris microvasculature using optical coherence tomography angiography in patients with systemic sclerosis.

Küçük, M F / Yaprak, L / Erol, M K / Ayan, A / Kök, M

Journal francais d'ophtalmologie

2021 Volume 45, Issue 1, Page(s) 81–92

Abstract: Purpose: To analyze the macular microvascular (MMV) architecture, radial peripapillary capillary (RPC) network and choriocapillaris using optical coherence tomography angiography (OCT-A) in patients with systemic sclerosis (SSc) without systemic ... ...

Abstract	Purpose: To analyze the macular microvascular (MMV) architecture, radial peripapillary capillary (RPC) network and choriocapillaris using optical coherence tomography angiography (OCT-A) in patients with systemic sclerosis (SSc) without systemic comorbidities. Methods: The vessel densities (VDs) of the MMV, foveal avascular zone (FAZ) parameters, choriocapillaris flow areas (CCFAs), RPC VDs, and optic nerve head (ONH) parameters were measured by OCT-A. Retinal thickness and subfoveal choroidal thickness (SFCT) were measured by spectral-domain optical coherence tomography (SD-OCT). The SD-OCT and OCT-A measurements of 53 eyes of 30 SSc patients were compared with 61 eyes of 33 healthy controls. Results: In the MMV analysis, a decrease in the VDs of the superficial capillary plexus and an increase in the FAZ area, FAZ perimeter and non-flow area were detected in the SSc group compared to the controls (P=0.007, P=0.001, P=0.029, P=0.018, and P=0.039, respectively). While there was a decrease in SFCT, no change was found in CCFA (P=0.001 and P=0.902, respectively). The RPC analysis revealed a decrease in the VDs of all vessels for the entire area and the intradisc area, as well as the VDs of the small vessels for the intradisc area (P=0.021, P=0.001, and P=0.003, respectively). In the ONH analysis, there was an increase in the C/D area ratios and cup volumes, and a decrease in the rim areas and nasal quadrant retinal nerve fiber layer thickness (P=0.004, P=0.004, P=0.013, and P=0.032, respectively). Conclusion: Decreases in RPC and MMV VDs and changes in ONH parameters were found in OCT-A measurements in patients with SSc.
MeSH term(s)	Choroid/diagnostic imaging ; Fluorescein Angiography ; Humans ; Microvessels/diagnostic imaging ; Retinal Vessels/diagnostic imaging ; Scleroderma, Systemic/complications ; Scleroderma, Systemic/diagnostic imaging ; Tomography, Optical Coherence
Language	English
Publishing date	2021-12-09
Publishing country	France
Document type	Journal Article
ZDB-ID	426662-6
ISSN	1773-0597 ; 0181-5512
ISSN (online)	1773-0597
ISSN	0181-5512
DOI	10.1016/j.jfo.2021.06.009
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Zs.A 1417: Show issues

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Article ; Online: Delayed diagnosed injuries in trauma patients after initial trauma assessment with a total-body computed tomography scan.

Kok, D / Oud, S / Giannakópoulos, G F / Scheerder, M J / Beenen, L F M / Halm, J A / Treskes, K

Injury

2023 Volume 55, Issue 5, Page(s) 111304

Abstract: Introduction: Even when using the Advanced Trauma Life Support (ATLS) guidelines and other diagnostic protocols for the initial assessment of trauma patients, not all injuries will be diagnosed in this early stage of care. The aim of this study was to ... ...

