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Article: Hundedame Kylie streicheln heisst einen Moment purer Freude geniessen : Therapiehunde-Besuche bedeuten Lebensqualität für Menschen mit einer Demenz

Sträuli, Esther / Furrer Dominique

2020 Volume 91, Issue 4, Page(s) 39–41

Keywords	Therapiehunde ; Menschen mit Demenz ; Bedürfnis
Language	German
Document type	Article
ZDB-ID	2101595-8
ISSN	1663-6058
ISSN	1663-6058
Database	bibnet.org

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Article ; Online: Therapiehunde-Besuche bedeuten Lebensqualität für Menschen mit einer Demenz

Sträuli, Esther / Furrer, Dominique

Curaviva : Fachzeitschrift ; 2101595-8 ; 1663-6058 ; 91 ; 2020 ; 4 ; 39

Hundedame Kylie streicheln heisst einen Moment purer Freude geniessen

2020

Publisher	Curaviva - Verband Heime und Institutionen Schweiz
Publishing country	ch
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Retrospective Case Series Reporting the Outcomes of Avance Nerve Allografts in the Treatment of Peripheral Nerve Injuries.

Leckenby, Jonathan I / Furrer, Curdin / Haug, Luzian / Juon Personeni, Bettina / Vögelin, Esther

Plastic and reconstructive surgery

2020 Volume 145, Issue 2, Page(s) 368e–381e

Abstract: Background: Acellular nerve allografts are a viable treatment modality for bridging nerve gaps. Several small studies have demonstrated results equal to those of autologous grafts; however, there is information lacking with regard to outcomes for wider ... ...

Abstract	Background: Acellular nerve allografts are a viable treatment modality for bridging nerve gaps. Several small studies have demonstrated results equal to those of autologous grafts; however, there is information lacking with regard to outcomes for wider indications. The authors evaluated the outcomes of patients treated with a nerve allograft in a variety of clinical situations. Methods: A retrospective chart analysis was completed between April of 2009 and October of 2017. Inclusion criteria were age 18 years or older at the time of surgery and treatment with a nerve allograft. Patients were excluded if they had not been followed up for a minimum of 6 months. The modified Medical Research Council Classification was used to monitor motor and sensory changes in the postoperative period. Results: Two hundred seven nerve allografts were used in 156 patients; of these, 129 patients with 171 nerve allografts fulfilled the inclusion criteria. Seventy-seven percent of patients achieved a sensory outcome score of S3 or above and 36 percent achieved a motor score of M3 or above. All patients with chronic pain had improvement of their symptoms. Graft length and diameter were negatively correlated with reported outcomes. One patient elected to undergo revision surgery, and the original graft was shown histologically to have extensive central necrosis. Anatomically, allografts used for lower limb reconstruction yielded the poorest results. All chronic patients had a significantly lower postoperative requirement for analgesia, and allografts were effective in not only reducing pain but also restoring a functional level of sensation. Conclusions: This study supports the wider application of allografts in managing nerve problems. However, caution must be applied to the use of long grafts with larger diameters. Clinical question/level of evidence: Therapeutic, IV.
MeSH term(s)	Adult ; Aged ; Allografts ; Female ; Humans ; Male ; Middle Aged ; Nerve Regeneration/physiology ; Neuralgia/surgery ; Peripheral Nerve Injuries/surgery ; Peripheral Nerves/transplantation ; Reconstructive Surgical Procedures/methods ; Retrospective Studies ; Young Adult
Language	English
Publishing date	2020-01-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	208012-6
ISSN	1529-4242 ; 0032-1052 ; 0096-8501
ISSN (online)	1529-4242
ISSN	0032-1052 ; 0096-8501
DOI	10.1097/PRS.0000000000006485
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Rate of treatment success and associated factors in the program for drug-susceptible tuberculosis in the Forest Region, Republic of Guinea, 2010-2017: A real-world retrospective observational cohort study.

Schoenbaechler, Valérie / Guilavogui, Yakpazouo / Onivogui, Sosso / Hébélamou, Jean / Mugglin, Catrina / Furrer, Hansjakob / Henzen, Corina / Bavogui, Esther Kolou / Kolié, Cécé / Zoumanigui, Pévé / Béavogui, Ismaël / Leuenberger, David / Staehelin, Cornelia

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

2021 Volume 110, Page(s) 6–14

Abstract: Objectives: To analyze the treatment success rate (TSR = sum of cured or treatment completed) in the tuberculosis (TB) program for drug-susceptible TB (DS-TB) at the "Centre Hospitalier Régional Spécialisé" in Macenta, Forest Region, Republic of Guinea.! ...

