Article ; Online: Immunoregulatory natural killer cells.
Clinica chimica acta; international journal of clinical chemistry
2024 , Page(s) 117896
Abstract: This review discusses a broader scope of functional roles for NK cells. Despite the well-known cytolytic and inflammatory roles of NK cells against tumors and pathogenic diseases, extensive evidence demonstrates certain subsets of NK cells have defacto ... ...
| Abstract | This review discusses a broader scope of functional roles for NK cells. Despite the well-known cytolytic and inflammatory roles of NK cells against tumors and pathogenic diseases, extensive evidence demonstrates certain subsets of NK cells have defacto immunoregulatory effects and have a role in inducing anergy or lysis of antigen-activated T cells and regulating several autoimmune diseases. Furthermore, recent evidence suggests certain subsets of immunoregulatory NK cells can cause anergy or lysis of antigen-activated T cells to regulate hyperinflammatory diseases, including multisystem inflammatory syndrome. Several pathogens induce T cell and NK cell exhaustion and/or suppression, which impair the immune system's control of the replication speed of virulent pathogens and tumors and result in extensive antigens and antigen-antibody immune complexes, potentially inducing a Type III hypersensitivity immune reaction. The Type III hypersensitivity immune reaction induces immune cell secretion of proteinases, which can create autoantigens which activate T cells to initiate autoimmune and/or hyperinflammatory diseases. Furthermore, pathogen induced NK cell exhaustion and/or suppression will inhibit NK cells which would have induced the anergy or lysis of activated T cells to regulate autoimmune and hyperinflammatory diseases. Autoimmune and hyperinflammatory diseases can be consequences of the dual lymphocyte exhaustion and/or suppression effects during infections, by creating autoimmune and/or hyperinflammatory diseases, while also impairing lymphocytes which would have regulated these diseases. |
|---|---|
| Language | English |
| Publishing date | 2024-04-05 |
| Publishing country | Netherlands |
| Document type | Journal Article ; Review |
| ZDB-ID | 80228-1 |
| ISSN | 1873-3492 ; 0009-8981 |
| ISSN (online) | 1873-3492 |
| ISSN | 0009-8981 |
| DOI | 10.1016/j.cca.2024.117896 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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