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  1. Article ; Online: Response to: weight gain stopping/switch rules for antiretroviral clinical trials.

    Taramasso, Lucia / Di Biagio, Antonio / Guaraldi, Giovanni

    AIDS (London, England)

    2022  Volume 36, Issue 13, Page(s) 1899–1900

    MeSH term(s) Anti-Retroviral Agents/therapeutic use ; HIV Infections/drug therapy ; Humans ; Research Design ; Weight Gain
    Chemical Substances Anti-Retroviral Agents
    Language English
    Publishing date 2022-09-29
    Publishing country England
    Document type Letter
    ZDB-ID 639076-6
    ISSN 1473-5571 ; 0269-9370 ; 1350-2840
    ISSN (online) 1473-5571
    ISSN 0269-9370 ; 1350-2840
    DOI 10.1097/QAD.0000000000003304
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  2. Article ; Online: Weight gain and aging in people with HIV.

    Taramasso, Lucia / Stapleton, Jack T / Siedner, Mark J

    AIDS (London, England)

    2021  Volume 35, Issue 6, Page(s) 987–989

    MeSH term(s) Aged ; Aging ; HIV Infections ; Heterocyclic Compounds, 3-Ring ; Humans ; Oxazines ; Piperazines ; Pyridones ; Weight Gain
    Chemical Substances Heterocyclic Compounds, 3-Ring ; Oxazines ; Piperazines ; Pyridones ; dolutegravir (DKO1W9H7M1)
    Language English
    Publishing date 2021-04-05
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 639076-6
    ISSN 1473-5571 ; 0269-9370 ; 1350-2840
    ISSN (online) 1473-5571
    ISSN 0269-9370 ; 1350-2840
    DOI 10.1097/QAD.0000000000002849
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Evaluating fostemsavir as a therapeutic option for patients with HIV.

    Berruti, Marco / Pincino, Rachele / Taramasso, Lucia / Di Biagio, Antonio

    Expert opinion on pharmacotherapy

    2021  Volume 22, Issue 12, Page(s) 1539–1545

    Abstract: ... ...

    Abstract ABSTRAC
    MeSH term(s) Anti-HIV Agents/pharmacology ; Anti-HIV Agents/therapeutic use ; HIV Infections/drug therapy ; HIV-1 ; Humans ; Organophosphates/therapeutic use ; Piperazines
    Chemical Substances Anti-HIV Agents ; Organophosphates ; Piperazines ; fostemsavir (97IQ273H4L)
    Language English
    Publishing date 2021-06-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2001535-5
    ISSN 1744-7666 ; 1465-6566
    ISSN (online) 1744-7666
    ISSN 1465-6566
    DOI 10.1080/14656566.2021.1937120
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  4. Article: Weight Gain in Overweight and Obese People with HIV-The OBHIV Cohort.

    Taramasso, Lucia / Dettori, Silvia / Ricci, Elena / Lerta, Sonia / Mora, Sara / Blanchi, Sabrina / Giacomini, Mauro / Vena, Antonio / Bassetti, Matteo / Di Biagio, Antonio

    Journal of clinical medicine

    2024  Volume 13, Issue 5

    Abstract: Background: HIV and non-HIV-related factors have been related to weight gain (WG); however, their specific impact on people with HIV (PWH) who are overweight or obese remains unclear.: Methods: This is a single-center observational study enrolling ... ...

    Abstract Background: HIV and non-HIV-related factors have been related to weight gain (WG); however, their specific impact on people with HIV (PWH) who are overweight or obese remains unclear.
    Methods: This is a single-center observational study enrolling PWH with a BMI > 25 kg/m
    Results: A total of 321 PWH were enrolled, 67% overweight and 33% obese, who gained an average of 0.2 ± 1.3 and 1.7 ± 1.5 kg/year, respectively (
    Conclusion: Among overweight and obese PWH, the amount of WG was higher in the first years after diagnosis of HIV and decreased thereafter, despite aging, regardless of the type of ART.
    Language English
    Publishing date 2024-02-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13051211
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  5. Article ; Online: Ten Years of Medical Informatics and Standards Support for Clinical Research in an Infectious Diseases Network.

    Mora, Sara / Giannini, Barbara / Di Biagio, Antonio / Cenderello, Giovanni / Nicolini, Laura Ambra / Taramasso, Lucia / Dentone, Chiara / Bassetti, Matteo / Giacomini, Mauro

    Applied clinical informatics

    2023  Volume 14, Issue 1, Page(s) 16–27

    Abstract: Background: It is 30 years since evidence-based medicine became a great support for individual clinical expertise in daily practice and scientific research. Electronic systems can be used to achieve the goal of collecting data from heterogeneous ... ...