Abstract	Objectives: To analyze the treatment success rate (TSR = sum of cured or treatment completed) in the tuberculosis (TB) program for drug-susceptible TB (DS-TB) at the "Centre Hospitalier Régional Spécialisé" in Macenta, Forest Region, Republic of Guinea. Methods: This cohort study included patients who started treatment for DS-TB between 2010 and 2017. Data collection was part of the documentation for the national TB program. Descriptive analysis was applied to determine the TSR in various patient groups. Further, logistic regression was performed to determine factors influencing the TSR in new and relapsed cases versus all other previously treated cases. A subgroup analysis for only microbiologically confirmed pulmonary TB was added. Results: The study included 3969 patients. The TSR increased from 68.3% in 2010 to 80.8% in 2017 (p < 0.001). Mortality (11.2%) mainly occurred in early treatment months, while loss to follow-up (5.9%) increased towards later treatment months. Risk factors for low TSR were advanced age, positive HIV status, long travel distances (>100 km) to the clinic, and late treatment refill. Conclusion: The TSR in the Forest Region of Guinea remained below the WHO goal of 90%. Reaching this target remains a challenge in rural areas with high early mortality and increased risk of loss to follow-up.
MeSH term(s)	Antitubercular Agents/therapeutic use ; Cohort Studies ; Forests ; Guinea/epidemiology ; HIV Infections/drug therapy ; Humans ; Pharmaceutical Preparations ; Retrospective Studies ; Treatment Outcome ; Tuberculosis/drug therapy ; Tuberculosis/epidemiology
Chemical Substances	Antitubercular Agents ; Pharmaceutical Preparations
Language	English
Publishing date	2021-06-10
Publishing country	Canada
Document type	Journal Article ; Observational Study
ZDB-ID	1331197-9
ISSN	1878-3511 ; 1201-9712
ISSN (online)	1878-3511
ISSN	1201-9712
DOI	10.1016/j.ijid.2021.06.014
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Gastrointestinal stability of therapeutic anti-TNF α IgG1 monoclonal antibodies.

Yadav, Vipul / Varum, Felipe / Bravo, Roberto / Furrer, Esther / Basit, Abdul W

International journal of pharmaceutics

2016 Volume 502, Issue 1-2, Page(s) 181–187

Abstract: Monoclonal antibodies (mAbs) are highly effective therapeutic agents, administered exclusively by the parenteral route owing to their previously-documented instability in the gastrointestinal (GI) tract when delivered orally. To investigate the extent of ...

Abstract	Monoclonal antibodies (mAbs) are highly effective therapeutic agents, administered exclusively by the parenteral route owing to their previously-documented instability in the gastrointestinal (GI) tract when delivered orally. To investigate the extent of the validity of this assumption, the stability of the tumor necrosis factor alpha (TNF-α) neutralizing IgG1 mAbs, infliximab and adalimumab, was studied in human GI conditions. In gastric fluid, infliximab and adalimumab degraded rapidly, with complete degradation occurring within 1 min. In small intestinal fluid, the molecules were shown to be more stable, but nonetheless degraded within a short time frame of 30 min. Investigations into the mechanisms responsible for infliximab and adalimumab instability in the small intestine revealed that the proteolytic enzyme elastase, and to a lesser extent the enzymes trypsin and chymotrypsin, was responsible for their degradation. By contrast, in the human colon, 75% and 50% of the dose of infliximab and adalimumab, respectively, were intact after 60 min, with conversion of mAbs into F(ab')2 Fab and Fc fragments detected in colonic conditions. These data indicate that therapeutic IgG1 antibodies are more stable in the colon than in the upper GI tract, therefore highlighting the potential for oral delivery of anti-TNF-α mAbs targeted to the colon.
MeSH term(s)	Adalimumab/chemistry ; Antirheumatic Agents/chemistry ; Chymotrypsin/chemistry ; Colon/metabolism ; Feces/chemistry ; Gastric Juice/chemistry ; Humans ; Immunoglobulin G/immunology ; Infliximab/chemistry ; Intestinal Secretions/chemistry ; Pancreatic Elastase/chemistry ; Pancreatin/chemistry ; Trypsin/chemistry ; Tumor Necrosis Factor-alpha/immunology
Chemical Substances	Antirheumatic Agents ; Immunoglobulin G ; Tumor Necrosis Factor-alpha ; Pancreatin (8049-47-6) ; Infliximab (B72HH48FLU) ; Chymotrypsin (EC 3.4.21.1) ; alpha-chymotrypsin (EC 3.4.21.1) ; Pancreatic Elastase (EC 3.4.21.36) ; Trypsin (EC 3.4.21.4) ; Adalimumab (FYS6T7F842)
Language	English
Publishing date	2016-04-11
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	428962-6
ISSN	1873-3476 ; 0378-5173
ISSN (online)	1873-3476
ISSN	0378-5173
DOI	10.1016/j.ijpharm.2016.02.014
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Inflammatory bowel disease: exploring gut pathophysiology for novel therapeutic targets.

