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  1. Article ; Online: Right-sided subcutaneous implantable cardioverter-defibrillator placement in a patient with "acquired mesocardia".

    Prousi, George S / Nichols, Judy / Jacob, Sony

    Heart rhythm O2

    2022  Volume 3, Issue 5, Page(s) 587–588

    Language English
    Publishing date 2022-10-21
    Publishing country United States
    Document type Editorial
    ISSN 2666-5018
    ISSN (online) 2666-5018
    DOI 10.1016/j.hroo.2022.08.003
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  2. Article ; Online: "Third Time's a Charm": Three Times Per Day Dosing of Dofetilide May Be Beneficial in Refractory Atrial Arrhythmias.

    Jacob, Sony / Nichols, Judy / Tanner, Heather / Prousi, George / Smith, Stuart

    The American journal of cardiology

    2022  Volume 176, Page(s) 143–144

    MeSH term(s) Arrhythmias, Cardiac/drug therapy ; Humans ; Phenethylamines ; Sulfonamides/therapeutic use
    Chemical Substances Phenethylamines ; Sulfonamides ; dofetilide (R4Z9X1N2ND)
    Language English
    Publishing date 2022-06-01
    Publishing country United States
    Document type Letter
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/j.amjcard.2022.04.042
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    Ui IV Zs.73: Show issues Location:
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  3. Article ; Online: Therapeutic Outlook of Pyrazole Analogs: A Mini Review.

    Ganguly, Swastika / Jacob, Sony K

    Mini reviews in medicinal chemistry

    2017  Volume 17, Issue 11, Page(s) 959–983

    Abstract: Background: Pyrazole is one of the excellent structural motifs in medicinal chemistry. Various physiological and therapeutic possibilities have been exploited by incorporating different pharmacophoric groups in the pyrazole moiety.: Objective: This ... ...

    Abstract Background: Pyrazole is one of the excellent structural motifs in medicinal chemistry. Various physiological and therapeutic possibilities have been exploited by incorporating different pharmacophoric groups in the pyrazole moiety.
    Objective: This has opened a new arena of pyrazole analogs that can be developed into medicinal agents such as anti-inflammatory, analgesic, antipyretic, antiviral, antibacterial, anticancer, anticonvulsant, hypoglycemic, carbonic anhydrase inhibitors, mono amino oxidase (MAO) inhibitors, etc. Though, pyrazole analogs have proven their clinical efficacy as different pharmacological agents, a few of them have been withdrawn from the market due to their side effects. Thus, research on potential new drug candidates bearing the pyrazole moiety with lesser side effects has fairly increased over the last few years.
    Conclusion: This review explores diverse pharmacological activities exhibited by pyrazole analogs reported recently, which may be of great help for researchers in the area of drug discovery to understand the current scenario of pyrazole based compounds and to design and develop newer drug candidates with improved efficacy.
    MeSH term(s) Analgesics/chemistry ; Analgesics/therapeutic use ; Anti-Infective Agents/therapeutic use ; Anti-Inflammatory Agents/chemistry ; Anti-Inflammatory Agents/therapeutic use ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/therapeutic use ; Antipyretics/chemistry ; Antipyretics/therapeutic use ; Humans ; Molecular Structure ; Pyrazoles/chemistry ; Pyrazoles/pharmacology ; Pyrazoles/therapeutic use
    Chemical Substances Analgesics ; Anti-Infective Agents ; Anti-Inflammatory Agents ; Antineoplastic Agents ; Antipyretics ; Pyrazoles
    Language English
    Publishing date 2017
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2104081-3
    ISSN 1875-5607 ; 1389-5575
    ISSN (online) 1875-5607
    ISSN 1389-5575
    DOI 10.2174/1389557516666151120115302
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5891: Show issues Location:
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  4. Article ; Online: Percutaneous epicardial defibrillation coil implantation: a viable technique to manage refractory defibrillation threshold.

