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Article ; Online: Biological variation of CA 15-3, CA 125 and HE 4 on lithium heparinate plasma in apparently healthy Caucasian volunteers.

Guillaume, Louise / Chapelle, Virginie / Deltombe, Matthieu / Nevraumont, Arnaud / Mairesse, Antoine / Maisin, Diane / Gruson, Damien

Clinical chemistry and laboratory medicine

2023 Volume 61, Issue 7, Page(s) 1319–1326

Abstract: Objectives: Tumor markers are well-known for being important tools in the support of diagnosis, monitoring of treatment efficacy and follow-up of cancers. CA 125, CA 15-3 and HE 4 have demonstrated potential efficacy in other clinical indications. The ... ...

Abstract	Objectives: Tumor markers are well-known for being important tools in the support of diagnosis, monitoring of treatment efficacy and follow-up of cancers. CA 125, CA 15-3 and HE 4 have demonstrated potential efficacy in other clinical indications. The main objective was to evaluate the biological variation of these glycoproteins using two different immunoassays in an apparently healthy Caucasian population. Methods: Nineteen healthy volunteers including 11 women and 8 men were sampled weekly for 5 consecutive weeks. Samples were analyzed in duplicate on Lumipulse Results: CV Conclusions: Our study provided updated data on the biological variation of CA 125, HE 4 and CA 15-3. These data allow to improve the clinical interpretation and thus the management of the patient.
MeSH term(s)	Humans ; Male ; Female ; Reference Values ; Lithium ; Healthy Volunteers ; White People
Chemical Substances	Lithium (9FN79X2M3F)
Language	English
Publishing date	2023-04-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1418007-8
ISSN	1437-4331 ; 1434-6621 ; 1437-8523
ISSN (online)	1437-4331
ISSN	1434-6621 ; 1437-8523
DOI	10.1515/cclm-2022-0966
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Article ; Online: Undisclosed interference in 25-OH-Vitamin D immunoassay on Liaison XL analyzer when using heparin plasma tubes.

Jacobs, Julie / Vanneste, Frank / Hotton, Julie / Miller, Nathalie / Cauchie, Mathieu / Brassinne, Laetitia / Mairesse, Antoine

Scandinavian journal of clinical and laboratory investigation

2023 Volume 83, Issue 6, Page(s) 390–393

Abstract: This study investigates the impact of sample type on the measurement of 25-OH-vitamin D using the Liaison XL (Diasorin) and Cobas e801 (Roche). This investigation was motivated by the need to optimize sample volume usage, which led us to adopt the use of ...

Abstract	This study investigates the impact of sample type on the measurement of 25-OH-vitamin D using the Liaison XL (Diasorin) and Cobas e801 (Roche). This investigation was motivated by the need to optimize sample volume usage, which led us to adopt the use of heparin plasma, an alternative proposed by Diasorin in their specification. Discordant and unexplainable results were observed, prompting us to evaluate the effect of sample type on the accuracy of the 25-OH-vitamin D measurements. We collected 34 different paired samples from a randomly selected patients who had two types of tubes taken simultaneously: serum-gel and lithium-heparin plasma tubes. The 25-OH-vitamin D levels were measured using Cobas e801 and Liaison. Statistical analysis was performed using the Mann-Whitney test to calculate the p-value. Biases were also calculated. When comparing the heparin matrix with the serum matrix on the Liaison XL analyzer, a higher proportion (
MeSH term(s)	Humans ; Vitamin D ; Heparin ; Reproducibility of Results ; Immunoassay/methods ; Vitamins
Chemical Substances	Vitamin D (1406-16-2) ; Heparin (9005-49-6) ; Vitamins
Language	English
Publishing date	2023-07-28
Publishing country	England
Document type	Journal Article
ZDB-ID	3150-1
ISSN	1502-7686 ; 0036-5513
ISSN (online)	1502-7686
ISSN	0036-5513
DOI	10.1080/00365513.2023.2241356
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Article ; Online: Quantum-Path-Resolved Attosecond High-Harmonic Spectroscopy.