    Abstract Background: It is 30 years since evidence-based medicine became a great support for individual clinical expertise in daily practice and scientific research. Electronic systems can be used to achieve the goal of collecting data from heterogeneous datasets and to support multicenter clinical trials. The
    Objectives: The objective of this work is to present an integrated system of ad hoc interfaces and tools that we use to perform pseudonymous clinical data collection, both manually and automatically, to support clinical trials.
    Methods: The project comprehends different scenarios of data collection systems, according to the degree of
    Results: Since 2011, the LIDN platform has involved more than 8,000 patients from eight different hospitals, treated or under treatment for at least one infectious disease among
    Conclusion: The LIDN was originally developed to support clinicians involved in the project in the management of data from HIV-infected patients through a web-based tool that could be easily used in primary-care units. Then, the developed system grew modularly to respond to the specific needs that arose over a time span of more than 10 years.
    MeSH term(s) Humans ; COVID-19 ; Communicable Diseases/therapy ; Primary Health Care ; Medical Informatics ; HIV Infections
    Language English
    Publishing date 2023-01-11
    Publishing country Germany
    Document type Multicenter Study ; Journal Article
    ISSN 1869-0327
    ISSN (online) 1869-0327
    DOI 10.1055/s-0042-1760081
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  6. Article ; Online: Injectable Antiretroviral Drugs: Back to the Future.

    Berruti, Marco / Riccardi, Niccolò / Canetti, Diana / Lo Caputo, Sergio / Taramasso, Lucia / Di Biagio, Antonio

    Viruses

    2021  Volume 13, Issue 2

    Abstract: Current HIV treatment regimens provide sustained virologic suppression, at least partially restore the immune system and have limited side effects; however, they do not allow viral eradication and they are burdened by daily pill intake with a life-long ... ...

    Abstract Current HIV treatment regimens provide sustained virologic suppression, at least partially restore the immune system and have limited side effects; however, they do not allow viral eradication and they are burdened by daily pill intake with a life-long commitment for the people living with HIV (PHIV). Injectable agents might represent a turning point in the care of PHIV, allowing less frequent administration of antiretroviral treatment (ART), more widespread use of pre-exposure prophylaxis (PrEP) and more stable drug levels in the blood, thus increasing the odds to get closer to end the HIV pandemic. The aim of this manuscript is to give a comprehensive review of injectable antiretrovirals that have been used in the past, which are available now, will be available in the future, and their role in the treatment of HIV infection.
    MeSH term(s) Anti-HIV Agents/administration & dosage ; Anti-HIV Agents/therapeutic use ; Antiretroviral Therapy, Highly Active/methods ; HIV Infections/drug therapy ; HIV-1/drug effects ; Humans ; Injections/methods ; Pre-Exposure Prophylaxis/methods
    Chemical Substances Anti-HIV Agents
    Language English
    Publishing date 2021-02-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v13020228
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The switch from tenofovir disoproxil fumarate to tenofovir alafenamide determines weight gain in patients on rilpivirine-based regimen.

    Taramasso, Lucia / Berruti, Marco / Briano, Federica / Di Biagio, Antonio

    AIDS (London, England)

    2020  Volume 34, Issue 6, Page(s) 877–881

    Abstract: Objective: To investigate whether the switch from tenofovir disoproxil fumarate/emtricitabine/rilpivirine (TDF/FTC/RPV) to tenofovir alafenamide (TAF)/FTC/RPV is associated with weight gain in people living with HIV (PLWHIV).: Design: Retrospective ... ...

    Abstract Objective: To investigate whether the switch from tenofovir disoproxil fumarate/emtricitabine/rilpivirine (TDF/FTC/RPV) to tenofovir alafenamide (TAF)/FTC/RPV is associated with weight gain in people living with HIV (PLWHIV).
    Design: Retrospective single-centre study.
    Methods: All PLWHIV on TDF/FTC/RPV who switched to TAF/FTC/RPV from January 2017 to December 2018 were considered if they had at least two weight measures in the year before and two after the switch. The weight trend across the study was evaluated by a generalized linear model for repeated measures, with pair comparison performed by Bonferroni adjustment.
    Results: Two hundred and fifty-two patients on TDF/FTC/RPV were included, 65% men, mean age 51.2 years (±9.6), history of 18 (±18.2) years of HIV infection and CD4 T-cell count of 744 (±329) cells/μl. All had HIV-RNA <50 copies/ml. Twelve months before the switch, baseline weight was 73.8 (±14.3) kg, and remained stable to 73.8 (±14.3) kg in the following 6 months. A weight increase was noticed 3 and 6 months after the switch, to 77.7 (±42.3) and 75.5 (±14.5) kg, respectively (P < 0.0001). A significant weight change exactly within the timeframe of the switch (between 6 months before and 3 months after) was found in women, patients with higher BMI (>25 kg/m), lower CD4 T-cell count (≤500 cells/μl) and history of previous drug abuse. The frequency of BMI greater than 25 kg/m rose from 122/252 patients (48.4%), to 133/252 (52.8%) (P < 0.0001).
    Conclusion: TAF appears to have an impact on weight gain, similarly to what observed in naïve patients, also in experienced PLWHIV with good virologic control.
    MeSH term(s) Adenine/adverse effects ; Adenine/analogs & derivatives ; Adenine/therapeutic use ; Adult ; Anti-HIV Agents/adverse effects ; Anti-HIV Agents/therapeutic use ; Emtricitabine/adverse effects ; Emtricitabine/therapeutic use ; Female ; Fumarates/adverse effects ; Fumarates/therapeutic use ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; HIV-1/genetics ; HIV-1/metabolism ; Humans ; Male ; Middle Aged ; RNA, Viral ; Retrospective Studies ; Rilpivirine/adverse effects ; Rilpivirine/therapeutic use ; Tenofovir/adverse effects ; Tenofovir/therapeutic use ; Treatment Outcome ; Viral Load ; Weight Gain/drug effects
    Chemical Substances Anti-HIV Agents ; Fumarates ; RNA, Viral ; Tenofovir (99YXE507IL) ; tenofovir alafenamide (EL9943AG5J) ; Rilpivirine (FI96A8X663) ; Emtricitabine (G70B4ETF4S) ; Adenine (JAC85A2161)
    Language English
    Publishing date 2020-04-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 639076-6
    ISSN 1473-5571 ; 0269-9370 ; 1350-2840
    ISSN (online) 1473-5571
    ISSN 0269-9370 ; 1350-2840
    DOI 10.1097/QAD.0000000000002496
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    Zs.A 2228: Show issues Location:
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  8. Article ; Online: Immunonutrition in Human Immunodeficiency Virus Infection: Which Populations to Target?

