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Article ; Online: Comparison of Ba-Hao burn ointment gauze and petrolatum gauze in split graft donor site healing: A randomized, prospective, and self-control study.

Liu, Wen-Jing / Qian, Han-Ying / Zhang, Yuan-Yuan / Qiu, Le / Wang, Fei / Chen, Xu-Lin

Health science reports

2024 Volume 7, Issue 4, Page(s) e1988

Abstract: ... up of split-skin graft donor sites treated with Ba-Hao burn ointment (BHBO) gauze, a compound ...

Abstract	Background and aims: To assess patient comfort, wound healing, and scarring at the 6-month follow-up of split-skin graft donor sites treated with Ba-Hao burn ointment (BHBO) gauze, a compound preparation of traditional Chinese medicine since 1970s, compared with petrolatum gauze. Methods: Thirty patients admitted to the Department of Burns of the First Affiliated Hospital of Anhui Medical University between September 2021 and September 2022 participated in this randomized, prospective, self-control clinical study. After harvesting the split skin, donor sites were divided into two parts along the midline. BHBO gauze was applied to half of the donor wounds, and petrolatum gauze was applied to the other half. The wound healing time, pain scores on the postoperative Days 3, 6, and 9, and Vancouver Scar Scale (VSS) score at the 6-month follow-up were assessed. Results: The wound healing time was significantly shorter in the BHBO group than in the control group (10.07 ± 1.48 days vs. 11.50 ± 1.74 days, Conclusion: BHBO resulted in faster donor-site healing, reduced postoperative pain, and improved scar quality at the 6-month follow-up than petrolatum gauze alone.
Language	English
Publishing date	2024-04-02
Publishing country	United States
Document type	Journal Article
ISSN	2398-8835
ISSN (online)	2398-8835
DOI	10.1002/hsr2.1988
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Toxicological evaluation of aqueous extract of the traditional Chinese formula Qing Hao Gan Cao.

Li, Yongchun / Zhang, Hui / Chen, Shanshan / Zhao, Liutao / Wu, Jie / Li, Pan / Wu, Guanlian / Wang, Qing / Wu, Chunli / Xu, Hongde

Toxicology research

2021 Volume 10, Issue 2, Page(s) 183–191

Abstract: Qing Hao Gan Cao ...

Abstract	Qing Hao Gan Cao
Language	English
Publishing date	2021-02-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2684701-2
ISSN	2045-4538 ; 2045-452X
ISSN (online)	2045-4538
ISSN	2045-452X
DOI	10.1093/toxres/tfaa103
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Article: Primula sinohumilis G. Hao & C.M. Hu (Primulaceae), a New Name for P. humilis Pax & Hoffm

Wu, Shu-Hua / Xu, Yuan / Hu, Chi-Ming / Hao, Gang

Annales botanici Fennici. 2020 Oct. 19, v. 58, no. 1-3

2020

Abstract: The replacement name Primula sinohumilis G. Hao & C.M. Hu is proposed for P. humilis Pax & Hoffm ...

Abstract	The replacement name Primula sinohumilis G. Hao & C.M. Hu is proposed for P. humilis Pax & Hoffm., which is an illegitimate later homonym.
Keywords	Primula ; homonym ; nomen novum
Language	English
Dates of publication	2020-1019
Size	p. 13-14.
Publishing place	Finnish Zoological and Botanical Publishing Board
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2017992-3
ISSN	1797-2442 ; 0003-3847
ISSN (online)	1797-2442
ISSN	0003-3847
DOI	10.5735/085.058.0102
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Article ; Online: Evaluation of the chemical consistency of Yin-Chen-Hao-Tang prepared by combined and separated decoction methods using high-performance liquid chromatography and quadrupole time-of-flight mass spectrometry coupled with multivariate statistical analysis.

Tian, Qiang / Liu, Fang / Xu, Zhou / Liu, Huan / Yin, Hao / Sun, Zhaolin / Chen, Mingcang / Li, Zhixiong / Ma, Lin / Huang, Chenggang

Journal of separation science

2019 Volume 42, Issue 9, Page(s) 1664–1675

Abstract: In this study, Yin-Chen-Hao-Tang prepared by two decoction methods, namely, combined decoction ...

