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  1. Article: Battle against therapeutic nihilism in caring for patients who exhibit the negative symptoms of schizophrenia (NSS)

    Bermanzohn, P C / Siris, S G

    Comprehensive psychiatry

    1994  Volume 35, Issue 6, Page(s) 478

    MeSH term(s) Antipsychotic Agents/administration & dosage ; Antipsychotic Agents/adverse effects ; Depression/drug therapy ; Depression/psychology ; Drug Therapy, Combination ; Humans ; Levodopa/administration & dosage ; Levodopa/adverse effects ; Schizophrenia/drug therapy ; Schizophrenic Psychology
    Chemical Substances Antipsychotic Agents ; Levodopa (46627O600J)
    Language English
    Publishing date 1994-11
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 127556-2
    ISSN 1532-8384 ; 0010-440X
    ISSN (online) 1532-8384
    ISSN 0010-440X
    DOI 10.1016/0010-440x(94)90232-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Noncompliance with antiparkinsonian medications in neuroleptic-treated schizophrenic patients: three cases of an unreported phenomenon.

    Bermanzohn, P C / Siris, S G

    The Journal of clinical psychiatry

    1994  Volume 55, Issue 11, Page(s) 488–491

    Abstract: Background: Depression is commonly associated with the longitudinal course of schizophrenia. Several etiologies for this problem have been proposed but, to our knowledge, noncompliance with antiparkinsonian medications has not been considered.: Method! ...

    Abstract Background: Depression is commonly associated with the longitudinal course of schizophrenia. Several etiologies for this problem have been proposed but, to our knowledge, noncompliance with antiparkinsonian medications has not been considered.
    Method: Case histories of two patients who were noncompliant and one who threatened noncompliance with antiparkinsonian medications are presented. All three patients were diagnosed with schizophrenia by DSM-III-R criteria and had been clinically stable for long periods.
    Results: All three patients became depressed when their adjunctive benztropine was stopped, and their depressions remitted when their benztropine was reinstated.
    Conclusion: Noncompliance with antiparkinsonian medications may be associated with a reversible depression in patients receiving maintenance neuroleptics for schizophrenia. Since this is a newly described phenomenon, the scope of the problem is not known; however, it may contribute to the wide prevalence of depressive symptoms in schizophrenia. Clinical measures to facilitate detection of such noncompliance are discussed.
    MeSH term(s) Adult ; Antiparkinson Agents/administration & dosage ; Antiparkinson Agents/therapeutic use ; Antipsychotic Agents/adverse effects ; Antipsychotic Agents/therapeutic use ; Basal Ganglia Diseases/chemically induced ; Benztropine/administration & dosage ; Benztropine/therapeutic use ; Depressive Disorder/chemically induced ; Dyskinesia, Drug-Induced/etiology ; Female ; Humans ; Male ; Parkinson Disease, Secondary/etiology ; Parkinson Disease, Secondary/prevention & control ; Schizophrenia/drug therapy ; Treatment Refusal
    Chemical Substances Antiparkinson Agents ; Antipsychotic Agents ; Benztropine (1NHL2J4X8K)
    Language English
    Publishing date 1994-11
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 716287-x
    ISSN 1555-2101 ; 0160-6689
    ISSN (online) 1555-2101
    ISSN 0160-6689
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  3. Article: Akinesia: a syndrome common to parkinsonism, retarded depression, and negative symptoms of schizophrenia.

    Bermanzohn, P C / Siris, S G

    Comprehensive psychiatry

    1992  Volume 33, Issue 4, Page(s) 221–232

    Abstract: A distinct hypokinetic syndrome appears to exist across several different neuropsychiatric diagnoses, involving (1) slowed motor activity with difficulty initiating and sustaining behaviors, (2) anhedonia with depressed mood and reduced affective range, ... ...

