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  1. Article ; Online: The Hippo Show Must Go On: YAP Activation as a Therapeutic Strategy in Colorectal Cancer.

    Veschi, Veronica / Stassi, Giorgio

    Cell stem cell

    2020  Volume 27, Issue 4, Page(s) 501–502

    Abstract: The role of Hippo pathway in colorectal cancer (CRC) initiation and progression has been controversial. In this issue of Cell Stem Cell, Cheung et al. (2020) shed new light on a distinct function of the transcriptional co-activator YAP as a tumor ... ...

    Abstract The role of Hippo pathway in colorectal cancer (CRC) initiation and progression has been controversial. In this issue of Cell Stem Cell, Cheung et al. (2020) shed new light on a distinct function of the transcriptional co-activator YAP as a tumor suppressor and Wnt pathway inhibitor in CRC.
    MeSH term(s) Colorectal Neoplasms/drug therapy ; Humans ; Protein-Serine-Threonine Kinases/metabolism ; Stem Cells/metabolism ; Transcription Factors ; Wnt Signaling Pathway
    Chemical Substances Transcription Factors ; Hippo protein, human (EC 2.7.11.1) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2020-09-30
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2375354-7
    ISSN 1875-9777 ; 1934-5909
    ISSN (online) 1875-9777
    ISSN 1934-5909
    DOI 10.1016/j.stem.2020.09.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article: High-SETD8 inactivates p53 in neuroblastoma.

    Veschi, Veronica / Thiele, Carol J

    Oncoscience

    2017  Volume 4, Issue 3-4, Page(s) 21–22

    Language English
    Publishing date 2017-04-14
    Publishing country United States
    Document type Editorial
    ISSN 2331-4737
    ISSN 2331-4737
    DOI 10.18632/oncoscience.344
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Targeting

    Liu, Zhihui / Chen, Samuel S / Clarke, Saki / Veschi, Veronica / Thiele, Carol J

    Frontiers in oncology

    2021  Volume 10, Page(s) 623679

    Abstract: The deregulation of ... ...

    Abstract The deregulation of the
    Language English
    Publishing date 2021-02-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2020.623679
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Cancer Stem Cells and Neuroblastoma: Characteristics and Therapeutic Targeting Options.

    Veschi, Veronica / Verona, Francesco / Thiele, Carol J

    Frontiers in endocrinology

    2019  Volume 10, Page(s) 782

    Abstract: The majority of embryonal tumors or childhood blastomas derive from pluripotent progenitors or fetal stem cells that acquire cancer stem cell (CSC) properties: multipotency, self-renewal ability, metastatic potential, chemoresistance, more pronounced ... ...

    Abstract The majority of embryonal tumors or childhood blastomas derive from pluripotent progenitors or fetal stem cells that acquire cancer stem cell (CSC) properties: multipotency, self-renewal ability, metastatic potential, chemoresistance, more pronounced levels of drug transporters, enhanced DNA-damage repair mechanisms, and a quiescent state. Neuroblastoma (NB) is considered a neuroendocrine tumor and is the most common extracranial neoplasm in children. NB pathogenesis has frequently been associated with epigenetic dysregulation and a failure to implement a differentiation program. The origin, characteristics, and isolation of the CSC subpopulation in NB are still incompletely understood, despite the evidence that this cell subset contributes to disease recurrence and acquired resistance to standard therapies. Here, we summarize the literature regarding the isolation and characterization of CSCs in NB over the past decades, from the early recognition of the expression of stem cell factor (SCF) or its receptor c-KIT to more recent studies identifying the ability of G-CSF and STAT3 to support stem cell-like properties in NB cells. Additionally, we review the morphological variants of NB tumors whose recent epigenetic analyses have shed light on the tumor heterogeneity so common in NB. NB-derived mesenchymal stem cells have recently been isolated from primary tumors of NB patients and associated with a pro-tumorigenic role in the tumor microenvironment, enabling immune escape by tumors, and contributing to their invasive and metastatic capabilities. In particular, we will focus on epigenetic reprogramming in the CSC subpopulation in NB and strategies to target CSCs in NB.
    Language English
    Publishing date 2019-11-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2019.00782
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Cancer Stem Cell Biomarkers Predictive of Radiotherapy Response in Rectal Cancer: A Systematic Review.