Abstract	Introduction: Even when using the Advanced Trauma Life Support (ATLS) guidelines and other diagnostic protocols for the initial assessment of trauma patients, not all injuries will be diagnosed in this early stage of care. The aim of this study was to quantify how many, and assess which type of injuries were diagnosed with delay during the initial assessment of trauma patients including a total-body computed tomography (TBCT) scan in a Level 1 Trauma Center in the Netherlands. Methods: We conducted a retrospective cohort study of 697 trauma patients who were assessed in the trauma bay of the Amsterdam University Medical Center (AUMC), using a TBCT. A delayed diagnosed injury was defined as an injury sustained during the initial trauma and not discovered nor suspected upon admission to the Intensive Care Unit (ICU) or surgical ward following the initial assessment, diagnostic studies, or during immediate surgery. A clinically significant delayed diagnosis of injury was defined as an injury requiring follow-up or further medical treatment. We aimed to identify variables associated with delayed diagnosed injuries. Results: In total, 697 trauma patients with a median age of 46 years (IQR 30-61) and a median Injury Severity Score (ISS) of 16 (IQR 9-25) were included. Delayed diagnosed injuries were found in 97 patients (13.9 %), of whom 79 injuries were clinically significant (81.4 %). Forty-eight of the delayed diagnosed injuries (49.5 %) were within the TBCT field. Ten delayed diagnosed injuries had an Abbreviated Injury Scale (AIS) of ≥3. Most injuries were diagnosed before or during the tertiary survey (60.8 %). The median time of delay was 34.5 h (IQR 17.5-157.3). Variables associated with delayed diagnosed injuries were primary ICU admission (OR 1.8, p = 0.014), an ISS ≥ 16 (OR 1.6, p = 0.042), and prolonged hospitalization (40+ days) (OR 8.5, p < 0.001). Conclusion: With the inclusion of the TBCT during the primary assessment of trauma patients, delayed diagnosed injuries still occurs in a significant number of patients (13.9 %). Factors associated with delayed diagnosed injuries were direct admission to ICU and an ISS ≥ 16.
MeSH term(s)	Humans ; Adult ; Middle Aged ; Retrospective Studies ; Injury Severity Score ; Trauma Centers ; Intensive Care Units ; Tomography, X-Ray Computed
Language	English
Publishing date	2023-12-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	218778-4
ISSN	1879-0267 ; 0020-1383
ISSN (online)	1879-0267
ISSN	0020-1383
DOI	10.1016/j.injury.2023.111304
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Zs.A 778: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 10: Show issues

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Article ; Online: An insight into clinicians' practices in breaking bad news of oral cancer diagnosis.

Mohd Desa, S N F / Doss, J G / Kadir, K / Ch'ng, L L / Kok, T C / Jelon, M A / Yahya, M R / Parumo, R / Chong, S M Y / Shim, C K

International journal of oral and maxillofacial surgery

2024

Abstract: Communication is an integral component of effective healthcare delivery to patients, and this includes breaking bad news (BBN). However, clinicians in dentistry are rarely exposed to diseases that can negatively and seriously affect an individual's view ... ...

Abstract	Communication is an integral component of effective healthcare delivery to patients, and this includes breaking bad news (BBN). However, clinicians in dentistry are rarely exposed to diseases that can negatively and seriously affect an individual's view of their future and pose a mortality risk, except for oral cancer. The aim of this study was to assess clinician practices in BBN of oral cancer diagnosis in Malaysia. An exploratory sequential mixed-methods study design was used. A qualitative study was conducted among 12 clinicians to gather relevant information regarding their practices in BBN of oral cancer diagnosis using a descriptive-interpretive approach. The themes that emerged were preparation for BBN, BBN setting, communication, emotional aspects, and summarizing the session. These themes were used to develop a questionnaire with 34 items. In the quantitative study, this questionnaire was sent to 87 clinicians who had experienced BBN of oral cancer diagnosis in the past 5 years; the response rate was 100%. An arbitrary cut-off score between the third and fourth quartiles was set to distinguish 'good' and 'poor' practice in BBN among the clinicians. The data analysis was performed using IBM SPSS Statistics version 23.0. Overall, at least two-thirds of the clinicians had good practices in BBN of oral cancer diagnosis. The clinicians' designation (oral and maxillofacial surgery consultant/specialist vs dental officer) and BBN experiences were factors associated with their practices in BBN of oral cancer diagnosis.
Language	English
Publishing date	2024-04-17
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	353721-3
ISSN	1399-0020 ; 0901-5027
ISSN (online)	1399-0020
ISSN	0901-5027
DOI	10.1016/j.ijom.2024.03.002
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Zs.A 931: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 401: Show issues

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Article ; Online: Modifiable prognostic factors in uterine fibroid development: a systematic review of literature.

