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Article ; Online: Experimental investigation on the performance of a novel resonance-assisted ejector under low pressurization

Xi, Xiuzhi / Xin, Yuhang / Duan, Dingli / Zhang, Bo

Energy Conversion and Management. 2023, p.116778-

2023 , Page(s) 116778–

Abstract: It is of great significance and value to apply different techniques to optimize the entrained performance of an ejector. In this paper, a novel resonance-assisted ejector is proposed by applying a mixing enhancement technique. Experimental studies were ... ...

Abstract	It is of great significance and value to apply different techniques to optimize the entrained performance of an ejector. In this paper, a novel resonance-assisted ejector is proposed by applying a mixing enhancement technique. Experimental studies were conducted to investigate the oscillation effect on the performance of the ejector under different geometries and operating conditions. The results show that adding high-frequency oscillations to the primary flow can provide up to a 14% improvement in entrainment performance. As the length of the resonance tube increases, the performance tends to increase and then decrease. The performance is sensitive to variations in the distance between the nozzle of the resonance generator and the inlet of the resonance tube. The shorter the distance, the greater the performance improvement. The critical pressure ratio of the resonance generator is approximately 5.5. The entrained performance enhancement rate increases gradually over the critical pressure ratio. Entrainment enhancement caused by resonance generator can be eliminated with small mixing cross-sectional areas. The oscillation effect enhances the entrained performance at different backpressures, and the higher the pressure the greater the enhancement rate. This paper provides new ideas for the optimization of ejector performance.
Keywords	administrative management ; area ; energy conservation ; energy conversion ; exhibitions ; geometry ; mixing ; nozzles ; oscillation ; tubes ; Resonance-assisted ejector ; Mixing enhancement technology ; Resonance tube ; Entrainment performance
Language	English
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	2000891-0
ISSN	0196-8904
ISSN	0196-8904
DOI	10.1016/j.enconman.2023.116778
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: One-pot electrochemical synthesis of quinazolinones by Fe(III)-catalyzed indirect anodic oxidation

Wu, Bin / Duan, Qixin / Chen, Fengyuan / Xu, Yingying / Zhang, Qi / Xu, Xiuzhi / Lin, Jin

Tetrahedron. 2023 Aug., v. 143 p.133563-

2023

Abstract: An operationally simple electrochemical approach for the one-pot synthesis of quinazolinones employing low-cost and relatively environmentally friendly FeCl₃ as electrocatalysts has been established. By use of readily available o-aminobenzamides and ... ...

Abstract	An operationally simple electrochemical approach for the one-pot synthesis of quinazolinones employing low-cost and relatively environmentally friendly FeCl₃ as electrocatalysts has been established. By use of readily available o-aminobenzamides and alcohols as starting materials, the Fe/acid electrocatalytic system was conducted under mild conditions to provide quinazolinones via indirect anodic oxidation/cyclization/dehydrogenation cascade in moderate to good yields. This protocol provides a practical and environmentally benign route for the preparation of quinazolinone derivatives under mild conditions.
Keywords	dehydrogenation ; electrochemistry ; electrosynthesis ; oxidation ; Iron ; Quinazolinones ; Tandem oxidation ; Green synthesis
Language	English
Dates of publication	2023-08
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	204285-x
ISSN	1464-5416 ; 0040-4020 ; 0563-2064
ISSN (online)	1464-5416
ISSN	0040-4020 ; 0563-2064
DOI	10.1016/j.tet.2023.133563
Database	NAL-Catalogue (AGRICOLA)

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Zs.B 1076: Show issues

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Article ; Online: Sequence-Guided Localization of DNA Hybridization Enables Highly Selective and Robust Genotyping.

Wang, Xuchu / Chen, Tao / Ping, Ying / Dai, Yibei / Yu, Pan / Xie, Yiyi / Liu, Zhenping / Sun, Bohao / Duan, Xiuzhi / Tao, Zhihua

Small (Weinheim an der Bergstrasse, Germany)

2023 , Page(s) e2307985

Abstract: Genetic variations are always related to human diseases or susceptibility to therapies. Nucleic acid probes that precisely distinguish closely related sequences become an indispensable requisite both in research and clinical applications. Here, a ... ...