Camper, Antoine / Ferré, Amélie / Blanchet, Valérie / Descamps, Dominique / Lin, Nan / Petit, Stéphane / Lucchese, Robert / Salières, Pascal / Ruchon, Thierry / Mairesse, Yann

Physical review letters

2023 Volume 130, Issue 8, Page(s) 83201

Abstract: Strong-field ionization of molecules releases electrons which can be accelerated and driven back to recombine with their parent ion, emitting high-order harmonics. This ionization also initiates attosecond electronic and vibrational dynamics in the ion, ... ...

Abstract	Strong-field ionization of molecules releases electrons which can be accelerated and driven back to recombine with their parent ion, emitting high-order harmonics. This ionization also initiates attosecond electronic and vibrational dynamics in the ion, evolving during the electron travel in the continuum. Revealing this subcycle dynamics from the emitted radiation usually requires advanced theoretical modeling. We show that this can be avoided by resolving the emission from two families of electronic quantum paths in the generation process. The corresponding electrons have the same kinetic energy, and thus the same structural sensitivity, but differ by the travel time between ionization and recombination-the pump-probe delay in this attosecond self-probing scheme. We measure the harmonic amplitude and phase in aligned CO_{2} and N_{2} molecules and observe a strong influence of laser-induced dynamics on two characteristic spectroscopic features: a shape resonance and multichannel interference. This quantum-path-resolved spectroscopy thus opens wide prospects for the investigation of ultrafast ionic dynamics, such as charge migration.
Language	English
Publishing date	2023-03-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.130.083201
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Article ; Online: Analytical performances and biological variation of PIVKA-II (des-y-carboxy-prothrombin) in European healthy adults.

Bayart, Jean-Louis / Mairesse, Antoine / Gruson, Damien / van Dievoet, Marie-Astrid

Clinica chimica acta; international journal of clinical chemistry

2020 Volume 509, Page(s) 264–267

Abstract: Background: PIVKA-II (DCP) is increasingly used for the diagnosis and the surveillance of hepatocellular carcinoma (HCC) in at-risk populations. However, to date, few data are available concerning the intra- and inter-individual variability of this ... ...

Abstract	Background: PIVKA-II (DCP) is increasingly used for the diagnosis and the surveillance of hepatocellular carcinoma (HCC) in at-risk populations. However, to date, few data are available concerning the intra- and inter-individual variability of this marker, which makes the interpretation of serial measurements difficult in the context of monitoring. Methods: 19 European healthy volunteers (HVs) were taken each week during five consecutive weeks. Samples were analyzed in duplicate on the Lumipulse® analyzer (Fujirebio, Gent, Belgium). Analytical variation (CV Results: No significant difference was observed for the mean values (p = 0.23) between men (mean: 30.66 mAU/mL) and women (mean: 33.90 mAU/mL) subgroups. CV Conclusion: We reported for the first-time biological variation data for PIVKA-II in a cohort of European HVs. We believe that our results can be used to set analytical specification goals as well as to improve the interpretation of serial measurements of PIVKA-II for monitoring purposes.
MeSH term(s)	Adult ; Biomarkers ; Biomarkers, Tumor ; Carcinoma, Hepatocellular ; Female ; Humans ; Liver Neoplasms ; Male ; Protein Precursors ; Prothrombin
Chemical Substances	Biomarkers ; Biomarkers, Tumor ; Protein Precursors ; acarboxyprothrombin (53230-14-1) ; Prothrombin (9001-26-7)
Language	English
Publishing date	2020-06-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	80228-1
ISSN	1873-3492 ; 0009-8981
ISSN (online)	1873-3492
ISSN	0009-8981
DOI	10.1016/j.cca.2020.06.035
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Article ; Online: Short-term biological variation study of plasma hemophilia and thrombophilia parameters in a population of apparently healthy Caucasian adults.