    Abstract A distinct hypokinetic syndrome appears to exist across several different neuropsychiatric diagnoses, involving (1) slowed motor activity with difficulty initiating and sustaining behaviors, (2) anhedonia with depressed mood and reduced affective range, and (3) cognitive impairment. Specifically, three well-recognized states--parkinsonism, retarded depression, and the negative symptoms of schizophrenia--prominently feature the components of this syndrome, and reduced dopamine turnover in the brain has been hypothesized to play a part in the pathophysiology of each. While aspects of this conceptualization remain controversial, it generates testable hypotheses that could have implications for the understanding and treatment of these states.
    MeSH term(s) Antipsychotic Agents/adverse effects ; Antipsychotic Agents/therapeutic use ; Depressive Disorder/diagnosis ; Depressive Disorder/physiopathology ; Dopamine/physiology ; Dyskinesia, Drug-Induced/diagnosis ; Dyskinesia, Drug-Induced/physiopathology ; Humans ; Motor Activity/drug effects ; Motor Activity/physiology ; Neurologic Examination/drug effects ; Parkinson Disease/diagnosis ; Parkinson Disease/physiopathology ; Receptors, Dopamine/drug effects ; Receptors, Dopamine/physiology ; Schizophrenia/diagnosis ; Schizophrenia/physiopathology ; Schizophrenic Psychology
    Chemical Substances Antipsychotic Agents ; Receptors, Dopamine ; Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 1992-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Review
    ZDB-ID 127556-2
    ISSN 1532-8384 ; 0010-440X
    ISSN (online) 1532-8384
    ISSN 0010-440X
    DOI 10.1016/0010-440x(92)90045-r
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  4. Article: Clinical trials and tribulations: implementation processes in schizophrenia research outcome.

    Mason, S E / Bermanzohn, P C / Siris, S G

    Psychiatry

    1998  Volume 61, Issue 4, Page(s) 288–301

    Abstract: This article focuses on an area in clinical drug trials for new antipsychotic medications for the treatment of schizophrenia which has not received sufficient attention in the literature: the day-to-day implementation tasks performed by research staff ... ...

    Abstract This article focuses on an area in clinical drug trials for new antipsychotic medications for the treatment of schizophrenia which has not received sufficient attention in the literature: the day-to-day implementation tasks performed by research staff which have potential effects on study results. Implementation tasks are viewed as dynamic processes involving interactions among research and nonresearch staff, patients, families, and pharmaceutical company staff. Research-related demands and possible sources of stress for all participants in the process, such as recruiting and maintaining patients in studies, are discussed. Suggestions are offered for increasing the ease of participation. Further investigation is called for in several areas including variability in the effectiveness of research teams and in the rarely discussed interactions between site staff and pharmaceutical company personnel, as they may affect research outcomes. It is posited that increased knowledge about implementation processes in schizophrenia drug development is needed to more fully understand study results and to enhance patients' and their families' willingness to participate.
    MeSH term(s) Antipsychotic Agents/adverse effects ; Antipsychotic Agents/therapeutic use ; Bias ; Clinical Trials as Topic/statistics & numerical data ; Humans ; Interprofessional Relations ; Patient Care Team ; Patient Dropouts/psychology ; Patient Dropouts/statistics & numerical data ; Patient Selection ; Schizophrenia/diagnosis ; Schizophrenia/drug therapy ; Treatment Outcome
    Chemical Substances Antipsychotic Agents
    Language English
    Publishing date 1998
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 209433-2
    ISSN 1943-281X ; 0033-2747
    ISSN (online) 1943-281X
    ISSN 0033-2747
    DOI 10.1080/00332747.1998.11024841
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Relationship of panic attacks to paranoia.

