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  1. Article ; Online: Androgen Suppression Combined With Elective Nodal and Dose Escalated Radiation Therapy: Brachytherapy as Dose Escalation for Localized Prostate Cancer.

    Pisansky, Thomas M

    International journal of radiation oncology, biology, physics

    2023  Volume 115, Issue 5, Page(s) 1071–1073

    MeSH term(s) Male ; Humans ; Brachytherapy ; Androgens ; Prostatic Neoplasms/radiotherapy ; Prostatic Neoplasms/drug therapy ; Prostate-Specific Antigen ; Androgen Antagonists/therapeutic use ; Radiotherapy Dosage
    Chemical Substances Androgens ; Prostate-Specific Antigen (EC 3.4.21.77) ; Androgen Antagonists
    Language English
    Publishing date 2023-03-14
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2022.12.007
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    Zs.A 1218: Show issues Location:
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  2. Article ; Online: Salvage Radiotherapy for Postoperative Biochemical Failure of Prostate Cancer: The Path Toward Personalized Medicine.

    Pisansky, Thomas M

    European urology

    2016  Volume 70, Issue 4, Page(s) 597–598

    Language English
    Publishing date 2016-10
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2016.01.033
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  3. Article ; Online: In Reply to Ghadjar et al.

    Pisansky, Thomas M / Tendulkar, Rahul D

    International journal of radiation oncology, biology, physics

    2017  Volume 97, Issue 2, Page(s) 439–440

    Language English
    Publishing date 2017-02-01
    Publishing country United States
    Document type Letter
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2016.10.025
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  4. Article ; Online: Reply to N. Fossati et al.

    Pisansky, Thomas M / Stish, Bradley J

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2016  Volume 35, Issue 4, Page(s) 470–471

    MeSH term(s) Humans ; Male ; Prostate ; Prostate-Specific Antigen ; Prostatectomy ; Salvage Therapy
    Chemical Substances Prostate-Specific Antigen (EC 3.4.21.77)
    Language English
    Publishing date 2016-11-07
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.2016.70.6119
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  5. Article ; Online: Reply to T. Seisen et al and P. Ghadjar et al.

    Tendulkar, Rahul D / Agrawal, Shree / Pisansky, Thomas M

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2017  Volume 35, Issue 13, Page(s) 1491–1492

    Language English
    Publishing date 2017-01-30
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.2016.70.7992
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  6. Article ; Online: A Phase II prospective study of hypofractionated proton therapy of prostate and pelvic lymph nodes: Acute effects on patient-reported quality of life.

    Wong, William W / Hillman, David W / Daniels, Thomas B / Vargas, Carlos E / Rwigema, Jean Claude / Corbin, Kimberly S / Keole, Sameer R / Merrell, Kenneth W / Stish, Bradley J / Pisansky, Thomas M / Davis, Brian J / Mitchell, Cecilia M / Choo, Richard

    The Prostate

    2022  Volume 82, Issue 14, Page(s) 1338–1345

    Abstract: Background: The objective of this study was to report acute changes in patient-reported quality of life (PRQOL) using the 26-item Expanded Prostate Index Composite (EPIC-26) questionnaire in a prospective study using hypofractionated intensity-modulated ...

    Abstract Background: The objective of this study was to report acute changes in patient-reported quality of life (PRQOL) using the 26-item Expanded Prostate Index Composite (EPIC-26) questionnaire in a prospective study using hypofractionated intensity-modulated proton beam therapy (H-IMPT) targeting the prostate and the pelvic lymph nodes for high-risk or unfavorable intermediate-risk prostate cancer.
    Methods: Fifty-five patients were enrolled. H-IMPT consisted of 45 GyE to the pelvic lymph nodes and 67.5 GyE to the prostate and seminal vesicles in 25 fractions. PRQOL was assessed with the urinary incontinence (UI), urinary irritative/obstructive symptoms (UO), and bowel function (BF) domains of EPIC-26 questionnaire. Mean changes in domain scores were analyzed from pretreatment to the end of treatment and 3 months posttreatment. A clinically meaningful change (or minimum important change) was defined as a score change > 50% of the baseline standard deviation.
    Results: The mean scores of UO, UI, and BF at baseline were 84.6, 91.1, and 95.3, respectively. At the end of treatment, there were statistically significant and clinically meaningful declines in UO and BF scores (-13.5 and -2.3, respectively), while the decline in UI score was statistically significant but not clinically meaningful (-13.7). A clinically meaningful decline in UO, UI, and BF scores occurred in 53.5%, 22.7%, and 73.2% of the patients, respectively. At 3 months posttreatment, all three mean scores showed an improvement, with fewer patients having a clinically meaningful decline in UO, UI, and BF scores (18.4%, 20.5%, and 45.0%, respectively). There was no significant reduction in the mean UO and UI scores compared to baseline, although the mean BF score remained lower than baseline and the difference was clinically meaningful.
    Conclusions: UO, UI, and BF scores of PRQOL declined at the end of H-IMPT. UO and UI scores showed improvement at 3 months posttreatment and were similar to the baseline scores. However, BF score remained lower at 3 months posttreatment with a clinically meaningful decline.
    MeSH term(s) Humans ; Lymph Nodes/pathology ; Male ; Patient Reported Outcome Measures ; Prospective Studies ; Prostate/pathology ; Prostatic Neoplasms/pathology ; Proton Therapy ; Quality of Life ; Urinary Incontinence
    Language English
    Publishing date 2022-07-05
    Publishing country United States
    Document type Clinical Trial, Phase II ; Journal Article
    ZDB-ID 604707-5
    ISSN 1097-0045 ; 0270-4137
    ISSN (online) 1097-0045
    ISSN 0270-4137
    DOI 10.1002/pros.24408
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    Zs.A 1608: Show issues Location:
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  7. Article ; Online: The prognostic value, sensitivity, and specificity of multiparametric magnetic resonance imaging before salvage radiotherapy for prostate cancer.

