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  1. Article ; Online: Epithelioid hemangioma, a benign vascular lesion mimicking malignancy in [

    Shimada, Masayuki / Yokoyama, Kota / Fujioka, Tomoyuki / Mori, Hiroki / Tateishi, Ukihide

    European journal of nuclear medicine and molecular imaging

    2024  

    Language English
    Publishing date 2024-02-12
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-024-06651-8
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1227: Show issues Location:
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  2. Article: Development and Reproduction of a Japanese Strain of

    Watanabe, Hiroki / Shimada, Megumi / Sato, Yoshinori / Kigawa, Rika

    Insects

    2023  Volume 14, Issue 6

    Abstract: Ctenolepisma ... ...

    Abstract Ctenolepisma calvum
    Language English
    Publishing date 2023-06-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662247-6
    ISSN 2075-4450
    ISSN 2075-4450
    DOI 10.3390/insects14060563
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  3. Article ; Online: Carcinogenic risk in the biliary epithelium of children with congenital biliary dilatation via the DNA damage repair pathway.

    Mori, Hiroki / Noma, Takayuki / Morine, Yuji / Ishibashi, Hiroki / Shimada, Mitsuo

    Surgery today

    2023  Volume 53, Issue 10, Page(s) 1126–1131

    Abstract: Purposes: Congenital biliary dilatation (CBD) is a high-risk factor for biliary tract cancer (BTC). We previously reported the potential for carcinogenesis in the biliary epithelium of patients with CBD. In this study, we investigated potential ... ...

    Abstract Purposes: Congenital biliary dilatation (CBD) is a high-risk factor for biliary tract cancer (BTC). We previously reported the potential for carcinogenesis in the biliary epithelium of patients with CBD. In this study, we investigated potential carcinogenetic pathways, focusing on the DNA damage repair response, in children with CBD and compared the findings with those in adults.
    Methods: We enrolled 6 children with CBD and 10 adults with CBD without BTC who underwent extrahepatic bile duct resections, plus 4 control patients who underwent pancreaticoduodenectomy for non-biliary cancer. Levels of phosphorylated histone H2AX (γH2AX), MRE11, and Ku-70 in the biliary tract epithelium were evaluated by immunohistochemistry.
    Results: The levels of γH2AX, MRE11, and Ku-70 were significantly higher in the gallbladder epithelium and bile duct epithelium of both children and adults than in controls.
    Conclusions: Children and adults with CBD might develop BTC via the DNA damage repair pathway, as evidenced by increased γH2AX, MRE11, and Ku-70 expression.
    MeSH term(s) Adult ; Humans ; Child ; Choledochal Cyst ; Carcinogens ; Biliary Tract ; Epithelium ; Biliary Tract Neoplasms/genetics ; Carcinogenesis ; DNA Damage ; Dilatation, Pathologic
    Chemical Substances Carcinogens
    Language English
    Publishing date 2023-02-24
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1115435-4
    ISSN 1436-2813 ; 0941-1291
    ISSN (online) 1436-2813
    ISSN 0941-1291
    DOI 10.1007/s00595-023-02664-2
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1077: Show issues Location:
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  4. Article: BALB.NCT-

    Kang, Xiaojing / Shimada, Shin / Miyahara, Hiroki / Higuchi, Keiichi / Mori, Masayuki

    Molecular genetics and metabolism reports

    2023  Volume 35, Page(s) 100964

    Abstract: In humans, mutations in the coproporphyrinogen oxidase ( ...

    Abstract In humans, mutations in the coproporphyrinogen oxidase (
    Language English
    Publishing date 2023-03-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2821908-9
    ISSN 2214-4269
    ISSN 2214-4269
    DOI 10.1016/j.ymgmr.2023.100964
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  5. Article ; Online: Risk factors for metachronous contralateral inguinal hernia after laparoscopic percutaneous extraperitoneal closure for unilateral inguinal hernia in children.

