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  1. Article ; Online: Immune tolerance of citrullinated peptides.

    Thomas, Ranjeny / Robinson, William H

    Nature reviews. Rheumatology

    2024  Volume 20, Issue 3, Page(s) 141–142

    MeSH term(s) Humans ; Peptides ; Arthritis, Rheumatoid ; Immune Tolerance ; Citrulline ; Autoantibodies ; Peptides, Cyclic
    Chemical Substances Peptides ; Citrulline (29VT07BGDA) ; Autoantibodies ; Peptides, Cyclic
    Language English
    Publishing date 2024-01-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2491532-4
    ISSN 1759-4804 ; 1759-4790
    ISSN (online) 1759-4804
    ISSN 1759-4790
    DOI 10.1038/s41584-024-01081-0
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  2. Article ; Online: Reinforcing the Checkpoint in Rheumatoid Arthritis.

    Gravallese, Ellen M / Thomas, Ranjeny

    The New England journal of medicine

    2023  Volume 388, Issue 20, Page(s) 1905–1907

    MeSH term(s) Humans ; Arthritis, Rheumatoid/drug therapy
    Language English
    Publishing date 2023-05-17
    Publishing country United States
    Document type Editorial
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe2300734
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  3. Article ; Online: Dendritic cells and antigen-specific immunotherapy in autoimmune rheumatic diseases.

    Cai, Benjamin / Thomas, Ranjeny

    Best practice & research. Clinical rheumatology

    2024  , Page(s) 101940

    Abstract: Dendritic cells (DCs) are professional antigen-presenting cells and trigger downstream immune responses to antigen while integrating cellular pathogen and damage-associated molecular pattern (PAMP and DAMP) or immunomodulatory signals. In healthy ... ...

    Abstract Dendritic cells (DCs) are professional antigen-presenting cells and trigger downstream immune responses to antigen while integrating cellular pathogen and damage-associated molecular pattern (PAMP and DAMP) or immunomodulatory signals. In healthy individuals, resting and tolerogenic DCs draining skin and intestine facilitate expansion of regulatory T cells (Treg) to maintain peripheral antigen-specific immune tolerance. In patients with rheumatic diseases, however, DCs activated by PAMPs and DAMPs expand self-reactive effector T cells, including follicular helper T cells that promote the expansion of activated autoreactive B cells, chronic inflammation and end-organ damage. With the development of cellular and nanoparticle (NP)-based self-antigen-specific immunotherapies we here consider the new opportunities and the challenges for restoring immunoregulation in the treatment and prevention of autoimmune inflammatory rheumatic conditions through DCs.
    Language English
    Publishing date 2024-03-13
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2052323-3
    ISSN 1532-1770 ; 1521-6942
    ISSN (online) 1532-1770
    ISSN 1521-6942
    DOI 10.1016/j.berh.2024.101940
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  4. Article ; Online: Liposomal delivery of self-peptide and calcitriol as tolerogenic immunotherapy in rheumatoid arthritis: an exploration using sensory science.

    Hee, Jia Yi / Cai, Benjamin / Thomas, Ranjeny

    Immunology and cell biology

    2024  

    Abstract: Immunology research holds significant potential for enhanced inclusivity at the beginning of the science literacy journey, but persistent challenges stem from limited awareness that improvement is needed in this field. At the 2023 Monash Sensory Science ... ...

    Abstract Immunology research holds significant potential for enhanced inclusivity at the beginning of the science literacy journey, but persistent challenges stem from limited awareness that improvement is needed in this field. At the 2023 Monash Sensory Science Exhibition, we had the opportunity to present several tactile posters, using simple materials, for visually impaired participants to showcase our research on the pathogenesis of rheumatoid arthritis as a result of immune tolerance breakdown and liposome-based tolerogenic immunotherapy. The posters stimulated lively discussions about autoimmune arthritic diseases and our research. With consideration of the diversity of the participants, the efforts of scientists in promoting science literacy for the community can promote a more inclusive environment and engage and inspire a broader audience.
    Language English
    Publishing date 2024-01-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 284057-1
    ISSN 1440-1711 ; 0818-9641
    ISSN (online) 1440-1711
    ISSN 0818-9641
    DOI 10.1111/imcb.12719
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  5. Article ; Online: Immune tolerance therapies for autoimmune diseases: Shifting the goalpost to cure.

    Sharkey, Patrick / Thomas, Ranjeny

    Current opinion in pharmacology

    2022  Volume 65, Page(s) 102242

    Abstract: Autoimmune rheumatic diseases are characterised by an autoimmune inflammatory response to antigens of synovial tissue, muscles, and other organs. While the prognosis of these disorders has improved remarkably over recent years with the advent of ... ...

