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  1. Article: Interview with David S. Fedson, MD, Former Professor of Medicine, University of Virginia School of Medicine, and Director of Medical Affairs, Aventis Pasteur MSD by Madeline Drexler.

    Fedson, David S

    Biosecurity and bioterrorism : biodefense strategy, practice, and science

    2005  Volume 3, Issue 1, Page(s) 9–15

    MeSH term(s) Bioterrorism/prevention & control ; Disease Outbreaks/prevention & control ; Drug Industry/organization & administration ; Global Health ; Health Planning Organizations/organization & administration ; Humans ; Influenza A virus/pathogenicity ; Influenza Vaccines/chemical synthesis ; Influenza Vaccines/economics ; Influenza, Human/epidemiology ; Influenza, Human/prevention & control ; Influenza, Human/virology ; Mass Vaccination/ethics ; Mass Vaccination/organization & administration ; National Institutes of Health (U.S.) ; Politics ; United States/epidemiology
    Chemical Substances Influenza Vaccines
    Language English
    Publishing date 2005
    Publishing country United States
    Document type Interview
    ISSN 1538-7135
    ISSN 1538-7135
    DOI 10.1089/bsp.2005.3.9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Recommending Higher Valent Pneumococcal Conjugate Vaccine for Older Adults.

    Fedson, David S

    JAMA internal medicine

    2023  Volume 183, Issue 6, Page(s) 623

    MeSH term(s) Humans ; Aged ; Vaccines, Conjugate ; Pneumococcal Infections/prevention & control ; Pneumococcal Vaccines
    Chemical Substances Vaccines, Conjugate ; Pneumococcal Vaccines
    Language English
    Publishing date 2023-04-02
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2699338-7
    ISSN 2168-6114 ; 2168-6106
    ISSN (online) 2168-6114
    ISSN 2168-6106
    DOI 10.1001/jamainternmed.2023.0548
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  3. Article: Treating COVID-19: Targeting the Host Response, Not the Virus.

    Fedson, David S

    Life (Basel, Switzerland)

    2023  Volume 13, Issue 3

    Abstract: In low- and middle-income countries (LMICs), inexpensive generic drugs like statins, ACE inhibitors, and ARBs, especially if used in combination, might be the only practical way to save the lives of patients with severe COVID-19. These drugs will already ...

    Abstract In low- and middle-income countries (LMICs), inexpensive generic drugs like statins, ACE inhibitors, and ARBs, especially if used in combination, might be the only practical way to save the lives of patients with severe COVID-19. These drugs will already be available in all countries on the first pandemic day. Because they target the host response to infection instead of the virus, they could be used to save lives during any pandemic. Observational studies show that inpatient statin treatment reduces 28-30-day mortality but randomized controlled trials have failed to show this benefit. Combination treatment has been tested for antivirals and dexamethasone but, with the exception of one observational study in Belgium, not for inexpensive generic drugs. Future pandemic research must include testing combination generic drug treatments that could be used in LMICs.
    Language English
    Publishing date 2023-03-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life13030712
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  4. Article ; Online: In-Hospital Statin Treatment of COVID-19.

    Fedson, David S

    The Journal of infectious diseases

    2021  Volume 227, Issue 5, Page(s) 731–732

    MeSH term(s) Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; COVID-19 ; Hospitals ; Retrospective Studies
    Chemical Substances Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Language English
    Publishing date 2021-12-11
    Publishing country United States
    Document type Letter
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiab601
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  5. Article ; Online: Treating COVID-19

    David S. Fedson

    Life, Vol 13, Iss 712, p

    Targeting the Host Response, Not the Virus

    2023  Volume 712

    Abstract: In low- and middle-income countries (LMICs), inexpensive generic drugs like statins, ACE inhibitors, and ARBs, especially if used in combination, might be the only practical way to save the lives of patients with severe COVID-19. These drugs will already ...

    Abstract In low- and middle-income countries (LMICs), inexpensive generic drugs like statins, ACE inhibitors, and ARBs, especially if used in combination, might be the only practical way to save the lives of patients with severe COVID-19. These drugs will already be available in all countries on the first pandemic day. Because they target the host response to infection instead of the virus, they could be used to save lives during any pandemic. Observational studies show that inpatient statin treatment reduces 28–30-day mortality but randomized controlled trials have failed to show this benefit. Combination treatment has been tested for antivirals and dexamethasone but, with the exception of one observational study in Belgium, not for inexpensive generic drugs. Future pandemic research must include testing combination generic drug treatments that could be used in LMICs.
    Keywords host response treatment ; COVID-19 ; generic drugs ; statins ; ACE inhibitors ; angiotensin receptor blockers ; Science ; Q
    Subject code 630
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Statin Treatment of COVID-19.

    Fedson, David S

    The American journal of cardiology

    2020  Volume 136, Page(s) 171–173

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Chemical Substances Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Keywords covid19
    Language English
    Publishing date 2020-09-28
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/j.amjcard.2020.09.050
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  7. Article ; Online: Statin withdrawal and treating COVID-19 patients.

