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Article ; Online: Evaluation of CO

Qian, Zhicheng / He, Hao / Wang, Yuxuan / Geng, Shike / Li, Yang / Yuan, Xueyan / Zhang, Rui / Yang, Yi / Qiu, Haibo / Liu, Songqiao / Liu, Ling

Artificial organs

2024

Abstract: Background: A critical parameter of extracorporeal CO: Methods: Twelve healthy pigs were placed under mechanical ventilation and connected to an ECCO: Results: VCO: Conclusions: Low-flow venovenous extracorporeal ... ...

Abstract	Background: A critical parameter of extracorporeal CO Methods: Twelve healthy pigs were placed under mechanical ventilation and connected to an ECCO Results: VCO Conclusions: Low-flow venovenous extracorporeal ECCO
Language	English
Publishing date	2024-02-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	441812-8
ISSN	1525-1594 ; 0160-564X
ISSN (online)	1525-1594
ISSN	0160-564X
DOI	10.1111/aor.14718
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Prevention of urinary tract infection using a silver alloy hydrogel-coated catheter in critically ill patients: A single-center prospective randomized controlled study.

Zhao, Menglong / Geng, Shike / Zhang, Lei / Fan, Xiaoqin / Tong, Fei / Meng, Xianlin / Wang, Tianfeng / Fang, Xiaowei / Mei, Qing / Pan, Aijun

Journal of intensive medicine

2023 Volume 4, Issue 1, Page(s) 118–124

Abstract: Background: A new type of silver alloy hydrogel-coated (SAH) catheter has been shown to prevent bacterial adhesion and colonization by generating a microcurrent, and to block the retrograde infection pathway. However, these have only been confirmed in ... ...

Abstract	Background: A new type of silver alloy hydrogel-coated (SAH) catheter has been shown to prevent bacterial adhesion and colonization by generating a microcurrent, and to block the retrograde infection pathway. However, these have only been confirmed in ordinary patients. This study aims to evaluate the effectiveness of a SAH catheter for preventing urinary tract infections in critically ill patients. Methods: This was a prospective single-center, single-blind, randomized, controlled study. A total of 132 patients requiring indwelling catheterization in the intensive care unit (ICU) of the First Affiliated Hospital of the University of Science and Technology of China between October 2022 and February 2023 and who met the study inclusion/exclusion criteria were randomly divided into two groups. Patients in the SAH catheter group received a SAH catheter, while patients in the conventional catheter group received a conventional siliconized latex Foley catheter. The main outcome measure was the incidence of catheter-associated urinary tract infections (CAUTIs). Secondary outcome indicators included urine positivity for white blood cells and positive urine cultures on 3 days, 7 days, 10 days, and 14 days after catheterization, number of viable bacteria in the catheter biofilm on day 14, pathogenic characteristics of positive urine cultures, length of ICU stay, overall hospital stay, ICU mortality, and 28-day mortality. All the data were compared between the two groups. Results: A total of 68 patients in the conventional catheter group and 64 patients in the SAH catheter group were included in the study. On day 7 after catheter placement, the positivity rate for urinary white blood cells was significantly higher in the conventional catheter group than in the SAH catheter group (33.8% Conclusion: SAH catheters can effectively inhibit the formation of catheter-related bacterial biofilms in critically ill patients and reduce the incidence of CAUTIs, compared with conventional siliconized latex Foley catheters; however, regular replacement of the catheter is still necessary.
Language	English
Publishing date	2023-07-12
Publishing country	China
Document type	Journal Article
ISSN	2667-100X
ISSN (online)	2667-100X
DOI	10.1016/j.jointm.2023.06.003
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Article ; Online: Damage-Associated Molecular Patterns and Their Signaling Pathways in Primary Blast Lung Injury

Ning Li / Chenhao Geng / Shike Hou / Haojun Fan / Yanhua Gong

International Journal of Molecular Sciences, Vol 21, Iss 6303, p

New Research Progress and Future Directions

2020 Volume 6303

Abstract: Primary blast lung injury (PBLI) is a common cause of casualties in wars, terrorist attacks, and explosions. It can exist in the absence of any other outward signs of trauma, and further develop into acute lung injury (ALI) or a more severe acute ... ...

