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  1. Article: Prognostic Value of Hematological Parameters in Oral Squamous Cell Carcinoma.

    Trevisani, Lorenzo Fernandes Moça / Kulcsar, Isabelle Fernandes / Kulcsar, Marco Aurélio Vamondes / Dedivitis, Rogerio Aparecido / Kowalski, Luiz Paulo / Matos, Leandro Luongo

    Cancers

    2023  Volume 15, Issue 21

    Abstract: Introduction: Oral squamous cell carcinoma (OSCC) remains a significant public health concern. The variables utilized to determine appropriate treatment for this disease also represent its most unfavorable prognostic factors, with these parameters ... ...

    Abstract Introduction: Oral squamous cell carcinoma (OSCC) remains a significant public health concern. The variables utilized to determine appropriate treatment for this disease also represent its most unfavorable prognostic factors, with these parameters solely determined by the neoplasm and its behavior. However, a lack of well-established indices is evident in the literature that specifically relate to the patient and indicate a worse prognosis.
    Objective: To assess the prognostic impact of hematological indices in patients with OSCC.
    Methods: This retrospective cohort study included patients with oral squamous cell carcinoma (OSCC) who underwent curative-intent treatment. Treatment encompassed surgery, followed by adjuvant therapy, as necessary. Laboratory tests were conducted immediately prior to surgery, and demographic information was obtained from medical records.
    Results: The cohort comprised 600 patients, with 73.5% being male subjects. Adjuvant treatment was recommended for 60.3% of patients. Throughout the follow-up period, 48.8% of participants died. Univariate analysis indicated that perineural invasion, angiolymphatic invasion, pT4 tumors, lymph node metastases, extranodal extravasation, RDW > 14.3%, NLR (neutrophil-lymphocyte ratio) > 3.38, PLR (platelet-lymphocyte ratio) > 167.3, and SII (systemic inflammatory/immune response index) > 416.1 were factors associated with increased mortality. These threshold values were established through ROC curve analysis. In the multivariate analysis, angiolymphatic invasion (HR = 1.43; 95% CI: 1.076-1.925;
    Conclusions: RDW > 14.3% was proven to be a reliable parameter for assessing overall survival in patients with OSCC. Further studies are required to evaluate the clinical applicability of other hematological indices.
    Language English
    Publishing date 2023-10-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15215245
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  2. Article: Ultrasound-guided cervical selective nerve root block in the approach to cervical traumatic neuromas: a technical note.

    Marcos, Vinícius Neves / Kulcsar, Marco Aurelio Vamondes / Hoff, Ana Oliveira / Chammas, Maria Cristina / de Freitas, Ricardo Miguel Costa

    Radiologia brasileira

    2022  Volume 55, Issue 4, Page(s) 267–269

    Language English
    Publishing date 2022-08-02
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2078806-X
    ISSN 1678-7099 ; 0100-3984
    ISSN (online) 1678-7099
    ISSN 0100-3984
    DOI 10.1590/0100-3984.2021.0173
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  3. Article ; Online: Malignant neoplasms of the oral cavity and oropharynx treated in Brazil: what do hospital cancer records reveal?

    Faria, Sheilla de Oliveira / Nascimento, Murilo César do / Kulcsar, Marco Aurélio Vamondes

    Brazilian journal of otorhinolaryngology

    2020  Volume 88, Issue 2, Page(s) 168–173

    Abstract: Introduction: Head and neck cancer has an impact on the global burden of diseases, representing an important cause of morbidity and mortality in Brazil, as well as worldwide.: Objective: To learn and describe the clinical, epidemiological and care ... ...

