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  1. Article: Study Limitations and Harmonious Discord of Results Reveal Melody to Public Health Measures.

    Remy, Kenneth E / Kissoon, Niranjan

    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

    2023  Volume 24, Issue 1, Page(s) 77–79

    MeSH term(s) Humans ; Public Health ; Dissent and Disputes ; Music
    Language English
    Publishing date 2023-01-03
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2052349-X
    ISSN 1947-3893 ; 1529-7535
    ISSN (online) 1947-3893
    ISSN 1529-7535
    DOI 10.1097/PCC.0000000000003132
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5600: Show issues Location:
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  2. Article: Help Wanted for Sepsis: Biomarkers in Low- and Middle-Income Countries Please Apply.

    Mount, Michael C / Remy, Kenneth E

    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

    2023  Volume 24, Issue 7, Page(s) 619–621

    MeSH term(s) Humans ; Developing Countries ; Sepsis/diagnosis ; Sepsis/therapy ; Biomarkers
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-07-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2052349-X
    ISSN 1947-3893 ; 1529-7535
    ISSN (online) 1947-3893
    ISSN 1529-7535
    DOI 10.1097/PCC.0000000000003278
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Tickle Me ECMO…Differences and Outcomes Unearthed for Kids Requiring Extracorporeal Membrane Oxygenation in Severe Acute Respiratory Syndrome Coronavirus 2-Associated Disease.

    Kilgallon, Kevin B / Remy, Kenneth E

    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

    2023  Volume 24, Issue 5, Page(s) 419–422

    MeSH term(s) Humans ; SARS-CoV-2 ; COVID-19/therapy ; Extracorporeal Membrane Oxygenation ; Respiratory Distress Syndrome/etiology ; Respiratory Distress Syndrome/therapy ; Respiratory Insufficiency
    Language English
    Publishing date 2023-05-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2052349-X
    ISSN 1947-3893 ; 1529-7535
    ISSN (online) 1947-3893
    ISSN 1529-7535
    DOI 10.1097/PCC.0000000000003225
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Obesity and Extracorporeal Membrane Oxygenation.

    Coccola, Dana E / Remy, Kenneth E / Cheifetz, Ira M

    Respiratory care

    2024  Volume 69, Issue 4, Page(s) 474–481

    Abstract: Obesity is increasing in prevalence worldwide and carries a theoretical increased risk of morbidity and mortality in critical illness, including hypercoagulability, thrombosis, and renal dysfunction. Obesity has historically been considered a relative ... ...

    Abstract Obesity is increasing in prevalence worldwide and carries a theoretical increased risk of morbidity and mortality in critical illness, including hypercoagulability, thrombosis, and renal dysfunction. Obesity has historically been considered a relative contraindication to candidacy for extracorporeal membrane oxygenation (ECMO); however, recent research has suggested that obesity may be associated with improved outcomes in ECMO. This review was conducted to assess and synthesize the existing literature on ECMO outcomes in the obese population. We searched PubMed, Scopus, and CENTRAL databases for obesity and ECMO outcomes, and articles were screened independently by 2 authors. The selection process yielded 29 articles, with one ambispective and 28 retrospective cohort studies. Analyses of these studies show no evidence of globally increased mortality or complications in obesity. Prospective evaluation is needed to further investigate this relationship, but there is currently no evidence to support using body mass index as exclusionary criteria for ECMO.
    MeSH term(s) Humans ; Extracorporeal Membrane Oxygenation ; Retrospective Studies ; Obesity/complications ; Obesity/therapy ; Body Mass Index ; Critical Illness
    Language English
    Publishing date 2024-03-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 603252-7
    ISSN 1943-3654 ; 0098-9142 ; 0020-1324
    ISSN (online) 1943-3654
    ISSN 0098-9142 ; 0020-1324
    DOI 10.4187/respcare.11565
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Finding ways for children's doctors to care for big 'Kids' and save adults in a pandemic.

    Robison, Justin / Remy, Kenneth E

    Archives of disease in childhood

    2021  Volume 106, Issue 6, Page(s) 521–522

    MeSH term(s) Adult ; COVID-19 ; Child ; Critical Illness ; England ; Humans ; Intensive Care Units, Pediatric ; Pandemics/prevention & control ; SARS-CoV-2
    Language English
    Publishing date 2021-03-30
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 524-1
    ISSN 1468-2044 ; 0003-9888 ; 1359-2998
    ISSN (online) 1468-2044
    ISSN 0003-9888 ; 1359-2998
    DOI 10.1136/archdischild-2021-321628
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: What's New in Critical Illness and Injury Science? Weighing the evidence for dexmedetomidine dosing in critically ill patients with obesity.

    Hejal, Rana / Popa, Andrea / Rangel, Maribel Llamas / Remy, Kenneth E

    International journal of critical illness and injury science

    2023  Volume 13, Issue 2, Page(s) 45–47

    Language English
    Publishing date 2023-06-26
    Publishing country India
    Document type Editorial
    ZDB-ID 2638865-0
    ISSN 2231-5004 ; 2229-5151
    ISSN (online) 2231-5004
    ISSN 2229-5151
    DOI 10.4103/ijciis.ijciis_25_23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Coronavirus Disease 2019: A Pandemic Spawning an Infodemic.