Keizer, Alieke L / Semmler, Annika / Kok, Helen S / van Kesteren, Paul J M / Huirne, Judith A F / Hehenkamp, Wouter J K

Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology

2023 Volume 44, Issue 1, Page(s) 2288225

Abstract: Background: Many risk factors in uterine fibroid development have been identified, but women and their physicians are less aware of the influence of lifestyle on uterine fibroid development. The objective of this systematic review is to investigate and ... ...

Abstract	Background: Many risk factors in uterine fibroid development have been identified, but women and their physicians are less aware of the influence of lifestyle on uterine fibroid development. The objective of this systematic review is to investigate and summarize modifiable prognostic factors associated with uterine fibroid development. Methods: Pubmed and Embase were searched for relevant articles according to PRISMA guidelines. References from included articles were screened and when relevant also included. Human in vivo studies on modifiable factors in fibroid development were included. Studies on non-modifiable factors and treatment, in vitro studies and animal studies were excluded. 607 articles were screened and 33 articles were included. Two independent investigators collected data from the report. Results: The strongest risk factor for fibroid development was a high BMI, while the strongest protective factors were a high fruit and vegetable intake and high vitamin D intake. Conclusion: More high-quality studies are necessary to better understand the impact of the abovementioned factors as well as the role they play in the growth of already existing fibroids.
MeSH term(s)	Animals ; Female ; Humans ; Uterine Neoplasms/complications ; Prognosis ; Leiomyoma/complications ; Risk Factors
Language	English
Publishing date	2023-12-16
Publishing country	England
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	604639-3
ISSN	1364-6893 ; 0144-3615
ISSN (online)	1364-6893
ISSN	0144-3615
DOI	10.1080/01443615.2023.2288225
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Zs.B 2461: Show issues

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Article ; Online: A novel insight into differential expression profiles of sporadic cerebral cavernous malformation patients with different symptoms.

Eren Gozel, Hilal / Kök, Kıvanç / Ozlen, Fatma / Isler, Cihan / Pence, Sadrettin

Scientific reports

2021 Volume 11, Issue 1, Page(s) 19351

Abstract: Cerebral cavernous malformation (CCM) is a vascular lesion of the central nervous system that may lead to distinct symptoms among patients including cerebral hemorrhages, epileptic seizures, focal neurologic deficits, and/or headaches. Disease-related ... ...