    Bermanzohn, P C / Arlow, P B / Albert, C / Siris, S G

    The American journal of psychiatry

    1999  Volume 156, Issue 9, Page(s) 1469

    MeSH term(s) Adult ; Comorbidity ; Humans ; Male ; Panic Disorder/diagnosis ; Panic Disorder/epidemiology ; Panic Disorder/psychology ; Paranoid Disorders/diagnosis ; Paranoid Disorders/epidemiology ; Paranoid Disorders/psychology ; Psychotic Disorders/diagnosis ; Psychotic Disorders/psychology ; Schizophrenia/diagnosis ; Schizophrenia/epidemiology ; Schizophrenic Psychology
    Language English
    Publishing date 1999-09
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 280045-7
    ISSN 1535-7228 ; 0002-953X
    ISSN (online) 1535-7228
    ISSN 0002-953X
    DOI 10.1176/ajp.156.9.1469
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  6. Article: Improvement of clozapine-induced sialorrhea after septoplasty.

    Conry, A / Siris, S G / Bermanzohn, P C

    The American journal of psychiatry

    1996  Volume 153, Issue 3, Page(s) 444

    MeSH term(s) Adult ; Clozapine/adverse effects ; Deglutition ; Humans ; Male ; Mouth Breathing/complications ; Nasal Septum/injuries ; Nasal Septum/surgery ; Schizophrenia, Paranoid/drug therapy ; Sialorrhea/chemically induced
    Chemical Substances Clozapine (J60AR2IKIC)
    Language English
    Publishing date 1996-03
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 280045-7
    ISSN 1535-7228 ; 0002-953X
    ISSN (online) 1535-7228
    ISSN 0002-953X
    DOI 10.1176/ajp.153.3.444
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  7. Article: Predicting rehabilitation outcome among patients with schizophrenia.

    Ferdinandi, A D / Yoottanasumpun, V / Pollack, S / Bermanzohn, P C

    Psychiatric services (Washington, D.C.)

    1998  Volume 49, Issue 7, Page(s) 907–909

    MeSH term(s) Adult ; Day Care, Medical/methods ; Female ; Humans ; Interpersonal Relations ; Male ; Mental Disorders/rehabilitation ; Motivation ; New York ; Patient Acceptance of Health Care ; Patient Care Planning ; Pilot Projects ; Psychiatric Status Rating Scales ; Psychometrics/methods ; Schizophrenia/rehabilitation ; Schizophrenic Psychology ; Treatment Outcome
    Language English
    Publishing date 1998-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1220173-x
    ISSN 1557-9700 ; 1075-2730
    ISSN (online) 1557-9700
    ISSN 1075-2730
    DOI 10.1176/ps.49.7.907
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  8. Article: Panic and paranoia.

    Bermanzohn, P C / Arlow, P B / Pitch, R J / Siris, S G

    The Journal of clinical psychiatry

    1997  Volume 58, Issue 7, Page(s) 325–326

    MeSH term(s) Humans ; Panic Disorder/complications ; Panic Disorder/psychology ; Paranoid Disorders/etiology ; Paranoid Personality Disorder/etiology ; Schizophrenia/etiology
    Language English
    Publishing date 1997-08-15
    Publishing country United States
    Document type Letter
    ZDB-ID 716287-x
    ISSN 1555-2101 ; 0160-6689
    ISSN (online) 1555-2101
    ISSN 0160-6689
    DOI 10.4088/jcp.v58n0707e
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  9. Article: Hierarchical diagnosis in chronic schizophrenia: a clinical study of co-occurring syndromes.

    Bermanzohn, P C / Porto, L / Arlow, P B / Pollack, S / Stronger, R / Siris, S G

    Schizophrenia bulletin

    2000  Volume 26, Issue 3, Page(s) 517–525

    Abstract: Co-occurring or associated psychiatric syndromes (APS) such as depression, obsessive-compulsive disorder (OCD), and panic disorder have largely been hidden from view by exclusion rules that prohibit their being diagnosed in the presence of schizophrenia. ...

