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Article ; Online: Occurrence and seasonal variations of antibiotic micro-pollutants in the Wei River, China.

Cao, Shengkai / Zhang, Peng / Halsall, Crispin / Hou, Zhimin / Ge, Linke

2024 Volume 252, Issue Pt 1, Page(s) 118863

Abstract: ... macrolides (MLs), fluoroquinolones (FQs) and sulfonamides (SAs) was performed in the Xi'an section of the Wei ... that the distribution of antibiotics in the Wei River was affected by the confluence with dilution of tributaries and ...

Abstract	In this study, a systematic monitoring campaign of 30 antibiotics belonging to tetracyclines (TCs), macrolides (MLs), fluoroquinolones (FQs) and sulfonamides (SAs) was performed in the Xi'an section of the Wei River during three sampling events (December 2021, June 2022, and September 2022). The total concentrations of antibiotics in water ranged from 297 to 461 ng/L with high detection frequencies ranging from 45% to 100% for the various antibiotics. A marked seasonal variation in concentrations was found with total antibiotic concentrations in winter being 1.5 and 2 times higher than those in the summer and autumn seasons, respectively. The main contaminants in both winter and summer seasons were FQs, but in the autumn SAs were more abundant, suggesting different seasonal sources or more effective runoff for certain antibiotics during periods of rainfall. Combined analysis using redundancy and clustering analysis indicated that the distribution of antibiotics in the Wei River was affected by the confluence with dilution of tributaries and outlet of domestic sewage. Ecological risk assessment based on risk quotient (RQ) showed that most antibiotics in water samples posed insignificant risk to fish and green algae, as well as insignificant to low risk to Daphnia. The water-sediment distribution coefficients of SAs were higher than those of other antibiotics, indicating that particle-bound runoff could be a significant source for this class of antibiotics.
Language	English
Publishing date	2024-04-03
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2024.118863
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Article ; Online: Assessing ecological health in a semi-arid basin: a case study of the Wei River Basin, China.

Yang, Yonglin / Cao, Hongye / Xia, Yuyun / Liu, Dong / Liu, Yang / Qiao, Jianwei

Environmental science and pollution research international

2024 Volume 31, Issue 14, Page(s) 21687–21708

Abstract: ... health has emerged as a primary focus in current research. In this study, we selected the Wei River Basin ... River Ecological Health Assessment Index (REHAI) system. The research findings indicate that the Wei ... as sub-healthy. Furthermore, we observed variations within the Wei River system itself; the upper reaches ...

Abstract	A healthy water ecosystem within a river basin is essential for maintaining ecological security, preserving species diversity, and ensuring sustainable socio-economic development. Unfortunately, human activities have significantly threatened the health of water ecosystems in various basins. Consequently, timely restoration and targeted protection of damaged river ecosystems have become crucial objectives in watershed management. As a prerequisite and cornerstone for river protection and management, assessing river ecological health has emerged as a primary focus in current research. In this study, we selected the Wei River Basin, a representative area of the Yellow River Basin, as our research subject. We identified multiple influencing factors, including society, biology, water quality, and habitat, which collectively impact this semi-arid region. To assess the overall impact of these factors on ecological health, we developed a comprehensive River Ecological Health Assessment Index (REHAI) system. The research findings indicate that the Wei River system, as a whole, is currently in a healthy state, while the Jing and Luo River systems are classified as sub-healthy. Furthermore, we observed variations within the Wei River system itself; the upper reaches of the Wei River exhibit higher levels of health compared to the middle reaches, whereas the water environment in the lower reaches is the most compromised. This degradation can be attributed to downstream subsidence, increased pollution, and rapid urbanization. By establishing a river ecosystem health assessment methodology and conducting a comprehensive evaluation of the health status of river ecosystems, this paper puts forward management recommendations for river basins. These findings provide a scientific basis for the sustainable utilization of water resources in river basins and promote the harmonious coexistence of humanity and nature.
MeSH term(s)	Humans ; Ecosystem ; Water Quality ; Water Resources ; Rivers ; China
Language	English
Publishing date	2024-02-23
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-024-32377-z
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Article ; Online: Liquid chromatography-mass spectrometry-based strategy for systematic profiling of chemical components and associated quantitative analysis of quality markers in Qi-Wei-Tong-Bi oral liquid.