    Abstract Introduction: Head and neck cancer has an impact on the global burden of diseases, representing an important cause of morbidity and mortality in Brazil, as well as worldwide.
    Objective: To learn and describe the clinical, epidemiological and care configuration provided to patients with cancer of the oral cavity and oropharynx recorded in Brazil, diagnosed from 2007 to 2016.
    Methods: This is a cross-sectional study, carried out using secondary hospital-based data, using the indirect documentation technique.
    Results: There were 52,799 hospital records of oral cavity cancer and 34,516 cases of oropharyngeal cancer in the assessed period. There was a predominance of male patients, aged 50-59 years, mostly Caucasians, and with a low level of schooling. Throughout the period there was a significant reduction in the positive history of alcohol and tobacco consumption, except for alcoholic beverages in oral cavity cancer. Most patients were diagnosed at an advanced stage of the disease (III or IV). Most patients with oral cavity cancer had no evidence of the disease on follow-up, while most patients with oropharyngeal cancer died. The first most frequent treatment offered to patients with oral cavity cancer was surgery, while for patients with oropharyngeal cancer it chemoradiotherapy predominated.
    Conclusion: Despite the fact that, in general, there was a reduction in the records of patient alcohol and tobacco consumption, the increase in the number of medical consultations, the predominantly late diagnosis and the patients' low level of schooling indicate the need for health education, primary prevention and early diagnosis of cancer of the oral cavity and oropharynx.
    MeSH term(s) Brazil/epidemiology ; Cross-Sectional Studies ; Female ; Hospital Records ; Hospitals ; Humans ; Male ; Mouth Neoplasms/epidemiology ; Mouth Neoplasms/therapy ; Oropharyngeal Neoplasms/epidemiology ; Oropharyngeal Neoplasms/therapy
    Language English
    Publishing date 2020-06-24
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2428110-4
    ISSN 1808-8686 ; 1808-8694
    ISSN (online) 1808-8686
    ISSN 1808-8694
    DOI 10.1016/j.bjorl.2020.05.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: High Risk of COVID-19 Infection for Head and Neck Surgeons.

    Kulcsar, Marco Aurélio / Montenegro, Fabio L / Arap, Sergio S / Tavares, Marcos Roberto / Kowalski, Luiz Paulo

    International archives of otorhinolaryngology

    2020  Volume 24, Issue 2, Page(s) e129–e130

    Keywords covid19
    Language English
    Publishing date 2020-04-13
    Publishing country Brazil
    Document type Editorial
    ZDB-ID 2578584-9
    ISSN 1809-4864 ; 1809-9777
    ISSN (online) 1809-4864
    ISSN 1809-9777
    DOI 10.1055/s-0040-1709725
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  5. Article ; Online: Amelanotic melanoma presenting as a tongue tumor.

    Leite, Ana Kober / Kulcsar, Marco Aurélio V / Matsuura, Danielli / Matos, Leandro Luongo / Kowalski, Luiz Paulo

    Oral oncology

    2020  Volume 114, Page(s) 105075

    MeSH term(s) Humans ; Male ; Melanoma, Amelanotic/complications ; Melanoma, Amelanotic/pathology ; Middle Aged ; Tongue Neoplasms/etiology ; Tongue Neoplasms/physiopathology
    Language English
    Publishing date 2020-11-11
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 1120465-5
    ISSN 1879-0593 ; 0964-1955 ; 1368-8375
    ISSN (online) 1879-0593
    ISSN 0964-1955 ; 1368-8375
    DOI 10.1016/j.oraloncology.2020.105075
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    Zs.A 4869: Show issues Location:
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  6. Article ; Online: How to Identify Cervical Traumatic Neuromas in the Post-operative Neck Dissection: Brief Review of the Cervical Plexus Ultrasound.

    Marcos, Vinícius Neves / Kulcsar, Marco Aurelio Vamondes / Hoff, Ana Oliveira / Chammas, Maria Cristina / de Freitas, Ricardo Miguel Costa

    Ultrasound in medicine & biology

    2022  Volume 48, Issue 9, Page(s) 1695–1710

    Abstract: Cervical traumatic neuromas (CTNs) are a non-neoplastic hyperplasia of damaged nerves and may be misinterpreted as metastatic lymph nodes during cervical ultrasound of patients with thyroid cancer after lateral neck dissection, resulting in unnecessary ... ...

    Abstract Cervical traumatic neuromas (CTNs) are a non-neoplastic hyperplasia of damaged nerves and may be misinterpreted as metastatic lymph nodes during cervical ultrasound of patients with thyroid cancer after lateral neck dissection, resulting in unnecessary and painful fin-needle aspiration biopsy. The anatomy of the cervical plexus is challenging, and the correct identification and recognition of its neural roots and branches on ultrasound are key to the correct CTN diagnosis. This review outlines the US technique used to characterize CTNs in 10 standardized steps and describes the sonographic features of the cervical plexus, to assist the radiologist in the recognition of CTNs and their differentiation from lymph node metastases.
    MeSH term(s) Biopsy, Fine-Needle ; Cervical Plexus/diagnostic imaging ; Humans ; Lymph Nodes/pathology ; Neck/diagnostic imaging ; Neck Dissection/methods ; Neuroma/diagnostic imaging ; Neuroma/pathology ; Neuroma/surgery ; Thyroid Neoplasms/diagnostic imaging ; Thyroid Neoplasms/surgery
    Language English
    Publishing date 2022-06-07
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 186150-5
    ISSN 1879-291X ; 0301-5629
    ISSN (online) 1879-291X
    ISSN 0301-5629
    DOI 10.1016/j.ultrasmedbio.2022.04.215
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    Zs.A 963: Show issues Location:
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  7. Article ; Online: Sialendoscopy for treatment of major salivary glands diseases: a comprehensive analysis of published systematic reviews and meta-analyses.

