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Article ; Online: Wide Resection for Pediatric Extremity Vascular Malformation-A Tertiary Hospital's Experience.

Wong, Kenneth P L / Tan, Tessa W X / Chan, Lester W M / Mahadev, Arjandas / Cheng, Mathew H W

2023 Volume 44, Issue 1, Page(s) 55–60

Abstract: Background: Vascular malformations of the extremities (VM) are common benign lesions that tend to grow throughout the patient's lifetime. They can cause various issues like pain, swelling, and even limb length discrepancies. Sclerotherapy was the ... ...

Abstract	Background: Vascular malformations of the extremities (VM) are common benign lesions that tend to grow throughout the patient's lifetime. They can cause various issues like pain, swelling, and even limb length discrepancies. Sclerotherapy was the preferred treatment choice in previous studies. However, sclerotherapy and many other treatments have the potential to result in higher recurrence rates. Surgical treatment has been shown to be effective and safe in many cases. Hence, this study aims to evaluate the suitability of wide resection surgery for VM to reduce recurrence. Methods: Fort-seven VM cases that underwent wide resection were identified retrospectively in the institution of study. Demographics, depth of malformation, whether malformations were local or diffuse, location and size of malformations, and histology records were taken note of. Records of recurrence and postoperative function were also gathered. We utilized self-reported questionnaires, QuickDASH and Lower Extremity Functional Scale, to determine patients' postsurgical physical function. Results: Out of 47 cases that underwent wide resection, we found a recurrence rate of 2.1%. No patients sustained any loss of function postsurgery, with few patients experiencing minor complications like tenderness, hypertrophic scars/keloids, as well as numbness. Good functionality posttreatment was also seen through self-reported questionnaires, with an average score of 2.12 for QuickDASH and 99.96% for LEFS. Conclusion: Where margins can be obtained without functional impairment, surgical-wide resection for VM is a viable treatment option to minimize recurrence. Level of evidence: Level-IV.
MeSH term(s)	Humans ; Child ; Retrospective Studies ; Tertiary Care Centers ; Treatment Outcome ; Vascular Malformations/surgery ; Extremities/surgery
Language	English
Publishing date	2023-10-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	604642-3
ISSN	1539-2570 ; 0271-6798
ISSN (online)	1539-2570
ISSN	0271-6798
DOI	10.1097/BPO.0000000000002546
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Zs.A 1681: Show issues

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Article ; Online: Blinatumomab with donor lymphocyte infusions post haploidentical hematopoietic stem cell transplantation as salvage therapy for relapsed refractory acute lymphoblastic leukemia post chimeric antigen receptor T-cell therapy.

Chan, Wilson Y K / Lee, Pamela P W / Cheuk, Daniel K L / Yeung, Eva W M / Wong, Kenneth C W / Li, C K / Chan, Godfrey C F / Leung, Wing

Pediatric blood & cancer

2022 Volume 70, Issue 1, Page(s) e29852

MeSH term(s)	Humans ; Salvage Therapy ; Receptors, Chimeric Antigen ; Antibodies, Bispecific/therapeutic use ; Hematopoietic Stem Cell Transplantation ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/therapy ; Lymphocytes
Chemical Substances	blinatumomab (4FR53SIF3A) ; Receptors, Chimeric Antigen ; Antibodies, Bispecific
Language	English
Publishing date	2022-06-23
Publishing country	United States
Document type	Letter
ZDB-ID	2131448-2
ISSN	1545-5017 ; 1545-5009
ISSN (online)	1545-5017
ISSN	1545-5009
DOI	10.1002/pbc.29852
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Zs.A 1131: Show issues

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Article ; Online: Association between the mood stabilizing treatment of bipolar disorder and risk of suicide attempts: A self-controlled case series study.

