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Article: Correction: Palmeira et al. Preliminary Virtual Screening Studies to Identify GRP78 Inhibitors Which May Interfere with SARS-CoV-2 Infection.

Palmeira, Andreia / Sousa, Emília / Köseler, Aylin / Sabirli, Ramazan / Gören, Tarık / Türkçüer, İbrahim / Kurt, Özgür / Pinto, Madalena M / Vasconcelos, M Helena

Pharmaceuticals (Basel, Switzerland)

2024 Volume 17, Issue 4

Abstract: There was an error in the original publication [ ... ]. ...

Abstract	There was an error in the original publication [...].
Language	English
Publishing date	2024-03-25
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2193542-7
ISSN	1424-8247
ISSN	1424-8247
DOI	10.3390/ph17040411
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Article: Evaluation of Serum Ischemia Modified Albumin in Patients With COVID-19 Pneumonia: A Case-Control Study.

Altintas, Emel / Sabirli, Ramazan / Yuksekkaya, Esra / Kurt, Ozgur / Koseler, Aylin

Cureus

2022 Volume 14, Issue 8, Page(s) e28334

Abstract: Introduction: Various biomarkers are used when evaluating the hospitalization needs of patients diagnosed with Coronavirus disease (COVID-19). Ischemia-modified albumin (IMA) is a biomarker that causes blood levels to increase as a result of hypoxia and ...

Abstract	Introduction: Various biomarkers are used when evaluating the hospitalization needs of patients diagnosed with Coronavirus disease (COVID-19). Ischemia-modified albumin (IMA) is a biomarker that causes blood levels to increase as a result of hypoxia and acidosis. We think that an increase in IMA in the blood may be caused by hypoxia stemming from lung damage. This study aimed to compare the mean/median of the blood IMA value in patients with pneumonia due to COVID-19 infection with a control group. Methods: The case group included patients with COVID-19 pneumonia detected by lung imaging and a positive COVID test. Demographic information of the case group, the severity of pneumonia, and their PCR test results were recorded in the data set. Findings: A total of 150 people, 90 of whom were in the case group and 60 of whom were in the control group, participated in the study. No statistically significant differences were found between the blood IMA levels of the case group and the control group. When the blood IMA levels of the case group were compared according to pneumonia severity, no statistically significant differences were found between the mild-moderate and severe pneumonia groups. Conclusion: Blood IMA levels are not a diagnostic biomarker for patients with COVID-19 pneumonia and are not helpful in predicting the severity of pneumonia.
Language	English
Publishing date	2022-08-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.28334
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Article ; Online: CYP2C191 and CYP2C192 Polymorphism in Turkish Patients Being Diagnosed with Stable Coronary Artery Disease and Using Clopidogrel

Ramazan Sabırlı / Aylin Köseler / Atakan Yılmaz / İsmail Doğu Kılıç

Bagcilar Medical Bulletin, Vol 6, Iss 1, Pp 53-

2021 Volume 60

Abstract: Objective:The CYP2C19*1 has an entirely normal activity allele whose clopidogrel metabolism is normal. CYP2C19*2 called as non-functional alleles. In this study, we aimed to establish the CYP2C19*1 and CYP2C19*2 genotype frequencies both in Turkish ... ...