Abstract	Primary blast lung injury (PBLI) is a common cause of casualties in wars, terrorist attacks, and explosions. It can exist in the absence of any other outward signs of trauma, and further develop into acute lung injury (ALI) or a more severe acute respiratory distress syndrome (ARDS). The pathogenesis of PBLI at the cellular and molecular level has not been clear. Damage-associated molecular pattern (DAMP) is a general term for endogenous danger signals released by the body after injury, including intracellular protein molecules (HMGB1, histones, s100s, heat shock proteins, eCIRP, etc.), secretory protein factors (IL-1β, IL-6, IL-10, TNF-α, VEGF, complements, etc.), purines and pyrimidines and their derived degradation products (nucleic acids, ATP, ADP, UDPG, uric acid, etc.), and extracellular matrix components (hyaluronic acid, fibronectin, heparin sulfate, biglycan, etc.). DAMPs can be detected by multiple receptors including pattern recognition receptors (PRRs). The study of DAMPs and their related signaling pathways, such as the mtDNA-triggered cGAS-YAP pathway, contributes to revealing the molecular mechanism of PBLI, and provides new therapeutic targets for controlling inflammatory diseases and alleviating their symptoms. In this review, we focus on the recent progress of research on DAMPs and their signaling pathways, as well as the potential therapeutic targets and future research directions in PBLI.
Keywords	primary blast lung injury ; ALI ; DAMPs ; PRRs ; signaling pathways ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	572
Language	English
Publishing date	2020-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Damage-Associated Molecular Patterns and Their Signaling Pathways in Primary Blast Lung Injury: New Research Progress and Future Directions.

Li, Ning / Geng, Chenhao / Hou, Shike / Fan, Haojun / Gong, Yanhua

International journal of molecular sciences

2020 Volume 21, Issue 17

Abstract	Primary blast lung injury (PBLI) is a common cause of casualties in wars, terrorist attacks, and explosions. It can exist in the absence of any other outward signs of trauma, and further develop into acute lung injury (ALI) or a more severe acute respiratory distress syndrome (ARDS). The pathogenesis of PBLI at the cellular and molecular level has not been clear. Damage-associated molecular pattern (DAMP) is a general term for endogenous danger signals released by the body after injury, including intracellular protein molecules (HMGB1, histones, s100s, heat shock proteins, eCIRP, etc.), secretory protein factors (IL-1β, IL-6, IL-10, TNF-α, VEGF, complements, etc.), purines and pyrimidines and their derived degradation products (nucleic acids, ATP, ADP, UDPG, uric acid, etc.), and extracellular matrix components (hyaluronic acid, fibronectin, heparin sulfate, biglycan, etc.). DAMPs can be detected by multiple receptors including pattern recognition receptors (PRRs). The study of DAMPs and their related signaling pathways, such as the mtDNA-triggered cGAS-YAP pathway, contributes to revealing the molecular mechanism of PBLI, and provides new therapeutic targets for controlling inflammatory diseases and alleviating their symptoms. In this review, we focus on the recent progress of research on DAMPs and their signaling pathways, as well as the potential therapeutic targets and future research directions in PBLI.
MeSH term(s)	Alarmins/metabolism ; Animals ; Blast Injuries/metabolism ; Blast Injuries/pathology ; Humans ; Lung Injury/metabolism ; Lung Injury/pathology ; Signal Transduction
Chemical Substances	Alarmins
Keywords	covid19
Language	English
Publishing date	2020-08-31
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms21176303
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Article ; Online: High flow nasal cannula is a good treatment option for COVID-19.

Geng, Shike / Mei, Qing / Zhu, Chunyan / Yang, Tianjun / Yang, Yun / Fang, Xiaowei / Pan, Aijun

Heart & lung : the journal of critical care

2020 Volume 49, Issue 5, Page(s) 444–445

MeSH term(s)	Betacoronavirus ; COVID-19 ; Cannula ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; Respiratory Rate ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-04-11
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	193129-5
ISSN	1527-3288 ; 0147-9563
ISSN (online)	1527-3288
ISSN	0147-9563
DOI	10.1016/j.hrtlng.2020.03.018
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Zs.A 1035: Show issues

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Article ; Online: Comparison of endotracheal aspirate and bronchoalveolar lavage fluid metagenomic next-generation sequencing in severe pneumonia: a nested, matched case-control study.