Ng, Vanessa W S / Leung, Miriam T Y / Chan, Esther W / Lee, Edwin H M / Hayes, Joseph F / Osborn, David P J / Wing, Yun Kwok / Lau, Wallis C Y / Man, Kenneth K C / Wong, Ian C K

Psychiatry research

2023 Volume 325, Page(s) 115236

Abstract: Bipolar disorder (BPD) is associated with high rates of suicide attempts but the anti-suicidal effect of mood stabilizing agents remains unclear. This study aimed to examine the association between mood stabilizing agents (lithium, valproate, lamotrigine, ...

Abstract	Bipolar disorder (BPD) is associated with high rates of suicide attempts but the anti-suicidal effect of mood stabilizing agents remains unclear. This study aimed to examine the association between mood stabilizing agents (lithium, valproate, lamotrigine, carbamazepine or antipsychotics) and risk of suicide attempts in patients with BPD using self-controlled case series study design. Among 14,087 patients with BPD who received mood stabilizing agents from 2001 to 2020 in Hong Kong, 1316 patients had at least one suicide attempts during the observation period. An increased risk of suicide attempts was observed 14 days before treatment initiation compared to non-exposed period. Following treatment initiation, an increased risk with smaller magnitude was found with the use of mood stabilizing agents. A lower risk was observed with lithium and antiepileptics while the risk remained attenuated with decreasing magnitude with antipsychotics. During 30-day post-treatment period, the risk was elevated. Therefore, this study suggests that use of mood stabilizing agents is not causally associated with an increased risk of suicide attempts. Indeed, there are potential protective effects of lithium and antiepileptics against suicide attempts. Assiduous monitoring of symptoms relapse and warning signs of suicide should be part of the management plan and discussed between clinicians, caregivers and patients.
MeSH term(s)	Bipolar Disorder/drug therapy ; Suicide, Attempted ; Risk Factors ; Antipsychotic Agents/therapeutic use ; Humans ; Excipients/therapeutic use ; Anticonvulsants ; Lithium/therapeutic use ; Male ; Female ; Adult ; Middle Aged ; Treatment Outcome
Chemical Substances	Antipsychotic Agents ; Excipients ; Anticonvulsants ; Lithium (9FN79X2M3F)
Language	English
Publishing date	2023-05-07
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	445361-x
ISSN	1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
ISSN (online)	1872-7123 ; 1872-7506
ISSN	0925-4927 ; 0165-1781
DOI	10.1016/j.psychres.2023.115236
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Zs.A 1541: Show issues

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Article: Application of virtual reality for peritoneal dialysis exchange learning in patients with end-stage renal disease and cognitive impairment.

Lee, Connie M S / Fong, Kenneth N K / Mok, Maggie M Y / Lam, M K / Kung, Y / Chan, Paven P W / Ma, Maggie K M / Lui, S L / Kwan, Lorraine P Y / Chu, W L / Hui, P C / Yau, Christina S F / Kwan, Ivan W L / Chan, Kelsey Y M / Chan, T M

Virtual reality

2022 , Page(s) 1–13

Abstract: Cognitive impairment is not uncommon in patients with end-stage renal disease and can make it more difficult for these patients to carry out peritoneal dialysis (PD) on their own. Their attempts to do so may result in adverse consequences such as ... ...

Abstract	Cognitive impairment is not uncommon in patients with end-stage renal disease and can make it more difficult for these patients to carry out peritoneal dialysis (PD) on their own. Their attempts to do so may result in adverse consequences such as peritonitis. PD exchange is a complex procedure demanding knowledge and skill which requires close supervision and guidance by a renal nurse specialist. In this study, a non-immersive virtual reality (VR) training program using a Leap motion hand tracking device was developed to facilitate patients' understanding and learning of the PD exchange procedure before attempting real task practice. This study was a two-center single-blinded randomized controlled trial on 23 incident PD patients. Patients in the experimental group received 8 sessions of VR training, while patients in the control were provided with printed educational materials. The results showed that there were significant differences between the two groups in performance of the overall PD exchange sequence, especially on the crucial steps. VR had a patient satisfaction rate of 89%, and all patients preferred to have the VR aid incorporated in PD training. Our findings conclude VR can be a useful aid in the training and reinforcement of PD exchange procedures, with distinct merits of being free from restrictions of time, space, and manpower.
Language	English
Publishing date	2022-12-03
Publishing country	England
Document type	Journal Article
ZDB-ID	1481468-7
ISSN	1434-9957 ; 1359-4338
ISSN (online)	1434-9957
ISSN	1359-4338
DOI	10.1007/s10055-022-00728-1
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Article ; Online: Opportunities and challenges in combining immunotherapy and radiotherapy in head and neck cancers.