Abstract	In this study, Yin-Chen-Hao-Tang prepared by two decoction methods, namely, combined decoction (modern decoction method) and separated decoction (traditional decoction method), was analyzed by high-performance liquid chromatography with quadrupole time-of-flight mass spectrometry. The acquired datasets containing sample codes, t
MeSH term(s)	Caffeic Acids/analysis ; Chromatography, High Pressure Liquid/methods ; Discriminant Analysis ; Drugs, Chinese Herbal/analysis ; Iridoids/analysis ; Mass Spectrometry/methods ; Multivariate Analysis
Chemical Substances	Caffeic Acids ; Drugs, Chinese Herbal ; Iridoids ; yin-chen-hao-tang ; geniposide (145295QLXY) ; genipin (A3V2NE52YG) ; caffeic acid (U2S3A33KVM)
Language	English
Publishing date	2019-03-08
Publishing country	Germany
Document type	Evaluation Studies ; Journal Article
ZDB-ID	2047990-6
ISSN	1615-9314 ; 1615-9306
ISSN (online)	1615-9314
ISSN	1615-9306
DOI	10.1002/jssc.201800961
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Article: The Study of Yin-Chen-Hao-Tang Preventing and Treating Alcoholic Fatty Liver Disease through PPAR Signaling Pathway Based on Network Pharmacology and RNA-Seq Transcriptomics.

Zhu, Yi-Wei / Li, Du / Ye, Ting-Jie / Qiu, Feng-Jun / Wang, Xiao-Ling / Yan, Xiao-Feng / Lu, Yan-Lin / Xu, Wei / Li, Hua / Hu, Xu-Dong

Evidence-based complementary and alternative medicine : eCAM

2021 Volume 2021, Page(s) 8917993

Abstract: ... course. Yin-Chen-Hao-Tang (YCHT) has a good clinical effect on the treatment of AFLD, but its molecular ...

Abstract	Background: Alcoholic fatty liver disease (AFLD) is the first stage of the alcoholic liver disease course. Yin-Chen-Hao-Tang (YCHT) has a good clinical effect on the treatment of AFLD, but its molecular mechanism has not been elucidated. In this study, we tried to explore the molecular mechanism of YCHT in improving hepatocyte steatosis in AFLD mice through network pharmacology and RNA sequencing (RNA-Seq) transcriptomics. Methods: Network pharmacological methods were used to analyze the potential therapeutic signaling pathways and targets of YCHT on AFLD. Then, the AFLD mice model was induced and YCHT was administered concurrently. Liver injury was measured by serum alanine aminotransferase (ALT) activity and liver tissue H&E staining, and liver steatosis was determined by serum triglyceride (TG) level and liver tissue Oil Red staining. The molecular mechanism of YCHT on prevention and treatment of mice AFLD was investigated according to the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of the differential expression genes data obtained by liver tissue RNA-Seq. Finally, ethanol-induced AFLD AML12 hepatocyte model was established, YCHT with or without PPAR Results: The results of network pharmacology analysis showed that YCHT may exert its pharmacological effect on AFLD through 312 potential targets which are involved in many signaling pathways including the PPAR signaling pathway. AFLD mice experiments results showed that YCHT markedly decreased mice serum ALT activity and serum TG levels. YCHT also significantly improved alcohol-induced hepatic injury and steatosis in mice livers. Furthermore, KEGG pathway enrichment results of RNA-Seq showed that the PPAR signaling pathway should be the most relevant pathway of YCHT in the prevention and treatment of AFLD. AFLD hepatocyte model experiment results showed that YCHT could remarkably reduce hepatocyte steatosis through reducing PPAR Conclusions: Our study discovered that PPAR
Language	English
Publishing date	2021-12-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2021/8917993
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Article: Evaluation of the chemical consistency of Yin‐Chen‐Hao‐Tang prepared by combined and separated decoction methods using high‐performance liquid chromatography and quadrupole time‐of‐flight mass spectrometry coupled with multivariate statistical analysis

Tian, Qiang / Liu, Fang / Xu, Zhou / Liu, Huan / Yin, Hao / Sun, Zhaolin / Chen, Mingcang / Li, Zhixiong / Ma, Lin / Huang, Chenggang

Journal of separation science. 2019 May, v. 42, no. 9

2019

Abstract: In this study, Yin‐Chen‐Hao‐Tang prepared by two decoction methods, namely, combined decoction ... only establish a strategy to evaluate chemical consistency of Yin‐Chen‐Hao‐Tang but also provide ...