    Kallas-Silva, Lucas / Azevedo, Maria Fernanda Dias / de Matos, Fátima Cristina Mendes / Petrarrolha, Silvia Picado / Dedivitis, Rogério Aparecido / Kulcsar, Marco Aurélio Vamondes / Matos, Leandro Luongo

    Brazilian journal of otorhinolaryngology

    2023  Volume 89, Issue 5, Page(s) 101293

    Abstract: Objectives: Sialendoscopy is a minimally invasive procedure used to diagnose and treat obstructive salivary gland diseases. Previous studies in the topic have shown mixed results. The present study aimed to evaluate the efficacy and safety of ... ...

    Abstract Objectives: Sialendoscopy is a minimally invasive procedure used to diagnose and treat obstructive salivary gland diseases. Previous studies in the topic have shown mixed results. The present study aimed to evaluate the efficacy and safety of sialendoscopy through previous systematic reviews for different outcomes of several diseases. We also aimed to assess studies' methodological quality and heterogeneity.
    Methods: We conducted a comprehensive systematic literature search of Pubmed, Embase, Lilacs and Cochrane Library. We included systematic reviews and meta-analyses that used sialendoscopy to treat both lithiasic and alithiasic salivary glands diseases. Data extraction included studies' characteristics and results. We assessed studies' methodological quality using the AMSTAR-2 (A MeaSurement Tool to Assess systematic Reviews 2) tool.
    Results: 13 studies were included in the review, being 9 in adult populations and 4 in pediatric populations. Sialendoscopy proved to be effective at the treatment of different lithiasic and other obstructive diseases, but with important heterogeneity. The technique was also considered highly safe in most studies. However, studies had a critically low quality of evidence.
    Conclusions: Most studies demonstrated high efficacy and safety of sialendoscopy, but with critically low quality of evidence. We still lack randomized studies in this field, and future systematic reviews on the topic should follow current guidelines to improve conduction and reporting.
    MeSH term(s) Adult ; Child ; Humans ; Endoscopy/methods ; Salivary Gland Diseases/surgery ; Salivary Glands ; Treatment Outcome ; Systematic Reviews as Topic ; Meta-Analysis as Topic
    Language English
    Publishing date 2023-07-15
    Publishing country Brazil
    Document type Journal Article ; Review
    ZDB-ID 2428110-4
    ISSN 1808-8686 ; 1808-8694
    ISSN (online) 1808-8686
    ISSN 1808-8694
    DOI 10.1016/j.bjorl.2023.101293
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  8. Article ; Online: Expression data of FOS and JUN genes and FTIR spectra provide diagnosis of thyroid carcinoma.

    da Silva Queiroz, João Paulo / Pupin, Breno / Bhattacharjee, Tanmoy Tapobrata / Uno, Miyuki / Chammas, Roger / Vamondes Kulcsar, Marco Aurélio / de Azevedo Canevari, Renata

    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

    2023  Volume 304, Page(s) 123305

    Abstract: We explore the feasibility of using FOS and JUN gene expression and ATR-FTIR for diagnosis of thyroid cancer. For the study, 38 samples (6 non-neoplastic (NN), 10 papillary thyroid carcinoma (PTC), 7 follicular thyroid carcinoma (FTC), and 15 benign ... ...