Brochier, Alice / Mairesse, Antoine / Saussoy, Pascale / Gavard, Christel / Desmet, Sandrine / Hermans, Cédric / Gruson, Damien / van Dievoet, Marie-Astrid

Clinical chemistry and laboratory medicine

2022 Volume 60, Issue 9, Page(s) 1409–1415

Abstract: Objectives: Biological variation (BV) data obtained in a standardized way is valuable to assess the analytical requirements and the utility of a reference interval. Our study aimed to determine the short-term BV of thrombophilia (protein S, protein C, ... ...

Abstract	Objectives: Biological variation (BV) data obtained in a standardized way is valuable to assess the analytical requirements and the utility of a reference interval. Our study aimed to determine the short-term BV of thrombophilia (protein S, protein C, activated protein C resistance (APCR) and factor VIII) and hemophilia (factors VIII, IX and XI) parameters in plasma. Coagulation factors V and XII were also evaluated. Based on the obtained data, we assessed analytical performance specifications for the parameters. Finally, we intended to provide a robust tool for comparison of serial measurements of factors V, VIII, IX and XI. Methods: A blood draw was performed weekly in 19 apparently healthy Caucasian adults for five weeks at Saint-Luc University Hospital (Brussels, Belgium). Parameters were measured in duplicate. BV components were calculated with a nested analysis of variance after exclusion of outliers. Results: The analytical coefficient of variation (CV) varied from 1.5 to 4.6%, the within-subject CV from 1.6 to 8.9% and the between-subject CV from 3.8 to 24.1%. All parameters showed high individuality. For most parameters, the analytical goal was met with our assays. Reference change values (RCV) of -16.7% to +20.0%, -20.7% to +26.0%, -15.3% to +18.1% and -13.1% to +15.1% were obtained for factors V, VIII, IX and XI respectively. Conclusions: All studied parameters were highly individualized. The assessment of BV data can guide setting analytical goal specifications. Comparison of serial measurements in the follow-up of patients suffering from hepatic failure or mild hemophilia is facilitated by evaluation of the RCV.
MeSH term(s)	Adult ; Belgium ; Hemophilia A ; Humans ; Reference Values ; Thrombophilia/diagnosis
Language	English
Publishing date	2022-06-27
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1418007-8
ISSN	1437-4331 ; 1434-6621 ; 1437-8523
ISSN (online)	1437-4331
ISSN	1434-6621 ; 1437-8523
DOI	10.1515/cclm-2022-0377
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Article ; Online: Fast and precise chiroptical spectroscopy by photoelectron elliptical dichroism.

Comby, Antoine / Descamps, Dominique / Petit, Stéphane / Valzer, Emmanuel / Wloch, Morgan / Pouységu, Laurent / Quideau, Stéphane / Bocková, Jana / Meinert, Cornelia / Blanchet, Valérie / Fabre, Baptiste / Mairesse, Yann

Physical chemistry chemical physics : PCCP

2023 Volume 25, Issue 24, Page(s) 16246–16263

Abstract: The photoionization of chiral molecules by elliptically polarized femtosecond laser pulses produces photoelectron angular distributions which show a strong and enantio-sensitive forward/backward asymmetry along the light propagation direction. We report ... ...

Abstract	The photoionization of chiral molecules by elliptically polarized femtosecond laser pulses produces photoelectron angular distributions which show a strong and enantio-sensitive forward/backward asymmetry along the light propagation direction. We report on high precision measurements of this photoelectron elliptical dichroism (PEELD). Using an optical cavity to recycle the laser pulses and increase the signal-to-noise ratio, we determine enantiomeric excesses with a 0.04% precision with a low-power femtosecond laser (4 W) in a compact scheme. We perform momentum-resolved PEELD measurements in 16 molecules, from volatile terpenes to non-volatile amino acids and large iodoarenes. The results demonstrate the high structural sensitivity of PEELD, confirming the spectroscopic interest of this technique. Last, we show how a convolutional neural network can be used to retrieve the chemical and enantiomeric composition of a sample from the momentum-resolved PEELD maps.
Language	English
Publishing date	2023-06-21
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/d3cp01057k
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Article ; Online: Aromatic Formation Promoted by Ion-Driven Radical Pathways in EUV Photochemical Experiments Simulating Titan's Atmospheric Chemistry.