    Mori, Hiroki / Ishibashi, Hiroki / Yokota, Noriko / Shimada, Mitsuo

    Surgery today

    2022  Volume 52, Issue 10, Page(s) 1491–1496

    Abstract: Purposes: We use the laparoscopic percutaneous extraperitoneal closure (LPEC) method as the standard procedure for pediatric inguinal hernia. Despite judging there to be no contralateral patent processus vaginalis (PPV) at the time of the first LPEC, we ...

    Abstract Purposes: We use the laparoscopic percutaneous extraperitoneal closure (LPEC) method as the standard procedure for pediatric inguinal hernia. Despite judging there to be no contralateral patent processus vaginalis (PPV) at the time of the first LPEC, we experienced five cases in which metachronous contralateral inguinal hernia (MCH) developed, so we report the characteristics, including the predictors.
    Methods: For pediatric inguinal hernia, the LPEC method was used in 1277 cases from 2005 to 2019 in our department. Of these, 374 patients underwent unilateral LPEC, and we compared the 5 patients with MCH onset and the 369 without MCH onset. The items to be examined were the gender, age, presence of a low birth weight, initial-onset side, and contralateral internal inguinal ring classification.
    Results: There was no significant difference in the gender, age, initial-onset side, or contralateral internal inguinal ring classification between the two groups. Low-birth-weight infants were significantly more common among those with MCH than among those without MCH.
    Conclusions: The only predictor of a contralateral onset after LPEC for pediatric inguinal hernia was a low birth weight. Therefore, for the above-mentioned unilateral LPEC cases, the possibility of a contralateral onset after LPEC due to acquired factors rather than congenital factors should be considered.
    MeSH term(s) Child ; Hernia, Inguinal/etiology ; Hernia, Inguinal/surgery ; Herniorrhaphy/methods ; Humans ; Infant ; Laparoscopy/methods ; Male ; Retrospective Studies ; Risk Factors ; Testicular Hydrocele/surgery
    Language English
    Publishing date 2022-02-24
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1115435-4
    ISSN 1436-2813 ; 0941-1291
    ISSN (online) 1436-2813
    ISSN 0941-1291
    DOI 10.1007/s00595-022-02480-0
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  6. Article: A Case of Primary Aldosteronism Turned Out to Be Adrenocortical Carcinoma With Disorganized Steroidogenesis.

    Ohkubo, Yohsuke / Shimada, Yasuho / Tanaka, Hiroki / Yamazaki, Masanori / Komatsu, Mitsuhisa

    Cureus

    2024  Volume 16, Issue 1, Page(s) e52137

    Abstract: Adrenocortical carcinoma (ACC) is a rare disease with a poor prognosis, which essentially needs an early diagnosis because surgery is the only hope of a cure. On the other hand, primary aldosteronism (PA) is an overproduction of aldosterone from the ... ...

    Abstract Adrenocortical carcinoma (ACC) is a rare disease with a poor prognosis, which essentially needs an early diagnosis because surgery is the only hope of a cure. On the other hand, primary aldosteronism (PA) is an overproduction of aldosterone from the adrenal glands and is known as one of the most common causes of secondary hypertension and hypokalemia. It is mostly a benign disease. ACC accompanied by PA is extremely rare, which can result in delayed diagnosis and clinical pitfalls. A 56-year-old woman was diagnosed with PA. Mild, symptomatic PA was clinically diagnosed as a right-sided aldosterone-producing adenoma (APA) with adrenal tumor using adrenal vein sampling (AVS). The tumor imaging findings showed abnormalities on computed tomography (CT) in terms of size and attenuation value compared with typical benign adenomas. Twelve months later, the tumor was confirmed to be an ACC with cortisol hypersecretion. The resected ACC specimen did not clearly show positive findings for CYP11B1 or CYP11B2, and disorganized steroid production was suspected. However, the prevalence and clinical characteristics of adrenocortical carcinomas with disorganized steroid production remain unclear. Steroidogenic enzyme immunostaining analysis is important not only for the diagnosis of adrenal adenoma but also for a better understanding of the clinical course of hormone-producing ACC.
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.52137
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  7. Article ; Online: The GR-SGK1-NDRG1 Pathway as a Predictor of Recurrence and Prognosis in Lung Adenocarcinoma After Radical Surgery.