Wong, Kenneth C W / Johnson, David / Hui, Edwin P / Lam, Rachel C T / Ma, Brigette B Y / Chan, Anthony T C

Cancer treatment reviews

2022 Volume 105, Page(s) 102361

Abstract: Locally advanced and recurrent/ metastatic (R/M) head and neck cancers have poor prognosis generally. Radiotherapy (RT) is known to have multiple immunomodulatory effects, and various immune checkpoint inhibitors (ICIs) have been shown to be efficacious ... ...

Abstract	Locally advanced and recurrent/ metastatic (R/M) head and neck cancers have poor prognosis generally. Radiotherapy (RT) is known to have multiple immunomodulatory effects, and various immune checkpoint inhibitors (ICIs) have been shown to be efficacious in the R/M setting in recent years. Hence, it is logical to combine RT and ICIs to improve the outlook for such patients, especially in view of the promising pre-clinical data on this novel combination. In this review, we highlighted the key mechanisms underlying the immunostimulatory and immunoinhibitory effects of RT, with a view to suggesting strategies to overcome radioresistance. We also discussed how the unique immune landscapes of virus-induced cancers, namely Epstein-Barr virus-induced nasopharyngeal carcinoma and human papillomavirus-mediated oropharyngeal cancer, could be exploited with ICIs. The landmark clinical trials in both the locally advanced and R/M settings were reviewed, and these trials showed that the combination of RT and ICIs is generally well tolerated. The potential reasons behind the largely negative results of these studies were also explored, focusing on various parameters including dose fractionation, sequencing, irradiated volume and the use of predictive biomarkers.
MeSH term(s)	Epstein-Barr Virus Infections/complications ; Head and Neck Neoplasms/drug therapy ; Head and Neck Neoplasms/radiotherapy ; Herpesvirus 4, Human ; Humans ; Immunotherapy/methods ; Nasopharyngeal Neoplasms ; Neoplasm Recurrence, Local/drug therapy ; Squamous Cell Carcinoma of Head and Neck
Language	English
Publishing date	2022-02-16
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	125102-8
ISSN	1532-1967 ; 0305-7372
ISSN (online)	1532-1967
ISSN	0305-7372
DOI	10.1016/j.ctrv.2022.102361
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Zs.A 1022: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 611: Show issues

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Article ; Online: Protocol for a prospective open-label clinical trial to investigate the utility of concurrent TBS/fNIRS for antidepressant treatment optimisation.

Kan, Rebecca L D / Mak, Arthur D P / Chan, Sherry K W / Zhang, Bella B B / Fong, Kenneth N K / Kranz, Georg S

BMJ open

2022 Volume 12, Issue 2, Page(s) e053896

Abstract: Introduction: Repetitive transcranial magnetic stimulation (rTMS) with theta burst stimulation (i.e. TBS) of the dorsolateral prefrontal cortex (DLPFC) is an innovative treatment for major depressive disorder (MDD). However, fewer than 50% of patients ... ...