Abstract	Objective:The CYP2C191 has an entirely normal activity allele whose clopidogrel metabolism is normal. CYP2C192 called as non-functional alleles. In this study, we aimed to establish the CYP2C191 and CYP2C192 genotype frequencies both in Turkish patients with coronary artery disease (CAD), who used clopidogrel, and in healthy Turkish population as well as to present the differences in genotypes and alleles between both groups.Method:One hundred healthy individuals and 200 patients diagnosed with CAD were included in the study. DNA was isolated and CYP2C19 gene was amplified through the polymerase chain reaction method in the genomic DNAs obtained, and the polymorphic foci in these regions were specified.Results:CYP2C191/1 genotype was identified in 132 patients (66%), CYP2C191/2 genotype in 62 patients (31%) and CYP2C192/2 genotype in 6 patients (3%) in the CAD group. In the control group, by contrast, 72 patients (72%) were identified with CYP2C191/1 genotype, 20 patients with CYP2C191/2 genotype and 8 patients with CYP2C192/2 genotype. There was a significant difference between the groups in terms of genotypes (p=0.034).Conclusion:We found CYP2C191/2 and CYP2C192/2 genotype to be higher in the CAD patients than in the control group, highlighting the importance of checking CYP2C19 gene polymorphism prior to the initiation of antiplatelet therapy in CAD patients.
Keywords	clopidogrel metabolism ; coronary artery disease ; cyp2c19 polymorphism ; turkish population ; Medicine ; R
Subject code	610
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	Galenos Yayinevi
Document type	Article ; Online
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Article ; Online: DNA methylation profiles in pneumonia patients reflect changes in cell types and pneumonia severity.

Morselli, Marco / Farrell, Colin / Montoya, Dennis / Gören, Tarık / Sabırlı, Ramazan / Türkçüer, İbrahim / Kurt, Özgür / Köseler, Aylin / Pellegrini, Matteo

Epigenetics

2022 Volume 17, Issue 12, Page(s) 1646–1660

Abstract: Immune cell-type composition changes with age, potentially weakening the response to infectious diseases. Profiling epigenetics marks of immune cells can help us understand the relationship with disease severity. We therefore leveraged a targeted DNA ... ...

Abstract	Immune cell-type composition changes with age, potentially weakening the response to infectious diseases. Profiling epigenetics marks of immune cells can help us understand the relationship with disease severity. We therefore leveraged a targeted DNA methylation method to study the differences in a cohort of pneumonia patients (both COVID-19 positive and negative) and unaffected individuals from peripheral blood.This approach allowed us to predict the pneumonia diagnosis with high accuracy (AUC = 0.92), and the PCR positivity to the SARS-CoV-2 viral genome with moderate, albeit lower, accuracy (AUC = 0.77). We were also able to predict the severity of pneumonia (PORT score) with an R
MeSH term(s)	Humans ; SARS-CoV-2/genetics ; COVID-19/genetics ; DNA Methylation ; Pneumonia/genetics ; Biomarkers
Chemical Substances	Biomarkers
Language	English
Publishing date	2022-03-21
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	1559-2308
ISSN (online)	1559-2308
DOI	10.1080/15592294.2022.2051862
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Article: A Hypertrophic Spinal Pachymeningitis Patient With Factor V Leiden (G1691A), MTHFR C677T, MTHFR A1298C, PAI-1 4G-5G, Glycoprotein IIIa L33P Gene Mutations.

Civlan, Serkan / Harvey, Cemre / Herek, Duygu / Türkçüer, İbrahim / Sabirli, Ramazan / Pellegrini, Matteo / Koseler, Aylin

Cureus

2022 Volume 14, Issue 10, Page(s) e29937

Abstract: Hypertrophic pachymeningitis (HP) is a rare clinical entity of diverse etiology, characterized by a chronic inflammation that causes dura thickening. Reports of Idiopathic hypertrophic cranial pachymeningitis (IHCP) were related to infections, trauma, ... ...

Abstract	Hypertrophic pachymeningitis (HP) is a rare clinical entity of diverse etiology, characterized by a chronic inflammation that causes dura thickening. Reports of Idiopathic hypertrophic cranial pachymeningitis (IHCP) were related to infections, trauma, tumors, and rheumatologic conditions. It was first described by Charcot and Joffroy regarding spinal meninges in 1869. HP has three stages; progressive radicular symptoms begin first, then muscle weakness and atrophy start. Findings such as paraplegia, loss of bladder and bowel control, and respiratory distress caused by intercostal and diaphragmatic denervation are considered the third stage of the disease. Especially in the cranial form of the disease, nerve ischemia and various cranial neuropathic findings may occur. Factor V Leiden (G1691A), MTHFR C677T, MTHFR A1298C, and PAI-1 4G-5G gene mutation analysis were measured with an ABI Prism. In this case report, the authors present a case of hypertrophic mutations pachymeningitis with Factor V Leiden (G1691A), MTHFR C677T, MTHFR A1298C, PAI-1 4G-5G, Glycoprotein IIIa L33P gene. In conclusion, we report a case of HP with Factor V Leiden (G1691A), MTHFR C677T, MTHFR A1298C, PAI-1 4G-5G, and Glycoprotein IIIa L33P gene mutations. We emphasize that the identification of pachymeningitis can be easily bypassed with the application of limited laboratory techniques. As in this case report, we think that these mutations should be analyzed in patients diagnosed with pachymeningitis.
Language	English
Publishing date	2022-10-05
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.29937
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Article ; Online: Knowledge and Skill Levels of the Medical Students with Basic Life Support Education