Abstract	Cerebral cavernous malformation (CCM) is a vascular lesion of the central nervous system that may lead to distinct symptoms among patients including cerebral hemorrhages, epileptic seizures, focal neurologic deficits, and/or headaches. Disease-related mutations were identified previously in one of the three CCM genes: CCM1, CCM2, and CCM3. However, the rate of these mutations in sporadic cases is relatively low, and new studies report that mutations in CCM genes may not be sufficient to initiate the lesions. Despite the growing body of research on CCM, the underlying molecular mechanism has remained largely elusive. In order to provide a novel insight considering the specific manifested symptoms, CCM patients were classified into two groups (as Epilepsy and Hemorrhage). Since the studied patients experience various symptoms, we hypothesized that the underlying cause for the disease may also differ between those groups. To this end, the respective transcriptomes were compared to the transcriptomes of the control brain tissues and among each other. This resulted into the identification of the differentially expressed coding genes and the delineation of the corresponding differential expression profile for each comparison. Notably, some of those differentially expressed genes were previously implicated in epilepsy, cell structure formation, and cell metabolism. However, no CCM1-3 gene deregulation was detected. Interestingly, we observed that when compared to the normal controls, the expression of some identified genes was only significantly altered either in Epilepsy (EGLN1, ELAVL4, and NFE2l2) or Hemorrhage (USP22, EYA1, SIX1, OAS3, SRMS) groups. To the best of our knowledge, this is the first such effort focusing on CCM patients with epileptic and hemorrhagic symptoms with the purpose of uncovering the potential CCM-related genes. It is also the first report that presents a gene expression dataset on Turkish CCM patients. The results suggest that the new candidate genes should be explored to further elucidate the CCM pathology. Overall, this work constitutes a step towards the identification of novel potential genetic targets for the development of possible future therapies.
MeSH term(s)	Adolescent ; Adult ; Aged ; Case-Control Studies ; Central Nervous System Neoplasms/complications ; Central Nervous System Neoplasms/diagnosis ; Central Nervous System Neoplasms/genetics ; Central Nervous System Neoplasms/pathology ; Cerebral Hemorrhage/diagnosis ; Cerebral Hemorrhage/genetics ; Epilepsy/diagnosis ; Epilepsy/genetics ; Female ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Hemangioma, Cavernous, Central Nervous System/complications ; Hemangioma, Cavernous, Central Nervous System/diagnosis ; Hemangioma, Cavernous, Central Nervous System/genetics ; Hemangioma, Cavernous, Central Nervous System/pathology ; Humans ; Male ; Middle Aged
Language	English
Publishing date	2021-09-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-98647-9
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Article ; Online: Ingeslikte blisterverpakkingen.

de Leijer, J F / Geel, D R / Kok, K F / Kramers, C

Nederlands tijdschrift voor geneeskunde

2021 Volume 165

Abstract: Background: Single dose blister packs (BP) are commonly used in pharmaceutical packaging. Accidental ingestion of medication BPs can cause serious harm as the sharp edges can severely damage the esophageal wall.: Case descriptions: We describe 2 ... ...

Title translation	Ingested medication blister packs.
Abstract	Background: Single dose blister packs (BP) are commonly used in pharmaceutical packaging. Accidental ingestion of medication BPs can cause serious harm as the sharp edges can severely damage the esophageal wall. Case descriptions: We describe 2 cases of accidental BP ingestion. An 88-year-old man self-administered his medication during hospital admission. Afterwards, he started to complain about dysphagia. Endoscopic examination the next day revealed a BP stuck in the esophageal wall, which was successfully removed. A 66-year-old man presented to the emergency department with acute onset hematemesis and dysphagia for one week. Upper endoscopy showed a deep tear in the esophageal mucosa and an intact BP in the stomach. The BP was removed and the patient recovered. Conclusion: Patients are often not aware of the ingested BP. Urgent endoscopic intervention is needed in order to prevent further damage to the esophageal wall. Supervision during specific moments of intake could help to prevent accidental ingestion.
MeSH term(s)	Accidents ; Aged ; Aged, 80 and over ; Deglutition Disorders/etiology ; Drug Packaging ; Emergency Service, Hospital ; Esophagus/injuries ; Foreign Bodies/complications ; Humans ; Male ; Stomach/injuries
Language	Dutch
Publishing date	2021-03-25
Publishing country	Netherlands
Document type	Case Reports ; Journal Article
ZDB-ID	82073-8
ISSN	1876-8784 ; 0028-2162
ISSN (online)	1876-8784
ISSN	0028-2162
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Ua VI Zs.18: Show issues

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Article ; Online: The military gear microbiome: risk factors surrounding the warfighter.

Kok, Car Reen / Bram, Zakariae / Thissen, James B / Horseman, Timothy S / Fong, Keith S K / Reichert-Scrivner, Susan A / Paguirigan, Carmen / O'Connor, Kelsey / Thompson, Kristina / Scheiber, Alexander E / Mabery, Shalini / Ngauy, Viseth / Uyehara, Catherine F / Be, Nicholas A

Applied and environmental microbiology

2024 Volume 90, Issue 1, Page(s) e0117623

Abstract: Combat extremity wounds are highly susceptible to contamination from surrounding environmental material. This bioburden could be partially transferred from materials in immediate proximity to the wound, including fragments of the uniform and gear. ... ...