Abstract	Introduction: Repetitive transcranial magnetic stimulation (rTMS) with theta burst stimulation (i.e. TBS) of the dorsolateral prefrontal cortex (DLPFC) is an innovative treatment for major depressive disorder (MDD). However, fewer than 50% of patients show sufficient response to this treatment; markers for response prediction are urgently needed. Research shows considerable individual variability in the brain responses to rTMS. However, whether differences in individual DLPFC modulation by rTMS can be used as a predictive marker for treatment response remains to be investigated. Here, we present a research programme that will exploit the combination of functional near-infrared spectroscopy (fNIRS) with brain stimulation. Concurrent TBS/fNIRS will allow us to systematically investigate TBS-induced modulation of blood oxygenation as a proxy for induced brain activity changes. The findings from this study will (1) elucidate the immediate effects of excitatory and inhibitory TBS on prefrontal activity in TBS treatment-naïve patients with MDD and (2) validate the potential utility of TBS-induced brain modulation at baseline for the prediction of antidepressant response to 4 weeks of daily TBS treatment. Methods and analysis: Open-label, parallel-group experiment consisting of two parts. In part 1, 70 patients and 37 healthy controls will be subjected to concurrent TBS/fNIRS. Intermittent TBS (iTBS) and continuous TBS (cTBS) will be applied on the left and right DLPFC, respectively. fNIRS data will be acquired before, during and several minutes after stimulation. In part 2, patients who participated in part 1 will receive a 4 week iTBS treatment of the left DLPFC, performed daily for 5 days per week. Psychometric evaluation will be performed periodically and at 1 month treatment follow-up. Statistical analysis will include a conventional, as well as a machine learning approach. Ethics and dissemination: Ethics approval was obtained from the Institutional Review Board. Findings will be disseminated through scientific journals, conferences and university courses. Trial registration number: NCT04526002.
MeSH term(s)	Antidepressive Agents/therapeutic use ; Brain/diagnostic imaging ; Depressive Disorder, Major/drug therapy ; Humans ; Prospective Studies ; Transcranial Magnetic Stimulation/methods
Chemical Substances	Antidepressive Agents
Language	English
Publishing date	2022-02-10
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2021-053896
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Article ; Online: Protocol for a prospective open-label clinical trial to investigate the utility of concurrent TBS/fNIRS for antidepressant treatment optimisation

Kenneth N K Fong / Rebecca L D Kan / Arthur D P Mak / Sherry K W Chan / Bella B B Zhang / Georg S Kranz

BMJ Open, Vol 12, Iss

2022 Volume 2

Keywords	Medicine ; R
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Retraction for Lau et al., "Coexistence of Different Genotypes in the Same Bat and Serological Characterization of

Lau, Susanna K P / Poon, Rosana W S / Wong, Beatrice H L / Wang, Ming / Huang, Yi / Xu, Huifang / Guo, Rongtong / Li, Kenneth S M / Gao, Kai / Chan, Kwok-Hung / Zheng, Bo-Jian / Woo, Patrick C Y / Yuen, Kwok-Yung

Journal of virology

2022 Volume 96, Issue 22, Page(s) e0148522

Language	English
Publishing date	2022-10-31
Publishing country	United States
Document type	Retraction of Publication
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/jvi.01485-22
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Zs.A 609: Show issues

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Article ; Online: Incidence of mental health diagnoses during the COVID-19 pandemic: a multinational network study.

Epidemiology and psychiatric sciences

2024 Volume 33, Page(s) e9

Abstract: Aims: Population-wide restrictions during the COVID-19 pandemic may create barriers to mental health diagnosis. This study aims to examine changes in the number of incident cases and the incidence rates of mental health diagnoses during the COVID-19 ... ...