Abstract	Genetic variations are always related to human diseases or susceptibility to therapies. Nucleic acid probes that precisely distinguish closely related sequences become an indispensable requisite both in research and clinical applications. Here, a Sequence-guided DNA LOCalization for leaKless DNA detection (SeqLOCK) is introduced as a technique for DNA hybridization, where the intended targets carrying distinct "guiding sequences" act selectively on the probes. In silicon modeling, experimental results reveal considerable agreement (R
Language	English
Publishing date	2023-12-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2168935-0
ISSN	1613-6829 ; 1613-6810
ISSN (online)	1613-6829
ISSN	1613-6810
DOI	10.1002/smll.202307985
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Article ; Online: How to better select SARS-CoV-2 preservation solution of virus nucleic acid testing.

Duan, Xiuzhi / Huang, Letao / Wang, Xuchu / Ping, Ying / Yu, Pan / Liu, Weiwei / Xie, Yiyi / Tao, Zhihua

Journal of clinical laboratory analysis

2023 Volume 37, Issue 15-16, Page(s) e24956

Abstract: Background: Sampling and testing for SARS-CoV-2 is a widely recognized method for identifying patients with COVID-19. However, there is limited research available on the stability of nucleic acids in viral storage solutions.: Methods: This paper ... ...

Abstract	Background: Sampling and testing for SARS-CoV-2 is a widely recognized method for identifying patients with COVID-19. However, there is limited research available on the stability of nucleic acids in viral storage solutions. Methods: This paper investigates the components that provide better protection for virus and nucleic acid detection. The study utilized real-time quantitative fluorescent PCR to detect SARS-CoV-2 and evaluate the preservation effect and stability of SARS-CoV-2 viral storage solution under various conditions, including different guanidinium salts, brands, and storage conditions. Results: All brands of inactivated virus preservation solutions demonstrated effective preservation and stability. However, 0.5 mol/L guanidine hydrochloride and guanidine isothiocyanate solutions exhibited poor antiseptic effects. Additionally, refrigerated storage showed better preservation compared to room temperature storage. Conclusions: We recommend using inactivated virus collection solution to preserve and transport samples and testing preferably within 6 hours to reduce false negatives of NAT results.
Language	English
Publishing date	2023-09-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	645095-7
ISSN	1098-2825 ; 0887-8013
ISSN (online)	1098-2825
ISSN	0887-8013
DOI	10.1002/jcla.24956
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Zs.A 2471: Show issues

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Article ; Online: Effect observation of individualized graded nursing on blood coagulation function in children with henoch schonlein purpura nephritis.

Duan, Xiuzhi / Meng, Xue / An, Qing / Li, Yanyan / Shan, Xin / Chen, Zhe

Panminerva medica

2020

Language	English
Publishing date	2020-09-18
Publishing country	Italy
Document type	Journal Article
ZDB-ID	123572-2
ISSN	1827-1898 ; 0031-0808
ISSN (online)	1827-1898
ISSN	0031-0808
DOI	10.23736/S0031-0808.20.04060-4
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Zs.B 179: Show issues

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Article ; Online: The rs9402373 polymorphism of CTGF gene may not be related to inflammatory bowel disease susceptibility in Chinese population based on ARMS-PCR genotyping

Yiyi Xie / Ying Ping / Pan Yu / Weiwei Liu / Xinan Chen / Qi Wang / Yuhua Chen / Xiuzhi Duan / Xuchu Wang

Heliyon, Vol 9, Iss 6, Pp e17003- (2023)

2023

Abstract: Background: It has been confirmed that the connective tissue growth factor (CTGF) gene rs9402373 polymorphism is associated with fibrotic and inflammatory diseases. However, studies on the relationship between polymorphisms in CTGF rs9402373 and ... ...