    Sasaki, Takanobu / Nakamura, Yasuhiro / Hata, Shuko / Shimada, Hiroki

    Anticancer research

    2023  Volume 43, Issue 7, Page(s) 2965–2974

    Abstract: Background/aim: The glucocorticoids (GCs)-glucocorticoid receptor (GR)-SGK1-NDRG1 pathway plays an important role in the response of tumor cells to various stresses including chemotherapy. In many solid tumors, the GCs-GR pathway acts as a tumor ... ...

    Abstract Background/aim: The glucocorticoids (GCs)-glucocorticoid receptor (GR)-SGK1-NDRG1 pathway plays an important role in the response of tumor cells to various stresses including chemotherapy. In many solid tumors, the GCs-GR pathway acts as a tumor suppressor; however, its function varies depending on the type of cancer. This study investigated the relationship between the GR-SGK1-NDRG1 pathway and lung adenocarcinoma recurrence and overall survival.
    Materials and methods: Lung adenocarcinoma cases (n=121, Stage I-III) were included. Immunohistochemistry for GR, N-myc downstream regulated gene 1 (NDRG-1), serum and glucocorticoid-induced protein kinase 1 (SGK-1), Ki-67, and programmed cell death ligand 1 (PD-L1) was performed to examine their relationship with clinicopathological features, recurrence, and prognosis.
    Results: SGK-1 and NDRG-1 were significant prognostic factors. Recurren ce was more likely in the SGK-1, NDRG-1, and Ki-67 high/positive groups.
    Conclusion: The GR-SGK1-NDRG1 pathway may be involved in the recurrence and prognosis of lung adenocarcinoma.
    MeSH term(s) Humans ; Protein Serine-Threonine Kinases/metabolism ; Receptors, Glucocorticoid/metabolism ; Ki-67 Antigen ; Immediate-Early Proteins/genetics ; Prognosis ; Adenocarcinoma of Lung/surgery ; Lung Neoplasms/surgery ; Lung Neoplasms/pathology
    Chemical Substances Protein Serine-Threonine Kinases (EC 2.7.11.1) ; Receptors, Glucocorticoid ; Ki-67 Antigen ; Immediate-Early Proteins
    Language English
    Publishing date 2023-06-23
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 604549-2
    ISSN 1791-7530 ; 0250-7005
    ISSN (online) 1791-7530
    ISSN 0250-7005
    DOI 10.21873/anticanres.16467
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1642: Show issues Location:
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  8. Article ; Online: Primary aldosteronism and obstructive sleep apnea: the strong ties between them.

    Sugawara, Akira / Shimada, Hiroki / Otsubo, Yuri / Kouketsu, Takumi / Yokoyama, Atsushi

    Hypertension research : official journal of the Japanese Society of Hypertension

    2023  Volume 46, Issue 7, Page(s) 1712–1713

    MeSH term(s) Humans ; Prevalence ; Hypertension/physiopathology ; Sleep Apnea, Obstructive/complications ; Sleep Apnea, Obstructive/physiopathology ; Hyperaldosteronism/complications
    Language English
    Publishing date 2023-05-09
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1175297-x
    ISSN 1348-4214 ; 0916-9636
    ISSN (online) 1348-4214
    ISSN 0916-9636
    DOI 10.1038/s41440-023-01303-0
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3898: Show issues Location:
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  9. Article ; Online: Development and Reproduction of a Japanese Strain of Ctenolepisma calvum (Ritter, 1910) at Room Temperature

    Hiroki Watanabe / Megumi Shimada / Yoshinori Sato / Rika Kigawa

    Insects, Vol 14, Iss 563, p

    2023  Volume 563

    Abstract: Ctenolepisma calvum (Ritter, 1910) (Zygentoma: Lepismatidae) is a primitive wingless insect that causes damage to paper, and it is regarded as a pest of collections in museums, archives, and libraries. This species was recently discovered in Japan for ... ...