Abstract	In this study, Yin‐Chen‐Hao‐Tang prepared by two decoction methods, namely, combined decoction (modern decoction method) and separated decoction (traditional decoction method), was analyzed by high‐performance liquid chromatography with quadrupole time‐of‐flight mass spectrometry. The acquired datasets containing sample codes, tR‐m/z pairs and ion intensities were processed with multivariate statistical analyses, such as principal component analysis and an orthogonal partial least squared discriminant analysis model, to globally compare the chemical differences between the different decoction samples. Then, the chemical differences between the combined and separated decoctions were screened out by S‐plots generated from the orthogonal partial least squared discriminant analysis model and compared with chemical information from an established in‐house library. The six components that contributed the most to the chemical differences were identified as chlorogenic acid, caffeic acid, geniposide, genipin, scopoletin, and 3,5‐dicaffeoylquinic acid. The concentrations of genipin and caffeic acid from the separated decoction were higher than those from the combined decoction, indicating that the separated decoction may present a stronger hepatoprotective effect. However, the results still require further investigation through pharmacological and clinical studies. Our findings not only establish a strategy to evaluate chemical consistency of Yin‐Chen‐Hao‐Tang but also provide the scientific basis for using traditional separated decoction method.
Keywords	caffeic acid ; chlorogenic acid ; clinical trials ; data collection ; discriminant analysis ; hepatoprotective effect ; high performance liquid chromatography ; mass spectrometry ; models ; multivariate analysis ; principal component analysis ; scopoletin
Language	English
Dates of publication	2019-05
Size	p. 1664-1675.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	2047990-6
ISSN	1615-9314 ; 1615-9306
ISSN (online)	1615-9314
ISSN	1615-9306
DOI	10.1002/jssc.201800961
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Article ; Online: Determining the protective effects of Yin-Chen-Hao Tang against acute liver injury induced by carbon tetrachloride using 16S rRNA gene sequencing and LC/MS-based metabolomics.

Liu, Fang / Sun, Zhaolin / Hu, Pei / Tian, Qiang / Xu, Zhou / Li, Zhixiong / Tian, Xiaoting / Chen, Mingcang / Huang, Chenggang

Journal of pharmaceutical and biomedical analysis

2019 Volume 174, Page(s) 567–577

Abstract: Yin-Chen-Hao Tang (YCHT), consisting of Artemisia annua L., Gardenia jasminoides Ellis, and Rheum ...

Abstract	Yin-Chen-Hao Tang (YCHT), consisting of Artemisia annua L., Gardenia jasminoides Ellis, and Rheum Palmatum L., has been used to relieve liver diseases in China for thousands of years. Several protective mechanisms of YCHT on liver injury have been investigated based on metabolomics, but the effects of YCHT on the alterations in the gut microbiota are still unclear. In this study, an integrated approach based on 16S rRNA gene sequencing combined with high-performance liquid chromatography-mass spectrometry (HPLC-MS) metabolic profiling was performed to assess the effects of YCHT on liver injury induced by carbon tetrachloride (CCl
MeSH term(s)	Animals ; Carbon Tetrachloride ; Chromatography, Liquid ; Drugs, Chinese Herbal/pharmacology ; Gastrointestinal Microbiome ; Liver/drug effects ; Liver Failure, Acute/chemically induced ; Liver Failure, Acute/drug therapy ; Male ; Mass Spectrometry ; Medicine, Chinese Traditional ; Metabolome ; Metabolomics ; Multivariate Analysis ; Phenotype ; RNA, Ribosomal, 16S/analysis ; Rats ; Rats, Sprague-Dawley
Chemical Substances	Drugs, Chinese Herbal ; RNA, Ribosomal, 16S ; yin-chen-hao-tang ; Carbon Tetrachloride (CL2T97X0V0)
Language	English
Publishing date	2019-06-21
Publishing country	England
Document type	Journal Article
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2019.06.028
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Article ; Online: The Study of Yin-Chen-Hao-Tang Preventing and Treating Alcoholic Fatty Liver Disease through PPAR Signaling Pathway Based on Network Pharmacology and RNA-Seq Transcriptomics

Yi-Wei Zhu / Du Li / Ting-Jie Ye / Feng-Jun Qiu / Xiao-Ling Wang / Xiao-Feng Yan / Yan-Lin Lu / Wei Xu / Hua Li / Xu-Dong Hu

Evidence-Based Complementary and Alternative Medicine, Vol

2021 Volume 2021

Abstract: ... course. Yin-Chen-Hao-Tang (YCHT) has a good clinical effect on the treatment of AFLD, but its molecular ...