Abstract	Background: It has been confirmed that the connective tissue growth factor (CTGF) gene rs9402373 polymorphism is associated with fibrotic and inflammatory diseases. However, studies on the relationship between polymorphisms in CTGF rs9402373 and inflammatory bowel disease (IBD) remain rare. Therefore, the aim of this study was to assess the association between the CTGF rs9402373 polymorphism and IBD susceptibility in a Chinese population. Materials and methods: To establish an amplification refractory mutation system (ARMS) PCR technology for genotyping CTGF gene rs9402373 polymorphism, we designed two specific forward primers for the wild and mutant types by placing the allele-specific nucleotide at the penultimate position of the ‘3′ end of the primer. Then, 10 samples were randomly selected and rechecked by DNA sequencing to verify the accuracy of this method. We further used the established method to detect specimens collected from 191 patients with inflammatory bowel disease, including 120 Crohn's disease (CD) and 71 ulcerative colitis (UC), and 110 healthy Han Chinese individuals. Results: We successfully established the ARMS-PCR method for genotyping, and the results of 10 randomly selected samples were completely consistent with DNA sequencing. The rs9402373 G allele frequencies in UC and CD cases were 38.03% and 43.75%, respectively, and in controls, they were 41.82%. No significant difference was found in minor allele frequencies between the UC or CD and control groups (P = 0.473, P = 0.676). Genotype analysis demonstrated that there was no relationship between CTGF rs9402373 polymorphism and the risk of IBD regardless of the inheritance mode (P > 0.05). Conclusions: In this preliminary study, we successfully developed a simple, efficient and cost-effective method for genotyping CTGF rs9402373 polymorphism. The polymorphism may not be related to IBD susceptibility in the Chinese Han population.
Keywords	Inflammatory bowel disease ; Connective tissue growth factor ; Amplification refractory mutation system ; Single nucleotide polymorphism ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	630
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: New insights into lipid metabolism and prostate cancer (Review).

Zhang, Zhengliang / Wang, Weixi / Kong, Piaoping / Feng, Kangle / Liu, Chunhua / Sun, Tao / Sang, Yiwen / Duan, Xiuzhi / Tao, Zhihua / Liu, Weiwei

International journal of oncology

2023 Volume 62, Issue 6

Abstract: Prostate cancer (PCa) is the most common malignant tumor of the male urological system and poses a severe threat to the survival of middle‑aged and elderly males worldwide. The development and progression of PCa are affected by a variety of biological ... ...

Abstract	Prostate cancer (PCa) is the most common malignant tumor of the male urological system and poses a severe threat to the survival of middle‑aged and elderly males worldwide. The development and progression of PCa are affected by a variety of biological processes, including proliferation, apoptosis, migration, invasion and the maintenance of membrane homeostasis of PCa cells. The present review summarizes recent research advances in lipid (fatty acid, cholesterol and phospholipid) metabolic pathways in PCa. In the first section, the metabolism of fatty acids is highlighted, from formation to catabolism and associated proteins. Subsequently, the role of cholesterol in the pathogenesis and evolution of PCa is described in detail. Finally, the different types of phospholipids and their association with PCa progression is also discussed. In addition to the impact of key proteins of lipid metabolism on PCa growth, metastasis and drug resistance, the present review also summarizes the clinical value of fatty acids, cholesterol and phospholipids, as diagnostic and prognostic indicators and therapeutic targets in PCa.
MeSH term(s)	Aged ; Middle Aged ; Humans ; Male ; Lipid Metabolism ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/metabolism ; Proteins/metabolism ; Cholesterol ; Fatty Acids ; Phospholipids
Chemical Substances	Proteins ; Cholesterol (97C5T2UQ7J) ; Fatty Acids ; Phospholipids
Language	English
Publishing date	2023-05-19
Publishing country	Greece
Document type	Review ; Journal Article
ZDB-ID	1154403-x
ISSN	1791-2423 ; 1019-6439
ISSN (online)	1791-2423
ISSN	1019-6439
DOI	10.3892/ijo.2023.5522
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Zs.A 3690: Show issues

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Article ; Online: Gestational diabetes mellitus in the COVID-19 pandemic: A retrospective study from Hangzhou, China.