Atakan Yılmaz / Ramazan Sabırlı / Murat Seyit / Mert Özen

Van Tip Dergisi, Vol 26, Iss 3, Pp 324-

2019 Volume 330

Abstract: INTRODUCTION: The purpose of our study is to determine the level of knowledge and skills of the medical students, who are medical candidates for the future,about the subject and the self-confidence of initiating BLS immediately without the 112 emergency ... ...

Abstract	INTRODUCTION: The purpose of our study is to determine the level of knowledge and skills of the medical students, who are medical candidates for the future,about the subject and the self-confidence of initiating BLS immediately without the 112 emergency aid ambulance crew arriving at the scene in case of a sudden cardiac arrest. METHODS: The participants include 289 freshmen, sophomores, and junior students studying at the Faculty of Medicine,XXXXXX University,XXXXX,Turkey during the 2014-2015 academic year.The effects of gender, driving license, sporting interest, receiving word attack skills education before, receiving word attack skills education at university, having CPR training on the model at university upon the location of press, depth of press, speed of press, and pressure rhythm scores were investigated. RESULTS: 159 students(55.1%) were female and 130 students(44.9%) were male.The number of students with a driving license was 151(52.2%).It was found that the scores for press location of the students who took word attack skills education at university prior to the study were significantly higher than their counterparts with no such education(p=0.003).The scores for press location of the students who received CPR training on the model at university before the study were found to be significantly higher than those with no such education (p=0.009). DISCUSSION AND CONCLUSION: As a result, medical faculty students who are often capable of reaching the scene faster than the health care professionals in the regions where they live should be provided with BLS trainings down from the start of their education life in an attempt to increase their knowledge and skills.
Keywords	basic life support ; bls ; medical students ; cardiopulmonary resusciation ; cpr ; Medicine ; R
Subject code	370
Language	English
Publishing date	2019-07-01T00:00:00Z
Publisher	Van Yuzuncu Yil University, School of Medicine
Document type	Article ; Online
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Article ; Online: The methylome of buccal epithelial cells is influenced by age, sex, and physiological properties.

Protti, Giulia / Rubbi, Liudmilla / Gören, Tarik / Sabirli, Ramazan / Civlan, Serkan / Kurt, Özgür / Türkçüer, İbrahim / Köseler, Aylin / Pellegrini, Matteo

Physiological genomics

2023 Volume 55, Issue 12, Page(s) 618–633

Abstract: Epigenetic modifications, particularly DNA methylation, have emerged as regulators of gene expression and are implicated in various biological processes and disease states. Understanding the factors influencing the epigenome is essential for unraveling ... ...