    Abstract We explore the feasibility of using FOS and JUN gene expression and ATR-FTIR for diagnosis of thyroid cancer. For the study, 38 samples (6 non-neoplastic (NN), 10 papillary thyroid carcinoma (PTC), 7 follicular thyroid carcinoma (FTC), and 15 benign tumors (BT) were subjected to RNA extraction followed by quantitative real time PCR (qRT-PCR) and 30 samples (5 NN, 9 PTC, 5 FTC, and 11 BT) were used for Attenuated Total Reflectance - Fourier Transform Infrared (ATR-FTIR) followed by multivariate analysis. Of the above, 20 samples were used for both gene expression and ATR-FTIR studies. We found FOS and JUN expression in malignant tumor samples to be significantly lower than NN and benign. ATR-FIR after multivariate analysis could identify the difficult to diagnose FTC with 93 % efficiency. Overall, results suggest the diagnostic potential of molecular biology techniques combined with ATR-FTIR spectroscopy in differentiated thyroid carcinomas (PTC and FTC) and BT.
    Language English
    Publishing date 2023-08-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 210413-1
    ISSN 1873-3557 ; 0370-8322 ; 0584-8539 ; 1386-1425
    ISSN (online) 1873-3557
    ISSN 0370-8322 ; 0584-8539 ; 1386-1425
    DOI 10.1016/j.saa.2023.123305
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  9. Article ; Online: Ultrasound in cervical traumatic neuromas after neck dissection in thyroid carcinoma patients: descriptive analysis and diagnostic accuracy.

    Marcos, Vinicius Neves / Danilovic, Debora Lucia Seguro / Pereira, Fernando Linhares / Tsunemi, Miriam Harumi / Kulcsar, Marco Aurelio Vamondes / Hoff, Ana Oliveira / Domingues, Regina Barros / Chammas, Maria Cristina / de Freitas, Ricardo Miguel Costa

    Archives of endocrinology and metabolism

    2023  Volume 67, Issue 5, Page(s) e000633

    Abstract: Objective: Cervical traumatic neuromas (CTNs) may appear after lateral neck dissection for metastatic thyroid carcinoma. If they are misdiagnosed as metastatic lymph nodes (LNs) in follow-up neck ultrasound (US), unnecessary and uncomfortable fine- ... ...

    Abstract Objective: Cervical traumatic neuromas (CTNs) may appear after lateral neck dissection for metastatic thyroid carcinoma. If they are misdiagnosed as metastatic lymph nodes (LNs) in follow-up neck ultrasound (US), unnecessary and uncomfortable fine-needle aspiration biopsy are indicated. The present study aimed to describe US features of CTNs and to assess the US performance in distinguishing CTNs from abnormal LNs.
    Subjects and methods: Retrospective evaluation of neck US images of 206 consecutive patients who had lateral neck dissection as a part of thyroid cancer treatment to assess CTN´s US features. Diagnostic accuracy study to evaluate US performance in distinguishing CTNs from abnormal LNs was performed.
    Results: Eight-six lateral neck nodules were selected for analysis: 38 CTNs and 48 abnormal LNs. CTNs with diagnostic cytology were predominantly hypoechogenic (100%
    Conclusion: US is a very useful method for assessing CTNs, with good performance in distinguishing CTNs from abnormal LNs.
    MeSH term(s) Humans ; Neck Dissection ; Retrospective Studies ; Lymphatic Metastasis ; Neck/diagnostic imaging ; Neck/pathology ; Thyroid Neoplasms/diagnostic imaging ; Thyroid Neoplasms/surgery ; Thyroid Neoplasms/pathology ; Lymph Nodes/diagnostic imaging ; Lymph Nodes/pathology ; Ultrasonography ; Neuroma/diagnostic imaging ; Neuroma/pathology
    Language English
    Publishing date 2023-05-30
    Publishing country Brazil
    Document type Journal Article
    ISSN 2359-4292
    ISSN (online) 2359-4292
    DOI 10.20945/2359-3997000000633
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  10. Article ; Online: Nutritional and immunological parameters as prognostic factors in patients with advanced oral cancer.

    Trevisani, Lorenzo Fernandes Moça / Kulcsar, Isabelle Fernandes / Leite, Ana Kober Nogueira / Kulcsar, Marco Aurélio Vamondes / Lima, Graziele Aparecida Simões / Dedivitis, Rogerio Aparecido / Kowalski, Luiz Paulo / Matos, Leandro Luongo

    Brazilian journal of otorhinolaryngology

    2021  Volume 88 Suppl 4, Page(s) S89–S97

    Language English
    Publishing date 2021-12-04
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2428110-4
    ISSN 1808-8686 ; 1808-8694
    ISSN (online) 1808-8686
    ISSN 1808-8694
    DOI 10.1016/j.bjorl.2021.11.003
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