    Jacob, Sony / Lieberman, Randy A

    Circulation. Arrhythmia and electrophysiology

    2010  Volume 3, Issue 2, Page(s) 214–217

    MeSH term(s) Aged ; Arrhythmias, Cardiac/diagnostic imaging ; Arrhythmias, Cardiac/etiology ; Arrhythmias, Cardiac/therapy ; Atrial Appendage ; Breast Neoplasms/surgery ; Cardiomyopathies/complications ; Cardiomyopathies/diagnostic imaging ; Defibrillators, Implantable ; Female ; Humans ; Mastectomy ; Pericardium ; Radiography
    Language English
    Publishing date 2010-04
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2426129-4
    ISSN 1941-3084 ; 1941-3149
    ISSN (online) 1941-3084
    ISSN 1941-3149
    DOI 10.1161/CIRCEP.109.930552
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6667: Show issues Location:
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  5. Article: Dysrhythmiartifact.

    Jacob, Sony / Ganguly, Joya A / Kommuri, Naga V A

    The Journal of emergency medicine

    2012  Volume 42, Issue 5, Page(s) e115–6

    MeSH term(s) Aged ; Arrhythmias, Cardiac/etiology ; Artifacts ; Electrocardiography ; Female ; Humans ; Implantable Neurostimulators/adverse effects ; Urinary Bladder, Neurogenic/therapy
    Language English
    Publishing date 2012-05
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 605559-x
    ISSN 0736-4679
    ISSN 0736-4679
    DOI 10.1016/j.jemermed.2010.05.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1895: Show issues Location:
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  6. Article ; Online: Homology model, molecular dynamics simulation and novel pyrazole analogs design of Candida albicans CYP450 lanosterol 14 α-demethylase, a target enzyme for antifungal therapy.

    Jacob K, Sony / Ganguly, Swastika / Kumar, Pravin / Poddar, Raju / Kumar, Anoop

    Journal of biomolecular structure & dynamics

    2017  Volume 35, Issue 7, Page(s) 1446–1463

    Abstract: Candida albicans infections and their resistance to clinically approved azole drugs are major concerns for human. The azole antifungal drugs inhibit the ergosterol synthesis by targeting lanosterol 14α-demethylase of cytochrome P450 family. The lack of ... ...

    Abstract Candida albicans infections and their resistance to clinically approved azole drugs are major concerns for human. The azole antifungal drugs inhibit the ergosterol synthesis by targeting lanosterol 14α-demethylase of cytochrome P450 family. The lack of high-resolution structural information of fungal pathogens has been a barrier for the design of modified azole drugs. Thus, a preliminary theoretical molecular dynamic study is carried out to develop and validate a simple homologous model using crystallographic structure of the lanosterol 14α-demethylase of Mycobacterium tuberculosis (PDB ID-1EA1) in which the active site residues are substituted with that of C. albicans (taxid 5476). Further, novel designed pyrazole analogs (SGS1-16) docked on chimeric 1EA1 and revealed that SGS-16 show good binding affinity through non-bonding interaction with the heme, which is different from the leading azole antifungals. The ADME-T results showed these analogs can be further explored in design of more safe and effective antifungal agents.
    Language English
    Publishing date 2017-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2016.1185380
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    Zs.A 2093: Show issues Location:
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  7. Article ; Online: Acquired coronary-cameral fistula.

    Jacob, Sony / Feigenbaum, Harvey

    Clinical cardiology

    2009  Volume 32, Issue 8, Page(s) E70

    MeSH term(s) Adult ; Biopsy/adverse effects ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/etiology ; Echocardiography, Doppler, Color ; Female ; Fistula/diagnostic imaging ; Fistula/etiology ; Heart Diseases/diagnostic imaging ; Heart Diseases/etiology ; Heart Transplantation ; Heart Ventricles/diagnostic imaging ; Heart Ventricles/pathology ; Humans ; Iatrogenic Disease
    Language English
    Publishing date 2009-07-16
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 391935-3
    ISSN 1932-8737 ; 0160-9289
    ISSN (online) 1932-8737
    ISSN 0160-9289
    DOI 10.1002/clc.20507
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    Zs.A 1423: Show issues Location:
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  8. Article ; Online: Pacemaker lead malfunction following superior vena cava stenting.

    Jacob, Sony / Mohamad, Tamam

    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology

    2009  Volume 11, Issue 10, Page(s) 1266

    MeSH term(s) Aged ; Electrodes, Implanted ; Equipment Failure ; Equipment Failure Analysis ; Humans ; Male ; Pacemaker, Artificial ; Stents ; Vena Cava, Superior
    Language English
    Publishing date 2009-10
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1449879-0
    ISSN 1532-2092 ; 1099-5129
    ISSN (online) 1532-2092
    ISSN 1099-5129
    DOI 10.1093/europace/eup200
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    Zs.A 5434: Show issues Location:
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  9. Article ; Online: The efficacy of sotalol in preventing postoperative atrial fibrillation: a meta-analysis.

