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  1. Article ; Online: Complex behavioral interventions targeting physical activity and dietary behaviors in pediatric oncology: A scoping review.

    Demers, Catherine / Brochu, Annie / Higgins, Johanne / Gélinas, Isabelle

    Pediatric blood & cancer

    2021  Volume 68, Issue 8, Page(s) e29090

    Abstract: As cancer and its treatment negatively impacts the long-term health and quality of life of survivors, there is a need to explore new avenues to prevent or minimize the impact of adverse effects in children with cancer and cancer survivors. Therefore, ... ...

    Abstract As cancer and its treatment negatively impacts the long-term health and quality of life of survivors, there is a need to explore new avenues to prevent or minimize the impact of adverse effects in children with cancer and cancer survivors. Therefore, this scoping review aimed to report on the state of the evidence on the use and effects of complex behavioral interventions (CBI) targeting physical activity and/or dietary behaviors in pediatric oncology. Fourteen quantitative studies were included, evaluating interventions that used a combination of two or three different treatment modalities. Overall, studies demonstrated that it is feasible to implement CBI and that they can potentially improve physical activity and dietary behaviors as well as patient outcomes such as physical and psychological health. Unfortunately, due to a paucity of studies and the heterogeneity of the studies included in this review, no conclusive evidence favoring specific interventions were identified.
    MeSH term(s) Child ; Diet ; Exercise ; Humans ; Medical Oncology ; Neoplasms/therapy ; Quality of Life
    Language English
    Publishing date 2021-05-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2131448-2
    ISSN 1545-5017 ; 1545-5009
    ISSN (online) 1545-5017
    ISSN 1545-5009
    DOI 10.1002/pbc.29090
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The effectiveness of stimulus control in cognitive behavioural therapy for insomnia in adults: A systematic review and network meta-analysis.

    Verreault, Mikael Demers / Granger, Élyse / Neveu, Xavier / Delage, Julia Pizzamiglio / Bastien, Célyne H / Vallières, Annie

    Journal of sleep research

    2023  , Page(s) e14008

    Abstract: Stimulus control is part of the widely used cognitive behavioural therapy for insomnia. However, there is a lack of knowledge about its mechanisms of action and effectiveness when used alone. This systematic review with network meta-analysis aimed to ... ...

    Abstract Stimulus control is part of the widely used cognitive behavioural therapy for insomnia. However, there is a lack of knowledge about its mechanisms of action and effectiveness when used alone. This systematic review with network meta-analysis aimed to evaluate stimulus control efficacy when used alone compared with cognitive behavioural therapy for insomnia or its components. The review also documented stimulus control mechanisms of action proposed by the authors. A search was conducted in several bibliographic databases (MEDLINE, PsycINFO, Embase, CINAHL, Psychology Behavioural Sciences Collection, Web of Science, and Cochrane Library) and in two registers from 1972 to June 2022. Randomised studies with adult participants presenting a diagnosis of insomnia and including at least one stimulus control instruction in a treatment group were included. Risk of bias was assessed with the Quality Assessment of Controlled Intervention Studies. Twenty-three studies were included and three network meta-analyses were conducted. The quality of included studies was generally poor. Results indicate that stimulus control is an effective intervention to improve insomnia compared with control conditions. Not all stimulus control instructions seem essential, especially those known to recondition the bedroom for sleep. The review challenges the classical conditioning hypothesis. Results should be interpreted cautiously given the small number of studies included, bias risk, and inconsistencies in the network meta-analysis. Rigorous research is needed in evaluating stimulus control efficacy and mechanisms.
    Language English
    Publishing date 2023-08-16
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1122722-9
    ISSN 1365-2869 ; 0962-1105
    ISSN (online) 1365-2869
    ISSN 0962-1105
    DOI 10.1111/jsr.14008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The effects of antipsychotic discontinuation or maintenance on the process of recovery in remitted first-episode psychosis patients - A systematic review and meta-analysis of randomized controlled trials.