Abstract	Epigenetic modifications, particularly DNA methylation, have emerged as regulators of gene expression and are implicated in various biological processes and disease states. Understanding the factors influencing the epigenome is essential for unraveling its complexity. In this study, we aimed to identify how the methylome of buccal epithelial cells, a noninvasive and easily accessible tissue, is associated with demographic and health-related variables commonly used in clinical settings, such as age, sex, blood immune composition, hemoglobin levels, and others. We developed a model to assess the association of multiple factors with the human methylome and identify the genomic loci significantly impacted by each trait. We demonstrated that DNA methylation variation is accurately modeled by several factors. We confirmed the well-known impact of age and sex and unveiled novel clinical factors associated with DNA methylation, such as blood neutrophils, hemoglobin, red blood cell distribution width, high-density lipoprotein cholesterol, and urea. Genomic regions significantly associated with these traits were enriched in relevant transcription factors, drugs, and diseases. Among our findings, we showed that neutrophil-impacted loci were involved in neutrophil functionality and maturation. Similarly, hemoglobin-influenced sites were associated with several diseases, including aplastic anemia, and the genomic loci affected by urea were related to congenital anomalies of the kidney and urinary tract. Our findings contribute to a better understanding of the human methylome plasticity and provide insights into novel factors shaping DNA methylation patterns, highlighting their potential clinical implications as biomarkers and the importance of considering these physiological traits in future medical epigenomic investigations.
MeSH term(s)	Humans ; Epigenome ; Epigenesis, Genetic ; DNA Methylation/genetics ; Epithelial Cells ; Hemoglobins ; Urea
Chemical Substances	Hemoglobins ; Urea (8W8T17847W)
Language	English
Publishing date	2023-10-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2038823-8
ISSN	1531-2267 ; 1094-8341
ISSN (online)	1531-2267
ISSN	1094-8341
DOI	10.1152/physiolgenomics.00063.2023
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Article ; Online: Associations between serum lipids and mannose levels in coronary artery disease among nondiabetic patients.

Koseler, Aylin / Arslan, Idris / Sabirli, Ramazan / Zeytunluoglu, Ali / Kılıç, Oğuz / Kilic, Ismail Dogu

Biomarkers in medicine

2021 Volume 15, Issue 12, Page(s) 1035–1042

Abstract: Aim: ...

Abstract	Aim:
MeSH term(s)	Coronary Artery Disease/blood ; Coronary Artery Disease/diagnosis ; Female ; Healthy Volunteers ; Humans ; Lipids/blood ; Lipids/chemistry ; Lipoproteins, HDL/blood ; Lipoproteins, LDL/blood ; Lipoproteins, VLDL/blood ; Male ; Mannose/blood ; Mannose/chemistry ; Molecular Structure ; ROC Curve ; Risk Factors ; Triglycerides/blood
Chemical Substances	Lipids ; Lipoproteins, HDL ; Lipoproteins, LDL ; Lipoproteins, VLDL ; Triglycerides ; Mannose (PHA4727WTP)
Language	English
Publishing date	2021-07-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2481014-9
ISSN	1752-0371 ; 1752-0363
ISSN (online)	1752-0371
ISSN	1752-0363
DOI	10.2217/bmm-2020-0468
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Zs.A 6985: Show issues

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Article ; Online: A Comparative Study of the Validity and Reliability of Two Wireless Telemetry Electrocardiogram Devices in the Emergency Medicine Department.

Sabirli, Ramazan / Erdur, Bulent / Yilmaz, Atakan

Medical science monitor : international medical journal of experimental and clinical research

2019 Volume 25, Page(s) 571–577

Abstract: BACKGROUND This study aimed to compare the clinical validity and reliability of two wireless telemetry electrocardiogram (ECG) devices in the Emergency Medicine Department. MATERIAL AND METHODS Patients who attended the Emergency Medicine Department ... ...