    Kerin, Nicholas Z / Jacob, Sony

    The American journal of medicine

    2011  Volume 124, Issue 9, Page(s) 875.e1–9

    Abstract: Objective: Supraventricular tachyarrhythmias including atrial fibrillation are common and troubling complications after cardiac surgery, and thus considerable interest in pharmacologic prophylaxis has developed. The aim of this study was to evaluate the ...

    Abstract Objective: Supraventricular tachyarrhythmias including atrial fibrillation are common and troubling complications after cardiac surgery, and thus considerable interest in pharmacologic prophylaxis has developed. The aim of this study was to evaluate the efficacy of sotalol in the prevention of postoperative supraventricular tachyarrhythmias.
    Methods: Standard methods of meta-analysis were used. Randomized clinical trials published in English language were eligible for the meta-analysis.
    Results: A systematic review revealed 15 eligible publications that provided 20 comparisons of sotalol with a control group. The incidence and relative risk (RR) with 95% confidence interval (CI) of developing postoperative supraventricular tachyarrhythmias while taking sotalol were sotalol (n=489) versus placebo (n=499): 22.5% versus 41.5%, RR=0.55 (CI, 0.454-0.667, P<.001); sotalol (n=304) versus no treatment (n=311): 12% versus 39%, RR=0.329 (CI, 0.236-0.459, P<.001); sotalol (n=488) versus beta-blocker (n=555): 14% versus 23%, RR=0.644 (CI, 0.495-0.838, P<.001); sotalol (n=139) versus amiodarone (n=146): no significant differences in supraventricular tachyarrhythmia prevention; and sotalol (n=51) versus magnesium (n=54): no significant differences in supraventricular tachyarrhythmia prevention. Initiating sotalol orally or intravenously had no significant effect on efficacy. Initiating sotalol after surgery showed a trend toward less adverse events (before: RR=1.700 [CI, 0.903-3.200] and after: RR=0.767 [CI, 0.391-1.505]).
    Conclusion: Sotalol is more effective in the prevention of supraventricular tachyarrhythmia than placebo or beta-blockers. Initiating sotalol before cardiac surgery has no advantage compared with initiating sotalol shortly after surgery. Starting sotalol intravenously after surgery may be a more reliable method than administering via a nasogastric tube or delaying treatment until the patient can take oral medication.
    MeSH term(s) Anti-Arrhythmia Agents/adverse effects ; Anti-Arrhythmia Agents/therapeutic use ; Atrial Fibrillation/prevention & control ; Double-Blind Method ; Drug Therapy, Combination ; Electrocardiography/drug effects ; Heart Diseases/surgery ; Humans ; Infusions, Intravenous ; Magnesium/adverse effects ; Magnesium/therapeutic use ; Postoperative Care ; Postoperative Complications/prevention & control ; Prospective Studies ; Randomized Controlled Trials as Topic ; Sotalol/adverse effects ; Sotalol/therapeutic use ; Tachycardia, Supraventricular/prevention & control
    Chemical Substances Anti-Arrhythmia Agents ; Sotalol (A6D97U294I) ; Magnesium (I38ZP9992A)
    Language English
    Publishing date 2011-09
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Meta-Analysis
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2011.04.025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.289: Show issues Location:
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  10. Article ; Online: Device lead screw tip induced pericarditis--a subtle complication in need of wider recognition.

    Panaich, Sidakpal S / Cardozo, Shaun / Jacob, Sony / Afonso, Luis

    International journal of cardiology

    2013  Volume 167, Issue 3, Page(s) e76–7

    MeSH term(s) Electrodes, Implanted/adverse effects ; Humans ; Male ; Middle Aged ; Pacemaker, Artificial/adverse effects ; Pericarditis/diagnostic imaging ; Pericarditis/etiology ; Ultrasonography
    Language English
    Publishing date 2013-08-10
    Publishing country Netherlands
    Document type Case Reports ; Letter
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2013.03.100
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    Zs.A 1673: Show issues Location:
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