    Abstract Autoimmune rheumatic diseases are characterised by an autoimmune inflammatory response to antigens of synovial tissue, muscles, and other organs. While the prognosis of these disorders has improved remarkably over recent years with the advent of biological therapeutics, prolonged drug-free remission is still rare. Advances in the understanding of the immunopathogenesis and response to immunotherapy of seropositive autoimmune rheumatic diseases, such as rheumatoid arthritis systemic lupus erythematosus, type 1 diabetes and the autoimmune-like celiac disease have revealed novel therapeutic opportunities. An improved understanding of preclinical disease states and how disease risk can be mitigated underpins further development of therapeutics to restore tolerance for disease prevention or early disease interception.
    MeSH term(s) Arthritis, Rheumatoid ; Autoimmune Diseases/drug therapy ; Autoimmunity ; Humans ; Immune Tolerance ; Lupus Erythematosus, Systemic ; Rheumatic Diseases
    Language English
    Publishing date 2022-05-22
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2037057-X
    ISSN 1471-4973 ; 1471-4892
    ISSN (online) 1471-4973
    ISSN 1471-4892
    DOI 10.1016/j.coph.2022.102242
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  6. Article ; Online: Antigen-specific immunotherapy to restore antigen-specific tolerance in Type 1 diabetes and Graves' disease.

    Zala, Aakansha / Thomas, Ranjeny

    Clinical and experimental immunology

    2022  Volume 211, Issue 2, Page(s) 164–175

    Abstract: Type 1 diabetes and Graves' disease are chronic autoimmune conditions, characterized by a dysregulated immune response. In Type 1 diabetes, there is beta cell destruction and subsequent insulin deficiency whereas in Graves' disease, there is unregulated ... ...

    Abstract Type 1 diabetes and Graves' disease are chronic autoimmune conditions, characterized by a dysregulated immune response. In Type 1 diabetes, there is beta cell destruction and subsequent insulin deficiency whereas in Graves' disease, there is unregulated excessive thyroid hormone production. Both diseases result in significant psychosocial, physiological, and emotional burden. There are associated risks of diabetic ketoacidosis and hypoglycaemia in Type 1 diabetes and risks of thyrotoxicosis and orbitopathy in Graves' disease. Advances in the understanding of the immunopathogenesis and response to immunotherapy in Type 1 diabetes and Graves' disease have facilitated the introduction of targeted therapies to induce self-tolerance, and subsequently, the potential to induce long-term remission if effective. We explore current research surrounding the use of antigen-specific immunotherapies, with a focus on human studies, in Type 1 diabetes and Graves' disease including protein-based, peptide-based, dendritic-cell-based, and nanoparticle-based immunotherapies, including discussion of factors to be considered when translating immunotherapies to clinical practice.
    MeSH term(s) Humans ; Diabetes Mellitus, Type 1/therapy ; Graves Disease/therapy ; Immunotherapy ; Immune Tolerance ; Self Tolerance
    Language English
    Publishing date 2022-12-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218531-3
    ISSN 1365-2249 ; 0009-9104 ; 0964-2536
    ISSN (online) 1365-2249
    ISSN 0009-9104 ; 0964-2536
    DOI 10.1093/cei/uxac115
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  7. Article ; Online: Potential for Antigen-Specific Tolerizing Immunotherapy in Systematic Lupus Erythematosus.

    Robinson, Sean / Thomas, Ranjeny

    Frontiers in immunology

    2021  Volume 12, Page(s) 654701

    Abstract: Systemic lupus erythematosus (SLE) is a chronic complex systemic autoimmune disease characterized by multiple autoantibodies and clinical manifestations, with the potential to affect nearly every organ. SLE treatments, including corticosteroids and ... ...

    Abstract Systemic lupus erythematosus (SLE) is a chronic complex systemic autoimmune disease characterized by multiple autoantibodies and clinical manifestations, with the potential to affect nearly every organ. SLE treatments, including corticosteroids and immunosuppressive drugs, have greatly increased survival rates, but there is no curative therapy and SLE management is limited by drug complications and toxicities. There is an obvious clinical need for safe, effective SLE treatments. A promising treatment avenue is to restore immunological tolerance to reduce inflammatory clinical manifestations of SLE. Indeed, recent clinical trials of low-dose IL-2 supplementation in SLE patients showed that
    MeSH term(s) Autoantigens/immunology ; Autoimmunity ; Dendritic Cells/immunology ; Dendritic Cells/metabolism ; Desensitization, Immunologic/methods ; Disease Management ; Disease Susceptibility/immunology ; Epitopes/immunology ; Humans ; Immune Tolerance ; Lupus Erythematosus, Systemic/immunology ; Lupus Erythematosus, Systemic/therapy ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism
    Chemical Substances Autoantigens ; Epitopes
    Language English
    Publishing date 2021-07-16
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.654701
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  8. Article ; Online: Dendritic cells as targets or therapeutics in rheumatic autoimmune disease.