    Fedson, David S

    Pharmacology research & perspectives

    2020  Volume 9, Issue 6, Page(s) e00861

    Abstract: Most but not all observational studies of statin treatment of COVID-19 patients suggest that treatment improves outcomes. However, almost all of these studies fail to consider that withdrawing statins after hospital admission may have detrimental effects, ...

    Abstract Most but not all observational studies of statin treatment of COVID-19 patients suggest that treatment improves outcomes. However, almost all of these studies fail to consider that withdrawing statins after hospital admission may have detrimental effects, a finding which cardiovascular investigators have known for 15-20 years. Continuing or starting statin treatment after hospital admission consistently improves cardiovascular outcomes. Similarly, inpatient statin treatment of COVID-19 improves survival. For this reason, observational studies of the effectiveness of outpatient-documented statin treatment of COVID-19 patients must consider the negative consequences of statin withdrawal after hospital admission.
    MeSH term(s) Hospital Mortality ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Meta-Analysis as Topic ; Observational Studies as Topic ; Patient Admission ; Treatment Outcome ; Withholding Treatment ; COVID-19 Drug Treatment
    Chemical Substances Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Language English
    Publishing date 2020-10-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2740389-0
    ISSN 2052-1707 ; 2052-1707
    ISSN (online) 2052-1707
    ISSN 2052-1707
    DOI 10.1002/prp2.861
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  8. Article ; Online: COVID-19, host response treatment, and the need for political leadership.

    Fedson, David S

    Journal of public health policy

    2020  Volume 42, Issue 1, Page(s) 6–14

    Abstract: Health officials and scientists have warned that we face the threat of a potentially devastating influenza pandemic. Instead, we are now in the midst of a global coronavirus (COVID-19) pandemic. National and international pandemic preparedness plans have ...

    Abstract Health officials and scientists have warned that we face the threat of a potentially devastating influenza pandemic. Instead, we are now in the midst of a global coronavirus (COVID-19) pandemic. National and international pandemic preparedness plans have focused on developing vaccines and antiviral treatments. Another way to confront the COVID-19 pandemic (and future pandemics) might be to treat patients with inexpensive and widely available generic drugs that target the host response to infection, not the virus itself. The feasibility of this idea was tested during the Ebola outbreak in West Africa in 2014. This experience should inform our approach to treating COVID-19 patients. It could also save lives during outbreaks of other emerging infectious diseases and episodes of everyday acute critical illness. If this "bottom up" syndromic approach to treating acute critical illness were shown to be effective, it could have a dramatic impact on health, equity and security throughout the world. HIGHLIGHTS: Uncertainty about the outcome of COVID-19 is driving the social, economic and political distress associated with the pandemic. Treating the host response to COVID-19 with inexpensive and widely available generic drugs might save lives and mitigate this distress. Undertaking research on this idea will require political leadership.
    MeSH term(s) Antiviral Agents/supply & distribution ; Antiviral Agents/therapeutic use ; Biomedical Research ; COVID-19/epidemiology ; COVID-19 Vaccines ; Drugs, Generic/supply & distribution ; Drugs, Generic/therapeutic use ; Humans ; Leadership ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/virology ; Politics ; SARS-CoV-2 ; COVID-19 Drug Treatment
    Chemical Substances Antiviral Agents ; COVID-19 Vaccines ; Drugs, Generic
    Language English
    Publishing date 2020-12-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 603208-4
    ISSN 1745-655X ; 0197-5897
    ISSN (online) 1745-655X
    ISSN 0197-5897
    DOI 10.1057/s41271-020-00266-7
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  9. Article ; Online: Treating Ebola in eastern DRC.

    Fedson, David S

    The Lancet. Infectious diseases

    2019  Volume 19, Issue 10, Page(s) 1059–1060

    MeSH term(s) Democratic Republic of the Congo ; Disease Outbreaks ; Hemorrhagic Fever, Ebola/epidemiology ; Humans
    Language English
    Publishing date 2019-09-27
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(19)30484-0
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    Zs.A 5743: Show issues Location:
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  10. Article: Influenza pandemic preparedness: A special challenge for India.

    Fedson, David S

    The Indian journal of medical research

    2019  Volume 150, Issue 3, Page(s) 217–220

    MeSH term(s) Adult ; Child ; China/epidemiology ; Disaster Planning/methods ; Humans ; India/epidemiology ; Influenza A Virus, H7N9 Subtype ; Influenza, Human/drug therapy ; Influenza, Human/epidemiology ; Influenza, Human/prevention & control ; Pandemics/prevention & control ; Patient Safety ; Public Health
    Language English
    Publishing date 2019-11-12
    Publishing country India
    Document type Journal Article
    ZDB-ID 390883-5
    ISSN 0971-5916 ; 0019-5340
    ISSN 0971-5916 ; 0019-5340
    DOI 10.4103/ijmr.IJMR_2034_18
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