Yin, Binbin / Wu, Kaiqi / Hu, Lingwei / Zheng, Wanlu / Zheng, Yidan / Duan, Xiuzhi / Zhu, Bo

Journal of diabetes

2022 Volume 14, Issue 10, Page(s) 711–720

Abstract: Aims: Our study aimed to investigate changes in the prevalence of gestational diabetes mellitus (GDM) in the COVID-19 pandemic and postpandemic era and the risk of adverse pregnancy outcomes in pregnant women diagnosed with GDM during the blockade ... ...

Abstract	Aims: Our study aimed to investigate changes in the prevalence of gestational diabetes mellitus (GDM) in the COVID-19 pandemic and postpandemic era and the risk of adverse pregnancy outcomes in pregnant women diagnosed with GDM during the blockade period. Methods: First, we investigated changes in the prevalence of GDM and the population undergoing oral glucose tolerance tests (OGTT) after the COVID-19 pandemic. We then collected clinical information from pregnant women diagnosed with GDM to explore the risk of adverse pregnancy outcomes in pregnant women with GDM during the COVID-19 pandemic. Results: After the COVID-19 pandemic, the proportion of pregnant women in the total number of outpatient OGTT tests decreased yearly. The ratio was 81.30%, 79.71%, and 75.48% from 2019 to 2021, respectively, with the highest proportion of pregnant women in February 2020 (92.03%). The prevalence of GDM was higher in March 2020 compared to the same period in 2019. However, from 2019 to 2021, the prevalence decreased year by year with 21.46%, 19.81%, and 18.48%, respectively. The risk of adverse pregnancy outcomes for pregnant women diagnosed with GDM during the most severe period of the COVID-19 pandemic did not differ from before the COVID-19 pandemic. Conclusions: After the COVID-19 pandemic, the prevalence of GDM increased during the most severe period of the epidemic, but the overall prevalence of GDM decreased year by year. In addition, the pandemic did not change the risk of adverse pregnancy outcomes in pregnant women with GDM.
MeSH term(s)	COVID-19/epidemiology ; China/epidemiology ; Diabetes, Gestational/diagnosis ; Diabetes, Gestational/epidemiology ; Female ; Humans ; Pandemics ; Pregnancy ; Pregnancy Outcome/epidemiology ; Retrospective Studies ; Risk Factors
Language	English
Publishing date	2022-10-01
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2503337-2
ISSN	1753-0407 ; 1753-0393
ISSN (online)	1753-0407
ISSN	1753-0393
DOI	10.1111/1753-0407.13324
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Zs.A 6791: Show issues

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Article: The rs9402373 polymorphism of CTGF gene may not be related to inflammatory bowel disease susceptibility in Chinese population based on ARMS-PCR genotyping.

Xie, Yiyi / Ping, Ying / Yu, Pan / Liu, Weiwei / Chen, Xinan / Wang, Qi / Chen, Yuhua / Duan, Xiuzhi / Wang, Xuchu