Huang, Xiaojun / Fei, Qingqing / Yu, Sheng / Qiu, Rongli / Geng, Ting / Chen, Xialin / Cao, Liang / Wang, Zhenzhong / Shan, Mingqiu

Journal of separation science

2024 Volume 47, Issue 5, Page(s) e2300922

Abstract: Qi-Wei-Tong-Bi oral liquid (QWTB), a famous Chinese medicine preparation composed of seven crude ...

Abstract	Qi-Wei-Tong-Bi oral liquid (QWTB), a famous Chinese medicine preparation composed of seven crude drugs has a good therapeutic effect on rheumatoid arthritis and is widely used in China. However, its chemical composition and quality control have not been comprehensively and systematically investigated. In this study, high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry was employed for its chemical profiling. As a result, 100 components were chemically characterized. Additionally, high-performance liquid chromatography coupled with a quadrupole linear ion trap mass spectrometry method was developed to simultaneously quantify nine bioactive components (hyperoside, ononin, quercetin, sinomenine, magnoflorine, gallic acid, protocatechuic acid, monotropein, and cyclo-(Pro-Tyr)) in multiple-reaction monitoring mode. After successful validation in terms of linearity, precision, repeatability, and recovery, the assay method was applied for the determination of 10 batches of QWTB. The results showed that QWTB was enriched in sinomenine and magnoflorine with the highest amount up to hundreds or even thousands of µg/mL, while quercetin, ononin, cyclo-(Pro-Tyr), and hyperoside were much lower with the lowest content below 10 µg/mL. This study work would help to reveal the chemical profiling and provide a valuable and reliable approach for quality evaluation and even pharmacodynamic material basis studies of QWTB.
MeSH term(s)	Chromatography, High Pressure Liquid/methods ; Drugs, Chinese Herbal/analysis ; Flavonoids/analysis ; Liquid Chromatography-Mass Spectrometry ; Quercetin/analysis ; Tandem Mass Spectrometry/methods
Chemical Substances	Drugs, Chinese Herbal ; Flavonoids ; Quercetin (9IKM0I5T1E)
Language	English
Publishing date	2024-03-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2047990-6
ISSN	1615-9314 ; 1615-9306
ISSN (online)	1615-9314
ISSN	1615-9306
DOI	10.1002/jssc.202300922
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Article ; Online: Response of aerosol composition to the clean air actions in Baoji city of Fen-Wei River Basin.

Wang, Yichen / Li, Xia / Wang, Qiyuan / Zhou, Bianhong / Liu, Suixin / Tian, Jie / Hao, Qiang / Li, Guohui / Han, Yongming / Hang Ho, Steven Sai / Cao, Junji

Environmental research

2022 Volume 210, Page(s) 112936

Abstract: ... control measures and provide more scientific basis for the formulation of new measures. The Fen-Wei River Basin is ... Baoji was selected as a representative city in the Fen-Wei River Basin. The compositions of submicron ...