    Abstract Ctenolepisma calvum (Ritter, 1910) (Zygentoma: Lepismatidae) is a primitive wingless insect that causes damage to paper, and it is regarded as a pest of collections in museums, archives, and libraries. This species was recently discovered in Japan for the first time and may have already spread over large areas of Japan, but, currently, no information is available on the biological characteristics of C. calvum in Japan. In this study, we observed the processes of development and reproduction of C. calvum found in Japan at room temperature. Oviposition was observed from April to November, with a peak in early June. The average egg period was 56.9 days at average temperatures above 24.0 °C, and was 72.4 days at average temperatures below 24.0 °C. The 1st, 2nd, and 3rd instars lasted 4.7 days, 13.2 days, and 26.1 days on average, respectively, at average temperatures above 22.0 °C. Average instar periods were 23–28 days in 4th–7th instars and tended to increase in later instars. Instar periods also increased when the average temperature was 22.0 °C or lower. In individual rearing, the longest-living individual lived for approximately two years, up to the 15th instar. The head width grew at an approximate ratio of 1.1 per molt. First oviposition occurred at the 10th or 11th instar. Individually observed females oviposited once or twice a year, laying 6–16 eggs at one time, but females at least two years old laid 78.2 eggs per year on average in a mass-culture cage. Through this study, only females were found, and the mature females produced their progenies parthenogenetically.
    Keywords Ctenolepisma calvum ; Lepismatidae ; insect development ; head width ; reproduction ; museum pests ; Science ; Q
    Subject code 590
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Comparative bonding performance of coronal dentin disks and CAD/CAM resin composite disks for biological restoration: The impact of resin-coating technique.

    Ishihara, Hiroki / Yonekura, Kazuhide / Ikeda, Masaomi / Inoue, Go / Nakajima, Masatoshi / Shimada, Yasushi / Hosaka, Keiichi

    Dental materials journal

    2024  Volume 43, Issue 2, Page(s) 303–311

    Abstract: This study evaluated the bonding performance of coronal dentin disks, designed for biological restoration, and CAD/CAM resin composite disks when bonded to flat dentin surfaces using dual-cure resin cements, with and without a resin-coating (RC) ... ...

    Abstract This study evaluated the bonding performance of coronal dentin disks, designed for biological restoration, and CAD/CAM resin composite disks when bonded to flat dentin surfaces using dual-cure resin cements, with and without a resin-coating (RC) technique. Three distinct groups were established within the non-RC group, each using one of the two types of resin cements in a self-adhesive mode: one-step self-etch adhesive (1-SEA) without light-cure, 1-SEA with light-cure, and a separate group using an alternate cement. Within the RC group, a subgroup was established for each cement. The microtensile bond strength (μTBS) of the disk-dentin beam was tested after 0 and 10,000 thermocycles in a 5°C/55°C. No significant μTBS difference was observed among the non-RC groups. However, when using RC, the μTBSs of coronal dentin disks significantly exceeded those of CAD/CAM resin composite disks. Thermocycle aging did not affect μTBS in any of the bonding methods, except in self-adhesive mode.
    MeSH term(s) Resin Cements/chemistry ; Dental Cements ; Dental Bonding/methods ; Tensile Strength ; Materials Testing ; Composite Resins/chemistry ; Dentin-Bonding Agents/chemistry ; Glass Ionomer Cements ; Dentin
    Chemical Substances Resin Cements ; Dental Cements ; Composite Resins ; Dentin-Bonding Agents ; Glass Ionomer Cements
    Language English
    Publishing date 2024-03-05
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 605650-7
    ISSN 1881-1361 ; 0287-4547
    ISSN (online) 1881-1361
    ISSN 0287-4547
    DOI 10.4012/dmj.2023-229
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