    Breen, William G / Stish, Bradley J / Harmsen, William S / Froemming, Adam T / Mynderse, Lance A / Choo, C Richard / Davis, Brian J / Pisansky, Thomas M

    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

    2021  Volume 161, Page(s) 9–15

    Abstract: Aim: To determine the operational characteristics of pelvic magnetic resonance imaging (MRI) prior to salvage radiation therapy (SRT) for biochemically recurrent prostate cancer following radical prostatectomy.: Methods and materials: We reviewed the ...

    Abstract Aim: To determine the operational characteristics of pelvic magnetic resonance imaging (MRI) prior to salvage radiation therapy (SRT) for biochemically recurrent prostate cancer following radical prostatectomy.
    Methods and materials: We reviewed the medical records of 386 patients who underwent MRI prior to SRT. We assessed associations of pre-SRT MRI findings with biochemical recurrence (BCR), distant metastasis (DM), prostate cancer-specific mortality (PCSM), and salvage androgen deprivation therapy (ADT) use following SRT. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of MRI for detecting local recurrence were also calculated.
    Results: Pre-SRT MRI was positive for local recurrence in 216 patients (56%), indeterminate in 46 (12%), and negative in 124 (32%). On univariate analysis, BCR following SRT was significantly less likely for patients with positive (HR: 0.58, 95% CI: 0.42-0.8) or indeterminate (HR: 0.6: 0.36-1) MRI findings, compared to patients with negative imaging (p = 0.003). These associations remained significant on multivariate analysis (p < 0.05) and across pre-SRT PSA groups. For the entire cohort, the sensitivity of MRI for local recurrence was 61.0% (53.5-68.1%), specificity 60.0% (44.3-73.0%), PPV 86.1% (78.9-91.5%) and NPV 27.6% (19.0-37.5%). Sensitivity of MRI was better in men with higher pre-SRT PSA (80.0% for PSA > 1.0), and specificity was improved with lower pre-SRT PSA (73.9% for PSA 0.1-0.5).
    Conclusions: Positive or indeterminate MRI findings prior to SRT were associated with improved biochemical control following SRT, across PSA levels. The sensitivity and specificity of MRI for local recurrence were 61% and 58.7%, respectively.
    MeSH term(s) Androgen Antagonists ; Humans ; Male ; Multiparametric Magnetic Resonance Imaging ; Neoplasm Recurrence, Local/diagnostic imaging ; Neoplasm Recurrence, Local/radiotherapy ; Prognosis ; Prostate-Specific Antigen ; Prostatectomy ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/radiotherapy ; Prostatic Neoplasms/surgery ; Retrospective Studies ; Salvage Therapy
    Chemical Substances Androgen Antagonists ; Prostate-Specific Antigen (EC 3.4.21.77)
    Language English
    Publishing date 2021-05-21
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 605646-5
    ISSN 1879-0887 ; 0167-8140
    ISSN (online) 1879-0887
    ISSN 0167-8140
    DOI 10.1016/j.radonc.2021.05.015
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    Zs.A 1926: Show issues Location:
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  8. Article ; Online: Adjuvant and Salvage Radiation Therapy After Prostatectomy: ASTRO/AUA Guideline Amendment, Executive Summary 2018.

    Pisansky, Thomas M / Thompson, Ian M / Valicenti, Richard K / D'Amico, Anthony V / Selvarajah, Shalini

    Practical radiation oncology

    2019  Volume 9, Issue 4, Page(s) 208–213

    Abstract: Purpose: The purpose of this amendment is to incorporate newly published literature into the original American Society for Radiation Oncology/American Urological Association Adjuvant and Salvage Radiotherapy After Prostatectomy Guideline and provide an ... ...