    Mare, Marzia / Colarossi, Lorenzo / Veschi, Veronica / Turdo, Alice / Giuffrida, Dario / Memeo, Lorenzo / Stassi, Giorgio / Colarossi, Cristina

    Genes

    2021  Volume 12, Issue 10

    Abstract: Background: Rectal cancer (RC) is one of the most commonly diagnosed and particularly challenging tumours to treat due to its location in the pelvis and close proximity to critical genitourinary organs. Radiotherapy (RT) is recognised as a key component ...

    Abstract Background: Rectal cancer (RC) is one of the most commonly diagnosed and particularly challenging tumours to treat due to its location in the pelvis and close proximity to critical genitourinary organs. Radiotherapy (RT) is recognised as a key component of therapeutic strategy to treat RC, promoting the downsizing and downstaging of large RCs in neoadjuvant settings, although its therapeutic effect is limited due to radioresistance. Evidence from experimental and clinical studies indicates that the likelihood of achieving local tumour control by RT depends on the complete eradication of cancer stem cells (CSC), a minority subset of tumour cells with stemness properties.
    Methods: A systematic literature review was conducted by querying two scientific databases (Pubmed and Scopus). The search was restricted to papers published from 2009 to 2021.
    Results: After assessing the quality and the risk of bias, a total of 11 studies were selected as they mainly focused on biomarkers predictive of RT-response in CSCs isolated from patients affected by RC. Specifically these studies showed that elevated levels of CD133, CD44, ALDH1, Lgr5 and G9a are associated with RT-resistance and poor prognosis.
    Conclusions: This review aimed to provide an overview of the current scenario of in vitro and in vivo studies evaluating the biomarkers predictive of RT-response in CSCs derived from RC patients.
    MeSH term(s) Biomarkers, Tumor/metabolism ; Humans ; Neoplastic Stem Cells/metabolism ; Rectal Neoplasms/metabolism ; Rectal Neoplasms/radiotherapy ; Treatment Outcome
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2021-09-25
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Systematic Review
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes12101502
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Targeting of the Peritumoral Adipose Tissue Microenvironment as an Innovative Antitumor Therapeutic Strategy.

    Lo Iacono, Melania / Modica, Chiara / Porcelli, Gaetana / Brancato, Ornella Roberta / Muratore, Giampaolo / Bianca, Paola / Gaggianesi, Miriam / Turdo, Alice / Veschi, Veronica / Todaro, Matilde / Di Franco, Simone / Stassi, Giorgio

    Biomolecules

    2022  Volume 12, Issue 5

    Abstract: The tumor microenvironment (TME) plays a key role in promoting and sustaining cancer growth. Adipose tissue (AT), due to its anatomical distribution, is a prevalent component of TME, and contributes to cancer development and progression. Cancer- ... ...

    Abstract The tumor microenvironment (TME) plays a key role in promoting and sustaining cancer growth. Adipose tissue (AT), due to its anatomical distribution, is a prevalent component of TME, and contributes to cancer development and progression. Cancer-associated adipocytes (CAAs), reprogrammed by cancer stem cells (CSCs), drive cancer progression by releasing metabolites and inflammatory adipokines. In this review, we highlight the mechanisms underlying the bidirectional crosstalk among CAAs, CSCs, and stromal cells. Moreover, we focus on the recent advances in the therapeutic targeting of adipocyte-released factors as an innovative strategy to counteract cancer progression.
    MeSH term(s) Adipocytes/metabolism ; Adipose Tissue/metabolism ; Humans ; Neoplasms/metabolism ; Neoplastic Stem Cells/metabolism ; Tumor Microenvironment
    Language English
    Publishing date 2022-05-14
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom12050702
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Meeting the Challenge of Targeting Cancer Stem Cells.