    Béchard, Laurent / Desmeules, Charles / Bachand, Lauryann / Huot-Lavoie, Maxime / Corbeil, Olivier / Anderson, Elizabeth / Brodeur, Sébastien / LeBlanc, Annie / Demers, Marie-France / Lauzier, Sophie / Roy, Marc-André

    European psychiatry : the journal of the Association of European Psychiatrists

    2024  Volume 67, Issue 1, Page(s) e13

    Abstract: Background: The optimal duration of antipsychotic treatment following remission of first-episode psychosis (FEP) is uncertain, considering potential adverse effects and individual variability in relapse rates. This study aimed to investigate the effect ... ...

    Abstract Background: The optimal duration of antipsychotic treatment following remission of first-episode psychosis (FEP) is uncertain, considering potential adverse effects and individual variability in relapse rates. This study aimed to investigate the effect of antipsychotic discontinuation compared to continuation on recovery in remitted FEP patients.
    Methods: CENTRAL, MEDLINE (Ovid), Embase, and PsycINFO databases were searched on November 2, 2023, with no language restrictions. RCTs evaluating antipsychotic discontinuation in remitted FEP patients were selected. The primary outcome was personal recovery, and secondary outcomes included functional recovery, global functioning, hospital admission, symptom severity, quality of life, side effects, and employment. Risk of bias was assessed using the Cochrane risk-of-bias tool 2, and the certainty of evidence was evaluated with GRADE. Meta-analysis used a random-effect model with an inverse-variance approach.
    Results: Among 2185 screened studies, 8 RCTs (560 participants) were included. No RCTs reported personal recovery as an outcome. Two studies measured functional recovery, and discontinuation group patients were more likely to achieve functional recovery (RR 2.19; 95% CIs: 1.13, 4.22; I
    Conclusions: Personal recovery was not reported in any antipsychotic discontinuation trial in remitted FEP. The observed positive effect of discontinuation on functional recovery came from an early terminated trial and an RCT followed by an uncontrolled period. These findings should be interpreted cautiously due to very low certainty of evidence.
    MeSH term(s) Humans ; Antipsychotic Agents/adverse effects ; Quality of Life ; Randomized Controlled Trials as Topic ; Psychotic Disorders/drug therapy ; Hospitalization
    Chemical Substances Antipsychotic Agents
    Language English
    Publishing date 2024-01-22
    Publishing country England
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 1074337-6
    ISSN 1778-3585 ; 0767-399X ; 0924-9338
    ISSN (online) 1778-3585
    ISSN 0767-399X ; 0924-9338
    DOI 10.1192/j.eurpsy.2024.5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Methods used to account for caregivers' sex and gender within studies examining the financial burden of caregivers of children and adolescents : Results from a scoping review.

    Guertin, Jason Robert / Gilbert-Ouimet, Mahée / Dugas, Michèle / Carnovale, Valérie / Jalbert, Laura / Svyntozelska, Olha / Demers, Juliette / Matteau, Léonie / Bergeron, Frédéric / LeBlanc, Annie

    ClinicoEconomics and outcomes research : CEOR

    2024  Volume 16, Page(s) 35–53

    Abstract: Background: Interest in the financial burden of informal caregivers has been growing. Unfortunately, it remains unclear which method(s) should be used when quantifying this burden.: Purpose: We conducted a scoping review aimed at identifying which ... ...