    Taramasso, Lucia / Bozzi, Giorgio / Muscatello, Antonio / Bandera, Alessandra / Gori, Andrea

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2019  Volume 69, Issue 12, Page(s) 2228–2229

    MeSH term(s) HIV ; HIV Infections ; Humans ; Postoperative Complications ; Surgical Wound Infection
    Language English
    Publishing date 2019-07-18
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciz337
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  9. Article ; Online: Hepatitis C virus direct acting antivirals impact on renal function in the first 4 weeks of treatment.

    Taramasso, Lucia / Montanari, Lara / Di Biagio, Antonio

    AIDS (London, England)

    2018  Volume 32, Issue 9, Page(s) 1202–1203

    MeSH term(s) Adult ; Aged ; Antiviral Agents/administration & dosage ; Antiviral Agents/adverse effects ; Female ; Glomerular Filtration Rate/drug effects ; HIV Infections/complications ; Hepatitis C, Chronic/drug therapy ; Humans ; Kidney/drug effects ; Kidney/physiopathology ; Male ; Middle Aged ; Prospective Studies
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2018-05-10
    Publishing country England
    Document type Letter
    ZDB-ID 639076-6
    ISSN 1473-5571 ; 0269-9370 ; 1350-2840
    ISSN (online) 1473-5571
    ISSN 0269-9370 ; 1350-2840
    DOI 10.1097/QAD.0000000000001804
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  10. Article ; Online: SARS-CoV-2 mRNA vaccination and short-term changes in viral load and CD4/CD8 T cell counts in people living with HIV.

    Vergori, Alessandra / Cozzi-Lepri, Alessandro / Tavelli, Alessandro / Mazzotta, Valentina / Azzini, Anna Maria / Gagliardini, Roberta / Mastrorosa, Ilaria / Latini, Alessandra / Pellicanò, Giovanni / Taramasso, Lucia / Ceccherini-Silberstein, Francesca / Giannella, Maddalena / Tacconelli, Evelina / Marchetti, Giulia / Monforte, Antonella d'Arminio / Antinori, Andrea

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2024  , Page(s) 107065

    Abstract: Objectives: To investigate if SARS-CoV-2 mRNA vaccination has an impact on HIV-related viro-immunological parameters.: Methods: PWH of the VAXICONA-ORCHESTRA cohort who received ≥1 dose of SARS-CoV-2 mRNA vaccine and for whom paired measures of ... ...

    Abstract Objectives: To investigate if SARS-CoV-2 mRNA vaccination has an impact on HIV-related viro-immunological parameters.
    Methods: PWH of the VAXICONA-ORCHESTRA cohort who received ≥1 dose of SARS-CoV-2 mRNA vaccine and for whom paired measures of immuno-virological markers [Viral Load (VL), CD4, CD8 count 1 month before and after a vaccine dose (VD)] were available, were included. Paired t-test and generalized estimating equation linear regression analyses were used to study changes over ± 1 month around the VD. Subgroup analyses were performed.
    Results: 510 PWH enrolled: median age 55 y (IQR 46-60), CD4 and CD8 count 489(287-719) and 790 (59-1104) cells/mm
    Conclusions: A small significant increase in CD4 count and a negligible drop in HIV-RNA were observed. Our findings are consistent with the hypothesis that SARS-CoV-2 mRNA vaccine can prime CD4 T spike specific cells even in the more immuno-compromised PWH.
    Language English
    Publishing date 2024-04-19
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2024.107065
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