    Turdo, Alice / Veschi, Veronica / Gaggianesi, Miriam / Chinnici, Aurora / Bianca, Paola / Todaro, Matilde / Stassi, Giorgio

    Frontiers in cell and developmental biology

    2019  Volume 7, Page(s) 16

    Abstract: Notwithstanding cancer patients benefit from a plethora of therapeutic alternatives, drug resistance remains a critical hurdle. Indeed, the high mortality rate is associated with metastatic disease, which is mostly incurable due to the refractoriness of ... ...

    Abstract Notwithstanding cancer patients benefit from a plethora of therapeutic alternatives, drug resistance remains a critical hurdle. Indeed, the high mortality rate is associated with metastatic disease, which is mostly incurable due to the refractoriness of metastatic cells to current treatments. Increasing data demonstrate that tumors contain a small subpopulation of cancer stem cells (CSCs) able to establish primary tumor and metastasis. CSCs are endowed with multiple treatment resistance capabilities comprising a highly efficient DNA damage repair machinery, the activation of survival pathways, enhanced cellular plasticity, immune evasion and the adaptation to a hostile microenvironment. Due to the presence of distinct cell populations within a tumor, cancer research has to face the major challenge of targeting the intra-tumoral as well as inter-tumoral heterogeneity. Thus, targeting molecular drivers operating in CSCs, in combination with standard treatments, may improve cancer patients' outcomes, yielding long-lasting responses. Here, we report a comprehensive overview on the most significant therapeutic advances that have changed the known paradigms of cancer treatment with a particular emphasis on newly developed compounds that selectively affect the CSC population. Specifically, we are focusing on innovative therapeutic approaches including differentiation therapy, anti-angiogenic compounds, immunotherapy and inhibition of epigenetic enzymes and microenvironmental cues.
    Language English
    Publishing date 2019-02-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2019.00016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Recapitulating thyroid cancer histotypes through engineering embryonic stem cells.

    Veschi, Veronica / Turdo, Alice / Modica, Chiara / Verona, Francesco / Di Franco, Simone / Gaggianesi, Miriam / Tirrò, Elena / Di Bella, Sebastiano / Iacono, Melania Lo / Pantina, Vincenzo Davide / Porcelli, Gaetana / Mangiapane, Laura Rosa / Bianca, Paola / Rizzo, Aroldo / Sciacca, Elisabetta / Pillitteri, Irene / Vella, Veronica / Belfiore, Antonino / Bongiorno, Maria Rita /
    Pistone, Giuseppe / Memeo, Lorenzo / Colarossi, Lorenzo / Giuffrida, Dario / Colarossi, Cristina / Vigneri, Paolo / Todaro, Matilde / Stassi, Giorgio

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 1351

    Abstract: Thyroid carcinoma (TC) is the most common malignancy of endocrine organs. The cell subpopulation in the lineage hierarchy that serves as cell of origin for the different TC histotypes is unknown. Human embryonic stem cells (hESCs) with appropriate in ... ...

    Abstract Thyroid carcinoma (TC) is the most common malignancy of endocrine organs. The cell subpopulation in the lineage hierarchy that serves as cell of origin for the different TC histotypes is unknown. Human embryonic stem cells (hESCs) with appropriate in vitro stimulation undergo sequential differentiation into thyroid progenitor cells (TPCs-day 22), which maturate into thyrocytes (day 30). Here, we create follicular cell-derived TCs of all the different histotypes based on specific genomic alterations delivered by CRISPR-Cas9 in hESC-derived TPCs. Specifically, TPCs harboring BRAF
    MeSH term(s) Humans ; Receptors, Kisspeptin-1/genetics ; Iodine Radioisotopes ; Tissue Inhibitor of Metalloproteinase-1/genetics ; Thyroid Neoplasms/genetics ; Embryonic Stem Cells ; Proto-Oncogene Proteins B-raf/genetics ; Mutation
    Chemical Substances Receptors, Kisspeptin-1 ; Iodine Radioisotopes ; Tissue Inhibitor of Metalloproteinase-1 ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1)
    Language English
    Publishing date 2023-03-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-36922-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Destroying the Shield of Cancer Stem Cells: Natural Compounds as Promising Players in Cancer Therapy.