    Abstract Background: Interest in the financial burden of informal caregivers has been growing. Unfortunately, it remains unclear which method(s) should be used when quantifying this burden.
    Purpose: We conducted a scoping review aimed at identifying which methods have been used to conduct such work and quantified their performance. We were also interested in examining how sex and gender considerations were considered within selected studies.
    Data sources: Using a standardized approach, we identified studies published between 2012 and 2022 that aimed to document the financial burden of caregivers to child and adolescent patients. Our search strategy was applied to the MEDLINE, Embase, CINHAL, and Academic Search Premier databases.
    Study selection: Manuscript selection was performed by pairs of reviewers.
    Data extraction: Data extraction was performed by one reviewer with a second reviewer performing quality control. Results were reported using a narrative approach.
    Data synthesis: We identified 9801 unique citations, of which 200 were included in our review. Selected studies covered various disease area (eg, infection/parasitic diseases [n = 31, 16%]) and included quantitative (n = 180, 90%), qualitative (n = 4, 2%) and mixed study designs (n = 16, 8%). Most studies (n = 182, 91%) used questionnaires/surveys, either alone or in combination with other methods, to assess caregivers' financial burden. Less than half (n = 93, 47%) of studies reported on caregivers' sex and none reported on their gender.
    Conclusion: We conducted an unrestricted review of published studies examining caregiver's financial burden which allowed us to identify general methodological trends observed in this literature. We believe this work may help improve future studies focusing on this important issue.
    Language English
    Publishing date 2024-01-26
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2520698-9
    ISSN 1178-6981
    ISSN 1178-6981
    DOI 10.2147/CEOR.S443077
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Downregulation of low-density lipoprotein receptor mRNA in lymphatic endothelial cells impairs lymphatic function through changes in intracellular lipids.

    Vachon, Laurent / Smaani, Ali / Tessier, Nolwenn / Jean, Gabriel / Demers, Annie / Milasan, Andreea / Ardo, Nadine / Jarry, Stéphanie / Villeneuve, Louis / Alikashani, Azadeh / Finherty, Vincent / Ruiz, Matthieu / Sorci-Thomas, Mary G / Mayer, Gaétan / Martel, Catherine

    Theranostics

    2022  Volume 12, Issue 3, Page(s) 1440–1458

    Abstract: Rationale: ...

    Abstract Rationale:
    MeSH term(s) Animals ; Atherosclerosis/genetics ; Atherosclerosis/metabolism ; Cholesterol/metabolism ; Down-Regulation ; Endothelial Cells/metabolism ; Hyperlipidemias/metabolism ; Lipids ; Lipoproteins, LDL/genetics ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Proprotein Convertase 9/genetics ; Proprotein Convertase 9/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Vascular Endothelial Growth Factor C/genetics ; Vascular Endothelial Growth Factor C/metabolism ; Vascular Endothelial Growth Factor Receptor-3/genetics ; Vascular Endothelial Growth Factor Receptor-3/metabolism
    Chemical Substances Lipids ; Lipoproteins, LDL ; RNA, Messenger ; Vascular Endothelial Growth Factor C ; Cholesterol (97C5T2UQ7J) ; Vascular Endothelial Growth Factor Receptor-3 (EC 2.7.10.1) ; PCSK9 protein, human (EC 3.4.21.-) ; Proprotein Convertase 9 (EC 3.4.21.-)
    Language English
    Publishing date 2022-01-01
    Publishing country Australia
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592097-2
    ISSN 1838-7640 ; 1838-7640
    ISSN (online) 1838-7640
    ISSN 1838-7640
    DOI 10.7150/thno.58780
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Development and validation of the FrBio, an international French adaptation of the AzBio sentence lists.

    Bergeron, François / Berland, Aurore / Fitzpatrick, Elizabeth M / Vincent, Christophe / Giasson, Annie / Leung Kam, Kevin / Chafiq, Walid / Fanouillère, Thibaut / Demers, Dominique

    International journal of audiology

    2019  Volume 58, Issue 8, Page(s) 510–515

    Abstract: Objectives: ...

    Abstract Objectives:
    MeSH term(s) Adolescent ; Adult ; Audiometry, Speech/methods ; Case-Control Studies ; Comprehension ; Female ; Hearing ; Hearing Disorders/diagnosis ; Hearing Disorders/physiopathology ; Hearing Disorders/psychology ; Humans ; Male ; Persons With Hearing Impairments/psychology ; Predictive Value of Tests ; Psychometrics ; Reproducibility of Results ; Speech Intelligibility ; Speech Perception ; Young Adult
    Language English
    Publishing date 2019-05-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2073098-6
    ISSN 1708-8186 ; 1499-2027
    ISSN (online) 1708-8186
    ISSN 1499-2027
    DOI 10.1080/14992027.2019.1581950
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The monster in the mirror: reasons for wanting to change appearance.