    Abstract Co-occurring or associated psychiatric syndromes (APS) such as depression, obsessive-compulsive disorder (OCD), and panic disorder have largely been hidden from view by exclusion rules that prohibit their being diagnosed in the presence of schizophrenia. This article presents data from a clinical study of APS in chronic schizophrenia and reviews the relevant literature. Thirty-seven chronic schizophrenia patients consecutively admitted to a day program were administered the Structured Clinical Interview for Diagnosis for DSM-IV and the Yale-Brown Obsessive Compulsive Scale symptom checklist. Exclusion rules prohibiting the diagnosis of APS were bypassed. Eighteen patients (48.6%) had one or more APS. Ten patients (27%) had major depression. Eleven (29.7%) met criteria for OCD. Four patients (10.8%) met criteria for panic disorder. These findings suggest that APS may be common in chronic schizophrenia and that there is a need to study these syndromes' clinical validity, including their treatability. A research plan to study the validity of these syndromes further is discussed.
    MeSH term(s) Adult ; Chronic Disease ; Clinical Trials as Topic ; Comorbidity ; Depressive Disorder, Major/complications ; Depressive Disorder, Major/epidemiology ; Female ; Humans ; Male ; Obsessive-Compulsive Disorder/complications ; Obsessive-Compulsive Disorder/epidemiology ; Panic Disorder/complications ; Panic Disorder/epidemiology ; Psychiatric Status Rating Scales ; Schizophrenia/complications ; Schizophrenia/diagnosis ; Severity of Illness Index ; Syndrome
    Language English
    Publishing date 2000
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 439173-1
    ISSN 1745-1701 ; 0586-7614
    ISSN (online) 1745-1701
    ISSN 0586-7614
    DOI 10.1093/oxfordjournals.schbul.a033472
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Bromocriptine for "negative" schizophrenia.

    Levi-Minzi, S / Bermanzohn, P C / Siris, S G

    Comprehensive psychiatry

    1991  Volume 32, Issue 3, Page(s) 210–216

    Abstract: The hypothesis that the pathophysiology of negative symptoms in schizophrenia may involve relative hypoactivity of central dopaminergic neurotransmission prompts the exploration of dopamine agonist strategies in the treatment of this condition. Although ... ...

    Abstract The hypothesis that the pathophysiology of negative symptoms in schizophrenia may involve relative hypoactivity of central dopaminergic neurotransmission prompts the exploration of dopamine agonist strategies in the treatment of this condition. Although the use of dopamine agonists in otherwise unmedicated schizophrenic patients often leads to the exacerbation of psychosis, trials of dopamine agonists in combination with neuroleptic agents warrant investigation. We therefore report on open clinical experience involving six patients with chronic negative symptoms of schizophrenia, maintained on neuroleptic medication, who appeared to have favorable responses to the addition of moderate doses of bromocriptine (10 to 20 mg/d orally in divided doses). One particular factor that makes these trials potentially informative is that five of the six patients had failed to respond to standard treatments with anticholinergic antiparkinsonian medication before the bromocriptine trial, making it unlikely that the bromocriptine had its effect purely by counteracting neuroleptic-induced akinesia. A trial of bromocriptine under these circumstances has never been reported. A second unique feature of this report concerns the lengthy period of follow-up. Adjunctive bromocriptine was continued for a total of 27 patient-years in the six individuals, with maintenance of favorable course and minimal incidence of psychotic exacerbation.
    MeSH term(s) Activities of Daily Living/psychology ; Adult ; Antipsychotic Agents/therapeutic use ; Bromocriptine/therapeutic use ; Dose-Response Relationship, Drug ; Drug Therapy, Combination ; Female ; Humans ; Male ; Middle Aged ; Schizophrenia/drug therapy ; Schizophrenic Psychology ; Social Environment
    Chemical Substances Antipsychotic Agents ; Bromocriptine (3A64E3G5ZO)
    Language English
    Publishing date 1991-05
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 127556-2
    ISSN 1532-8384 ; 0010-440X
    ISSN (online) 1532-8384
    ISSN 0010-440X
    DOI 10.1016/0010-440x(91)90041-a
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