    Abstract Purpose: The purpose of this amendment is to incorporate newly published literature into the original American Society for Radiation Oncology/American Urological Association Adjuvant and Salvage Radiotherapy After Prostatectomy Guideline and provide an updated clinical framework for clinicians.
    Methods and materials: The original systematic review yielded 294 studies published between January 1990 and December 2012. In April 2018, the guideline underwent an amendment and incorporated 155 references that were published between January 1990 and December 2017. Two new key questions were added: one on the use of genomic classifiers and the other on the treatment of oligo-metastases with radiation after radical prostatectomy.
    Results: A new statement on the use of hormone therapy with salvage radiation therapy (RT) after radical prostatectomy was added, and long-term data were used to update an existing statement on adjuvant RT. The balance of the guideline statements were reaffirmed, and references added to the existing literature base. A discussion on the use of genomic classifiers as a risk stratification tool was added to the future research discussion. No relevant data on oligo-metastases were found.
    Conclusions: Hormone therapy should be offered to patients who have had radical prostatectomy and who are candidates for salvage RT. Clinicians should discuss possible short- and long-term side effects with patients in addition to the potential benefits of preventing recurrence. The decision to use hormone therapy should be made by the patient and a multidisciplinary team of providers with full consideration of the patient's history, values, preferences, quality of life, and functional status.
    MeSH term(s) Guidelines as Topic ; History, 21st Century ; Humans ; Male ; Prostatectomy/methods ; Radiotherapy, Adjuvant/methods ; Salvage Therapy/methods
    Language English
    Publishing date 2019-04-30
    Publishing country United States
    Document type Historical Article ; Journal Article
    ZDB-ID 2655748-4
    ISSN 1879-8519 ; 1879-8500
    ISSN (online) 1879-8519
    ISSN 1879-8500
    DOI 10.1016/j.prro.2019.04.008
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  9. Article ; Online: Adjuvant and Salvage Radiotherapy after Prostatectomy: ASTRO/AUA Guideline Amendment 2018-2019.

    Pisansky, Thomas M / Thompson, Ian M / Valicenti, Richard K / D'Amico, Anthony V / Selvarajah, Shalini

    The Journal of urology

    2019  Volume 202, Issue 3, Page(s) 533–538

    Abstract: Purpose: The purpose of this amendment is to incorporate newly-published literature into the original ASTRO/AUA Adjuvant and Salvage Radiotherapy after Prostatectomy Guideline and to provide an updated clinical framework for clinicians.: Materials and ...

    Abstract Purpose: The purpose of this amendment is to incorporate newly-published literature into the original ASTRO/AUA Adjuvant and Salvage Radiotherapy after Prostatectomy Guideline and to provide an updated clinical framework for clinicians.
    Materials and methods: The original systematic review yielded 294 studies published between January 1990 and December 2012. In April 2018, the guideline underwent an amendment and incorporated 155 references that were published from January 1990 through December 2017. Two new key questions were added. One on the use of genomic classifiers and the other on the treatment of oligo-metastases with radiation post-radical prostatectomy.
    Results: A new statement on the use of hormone therapy with salvage radiotherapy after radical prostatectomy was added and long-term data was used to update an existing statement on adjuvant radiotherapy. The balance of the guideline statements were re-affirmed and references were added to the existing literature base. A discussion on the use of genomic classifiers as a risk stratification tool was added to the future research discussion. No relevant data on oligo-metastases was found.
    Conclusions: Hormone therapy should be offered to patients who have had radical prostatectomy and who are candidates for salvage radiotherapy. The clinician should discuss possible short- and long-term side effects with the patient as well as the potential benefits of preventing recurrence. The decision to use hormone therapy should be made by the patient and a multi-disciplinary team of providers with full consideration of the patient's history, values, preferences, quality of life, and functional status.
    MeSH term(s) Antineoplastic Agents, Hormonal/therapeutic use ; Chemoradiotherapy, Adjuvant/methods ; Chemoradiotherapy, Adjuvant/standards ; Clinical Decision-Making/methods ; Humans ; Male ; Neoplasm Recurrence, Local/prevention & control ; Patient Care Team/standards ; Patient Participation ; Prostatectomy ; Prostatic Neoplasms/therapy ; Quality of Life ; Radiation Oncology/standards ; Salvage Therapy/methods ; Salvage Therapy/standards ; Societies, Medical/standards ; Urology/standards
    Chemical Substances Antineoplastic Agents, Hormonal
    Language English
    Publishing date 2019-08-08
    Publishing country United States
    Document type Journal Article ; Practice Guideline
    ZDB-ID 3176-8
    ISSN 1527-3792 ; 0022-5347
    ISSN (online) 1527-3792
    ISSN 0022-5347
    DOI 10.1097/JU.0000000000000295
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  10. Article ; Online: External-beam radiotherapy for localized prostate cancer.

    Pisansky, Thomas M

    The New England journal of medicine

    2006  Volume 355, Issue 15, Page(s) 1583–1591

    MeSH term(s) Aged ; Carcinoma in Situ/radiotherapy ; Humans ; Male ; Practice Guidelines as Topic ; Prostatectomy ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/radiotherapy ; Prostatic Neoplasms/surgery ; Radiotherapy/adverse effects ; Radiotherapy/methods ; Radiotherapy, Conformal
    Language English
    Publishing date 2006-10-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMct055263
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