    Vandervoort, Julianne / Aimé, Annie / Green-Demers, Isabelle

    Eating and weight disorders : EWD

    2014  Volume 20, Issue 1, Page(s) 99–107

    Abstract: Purpose: Many adults are dissatisfied with their body, regardless of their weight, and weight loss is commonly perceived as an effective solution to this dissatisfaction. The main purpose of this study was to examine the reasons for wanting to modify ... ...

    Abstract Purpose: Many adults are dissatisfied with their body, regardless of their weight, and weight loss is commonly perceived as an effective solution to this dissatisfaction. The main purpose of this study was to examine the reasons for wanting to modify one's bodily appearance (shape and weight), and to compare these reasons by sex, age, and weight group.
    Methods: The sample consisted of 796 French-speaking Canadian adults (100 men, 696 women; M age = 27.00 years, SD = 7.88, range 18-64; M body mass index = 24.99 kg/m(2), SD = 6.37, range 12.6-66.5 kg/m(2)) who were asked online whether or not they wanted to change their appearance and if so, why. Answers were subjected to a content analysis wherein recurrent themes were grouped and labeled.
    Results: Most participants (83.2%) wanted to change their appearance. Women, participants with a higher BMI, and older participants were significantly more likely to report this desire. The three most frequently evoked reasons were body dissatisfaction, well-being, and health/shape.
    Conclusions: The results suggest that body dissatisfaction constitutes the primary motive for change for both men and women of all ages, especially for those who are of healthy weight or underweight. Women and younger adults seem to be under the impression that in changing their appearance they will be more comfortable in their own skin. Men, older adults, and overweight adults, on the other hand, are more preoccupied by their health/shape and seldom relate their appearance to their psychological balance.
    MeSH term(s) Adolescent ; Adult ; Age Factors ; Body Image/psychology ; Body Mass Index ; Body Weight/physiology ; Canada ; Female ; Humans ; Male ; Middle Aged ; Motivation ; Personal Satisfaction ; Self Concept ; Sex Factors ; Young Adult
    Language English
    Publishing date 2014-10-30
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2038625-4
    ISSN 1590-1262 ; 1124-4909
    ISSN (online) 1590-1262
    ISSN 1124-4909
    DOI 10.1007/s40519-014-0160-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Estimation of Needs for Addiction Services: A Youth Model.

    Tremblay, Joël / Bertrand, Karine / Blanchette-Martin, Nadine / Rush, Brian / Savard, Annie-Claude / L'Espérance, Nadia / Demers-Lessard, Geneviève / Genois, Rosalie

    Journal of studies on alcohol and drugs. Supplement

    2019  Volume Sup 18, Page(s) 64–75

    Abstract: Objective: In the field of health care services, resource allocation is increasingly determined based on a population needs model. Although service needs models have been developed for adults with substance use problems, it would seem inappropriate to ... ...