Abstract	The implementation of air pollution control measures could alter the compositions of submicron aerosols. Identifying the changes can evaluate the atmospheric responses of the implemented control measures and provide more scientific basis for the formulation of new measures. The Fen-Wei River Basin is the most air polluted region in China, and thereby is a key area for the reduction of emissions. Only limited studies determine the changes in the chemical compositions of submicron aerosols. In this study, Baoji was selected as a representative city in the Fen-Wei River Basin. The compositions of submicron aerosols were determined between 2014 and 2019. Organic fractions were determined through an online instrument (Quadrupole Aerosol Chemical Speciation Monitor, Q-ACSM) and source recognition was performed by the Multilinear Engine (ME-2). The Weather Research and Forecasting model coupled with Chemistry (WRF-Chem) was also employed to evaluate the contributions of emissions reduction and meteorological conditions to the changes of submicron aerosol compositions. The results indicate that the mass concentrations of submicron aerosols have been substantially decreased after implementation of air pollution control measures. This was mainly attributed to the emission reductions of sulfur dioxide (SO
MeSH term(s)	Aerosols/analysis ; Air Pollutants/analysis ; Air Pollution/analysis ; Air Pollution/prevention & control ; China ; Environmental Monitoring/methods ; Nitrates ; Nitrogen Oxides/analysis ; Particulate Matter/analysis ; Rivers
Chemical Substances	Aerosols ; Air Pollutants ; Nitrates ; Nitrogen Oxides ; Particulate Matter
Language	English
Publishing date	2022-02-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2022.112936
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Article: Response of aerosol composition to the clean air actions in Baoji city of Fen-Wei River Basin

Wang, Yichen / Li, Xia / Wang, Qiyuan / Zhou, Bianhong / Liu, Suixin / Tian, Jie / Hao, Qiang / Li, Guohui / Han, Yongming / Hang Ho, Steven Sai / Cao, Junji

Environmental research. 2022 July, v. 210

2022

Abstract	The implementation of air pollution control measures could alter the compositions of submicron aerosols. Identifying the changes can evaluate the atmospheric responses of the implemented control measures and provide more scientific basis for the formulation of new measures. The Fen-Wei River Basin is the most air polluted region in China, and thereby is a key area for the reduction of emissions. Only limited studies determine the changes in the chemical compositions of submicron aerosols. In this study, Baoji was selected as a representative city in the Fen-Wei River Basin. The compositions of submicron aerosols were determined between 2014 and 2019. Organic fractions were determined through an online instrument (Quadrupole Aerosol Chemical Speciation Monitor, Q-ACSM) and source recognition was performed by the Multilinear Engine (ME-2). The Weather Research and Forecasting model coupled with Chemistry (WRF-Chem) was also employed to evaluate the contributions of emissions reduction and meteorological conditions to the changes of submicron aerosol compositions. The results indicate that the mass concentrations of submicron aerosols have been substantially decreased after implementation of air pollution control measures. This was mainly attributed to the emission reductions of sulfur dioxide (SO₂) and primary organic aerosol (POA). In addition, the main components that drove the pollution episodes swapped from POA, sulfate, nitrate and less-oxidized organic (LO-OOA) in 2014 to nitrate and more-oxidized OOA (MO-OOA) in 2019. Due to the changes of chemical compositions of both precursors and secondary pollutants, the pollution control measures should be modernized to focus on the emissions of ammonia (NH₃), nitrogen oxides (NOₓ) and volatile organic compounds (VOCₛ) in this region.
Keywords	aerosols ; air ; air pollution control ; ammonia ; chemical speciation ; nitrates ; nitrogen ; pollution ; research ; sulfates ; sulfur dioxide ; volatile organic compounds ; watersheds
Language	English
Dates of publication	2022-07
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2022.112936
Database	NAL-Catalogue (AGRICOLA)

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Article: [A multicenter randomized controlled study of bismuth-containing quadruple therapy followed by Jing-Hua-Wei-Kang in the treatment of patients newly diagnosed with

Ma, P P / Meng, L N / Wang, M T / Jin, H F / Fan, Y H / Zha, A S / Huo, X H / Chen, D F / Cao, Z Q / Tang, X F / Yang, P / Shi, Z H / Li, T W / Meng, J / Gan, C / Chen, G X / Sha, W H / Du, Q / Li, Y /