Bao, Renren / Mei, Qing / Yang, Tianjun / Zhang, Lei / Zhu, Chunyan / Fan, Xiaoqin / Wang, Yinzhong / Tong, Fei / He, Yuxi / Fang, Xiaowei / Geng, Shike / Yang, Yu / Sheng, Ximei / Pan, Aijun

BMC infectious diseases

2023 Volume 23, Issue 1, Page(s) 389

Abstract: Objectives: To compare clinical outcomes in patients with severe pneumonia according to the diagnostic strategy used.: Methods: In this retrospective, nested, case-control study, patients with severe pneumonia who had undergone endotracheal aspirate ( ...

Abstract	Objectives: To compare clinical outcomes in patients with severe pneumonia according to the diagnostic strategy used. Methods: In this retrospective, nested, case-control study, patients with severe pneumonia who had undergone endotracheal aspirate (ETA) metagenomic next-generation sequencing of (mNGS) testing (n = 53) were matched at a ratio of 1 to 2 (n = 106) by sex, age, underlying diseases, immune status, disease severity scores, and type of pneumonia with patients who had undergone bronchoalveolar lavage fluid (BALF) mNGS. The microbiological characteristics and patient's prognosis of the two groups were compared. Results: An overall comparison between the two groups showed no significant differences in bacterial, fungal, viral, or mixed infections. However, subgroup analysis of 18 patients who received paired ETA and BALF mNGS showed a complete agreement rate for the two specimens of 33.3%. There were more cases for whom targeted treatment was initiated (36.79% vs. 22.64%; P = 0.043) and fewer cases who received no clinical benefit after mNGS (5.66% vs. 15.09%; P = 0.048) in the BALF group. The pneumonia improvement rate in the BALF group was significantly higher than in the ETA group (73.58% vs. 87.74%, P = 0.024). However, there were no significant differences in ICU mortality or 28-day mortality. Conclusions: We do not recommend using ETA mNGS as the first-choice method for analyzing airway pathogenic specimens from severe pneumonia patients.
MeSH term(s)	Humans ; Case-Control Studies ; Retrospective Studies ; Bronchoalveolar Lavage Fluid ; Pneumonia/diagnosis ; High-Throughput Nucleotide Sequencing
Language	English
Publishing date	2023-06-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2041550-3
ISSN	1471-2334 ; 1471-2334
ISSN (online)	1471-2334
ISSN	1471-2334
DOI	10.1186/s12879-023-08376-9
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Article: Diagnostic Value and Clinical Application of Metagenomic Next-Generation Sequencing for Infections in Critically Ill Patients.

He, Yuxi / Geng, Shike / Mei, Qing / Zhang, Lei / Yang, Tianjun / Zhu, Chunyan / Fan, Xiaoqin / Wang, Yinzhong / Tong, Fei / Gao, Yu / Fang, Xiaowei / Bao, Renren / Sheng, Ximei / Pan, Aijun

Infection and drug resistance

2023 Volume 16, Page(s) 6309–6322

Abstract: Objective: To evaluate the diagnostic value and clinical application of metagenomic next-generation sequencing (mNGS) for infections in critically ill patients.: Methods: Comparison of diagnostic performance of mNGS and conventional microbiological ... ...

Abstract	Objective: To evaluate the diagnostic value and clinical application of metagenomic next-generation sequencing (mNGS) for infections in critically ill patients. Methods: Comparison of diagnostic performance of mNGS and conventional microbiological testing for pathogens was analyzed in 234 patients. The differences between immunocompetent and immunocompromised individuals in mNGS-guided anti-infective treatment adjustment were also analyzed. Results: The sensitivity and specificity of mNGS for bacterial and fungal detection were 96.6% (95% confidence interval [CI], 93.5%-99.6%) and 83.1% (95% CI, 75.2%-91.1%), and 85.7% (95% CI, 71.9%-99.5%) and 93.2% (95% CI, 89.7%-96.7%), respectively. Overall, 152 viruses were detected by mNGS, but in which 28 viruses were considered causative agents. The proportion of mNGS-guided beneficial anti-infective therapy adjustments in the immunocompromised group was greater than in the immunocompetent group (48.5% vs 30.1%; Conclusion: mNGS might be a promising technology to provide precision medicine for critically ill patients with infection.
Language	English
Publishing date	2023-09-25
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494856-1
ISSN	1178-6973
ISSN	1178-6973
DOI	10.2147/IDR.S424802
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Article ; Online: Repetitive Low-Level Blast Exposure via Akt/NF-κB Signaling Pathway Mediates the M1 Polarization of Mouse Alveolar Macrophage MH-S Cells.