Abstract	Combat extremity wounds are highly susceptible to contamination from surrounding environmental material. This bioburden could be partially transferred from materials in immediate proximity to the wound, including fragments of the uniform and gear. However, the assessment of the microbial bioburden present on military gear during operational conditions of deployment or training is relatively unexplored. Opportunistic pathogens that can survive on gear represent risk factors for infection following injury, especially following combat blasts, where fibers and other materials are embedded in wounded tissue. We utilized 16S rRNA sequencing to assess the microbiome composition of different military gear types (boot, trouser, coat, and canteen) from two operational environments (training in Hawai'i and deployed in Indonesia) across time (days 0 and 14). We found that microbiome diversity, stability, and composition were dependent on gear type, training location, and sampling timepoint. At day 14, species diversity was significantly higher in Hawai'i samples compared to Indonesia samples for boot, coat, and trouser swabs. In addition, we observed the presence of potential microbial risk factors, as opportunistic pathogenic species, such as
MeSH term(s)	Humans ; Military Personnel ; RNA, Ribosomal, 16S ; Risk Factors ; Hawaii ; Indonesia
Chemical Substances	RNA, Ribosomal, 16S
Language	English
Publishing date	2024-01-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	223011-2
ISSN	1098-5336 ; 0099-2240
ISSN (online)	1098-5336
ISSN	0099-2240
DOI	10.1128/aem.01176-23
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Zs.B 201: Show issues

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Article ; Online: Metformin with Versus without Concomitant Probiotic Therapy in Newly Diagnosed Patients with Type 2 Diabetes or Prediabetes: A Comparative Analysis in Relation to Glycemic Control, Gastrointestinal Side Effects, and Treatment Compliance.

Şahin, Kübra / Şahintürk, Yasin / Köker, Gökhan / Özçelik Köker, Gülhan / Bostan, Feyzi / Kök, Mehmet / Uyar, Seyit / Çekin, Ayhan Hilmi

The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology

2022 Volume 33, Issue 11, Page(s) 925–933

Abstract: Background: To evaluate the impact of concomitant use of probiotic BB-12 in metformin-treated patients with type 2 diabetes or prediabetes on glycemic control, metformin-related gastrointestinal side effects, and treatment compliance.: Methods: A ... ...

Abstract	Background: To evaluate the impact of concomitant use of probiotic BB-12 in metformin-treated patients with type 2 diabetes or prediabetes on glycemic control, metformin-related gastrointestinal side effects, and treatment compliance. Methods: A total of 156 patients (mean [standard deviation] age: 50.9 [9.9 years], 74.4% females) with newly diagnosed type 2 diabetes or prediabetes were randomly assigned to receive either metformin alone (n = 84, MET group) or metformin plus Bifidobacterium animalis subsp. lactis (BB-12) probiotic (n = 72, MET-PRO group). Data on body mass index (kg/m2), fasting blood glucose (mg/dL), blood lipids, and glycated hemoglobin (HbA1c) levels were recorded at baseline and at the third month of therapy. Data on gastrointestinal intolerance symptoms and treatment noncompliance were also recorded during post-treatment week 1 to week 4. Results: MET-PRO versus MET therapy was associated with a significantly higher rate of treatment compliance (91.7% vs 71.4%, P = .001), greater reduction from baseline HbA1c values (0.9 [0.4-1.6] vs 0.4 [0-1.6] %, P < .001) and lower likelihood of gastrointestinal intolerance symptoms, including abdominal pain (P = .031 to <.001), diarrhea (P = .005 to <.001) and bloating (P = .010 to <.001). Noncompliance developed later (at least 15 days after the therapy) in a significantly higher percentage of patients in the MET group (P = .001 for 15-21 days and P = .002 for 22-28 days). Conclusion: In conclusion, the present study proposes the benefit of combining probiotics with metformin in the treatment of patients with T2D or prediabetes in terms of improved glycemic control and treatment adherence rather than correction of dyslipidemia or weight reduction.
MeSH term(s)	Female ; Humans ; Middle Aged ; Male ; Metformin/adverse effects ; Diabetes Mellitus, Type 2/drug therapy ; Glycated Hemoglobin A/analysis ; Glycated Hemoglobin A/therapeutic use ; Prediabetic State/chemically induced ; Prediabetic State/drug therapy ; Hypoglycemic Agents/adverse effects ; Glycemic Control ; Blood Glucose/analysis ; Patient Compliance ; Probiotics/adverse effects ; Bifidobacterium animalis ; Drug Therapy, Combination ; Double-Blind Method
Chemical Substances	Metformin (9100L32L2N) ; Glycated Hemoglobin A ; Hypoglycemic Agents ; Blood Glucose
Language	English
Publishing date	2022-09-13
Publishing country	Turkey
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	1340275-4
ISSN	2148-5607 ; 1300-4948
ISSN (online)	2148-5607
ISSN	1300-4948
DOI	10.5152/tjg.2022.211063
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Zs.A 4524: Show issues