Abstract	Background. Alcoholic fatty liver disease (AFLD) is the first stage of the alcoholic liver disease course. Yin-Chen-Hao-Tang (YCHT) has a good clinical effect on the treatment of AFLD, but its molecular mechanism has not been elucidated. In this study, we tried to explore the molecular mechanism of YCHT in improving hepatocyte steatosis in AFLD mice through network pharmacology and RNA sequencing (RNA-Seq) transcriptomics. Methods. Network pharmacological methods were used to analyze the potential therapeutic signaling pathways and targets of YCHT on AFLD. Then, the AFLD mice model was induced and YCHT was administered concurrently. Liver injury was measured by serum alanine aminotransferase (ALT) activity and liver tissue H&E staining, and liver steatosis was determined by serum triglyceride (TG) level and liver tissue Oil Red staining. The molecular mechanism of YCHT on prevention and treatment of mice AFLD was investigated according to the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of the differential expression genes data obtained by liver tissue RNA-Seq. Finally, ethanol-induced AFLD AML12 hepatocyte model was established, YCHT with or without PPARα agonist pemafibrate or PPARγ inhibitor GW9662 was administered, Nile Red fluorescent staining was used to evaluate steatosis levels in AML12 hepatocytes, and qRT-PCR was used to detect PPARα and PPARγ gene expression. Results. The results of network pharmacology analysis showed that YCHT may exert its pharmacological effect on AFLD through 312 potential targets which are involved in many signaling pathways including the PPAR signaling pathway. AFLD mice experiments results showed that YCHT markedly decreased mice serum ALT activity and serum TG levels. YCHT also significantly improved alcohol-induced hepatic injury and steatosis in mice livers. Furthermore, KEGG pathway enrichment results of RNA-Seq showed that the PPAR signaling pathway should be the most relevant pathway of YCHT in the prevention and treatment of AFLD. AFLD ...
Keywords	Other systems of medicine ; RZ201-999
Subject code	571
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
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Article ; Online: Chlorpromazine-induced perturbations of bile acids and free fatty acids in cholestatic liver injury prevented by the Chinese herbal compound Yin-Chen-Hao-Tang.

Yang, Qiaoling / Yang, Fan / Tang, Xiaowen / Ding, Lili / Xu, Ying / Xiong, Yinhua / Wang, Zhengtao / Yang, Li

BMC complementary and alternative medicine

2015 Volume 15, Page(s) 122

Abstract: Backgrounds: Yin-Chen-Hao-Tang (YCHT), a commonly used as a traditional chinese medicine ... of the pathogenesis of cholestatic liver injury and evaluate the effect of Yin-Chen-Hao-Tang (YCHT) on chlorpromazine ...