Bourgalais, Jérémy / Carrasco, Nathalie / Vettier, Ludovic / Comby, Antoine / Descamps, Dominique / Petit, Stéphane / Blanchet, Valérie / Gaudin, Jérôme / Mairesse, Yann / Marty, Bernard

The journal of physical chemistry. A

2021 Volume 125, Issue 15, Page(s) 3159–3168

Abstract: In the atmosphere of Titan, Saturn's main satellite, molecular growth is initiated by 85.6 nm extreme ultraviolet (EUV) photons triggering a chemistry with charged and free-radical species. However, the respective contribution of these species to the ... ...

Abstract	In the atmosphere of Titan, Saturn's main satellite, molecular growth is initiated by 85.6 nm extreme ultraviolet (EUV) photons triggering a chemistry with charged and free-radical species. However, the respective contribution of these species to the complexification of matter is far from being known. This work presents a chemical analysis in order to contribute to a better understanding of aromatic formation pathways. A gas mixture of N
Language	English
Publishing date	2021-04-12
Publishing country	United States
Document type	Journal Article
ISSN	1520-5215
ISSN (online)	1520-5215
DOI	10.1021/acs.jpca.1c00324
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Article ; Online: Biological variation and analytical goals of four thyroid function biomarkers in healthy European volunteers.

Mairesse, Antoine / Wauthier, Loris / Courcelles, Louisiane / Luyten, Urszula / Burlacu, Maria-Cristina / Maisin, Diane / Favresse, Julien / van Dievoet, Marie-Astrid / Gruson, Damien

Clinical endocrinology

2021 Volume 94, Issue 5, Page(s) 845–850

Abstract: Background: Interpretation of thyroid function tests by means of biological variation (BV) data is essential to identify significant changes between serial measurements at an individual level. Data on thyroid parameters in adults are limited.: ... ...

Abstract	Background: Interpretation of thyroid function tests by means of biological variation (BV) data is essential to identify significant changes between serial measurements at an individual level. Data on thyroid parameters in adults are limited. Objectives: We aimed at determining the BV of four thyroid function test (thyroid-stimulating hormone (TSH), free thyroxin (FT4), free triiodothyronine (FT3) and thyroglobulin (Tg)) by applying recent recommendations to acquire BV data on a latest generation of immunoassay. Methods: Nineteen healthy volunteers (8 males and 11 females) were drawn every week during 5 consecutive weeks. Samples were analysed in duplicate on the Cobas 602 analyzer (Roche Diagnostics). After normality assessment, outlier exclusion and homogeneity of variance analysis, analytical variation (CV Results: CV Conclusion: Based on recent international recommendations, our study provides updated BV data for four thyroid function tests in European healthy volunteers. Reliable BV characteristics, and especially RCV, can facilitate the interpretation of consecutive thyroid function tests in an individual and therefore have the potential to efficiently support clinical decisions regarding thyroid diseases.
MeSH term(s)	Adult ; Biomarkers ; Female ; Goals ; Healthy Volunteers ; Humans ; Male ; Reference Values ; Thyroid Gland ; Thyrotropin ; Thyroxine ; Triiodothyronine
Chemical Substances	Biomarkers ; Triiodothyronine (06LU7C9H1V) ; Thyrotropin (9002-71-5) ; Thyroxine (Q51BO43MG4)
Language	English
Publishing date	2021-03-14
Publishing country	England
Document type	Journal Article
ZDB-ID	121745-8
ISSN	1365-2265 ; 0300-0664
ISSN (online)	1365-2265
ISSN	0300-0664
DOI	10.1111/cen.14356
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Article ; Online: Using photoelectron elliptical dichroism (PEELD) to determine real-time variation of enantiomeric excess.