    Thomas, Ranjeny

    Current opinion in rheumatology

    2014  Volume 26, Issue 2, Page(s) 211–218

    Abstract: Purpose of review: Antigen-specific immunotherapy is a major goal for improvement in the treatment of autoimmune rheumatic disease. Dendritic cells are professional antigen-presenting cells, abundant at mucosal surfaces and in tissues. They also play a ... ...

    Abstract Purpose of review: Antigen-specific immunotherapy is a major goal for improvement in the treatment of autoimmune rheumatic disease. Dendritic cells are professional antigen-presenting cells, abundant at mucosal surfaces and in tissues. They also play a critical role in self-tolerance. This review covers recent advances in the field of dendritic cells as targets or therapeutics in rheumatic autoimmune disease.
    Recent findings: Key themes include the phenotypic and functional characterization, lineage relationships and transcription factors involved in the development of the various dendritic cell subsets. Phenotype and function of mouse and human subsets has now been much better mapped. Progress in the elucidation of targeting ligands and routes for induction of antigen-specific tolerance using either antigen-antibody fusion constructs or particulate conjugates is described. Various inflammatory molecules made by dendritic cells, including type I interferon, are important therapeutic targets in autoimmune rheumatic diseases. Approaches to block this and clinical trials in this area are discussed.
    Summary: There are considerable basic science developments in the field of dendritic cells and tolerance that will speed translation to human of the large amount of knowledge generated in mouse in-vivo systems. Various antigen-specific therapy approaches are in the process of translation to the clinic.
    MeSH term(s) Animals ; Autoantigens ; Autoimmune Diseases/immunology ; Autoimmune Diseases/therapy ; Dendritic Cells/classification ; Dendritic Cells/immunology ; Humans ; Immunosuppression/methods ; Immunotherapy/methods ; Inflammation Mediators/metabolism ; Mice ; Receptors, Immunologic/metabolism ; Rheumatic Diseases/immunology ; Rheumatic Diseases/therapy ; Self Tolerance
    Chemical Substances Autoantigens ; Inflammation Mediators ; Receptors, Immunologic
    Language English
    Publishing date 2014-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1045317-9
    ISSN 1531-6963 ; 1040-8711
    ISSN (online) 1531-6963
    ISSN 1040-8711
    DOI 10.1097/BOR.0000000000000032
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    Zs.A 3028: Show issues Location:
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  9. Article ; Online: RelB and the aryl hydrocarbon receptor: dendritic cell tolerance at the epithelial interface.

    Thomas, Ranjeny

    Immunology and cell biology

    2013  Volume 91, Issue 9, Page(s) 543–544

    MeSH term(s) Animals ; Dendritic Cells/immunology ; Female ; Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism ; NF-kappa B/metabolism ; Receptors, Aryl Hydrocarbon/metabolism ; Transcription Factor RelB/metabolism
    Chemical Substances IDO1 protein, mouse ; Indoleamine-Pyrrole 2,3,-Dioxygenase ; NF-kappa B ; Receptors, Aryl Hydrocarbon ; Relb protein, mouse ; Transcription Factor RelB (147337-75-5)
    Language English
    Publishing date 2013-10-08
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 284057-1
    ISSN 1440-1711 ; 0818-9641
    ISSN (online) 1440-1711
    ISSN 0818-9641
    DOI 10.1038/icb.2013.51
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  10. Article ; Online: The microbiome and rheumatoid arthritis.

    Bergot, Anne-Sophie / Giri, Rabina / Thomas, Ranjeny

    Best practice & research. Clinical rheumatology

    2020  Volume 33, Issue 6, Page(s) 101497

    Abstract: Rheumatoid Arthritis (RA) is a severe, chronic autoimmune disease that affects 1% of the world's population. Familial risk contributes 50% of the risk of seropositive RA, with strongest risks seen in first-degree relatives. Smoking increases the risk of ... ...

    Abstract Rheumatoid Arthritis (RA) is a severe, chronic autoimmune disease that affects 1% of the world's population. Familial risk contributes 50% of the risk of seropositive RA, with strongest risks seen in first-degree relatives. Smoking increases the risk of developing anti-citrullinated peptide antibody (ACPA)
    MeSH term(s) Animals ; Arthritis, Rheumatoid/microbiology ; Autoantibodies ; Autoimmunity ; Dysbiosis ; Humans ; Microbiota ; Smoking
    Chemical Substances Autoantibodies
    Language English
    Publishing date 2020-03-19
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2052323-3
    ISSN 1532-1770 ; 1521-6942
    ISSN (online) 1532-1770
    ISSN 1521-6942
    DOI 10.1016/j.berh.2020.101497
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