Abstract	Backgrounds: Yin-Chen-Hao-Tang (YCHT), a commonly used as a traditional chinese medicine for liver disease. Several studies indicated that YCHT may improving hepatic triglyceride metabolism and anti-apoptotic response as well as decreasing oxidative stress .However, little is known about the role of YCHT in chlorpromazine (CPZ) -induced chlolestatic liver injury. Therefore, we aimed to facilitate the understanding of the pathogenesis of cholestatic liver injury and evaluate the effect of Yin-Chen-Hao-Tang (YCHT) on chlorpromazine (CPZ)-induced cholestatic liver injury in rats based on the change of bile acids (BAs) and free fatty acids (FFAs) alone with the biochemical indicators and histological examination. Methods: We conducted an experiment on CPZ-induced cholestatic liver injury in Wistar rats with and without YCHT for nine consecutive days. Serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin (ALB), total bilirubin (TBIL), total cholesterol (TC), triglycerides (TG), low density lipoprotein-cholesterol (LDL-C) were measured to evaluate the protective effect of YCHT against chlorpromazine (CPZ)-induced cholestatic liver injury. Histopathology of the liver tissue showed that pathological injuries were relieved after YCHT pretreatment. In addition, ultra-performance lipid chromatography coupled with quadrupole mass spectrometry (UPLC-MS) and gas chromatography coupled with mass spectrometry (GC-MS) was applied to determine the content of bile acids, free fatty acids, respectively. Results: Obtained data showed that YCHT attenuated the effect of CPZ-induced cholestatic liver injury, which was manifested by the serum biochemical parameters and histopathology of the liver tissue. YCHT regulated the lipid levels as indicated by the reversed serum levels of TC, TG, and LDL-C. YCHT also regulated the disorder of BA and FFA metabolism by CPZ induction. Conclusions: Results indicated that YCHT exerted a protective effect on CPZ-induced cholestasis liver injury. The variance of BA and FFA concentrations can be used to evaluate the cholestatic liver injury caused by CPZ and the hepatoprotective effect of YCHT.
MeSH term(s)	Animals ; Artemisia ; Bile Acids and Salts/metabolism ; Chemical and Drug Induced Liver Injury/metabolism ; Chemical and Drug Induced Liver Injury/prevention & control ; Chlorpromazine/adverse effects ; Cholestasis/chemically induced ; Cholestasis/metabolism ; Cholestasis/prevention & control ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Fatty Acids, Nonesterified/metabolism ; Gardenia ; Liver/drug effects ; Liver/metabolism ; Liver/pathology ; Male ; Mass Spectrometry ; Medicine, Chinese Traditional ; Oxidative Stress/drug effects ; Phytotherapy ; Rats ; Rats, Wistar ; Rheum
Chemical Substances	Bile Acids and Salts ; Drugs, Chinese Herbal ; Fatty Acids, Nonesterified ; yin-chen-hao-tang ; Chlorpromazine (U42B7VYA4P)
Language	English
Publishing date	2015-04-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2050429-9
ISSN	1472-6882 ; 1472-6882
ISSN (online)	1472-6882
ISSN	1472-6882
DOI	10.1186/s12906-015-0627-2
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Article ; Online: Traditional Chinese medicine formula Qing Huo Yi Hao as superoxide anion scavenger in high glucose-treated endothelial cells.

Xu, Qiong / Zhang, Bin / Li, Xiao-mu / Gao, Xin

Acta pharmacologica Sinica

2012 Volume 33, Issue 4, Page(s) 496–502

Abstract: Aim: To investigate the effects of a traditional Chinese medicine formula Qing Huo Yi Hao (QHYH ...

Abstract	Aim: To investigate the effects of a traditional Chinese medicine formula Qing Huo Yi Hao (QHYH) and its components on hydroxyl radical (HO(•)) production in vitro and the activity of QHYH against free radicals in cultured endothelial cells induced by high glucose. Methods: Hydroxyl radicals (HO(•)) were generated through Fenton reactions in vitro, and 5,5-dimethyl-1-pyrroline N-oxide (DMPO) was used as a spin trap to form DMPO/HO(•) adducts detected using electron paramagnetic resonance (EPR). Immortalized mouse cerebral microvascular endothelial (bEnd.3) cells were treated with high glucose (35 mmol/L). The free radical scavenging ability of QHYH in the cells was evaluated using EPR. Superoxide dismutase (SOD) was used to identify the free radicals scavenged by QHYH in the cells. Results: QHYH and its 8 components concentration-dependently reduced DMPO/HO(•) signaling. The DMPO/HO(•) adduct scavenging ability of QHYH was 82.2%, which was higher than each individual component. The free radical scavenging ability of 1% QHYH in high glucose-treated bEnd.3 cells was approximately 70%. In these cells, the free radicals were also specifically reduced by SOD (400 U/mL), implying that the free radicals were primarily superoxide anions. Conclusion: The results demonstrate that the QHYH formula is potent antioxidant acting as scavenge of superoxide anions in high glucose-treated endothelial cells.
MeSH term(s)	Animals ; Cells, Cultured ; Drugs, Chinese Herbal/pharmacology ; Electron Spin Resonance Spectroscopy ; Endothelial Cells/drug effects ; Endothelial Cells/metabolism ; Endothelium, Vascular/cytology ; Free Radical Scavengers/pharmacology ; Glucose/metabolism ; Mice ; Superoxide Dismutase/metabolism ; Superoxides/metabolism
Chemical Substances	Drugs, Chinese Herbal ; Free Radical Scavengers ; Superoxides (11062-77-4) ; Superoxide Dismutase (EC 1.15.1.1) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2012-03-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1360774-1
ISSN	1745-7254 ; 0253-9756 ; 1671-4083
ISSN (online)	1745-7254
ISSN	0253-9756 ; 1671-4083
DOI	10.1038/aps.2011.191
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