    Lo Iacono, Melania / Gaggianesi, Miriam / Bianca, Paola / Brancato, Ornella Roberta / Muratore, Giampaolo / Modica, Chiara / Roozafzay, Narges / Shams, Kimiya / Colarossi, Lorenzo / Colarossi, Cristina / Memeo, Lorenzo / Turdo, Alice / Veschi, Veronica / Di Franco, Simone / Todaro, Matilde / Stassi, Giorgio

    Journal of clinical medicine

    2022  Volume 11, Issue 23

    Abstract: In a scenario where eco-sustainability and a reduction in chemotherapeutic drug waste are certainly a prerogative to safeguard the biosphere, the use of natural products (NPs) represents an alternative therapeutic approach to counteract cancer diseases. ... ...

    Abstract In a scenario where eco-sustainability and a reduction in chemotherapeutic drug waste are certainly a prerogative to safeguard the biosphere, the use of natural products (NPs) represents an alternative therapeutic approach to counteract cancer diseases. The presence of a heterogeneous cancer stem cell (CSC) population within a tumor bulk is related to disease recurrence and therapy resistance. For this reason, CSC targeting presents a promising strategy for hampering cancer recurrence. Increasing evidence shows that NPs can inhibit crucial signaling pathways involved in the maintenance of CSC stemness and sensitize CSCs to standard chemotherapeutic treatments. Moreover, their limited toxicity and low costs for large-scale production could accelerate the use of NPs in clinical settings. In this review, we will summarize the most relevant studies regarding the effects of NPs derived from major natural sources, e.g., food, botanical, and marine species, on CSCs, elucidating their use in pre-clinical and clinical studies.
    Language English
    Publishing date 2022-11-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11236996
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Cancer Stem Cell Biomarkers Predictive of Radiotherapy Response in Rectal Cancer: A Systematic Review

    Mare, Marzia / Colarossi, Lorenzo / Veschi, Veronica / Turdo, Alice / Giuffrida, Dario / Memeo, Lorenzo / Stassi, Giorgio / Colarossi, Cristina

    Genes. 2021 Sept. 25, v. 12, no. 10

    2021  

    Abstract: Background: Rectal cancer (RC) is one of the most commonly diagnosed and particularly challenging tumours to treat due to its location in the pelvis and close proximity to critical genitourinary organs. Radiotherapy (RT) is recognised as a key component ... ...

    Abstract Background: Rectal cancer (RC) is one of the most commonly diagnosed and particularly challenging tumours to treat due to its location in the pelvis and close proximity to critical genitourinary organs. Radiotherapy (RT) is recognised as a key component of therapeutic strategy to treat RC, promoting the downsizing and downstaging of large RCs in neoadjuvant settings, although its therapeutic effect is limited due to radioresistance. Evidence from experimental and clinical studies indicates that the likelihood of achieving local tumour control by RT depends on the complete eradication of cancer stem cells (CSC), a minority subset of tumour cells with stemness properties. Methods: A systematic literature review was conducted by querying two scientific databases (Pubmed and Scopus). The search was restricted to papers published from 2009 to 2021. Results: After assessing the quality and the risk of bias, a total of 11 studies were selected as they mainly focused on biomarkers predictive of RT-response in CSCs isolated from patients affected by RC. Specifically these studies showed that elevated levels of CD133, CD44, ALDH1, Lgr5 and G9a are associated with RT-resistance and poor prognosis. Conclusions: This review aimed to provide an overview of the current scenario of in vitro and in vivo studies evaluating the biomarkers predictive of RT-response in CSCs derived from RC patients.
    Keywords biomarkers ; colorectal neoplasms ; pelvis ; prognosis ; radiation resistance ; radiotherapy ; risk ; stem cells ; systematic review
    Language English
    Dates of publication 2021-0925
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2527218-4
    ISSN 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes12101502
    Database NAL-Catalogue (AGRICOLA)

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