Geng, Chenhao / Wang, Xinyue / Chen, Jiale / Sun, Na / Wang, Yuru / Li, Zizheng / Han, Lu / Hou, Shike / Fan, Haojun / Li, Ning / Gong, Yanhua

International journal of molecular sciences

2023 Volume 24, Issue 13

Abstract: Repetitive low-level blast (rLLB) exposure is a potential risk factor for the health of soldiers or workers who are exposed to it as an occupational characteristic. Alveolar macrophages (AMs) are susceptible to external blast waves and produce pro- ... ...

Abstract	Repetitive low-level blast (rLLB) exposure is a potential risk factor for the health of soldiers or workers who are exposed to it as an occupational characteristic. Alveolar macrophages (AMs) are susceptible to external blast waves and produce pro-inflammatory or anti-inflammatory effects. However, the effect of rLLB exposure on AMs is still unclear. Here, we generated rLLB waves through a miniature manual Reddy-tube and explored their effects on MH-S cell morphology, phenotype transformation, oxidative stress status, and apoptosis by immunofluorescence, real-time quantitative PCR (qPCR), western blotting (WB) and flow cytometry. Ipatasertib (GDC-0068) or PDTC was used to verify the role of the Akt/NF-κB signaling pathway in these processes. Results showed that rLLB treatment could cause morphological irregularities and cytoskeletal disorders in MH-S cells and promote their polarization to the M1 phenotype by increasing iNOS, CD86 and IL-6 expression. The molecular mechanism is through the Akt/NF-κB signaling pathway. Moreover, we found reactive oxygen species (ROS) burst, Ca
MeSH term(s)	Mice ; Animals ; NF-kappa B/metabolism ; Macrophages, Alveolar/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction
Chemical Substances	NF-kappa B ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; prolinedithiocarbamate (135467-92-4)
Language	English
Publishing date	2023-06-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241310596
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Article ; Online: Repetitive Low-Level Blast Exposure via Akt/NF-κB Signaling Pathway Mediates the M1 Polarization of Mouse Alveolar Macrophage MH-S Cells

Chenhao Geng / Xinyue Wang / Jiale Chen / Na Sun / Yuru Wang / Zizheng Li / Lu Han / Shike Hou / Haojun Fan / Ning Li / Yanhua Gong

International Journal of Molecular Sciences, Vol 24, Iss 10596, p

2023 Volume 10596

Abstract	Repetitive low-level blast (rLLB) exposure is a potential risk factor for the health of soldiers or workers who are exposed to it as an occupational characteristic. Alveolar macrophages (AMs) are susceptible to external blast waves and produce pro-inflammatory or anti-inflammatory effects. However, the effect of rLLB exposure on AMs is still unclear. Here, we generated rLLB waves through a miniature manual Reddy-tube and explored their effects on MH-S cell morphology, phenotype transformation, oxidative stress status, and apoptosis by immunofluorescence, real-time quantitative PCR (qPCR), western blotting (WB) and flow cytometry. Ipatasertib (GDC-0068) or PDTC was used to verify the role of the Akt/NF-κB signaling pathway in these processes. Results showed that rLLB treatment could cause morphological irregularities and cytoskeletal disorders in MH-S cells and promote their polarization to the M1 phenotype by increasing iNOS, CD86 and IL-6 expression. The molecular mechanism is through the Akt/NF-κB signaling pathway. Moreover, we found reactive oxygen species (ROS) burst, Ca 2+ accumulation, mitochondrial membrane potential reduction, and early apoptosis of MH-S cells. Taken together, our findings suggest rLLB exposure may cause M1 polarization and early apoptosis of AMs. Fortunately, it is blocked by specific inhibitors GDC-0068 or PDTC. This study provides a new treatment strategy for preventing and alleviating health damage in the occupational population caused by rLLB exposure.
Keywords	repetitive low-level blast ; Akt/NF-κB signaling pathway ; macrophage polarization ; early apoptosis ; inhibitor ; immune homeostasis ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	610
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Diagnostic Value of Metagenomic Next-Generation Sequencing for the Detection of Pathogens in Bronchoalveolar Lavage Fluid in Ventilator-Associated Pneumonia Patients.

Fang, Xiaowei / Mei, Qing / Fan, Xiaoqin / Zhu, Chunyan / Yang, Tianjun / Zhang, Lei / Geng, Shike / Pan, Aijun

Frontiers in microbiology

2020 Volume 11, Page(s) 599756

Abstract: ... ...

Abstract	Objective
Language	English
Publishing date	2020-12-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2020.599756
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