    Abstract Objective: In the field of health care services, resource allocation is increasingly determined based on a population needs model. Although service needs models have been developed for adults with substance use problems, it would seem inappropriate to apply them indiscriminately to young people.
    Method: The method used proposes six steps: (1) targeting the population, (2) estimating the proportion of the population affected by substance misuse and (3) the proportion of youths who should receive services, (4) identifying categories of services, (5) estimating the proportions of youths who should have access to each category of services, and (6) applying the model to real use of services by youths to recalibrate it.
    Results: Youths ages 12-17 from the Province of Québec were classified within a tiered model comprising four levels of substance use severity. Youths in need of services varied from 38% (weak response) to 95% (high response) for the highest severity cases. Service categories retained are detoxification/intoxication, outpatient, and residential, with each one being subdivided into four categories. The proportion of youths from each tier who should access categories and subcategories of services varied widely. After a pre-experimentation, the model was adjusted.
    Conclusions: The model can be applied in different jurisdictions, with the caution of adjusting prevalence to local reality. Further improvement will be based on more accurate information concerning the path of clients through services, better strategies to reach youths in need of services, and increased knowledge of optimal service categories. Models adapted to low- or moderate-income countries, where the health care system has minimal services in the areas of mental health and addiction, should be developed.
    MeSH term(s) Adult ; Female ; Finland/epidemiology ; Health Services Needs and Demand/trends ; Humans ; Male ; Mental Disorders/epidemiology ; Mental Disorders/therapy ; Mental Health Services/trends ; Middle Aged ; Statistics as Topic/trends ; Substance-Related Disorders/epidemiology ; Substance-Related Disorders/therapy
    Language English
    Publishing date 2019-01-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1946-5858
    ISSN (online) 1946-5858
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Lower plasma PCSK9 in normocholesterolemic subjects is associated with upregulated adipose tissue surface-expression of LDLR and CD36 and NLRP3 inflammasome.

    Cyr, Yannick / Lamantia, Valérie / Bissonnette, Simon / Burnette, Melanie / Besse-Patin, Aurèle / Demers, Annie / Wabitsch, Martin / Chrétien, Michel / Mayer, Gaétan / Estall, Jennifer L / Saleh, Maya / Faraj, May

    Physiological reports

    2021  Volume 9, Issue 3, Page(s) e14721

    Abstract: Background: LDL-cholesterol lowering variants that upregulate receptor uptake of LDL, such as in PCSK9 and HMGCR, are associated with diabetes via unclear mechanisms. Activation of the NLRP3 inflammasome/interleukin-1 beta (IL-1β) pathway promotes white ...

    Abstract Background: LDL-cholesterol lowering variants that upregulate receptor uptake of LDL, such as in PCSK9 and HMGCR, are associated with diabetes via unclear mechanisms. Activation of the NLRP3 inflammasome/interleukin-1 beta (IL-1β) pathway promotes white adipose tissue (WAT) dysfunction and type 2 diabetes (T2D) and is regulated by LDL receptors (LDLR and CD36). We hypothesized that: (a) normocholesterolemic subjects with lower plasma PCSK9, identifying those with higher WAT surface-expression of LDLR and CD36, have higher activation of WAT NLRP3 inflammasome and T2D risk factors, and; (b) LDL upregulate adipocyte NLRP3 inflammasome and inhibit adipocyte function.
    Methodology: Post hoc analysis was conducted in 27 overweight/ obese subjects with normal plasma LDL-C and measures of disposition index (DI during Botnia clamps) and postprandial fat metabolism. WAT was assessed for surface-expression of LDLR and CD36 (immunohistochemistry), protein expression (immunoblot), IL-1β secretion (AlphaLISA), and function (
    Results: Compared to subjects with higher than median plasma PCSK9, subjects with lower PCSK9 had higher WAT surface-expression of LDLR (+81%) and CD36 (+36%), WAT IL-1β secretion (+284%), plasma IL-1 receptor-antagonist (+85%), and postprandial hypertriglyceridemia, and lower WAT pro-IL-1β protein (-66%), WAT function (-62%), and DI (-28%), without group-differences in body composition, energy intake or expenditure. Adjusting for WAT LDLR or CD36 eliminated group-differences in WAT function, DI, and postprandial hypertriglyceridemia. Native LDL inhibited Simpson-Golabi Behmel-syndrome (SGBS) adipocyte differentiation and function and increased inflammation.
    Conclusion: Normocholesterolemic subjects with lower plasma PCSK9 and higher WAT surface-expression of LDLR and CD36 have higher WAT NLRP3 inflammasome activation and T2D risk factors. This may be due to LDL-induced inhibition of adipocyte function.
    MeSH term(s) Adipocytes, White/immunology ; Adipocytes, White/metabolism ; Adipogenesis ; Adipose Tissue, White/immunology ; Adipose Tissue, White/metabolism ; Aged ; Biomarkers/blood ; CD36 Antigens/metabolism ; Cells, Cultured ; Cholesterol/blood ; Diabetes Mellitus, Type 2/etiology ; Down-Regulation ; Female ; Humans ; Inflammasomes/metabolism ; Interleukin-1beta/metabolism ; Male ; Middle Aged ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Obesity/blood ; Obesity/complications ; Obesity/enzymology ; Obesity/immunology ; Proprotein Convertase 9/blood ; Receptors, LDL/metabolism ; Risk Assessment ; Risk Factors
    Chemical Substances Biomarkers ; CD36 Antigens ; CD36 protein, human ; IL1B protein, human ; Inflammasomes ; Interleukin-1beta ; LDLR protein, human ; NLR Family, Pyrin Domain-Containing 3 Protein ; NLRP3 protein, human ; Receptors, LDL ; Cholesterol (97C5T2UQ7J) ; PCSK9 protein, human (EC 3.4.21.-) ; Proprotein Convertase 9 (EC 3.4.21.-)
    Language English
    Publishing date 2021-02-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2724325-4
    ISSN 2051-817X ; 2051-817X
    ISSN (online) 2051-817X
    ISSN 2051-817X
    DOI 10.14814/phy2.14721
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Identification and feasibility of social participation initiatives reducing isolation and involving rural older Canadians in the development of their community.