    Remy, Kenneth E / Kissoon, Niranjan

    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

    2021  Volume 22, Issue 7, Page(s) 651–654

    MeSH term(s) COVID-19 ; Communication ; Humans ; Pandemics ; SARS-CoV-2 ; Social Media
    Language English
    Publishing date 2021-05-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2052349-X
    ISSN 1947-3893 ; 1529-7535
    ISSN (online) 1947-3893
    ISSN 1529-7535
    DOI 10.1097/PCC.0000000000002782
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5600: Show issues Location:
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  8. Article: What's New in Critical Illness and Injury Science? Alteplase for severe coronavirus disease 2019: Not quite ready to clot bust just hypoxemia.

    Areti, Sathya / Maki, Marwa K / Remy, Kenneth E

    International journal of critical illness and injury science

    2022  Volume 12, Issue 4, Page(s) 181–183

    Language English
    Publishing date 2022-12-26
    Publishing country India
    Document type Editorial
    ZDB-ID 2638865-0
    ISSN 2231-5004 ; 2229-5151
    ISSN (online) 2231-5004
    ISSN 2229-5151
    DOI 10.4103/ijciis.ijciis_82_22
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  9. Article ; Online: Utilizing big data from electronic health records in pediatric clinical care.

    Macias, Charles G / Remy, Kenneth E / Barda, Amie J

    Pediatric research

    2022  Volume 93, Issue 2, Page(s) 382–389

    Abstract: Big data has the capacity to transform both pediatric healthcare delivery and research, but its potential has yet to be fully realized. Curation of large multi-institutional datasets of high-quality data has allowed for significant advances in the ... ...

    Abstract Big data has the capacity to transform both pediatric healthcare delivery and research, but its potential has yet to be fully realized. Curation of large multi-institutional datasets of high-quality data has allowed for significant advances in the timeliness of quality improvement efforts. Improved access to large datasets and computational power have also paved the way for the development of high-performing, data-driven decision support tools and precision medicine approaches. However, implementation of these approaches and tools into pediatric practice has been hindered by challenges in our ability to adequately capture the heterogeneity of the pediatric population as well as the nuanced complexities of pediatric diseases such as sepsis. Moreover, there are large gaps in knowledge and definitive evidence demonstrating the utility, usability, and effectiveness of these types of tools in pediatric practice, which presents significant challenges to provider willingness to leverage these solutions. The next wave of transformation for pediatric healthcare delivery and research through big data and sophisticated analytics will require focusing efforts on strategies to overcome cultural barriers to adoption and acceptance. IMPACT: Big data from EHRs can be used to drive improvement in pediatric clinical care. Clinical decision support, artificial intelligence, machine learning, and precision medicine can transform pediatric care using big data from the EHR. This article provides a review of barriers and enablers for the effective use of data analytics in pediatric clinical care using pediatric sepsis as a use case. The impact of this review is that it will inform influencers of pediatric care about the importance of current trends in data analytics and its use in improving outcomes of care through EHR-based strategies.
    MeSH term(s) Humans ; Child ; Big Data ; Electronic Health Records ; Artificial Intelligence ; Machine Learning ; Sepsis
    Language English
    Publishing date 2022-11-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/s41390-022-02343-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Prolonged adaptive immune activation in COVID-19: implications for maintenance of long-term immunity?

    Mudd, Philip A / Remy, Kenneth E

    The Journal of clinical investigation

    2020  Volume 131, Issue 1

    Abstract: Ongoing observational clinical research has prioritized understanding the human immune response to SARS-CoV-2 during the coronavirus disease 2019 (COVID-19) pandemic. Several recent studies suggest that immune dysregulation with early and prolonged ... ...

    Abstract Ongoing observational clinical research has prioritized understanding the human immune response to SARS-CoV-2 during the coronavirus disease 2019 (COVID-19) pandemic. Several recent studies suggest that immune dysregulation with early and prolonged adaptive immune system activation can result in cellular exhaustion. In this issue of the JCI, Files et al. compared cellular immune phenotypes during the first two months of COVID-19 in hospitalized and less severe, non-hospitalized patients. The authors utilized flow cytometry to analyze circulating peripheral blood mononuclear cells. Both patient cohorts maintained B and T cell phenotypes consistent with activation and cellular exhaustion throughout the first two months of infection. Additionally, follow-up samples from the non-hospitalized patient cohort showed that activation markers and cellular exhaustion increased over time. These findings illustrate the persistent nature of the adaptive immune system changes that have been noted in COVID-19 and suggest longer term effects that may shape the maintenance of immunity to SARS-CoV-2.
    MeSH term(s) Adaptive Immunity ; B-Lymphocytes/immunology ; B-Lymphocytes/pathology ; COVID-19/immunology ; COVID-19/pathology ; Female ; Humans ; Male ; SARS-CoV-2/immunology ; T-Lymphocytes/immunology ; T-Lymphocytes/pathology
    Keywords covid19
    Language English
    Publishing date 2020-10-01
    Publishing country United States
    Document type Journal Article ; Observational Study ; Research Support, N.I.H., Extramural
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI143928
    Database MEDical Literature Analysis and Retrieval System OnLINE

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