Abstract	BACKGROUND This study aimed to compare the clinical validity and reliability of two wireless telemetry electrocardiogram (ECG) devices in the Emergency Medicine Department. MATERIAL AND METHODS Patients who attended the Emergency Medicine Department underwent wireless telemetry ECG testing (N=245) using the Infron Micro Cor and the Nihon Kohden Cardiofax M 1350 K devices. ECG recordings included heart rate, P-wave amplitude, PR segment length, QRS duration, QT and QTc intervals, ST depression and elevation, the number of ECG artifacts, the ECG diagnosis, and duration. Statistical analysis of reliability included the use of Cohen's kappa (κ) values. RESULTS One hundred women (40.8%) and 145 men (59.2%) were included in the study. The duration for the Infron Micro Cor ECG readings (57.5±0.93 seconds) was significantly shorter compared with the Nihon Kohden Cardiofax M ECG readings (65.2±9.72 seconds) (p=0.0001). The Infron Micro Cor ECG readings contained significantly more lead artifacts (93 or 37.9%) compared with the Nihon Kohden ECG readings (71 or 28.9%) (p=0.01). There was no difference between the two devices in terms of the other ECG parameters. The compatibility of ST-segment elevation detection was found to be almost in complete agreement between the Infron Micro Cor and Nihon Kohden Cardiofax M ECG devices, as determined by the k-values for ST elevation and ST depression. CONCLUSIONS Two wireless telemetry ECG devices were found to be reliable for use in the Emergency Medicine Department. The Infron Micro Cor wireless telemetry ECG device provided more rapid results.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Diagnosis, Differential ; Electrocardiography/instrumentation ; Electrocardiography/methods ; Emergency Medicine ; Emergency Service, Hospital ; Female ; Humans ; Male ; Middle Aged ; Reproducibility of Results ; Telemetry/instrumentation ; Wireless Technology
Language	English
Publishing date	2019-01-20
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	1439041-3
ISSN	1643-3750 ; 1234-1010
ISSN (online)	1643-3750
ISSN	1234-1010
DOI	10.12659/MSM.913299
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Article ; Online: Soluble P-selectin as a potential diagnostic and prognostic biomarker for COVID-19 disease: A case-control study.

Karsli, Emre / Sabirli, Ramazan / Altintas, Emel / Canacik, Omer / Sabirli, Gizem Tukenmez / Kaymaz, Buse / Kurt, Özgür / Koseler, Aylin

Life sciences

2021 Volume 277, Page(s) 119634

Abstract: Introduction: To our knowledge, the diagnostic value of the sP-Selectin level in the diagnosis of COVID-19 disease has not yet been investigated. In this study, we aimed to assess this by evaluating the relationship between sP-Selectin level and the ... ...

Abstract	Introduction: To our knowledge, the diagnostic value of the sP-Selectin level in the diagnosis of COVID-19 disease has not yet been investigated. In this study, we aimed to assess this by evaluating the relationship between sP-Selectin level and the clinical severity of COVID-19 infections. Methods: A total of 80 patients (50 with mild to moderate and 30 with severe COVID-19 pneumonia), and 60 non-symptomatic healthy volunteers participated in the study. Following serum isolation, sP-Selectin levels were assessed by Enzyme-Linked Immunosorbent Assay (ELISA) method. Results: The serum sP-Selectin level was 1.7 ng/ml in the control group (1-3.78); 6.24 ng/ml (5.14-7.23) in mild-to-moderate pneumonia group; and 6.72 ng/ml (5.36-8.03) in the severe pneumonia group. Serum sP-Selectin levels in both mild-to-moderate pneumonia and severe pneumonia groups were found to be higher than the control group, with statistical significance (p = 0.0001 and p = 0.0001, respectively). Receiver operating characteristic analysis (ROC) showed greater area under the curve (AUC) for the serum sP-Selectin levels of the COVID-19 patients (AUC = 0.913, 95% CI = 0.857-0.969; p = 0.0001). The serum sP-Selectin level was found to be 97.5% sensitive and 80% specific at 4.125 ng/ml level for diagnosis (p = 0.0001). The serum sP-Selectin level was found to be 76.9% sensitive and 51.9% specific at the level of 6.12 ng/ml (p = 0.005) to predict the need for intensive care treatment. Conclusion: This study showed that sP-Selectin can be used as a valuable biomarker in both diagnosing and predicting the need for intensive care treatment of COVID-19 infection.
MeSH term(s)	Biomarkers/blood ; COVID-19/blood ; COVID-19/diagnosis ; Case-Control Studies ; Female ; Humans ; Male ; P-Selectin/blood ; Prognosis ; Prospective Studies ; ROC Curve ; SARS-CoV-2/isolation & purification ; Severity of Illness Index
Chemical Substances	Biomarkers ; P-Selectin
Language	English
Publishing date	2021-05-18
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2021.119634
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