Comby, Antoine / Bond, Caoimhe M M / Bloch, Etienne / Descamps, Dominique / Fabre, Baptiste / Petit, Stephane / Mairesse, Yann / Greenwood, Jason B / Blanchet, Valerie

Chirality

2020 Volume 32, Issue 10, Page(s) 1225–1233

Abstract: In this work, the photoionization of chiral molecules by an elliptically polarized, high repetition rate, femtosecond laser is probed. The resulting 3D photoelectron angular distribution shows a strong forward-backward asymmetry, which is highly ... ...

Abstract	In this work, the photoionization of chiral molecules by an elliptically polarized, high repetition rate, femtosecond laser is probed. The resulting 3D photoelectron angular distribution shows a strong forward-backward asymmetry, which is highly dependent not only on the molecular structure but also on the ellipticity of the laser pulse. By continuously varying the laser ellipticity, we can observe molecular and enantiomer changes in real time at a previously unseen speed and precision. The technique allows enantiomeric excess of a pure compound to be measured with a 5% precision within 3 s, and a 10-min acquisition yields a precision of 0.4%. The isomers camphor and fenchone can be easily distinguished, unlike with conventional mass spectrometry. Preliminary results for the pharmaceutically interesting ibuprofen are also given, showing the capability of photoionization as a means of distinguishing larger molecular systems.
Language	English
Publishing date	2020-07-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1011639-4
ISSN	1520-636X ; 0899-0042
ISSN (online)	1520-636X
ISSN	0899-0042
DOI	10.1002/chir.23267
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Article ; Online: Biological variation data and analytical specification goal estimates of the thrombin generation assay with and without thrombomodulin in healthy individuals.

Mairesse, Antoine / Bayart, Jean-Louis / Desmet, Sandrine / Lopes Dos Santos, Helder / Saussoy, Pascale / Defour, Jean-Philippe / Eeckhoudt, Stéphane / van Dievoet, Marie-Astrid

International journal of laboratory hematology

2020 Volume 43, Issue 3, Page(s) 450–457

Abstract: Background: Evaluation of an individual's thrombin-generating capacity enables a global assessment of the coagulation cascade and is therefore thought to better reflect the clotting function of blood. However, the lack of standardization still hampers ... ...

Abstract	Background: Evaluation of an individual's thrombin-generating capacity enables a global assessment of the coagulation cascade and is therefore thought to better reflect the clotting function of blood. However, the lack of standardization still hampers the use in routine clinical practice. Methods: Nineteen healthy subjects were sampled once a week for 5 consecutive weeks. Thrombin generation assay (TGA) was performed in duplicate by calibrated automated thrombogram (CAT) on platelet poor plasma with and without thrombomodulin. After exclusion of outliers, a nested analysis of variance (ANOVA) was performed to evaluate the biological variability (BV) results. Analytical variation (CV Results: All parameters taken together, the CV Conclusion: CAT parameters are highly individualized and population-based reference values could be called into question. The assessment of BV and RCV for thrombin generation assays could optimize interpretation of serial patient results and guide setting of analytical specification goals.
MeSH term(s)	Adult ; Blood Coagulation Tests/methods ; Female ; Humans ; Male ; Middle Aged ; Plasma/metabolism ; Reference Values ; Thrombin/analysis ; Thrombin/metabolism ; Thrombomodulin/metabolism ; Young Adult
Chemical Substances	Thrombomodulin ; Thrombin (EC 3.4.21.5)
Language	English
Publishing date	2020-11-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2268590-X
ISSN	1751-553X ; 1751-5521 ; 0141-9854
ISSN (online)	1751-553X
ISSN	1751-5521 ; 0141-9854
DOI	10.1111/ijlh.13388
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