Abstract	Aims: Population-wide restrictions during the COVID-19 pandemic may create barriers to mental health diagnosis. This study aims to examine changes in the number of incident cases and the incidence rates of mental health diagnoses during the COVID-19 pandemic. Methods: By using electronic health records from France, Germany, Italy, South Korea and the UK and claims data from the US, this study conducted interrupted time-series analyses to compare the monthly incident cases and the incidence of depressive disorders, anxiety disorders, alcohol misuse or dependence, substance misuse or dependence, bipolar disorders, personality disorders and psychoses diagnoses before (January 2017 to February 2020) and after (April 2020 to the latest available date of each database [up to November 2021]) the introduction of COVID-related restrictions. Results: A total of 629,712,954 individuals were enrolled across nine databases. Following the introduction of restrictions, an immediate decline was observed in the number of incident cases of all mental health diagnoses in the US (rate ratios (RRs) ranged from 0.005 to 0.677) and in the incidence of all conditions in France, Germany, Italy and the US (RRs ranged from 0.002 to 0.422). In the UK, significant reductions were only observed in common mental illnesses. The number of incident cases and the incidence began to return to or exceed pre-pandemic levels in most countries from mid-2020 through 2021. Conclusions: Healthcare providers should be prepared to deliver service adaptations to mitigate burdens directly or indirectly caused by delays in the diagnosis and treatment of mental health conditions.
MeSH term(s)	Humans ; COVID-19/epidemiology ; Incidence ; Mental Health ; Pandemics ; Anxiety Disorders
Language	English
Publishing date	2024-03-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2607964-1
ISSN	2045-7979 ; 2045-7960
ISSN (online)	2045-7979
ISSN	2045-7960
DOI	10.1017/S2045796024000088
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Zs.A 5143: Show issues

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Article ; Online: Association between the pharmacological treatment of bipolar disorder and risk of traumatic injuries: a self-controlled case series study.

Ng, Vanessa W S / Gao, Le / Chan, Esther W / Lee, Ho Ming Edwin / Hayes, Joseph F / Osborn, David P J / Rainer, Timothy H / Man, Kenneth K C / Wong, Ian C K

Psychological medicine

2022 Volume 53, Issue 11, Page(s) 5185–5193

Abstract: Background: Patients with bipolar disorder (BPD) are prone to engage in risk-taking behaviours and self-harm, contributing to higher risk of traumatic injuries requiring medical attention at the emergency room (ER).We hypothesize that pharmacological ... ...

Abstract	Background: Patients with bipolar disorder (BPD) are prone to engage in risk-taking behaviours and self-harm, contributing to higher risk of traumatic injuries requiring medical attention at the emergency room (ER).We hypothesize that pharmacological treatment of BPD could reduce the risk of traumatic injuries by alleviating symptoms but evidence remains unclear. This study aimed to examine the association between pharmacological treatment and the risk of ER admissions due to traumatic injuries. Methods: Individuals with BPD who received mood stabilizers and/or antipsychotics were identified using a population-based electronic healthcare records database in Hong Kong (2001-2019). A self-controlled case series design was applied to control for time-invariant confounders. Results: A total of 5040 out of 14 021 adults with BPD who received pharmacological treatment and had incident ER admissions due to traumatic injuries from 2001 to 2019 were included. An increased risk of traumatic injuries was found 30 days before treatment [incidence rate ratio (IRR) 4.44 (3.71-5.31), Conclusions: This study supports the hypothesis that pharmacological treatment of BPD was associated with a lower risk of ER admissions due to traumatic injuries but an increased risk after treatment cessation. Close monitoring of symptoms relapse is recommended to clinicians and patients if treatment cessation is warranted.
MeSH term(s)	Adult ; Humans ; Bipolar Disorder/drug therapy ; Bipolar Disorder/epidemiology ; Antimanic Agents/therapeutic use ; Antipsychotic Agents/therapeutic use ; Self-Injurious Behavior/drug therapy ; Self-Injurious Behavior/epidemiology ; Hospitalization
Chemical Substances	Antimanic Agents ; Antipsychotic Agents
Language	English
Publishing date	2022-07-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	217420-0
ISSN	1469-8978 ; 0033-2917
ISSN (online)	1469-8978
ISSN	0033-2917
DOI	10.1017/S0033291722002215
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