    Clément, Annie-Pier / Djilas, Dusica / Vinet, Tanya / Aubin, Ariane / Demers, Karine / Levasseur, Mélanie

    Aging clinical and experimental research

    2017  Volume 30, Issue 7, Page(s) 845–859

    Abstract: Background: Although some social participation initiatives exist to counter the isolation of older adults, none were identified and prioritized according to the needs of rural regional county municipalities (RCM), including in Canada.: Aims: To ... ...

    Abstract Background: Although some social participation initiatives exist to counter the isolation of older adults, none were identified and prioritized according to the needs of rural regional county municipalities (RCM), including in Canada.
    Aims: To identify and prioritize social participation initiatives for older Canadians, and to document the feasibility of their implementation in a rural RCM.
    Methods: An action research was used to identify, based on a review of scientific and grey literature, social participation initiatives, enriched and prioritized by the community. Facilitators, challenges, and advice for the implementation of these initiatives were documented through nine group discussions (n = 85).
    Results: Two social participation initiatives were identified as more relevant to the RCM, combined and adapted as the Benevolent Community to locate and assist isolated older adults. Two other initiatives were prioritized to identify transportation needs and solutions, and create a website on social participation activities available. Most participants perceived these initiatives as feasible, and will address older adults' social participation needs. Two facilitators were a field worker for older adults and the preoccupations of the community toward isolated older adults. The main challenges concerned the difficulty in recruiting volunteers and locating isolated older adults, exacerbated by the RCM's vast territory. Main advice involved suggestions of people for the recruitment of volunteers.
    Discussion: Through valuable collaboration with the community, initiatives were identified and prioritized, and challenges were raised, with anticipated success.
    Conclusions: Further studies are needed to document the implementation and effects of these initiatives on the social participation of older adults in the RCM.
    MeSH term(s) Aged ; Aged, 80 and over ; Canada ; Community Health Services/methods ; Feasibility Studies ; Female ; Health Services Research/methods ; Humans ; Male ; Middle Aged ; Program Development/methods ; Rural Population ; Social Isolation ; Social Participation/psychology ; Volunteers
    Language English
    Publishing date 2017-11-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2104785-6
    ISSN 1720-8319 ; 1594-0667
    ISSN (online) 1720-8319
    ISSN 1594-0667
    DOI 10.1007/s40520-017-0849-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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