Heliyon

2023 Volume 9, Issue 6, Page(s) e17003

Abstract	Background: It has been confirmed that the connective tissue growth factor (CTGF) gene rs9402373 polymorphism is associated with fibrotic and inflammatory diseases. However, studies on the relationship between polymorphisms in CTGF rs9402373 and inflammatory bowel disease (IBD) remain rare. Therefore, the aim of this study was to assess the association between the CTGF rs9402373 polymorphism and IBD susceptibility in a Chinese population. Materials and methods: To establish an amplification refractory mutation system (ARMS) PCR technology for genotyping CTGF gene rs9402373 polymorphism, we designed two specific forward primers for the wild and mutant types by placing the allele-specific nucleotide at the penultimate position of the '3' end of the primer. Then, 10 samples were randomly selected and rechecked by DNA sequencing to verify the accuracy of this method. We further used the established method to detect specimens collected from 191 patients with inflammatory bowel disease, including 120 Crohn's disease (CD) and 71 ulcerative colitis (UC), and 110 healthy Han Chinese individuals. Results: We successfully established the ARMS-PCR method for genotyping, and the results of 10 randomly selected samples were completely consistent with DNA sequencing. The rs9402373 G allele frequencies in UC and CD cases were 38.03% and 43.75%, respectively, and in controls, they were 41.82%. No significant difference was found in minor allele frequencies between the UC or CD and control groups (P = 0.473, P = 0.676). Genotype analysis demonstrated that there was no relationship between CTGF rs9402373 polymorphism and the risk of IBD regardless of the inheritance mode (P > 0.05). Conclusions: In this preliminary study, we successfully developed a simple, efficient and cost-effective method for genotyping CTGF rs9402373 polymorphism. The polymorphism may not be related to IBD susceptibility in the Chinese Han population.
Language	English
Publishing date	2023-06-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e17003
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Naringenin prevents pregnancy-induced hypertension via suppression of JAK/STAT3 signalling pathway in mice.

Duan, Bide / Li, Yuan / Geng, Hui / Ma, Airong / Yang, Xiuzhi

International journal of clinical practice

2021 Volume 75, Issue 10, Page(s) e14509

Abstract: Background: Pregnancy-induced hypertension (PIH) is characterized by high blood pressure during pregnancy, which causes perinatal and maternal mortality. Inflammation, oxidative stress and the JAK2/STAT3 signalling pathway have been reported to play ... ...

Abstract	Background: Pregnancy-induced hypertension (PIH) is characterized by high blood pressure during pregnancy, which causes perinatal and maternal mortality. Inflammation, oxidative stress and the JAK2/STAT3 signalling pathway have been reported to play critical roles in the pathogenies of PIH. Due to the safety and side effects of current treatments for PIH, searching for new therapeutic agents is urgently needed. Naringenin is a flavonoid with anti-inflammation and anti-oxidation activities. In the current study, the effects of naringenin on PIH were investigated. Methods: We established the PIH mouse model and administrated naringenin to these mice. The blood pressure, total urine protein, plasma levels of vasodilation converting enzyme (VCE), α-1A adrenergic receptor (α-ADR) and angiotensin, inflammatory cytokines, oxidative stress markers were measured. The protein levels of reactive oxygen species proto-oncogene 1 (ROS1), superoxide dismutase 2 (SOD2), signal transducer and activator of transcription 3 (STAT3), phospho-STAT3, Src homology 2 domain-containing protein tyrosine phosphatase 1 (SHP-1), Janus kinase 2 (JAK2) and phospho-JAK2, in vascular endothelium cells were detected by western blot. Results: Administration of naringenin significantly decreased blood pressure, total urine protein level, plasma levels of VCE, α-ADR and angiotensin in PIH mice. Naringenin decreased serum levels of pro-inflammatory cytokines interleukin (IL)-2, IL-6 and tumour necrosis factor alpha (TNF-α), while increased IL-10. Naringenin decreased serum levels of ROS, endothelin while increased SOD and nitric oxide levels. Western blot analysis showed that naringenin inhibited ROS expression, while increased SOD expression in vascular endothelial cells of mice. In addition, western blot also showed that naringenin inhibited JAK2/STAT3 signalling by suppressing SHP-1 expression in vascular endothelial cells of mice. Conclusion: Naringenin suppressed the activation of JAK2/STAT3 signalling pathway and promoted SHP-1 expression, leading to ameliorated hypertension in pregnancy.
Language	English
Publishing date	2021-06-23
Publishing country	England
Document type	Journal Article
ZDB-ID	1386246-7
ISSN	1742-1241 ; 1368-5031
ISSN (online)	1742-1241
ISSN	1368-5031
DOI	10.1111/ijcp.14509
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