Yadav, Vipul / Varum, Felipe / Bravo, Roberto / Furrer, Esther / Bojic, Daniela / Basit, Abdul W

Translational research : the journal of laboratory and clinical medicine

2016 Volume 176, Page(s) 38–68

Abstract: Ulcerative colitis and Crohn's disease are the 2 major phenotypes of inflammatory bowel disease (IBD), which are influenced by a complex interplay of immunological and genetic elements, though the precise etiology still remains unknown. With IBD ... ...

Abstract	Ulcerative colitis and Crohn's disease are the 2 major phenotypes of inflammatory bowel disease (IBD), which are influenced by a complex interplay of immunological and genetic elements, though the precise etiology still remains unknown. With IBD developing into a globally prevailing disease, there is a need to explore new targets and a thorough understanding of the pathophysiological differences between the healthy and diseased gut could unearth new therapeutic opportunities. In this review, we provide an overview of the major aspects of IBD pathogenesis and thereafter present a comprehensive analysis of the gut pathophysiology leading to a discussion on some of the most promising targets and biologic therapies currently being explored. These include various gut proteins (CXCL-10, GATA-3, NKG2D, CD98, microRNAs), immune cells recruited to the gut (mast cells, eosinophils, toll-like receptors 2, 4), dysregulated proinflammatory cytokines (interleukin-6, -13, -18, -21), and commensal microbiota (probiotics and fecal microbiota transplantation). We also evaluate some of the emerging nonconventional therapies being explored in IBD treatment focusing on the latest developments in stem cell research, oral targeting of the gut-associated lymphoid tissue, novel anti-inflammatory signaling pathway targeting, adenosine deaminase inhibition, and the beneficial effects of antioxidant and nutraceutical therapies. In addition, we highlight the growth of biologics and their targets in IBD by providing information on the preclinical and clinical development of over 60 biopharmaceuticals representing the state of the art in ulcerative colitis and Crohn's disease drug development.
MeSH term(s)	Animals ; Biological Products/pharmacology ; Biological Products/therapeutic use ; Gastrointestinal Tract/drug effects ; Gastrointestinal Tract/microbiology ; Gastrointestinal Tract/pathology ; Gastrointestinal Tract/physiopathology ; Humans ; Inflammatory Bowel Diseases/drug therapy ; Inflammatory Bowel Diseases/genetics ; Inflammatory Bowel Diseases/physiopathology ; Inflammatory Bowel Diseases/therapy ; Microbiota/drug effects ; Molecular Targeted Therapy ; Signal Transduction/drug effects
Chemical Substances	Biological Products
Language	English
Publishing date	2016-10
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2246684-8
ISSN	1878-1810 ; 1532-6543 ; 1931-5244
ISSN (online)	1878-1810 ; 1532-6543
ISSN	1931-5244
DOI	10.1016/j.trsl.2016.04.009
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Thesis: Kontrolle des Virus der Bornaschen Krankheit durch neutralisierende Antikörper und eine frühe zelluläre Immunantwort

Furrer, Esther Maria

2000

Author's details	vorgelegt von Esther Maria Furrer
Language	German
Size	2 Mikrofiches, Ill., graph. Darst
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Eidgenössische Techn. Hochsch., Diss--Zürich, 2000
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: Intranasal delivery of ESBA105, a TNF-alpha-inhibitory scFv antibody fragment to the brain.

Furrer, Esther / Hulmann, Valérie / Urech, David M

Journal of neuroimmunology

2009 Volume 215, Issue 1-2, Page(s) 65–72

Abstract: Intranasal drug administration is an attractive route for targeted delivery of large molecular weight compounds to the central nervous system (CNS). The purpose of this study was to assess the feasibility of this non-invasive application method in mice, ... ...