Lyu, B

Zhonghua yi xue za zhi

2021 Volume 101, Issue 26, Page(s) 2060–2065

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Amoxicillin/therapeutic use ; Anti-Bacterial Agents/therapeutic use ; Bismuth/therapeutic use ; China ; Drug Therapy, Combination ; Dyspepsia/drug therapy ; Female ; Helicobacter Infections/drug therapy ; Helicobacter pylori ; Humans ; Male ; Middle Aged ; Treatment Outcome
Chemical Substances	Anti-Bacterial Agents ; Amoxicillin (804826J2HU) ; Bismuth (U015TT5I8H)
Language	Chinese
Publishing date	2021-07-18
Publishing country	China
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial
ZDB-ID	132513-9
ISSN	0376-2491
ISSN	0376-2491
DOI	10.3760/cma.j.cn112137-20210305-00563
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Article: Erratum: Zhao, J.; Shen, X.; Cao, X.; He, H.; Han, S.; Chen, Y.; Cui, C.; Wei, Y.; Wang, Y.; Li, D.; Zhu, Q.; Yin, H. HDAC4 Regulates the Proliferation, Differentiation and Apoptosis of Chicken Skeletal Muscle Satellite Cells.

Zhao, Jing / Shen, Xiaoxu / Cao, Xinao / He, Haorong / Han, Shunshun / Chen, Yuqi / Cui, Can / Wei, Yuanhang / Wang, Yan / Li, Diyan / Zhu, Qing / Yin, Huadong

Animals : an open access journal from MDPI

2020 Volume 10, Issue 12

Abstract: The authors wish to make the following corrections to their paper [ ... ]. ...

Abstract	The authors wish to make the following corrections to their paper [...].
Language	English
Publishing date	2020-12-07
Publishing country	Switzerland
Document type	Published Erratum
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani10122322
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Article ; Online: Geochemistry and environmental assessment of major and trace elements in the surface sediments of the Wei River, China.

Han, Y M / Cao, J J / Wu, F / Zhang, B C / Zhan, C L / Wei, C / Zhao, Z Z

Journal of environmental monitoring : JEM

2012 Volume 14, Issue 10, Page(s) 2762–2771

Abstract: ... and river pollution. The Wei River is the largest tributary of the Huang He River ... from the Wei and analyzed for 24 elements by WDXRF; objectives for the study were to investigate ... to dilution of contaminants by the large sand inflows into the Wei and a lower level of industrialization ...

Abstract	The development of western China in the past decade has led to increased discharges of wastewater and river pollution. The Wei River is the largest tributary of the Huang He River, but its geochemistry has not been thoroughly investigated. Sixty-three bed-surface sediment samples were collected from the Wei and analyzed for 24 elements by WDXRF; objectives for the study were to investigate the geochemical properties of the sediments; identify sources, and assess pollution levels and environmental risks. Major and trace element concentrations were comparable with those in other large rivers in China, but potentially hazardous trace elements (PHTEs) were lower than in the Yangzi or Pearl Rivers; most likely due to dilution of contaminants by the large sand inflows into the Wei and a lower level of industrialization. Nonetheless, pollution and risk analyses demonstrate slight contamination of Cr, Mn, Nb, Ni and Zn, moderate contamination of Cu and Pb, and strong contamination of As at some locations. Adverse biological effects from Ni and Cu are possible and are likely from As. Statistical and spatial analyses indicate that agriculture runoff and industrial wastewater discharge contribute to the contamination of this river. A comprehensive environmental management strategy, realistic national standards for wastewater discharge, and rigid enforcement are needed to address river pollution in China.
MeSH term(s)	Agriculture ; China ; Environmental Monitoring ; Geologic Sediments/chemistry ; Rivers/chemistry ; Trace Elements/analysis ; Waste Water/analysis ; Water Pollutants, Chemical/analysis ; Water Pollution, Chemical/statistics & numerical data
Chemical Substances	Trace Elements ; Waste Water ; Water Pollutants, Chemical
Language	English
Publishing date	2012-10-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1453583-x
ISSN	1464-0333 ; 1464-0325
ISSN (online)	1464-0333
ISSN	1464-0325
DOI	10.1039/c2em30269a
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Article: Jia-Wei-Kai-Xin-San, an Herbal Medicine Formula, Ameliorates Cognitive Deficits via Modulating Metabolism of Beta Amyloid Protein and Neurotrophic Factors in Hippocampus of Aβ