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Article ; Online: Disappearing colorectal liver metastases in the era of state-of-the-art triple-modality diagnostic imaging.

Kuhlmann, K F / Tufo, A / Kok, N F / Gordon-Weeks, A / Poston, G J / Diaz Nieto, R / Jones, R / Fenwick, S W / Malik, H Z

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

2023 Volume 49, Issue 5, Page(s) 1016–1022

Abstract: Introduction: Systemic therapy can result in disappearance of colorectal liver metastases in up to 40% of patients. This might be an overestimation caused by suboptimal imaging modalities. The aim of this study was to investigate the use of imaging ... ...

Abstract	Introduction: Systemic therapy can result in disappearance of colorectal liver metastases in up to 40% of patients. This might be an overestimation caused by suboptimal imaging modalities. The aim of this study was to investigate the use of imaging modalities and the incidence, management and outcome of patients with disappearing liver metastases (DLMs). Methods: This was a retrospective study of consecutive patients treated for colorectal liver metastases at a high volume hepatobiliary centre between January 2013 and January 2015 after receiving induction or neoadjuvant systemic therapy. Main outcomes were use of imaging modalities, incidence, management and longterm outcome of patients with DLMs. Results: Of 158 patients included, 32 (20%) had 110 DLMs. Most patients (88%) had initial diagnostic imaging with contrast enhanced-CT, primovist-MR and FDG-PET and 94% of patients with DLMs were restaged using primovist-MR. Patients with DLMs had significantly smaller metastases and the median initial size of DLMs was 10 mm (range 5-61). In the per lesion analysis, recurrence after "watch & wait" for DLMs occurred in 36%, while in 19 of 20 resected DLMs no viable tumour cells were found. Median overall (51 vs. 28 months, p < 0.05) and progression free survival (10 vs. 3 months, p = 0.003) were significantly longer for patients with DLMs. Conclusion: Even state-of-the-art imaging and restaging cannot solve problems associated with DLMs. Regrowth of these lesions occurs in approximately a third of the lesions. Patients with DLMs have better survival.
MeSH term(s)	Humans ; Colorectal Neoplasms/pathology ; Retrospective Studies ; Tomography, X-Ray Computed ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/therapy ; Liver Neoplasms/secondary ; Fluorodeoxyglucose F18 ; Magnetic Resonance Imaging
Chemical Substances	gadolinium ethoxybenzyl DTPA ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2023-01-12
Publishing country	England
Document type	Journal Article
ZDB-ID	632519-1
ISSN	1532-2157 ; 0748-7983
ISSN (online)	1532-2157
ISSN	0748-7983
DOI	10.1016/j.ejso.2023.01.011
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Zs.A 1149: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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