Abstract	Intranasal drug administration is an attractive route for targeted delivery of large molecular weight compounds to the central nervous system (CNS). The purpose of this study was to assess the feasibility of this non-invasive application method in mice, for delivery of ESBA105, a TNF-alpha inhibitory single-chain antibody fragment (scFv) with a molecular weight of 26.3kDa, to the brain. Pharmacokinetic parameters were determined for different brain regions (olfactory bulb, cerebrum, cerebellum, brain stem) and for serum, following both, intranasal and intravenous administrations of 400microg and 40microg ESBA105, respectively. ESBA105 efficiently migrated from the nasal cavity to the brain and maximum ESBA105 concentrations (C(max)) in the brain were measured between 1.1 and 12.2microg/mg of the total protein. Although a 10-fold higher dose was given intranasally, systemic exposure was about 33-fold lower for the intranasal route than following systemic application. Addition of a penetration enhancing peptide to the formulation enhanced the delivery of ESBA105 to the olfactory bulb and the cerebrum, without increasing systemic exposure.
MeSH term(s)	Administration, Intranasal ; Animals ; Antibody Affinity ; Brain/drug effects ; Brain/immunology ; Brain/metabolism ; Drug Delivery Systems/methods ; Humans ; Immunoglobulin Fragments/administration & dosage ; Immunoglobulin Fragments/metabolism ; Male ; Mice ; Mice, Inbred BALB C ; Tissue Distribution/immunology ; Tumor Necrosis Factor-alpha/antagonists & inhibitors ; Tumor Necrosis Factor-alpha/immunology ; Tumor Necrosis Factor-alpha/metabolism
Chemical Substances	Immunoglobulin Fragments ; Tumor Necrosis Factor-alpha
Language	English
Publishing date	2009-10-30
Publishing country	Netherlands
Document type	Comparative Study ; Journal Article
ZDB-ID	8335-5
ISSN	1872-8421 ; 0165-5728
ISSN (online)	1872-8421
ISSN	0165-5728
DOI	10.1016/j.jneuroim.2009.08.005
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Article: Polyclonal Intestinal Colonization with Extended-Spectrum Cephalosporin-Resistant Enterobacteriaceae upon Traveling to India.

Pires, João / Kuenzli, Esther / Kasraian, Sara / Tinguely, Regula / Furrer, Hansjakob / Hilty, Markus / Hatz, Christoph / Endimiani, Andrea

Frontiers in microbiology

2016 Volume 7, Page(s) 1069

Abstract: We aimed to assess the intestinal colonization dynamics by multiple extended-spectrum cephalosporin-resistant Enterobacteriaceae (ESC-R-Ent) clones in Swiss travelers to India, a country with high prevalence of these multidrug-resistant pathogens. ... ...

Abstract	We aimed to assess the intestinal colonization dynamics by multiple extended-spectrum cephalosporin-resistant Enterobacteriaceae (ESC-R-Ent) clones in Swiss travelers to India, a country with high prevalence of these multidrug-resistant pathogens. Fifteen healthy volunteers (HVs) colonized with ESC-R-Ent after traveling to India who provided stools before, after, and at 3- and 6-month follow-up are presented in this study. Stools were enriched in a LB broth containing 3 mg/L cefuroxime and plated in standard selective media (BLSE, ChromID ESBL, Supercarba) to detect carbapenem- and/or ESC-R-Ent. At least 5 Enterobacteriaceae colonies were analyzed for each stool provided. All strains underwent phenotypic tests (MICs in microdilution) and molecular typing to define bla genes (microarray, PCR/sequencing), clonality (MLST, rep-PCR), and plasmid content. While only three HVs were colonized before the trip, all participants had positive stools after returning, but the colonization rate decreased during the follow-up period (i.e., six HVs were still colonized at both 3 and 6 months). More importantly, polyclonal acquisition (median of 2 clones, range 1-5) was identified at return in all HVs. The majority of the Escherichia coli isolates belonged to phylogenetic groups A and B1 and to high diverse non-epidemic sequence types (STs); however, 15% of them belonged to clonal complex 10 and mainly possessed bla CTX-M-15 genes. F family plasmids were constantly found (~80%) in the recovered ESC-R-Ent. Our results indicate a possible polyclonal acquisition of the ESC-R-Ent via food-chain and/or through an environmental exposure. For some HVs, prolonged colonization in the follow-up period was observed due to clonal persistence or presence of the same plasmid replicon types in a new bacterial host. Travel medicine practitioners, clinicians, and clinical microbiologists who are facing the returning travelers and their samples for different reasons should be aware of this important phenomenon, so that better infection control measures, treatment strategies, and diagnostic tests can be adopted.
Language	English
Publishing date	2016-07-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2016.01069
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Book ; Online: Kontrolle des Virus der Bornaschen Krankheit durch neutralisierende Antikörper und eine frühe zelluläre Immunantwort

Furrer, Esther Maria

2000

Abstract: Diss. Naturwissenschaften ETH Zürich, Nr. 13626, ... ...

Abstract	Diss. Naturwissenschaften ETH Zürich, Nr. 13626, 2000
Keywords	BORNAVIRUS (VIROLOGIE) ; ANTIKÖRPER + IMMUNOGLOBULINE + GAMMAGLOBULINE (IMMUNOLOGIE) ; ZELLULÄRE IMMUNANTWORT (IMMUNOLOGIE)
Language	German
Publisher	Zürich
Publishing country	ch
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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