Zhu, Yue / Shi, Yiwei / Cao, Cheng / Han, Zhenxiang / Liu, Mengqiu / Qi, Mingzhu / Huang, Renjie / Zhu, Ziqiang / Qian, Dawei / Duan, Jin-Ao

Frontiers in pharmacology

2019 Volume 10, Page(s) 258

Abstract: Jia-Wei-Kai-Xin-San (JWKXS) is a Chinese medicine formula applied for treating morbid forgetfulness ...

Abstract	Jia-Wei-Kai-Xin-San (JWKXS) is a Chinese medicine formula applied for treating morbid forgetfulness in ancient China. Today, this formula is frequently applied for Alzheimer's disease and vascular dementia (VD) in clinic. Here, we developed it as granules and aimed to evaluate its anti-AD effect on β amyloid protein 1-42 (Aβ
Language	English
Publishing date	2019-03-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2019.00258
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Article ; Online: Comparative pharmacokinetic study of the components of Jia-Wei-Kai-Xin-San in normal and vascular dementia rats by ultra-fast liquid chromatography coupled with tandem mass spectrometry.

Shi, Yiwei / Cao, Cheng / Zhu, Yue / Gao, Ting / Yang, Wen / Liu Mingzhu Qi, Mengqiu / Huang, Renjie / Qian, Dawei / Duan, Jin-Ao

Journal of separation science

2018 Volume 41, Issue 12, Page(s) 2504–2516

Abstract: ... of extracts of Jia-Wei-Kai-Xin-San in normal and vascular dementia rats. The developed method was precise and ...

Abstract	A fast, sensitive, and reliable ultra-high performance liquid chromatography coupled with tandem mass spectrometry method has been developed and validated for simultaneous quantification of geniposide, polygalaxanthone III, 3,6'-disinapoyl sucrose, α-asarone, β-asarone, poricoic acid A, poricoic acid B, dehydrotumulosic acid, deoxyschizandrin, schizandrin B, and kaempferide in plasma after oral administration of extracts of Jia-Wei-Kai-Xin-San in normal and vascular dementia rats. The developed method was precise and accurate within the linearity range of the analytes. The lower limits of quantification were 1.04-2.68 ng/mL for all the analytes. Both intra- and inter day precision and accuracy of the analytes were all within accepted criteria. The mean extraction recoveries of the analytes and the internal standard from rat plasma were all >60.0%. The validated method had been successfully applied to compare pharmacokinetic profiles of the analytes in plasma of normal and vascular dementia rat treated with herbal extracts. Results indicated that differences existed between normal and vascular dementia model rats except dehydrotumulosic acid and kaempferide, which might be due to the pathology of vascular dementia and pharmacological effect of the analytes. These pharmacokinetic studies might benefit for the mechanism exploration and clinical use of traditional Chinese medicine formulae.
MeSH term(s)	Administration, Oral ; Animals ; Chromatography, High Pressure Liquid/methods ; Dementia, Vascular/blood ; Dementia, Vascular/drug therapy ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/analysis ; Drugs, Chinese Herbal/pharmacokinetics ; Humans ; Male ; Plasma/chemistry ; Rats ; Rats, Sprague-Dawley ; Tandem Mass Spectrometry/methods
Chemical Substances	Drugs, Chinese Herbal ; Kai-Xin-San
Language	English
Publishing date	2018-04-23
Publishing country	Germany
Document type	Comparative Study ; Evaluation Studies ; Journal Article
ZDB-ID	2047990-6
ISSN	1615-9314 ; 1615-9306
ISSN (online)	1615-9314
ISSN	1615-9306
DOI	10.1002/jssc.201701144
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