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Article ; Online: Charge Separation in Metal-Organic Framework Enables Heterogeneous Thiol Catalysis.

Cheng, Shengxian / Ouyang, Jing / Li, Muqing / Diao, Yingxue / Yao, Jiachen / Li, Fengxing / Lee, Yat-For / Sung, Herman Ho-Yung / Williams, Ian / Xu, Zhengtao / Quan, Yangjian

Angewandte Chemie (International ed. in English)

2023 Volume 62, Issue 25, Page(s) e202300993

Abstract: Photoinduced metal-organic framework (MOF) enabled heterogeneous thiol catalysis has been achieved for the first time. MOF Zr-TPDCS-1, consisting of ... ...

Abstract	Photoinduced metal-organic framework (MOF) enabled heterogeneous thiol catalysis has been achieved for the first time. MOF Zr-TPDCS-1, consisting of Zr
MeSH term(s)	Sulfhydryl Compounds/chemistry ; Metal-Organic Frameworks ; Catalysis ; Hydrogen/chemistry
Chemical Substances	Sulfhydryl Compounds ; Metal-Organic Frameworks ; Hydrogen (7YNJ3PO35Z)
Language	English
Publishing date	2023-05-05
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202300993
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Article ; Online: Extra-intestinal sodium polystyrene sulfonate crystal-induced inflammatory pseudotumour in an asymptomatic haemodialysis patient.

Goh, Li Herng / Wong, Jiunn / Chng, Tze Wei / Chew, Min Hoe / Kee, Terence / Ho, Quan Yao

International urology and nephrology

2021 Volume 53, Issue 6, Page(s) 1265–1266

MeSH term(s)	Female ; Granuloma, Plasma Cell/chemically induced ; Humans ; Middle Aged ; Polystyrenes/adverse effects ; Renal Dialysis
Chemical Substances	Polystyrenes ; polystyrene sulfonic acid (70KO0R01RY)
Language	English
Publishing date	2021-01-03
Publishing country	Netherlands
Document type	Case Reports ; Letter
ZDB-ID	204048-7
ISSN	1573-2584 ; 0301-1623 ; 0042-1162
ISSN (online)	1573-2584
ISSN	0301-1623 ; 0042-1162
DOI	10.1007/s11255-020-02702-9
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Zs.A 733: Show issues

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Article ; Online: Impact of tacrolimus versus cyclosporine on one-year renal transplant outcomes

Pei Wen Ong / Terence Kee / Quan Yao Ho

Proceedings of Singapore Healthcare, Vol

A single-centre retrospective cohort study

2020 Volume 29

Abstract: Background: Calcineurin inhibitors are the cornerstone of maintenance immunosuppression after kidney transplant. While studies on predominantly Caucasian populations recommend tacrolimus over cyclosporine, the effects on Singapore’s local population ... ...

Abstract	Background: Calcineurin inhibitors are the cornerstone of maintenance immunosuppression after kidney transplant. While studies on predominantly Caucasian populations recommend tacrolimus over cyclosporine, the effects on Singapore’s local population remain unclear. Objectives: This study aimed to compare the impact of tacrolimus against cyclosporine on post-transplant outcomes in our local kidney transplant population. Methods: A single-centre retrospective chart review was conducted on ABO- and human leucocyte antigen (HLA)-compatible kidney transplantations between 1 January 2011 and 15 August 2018. Patients who received basiliximab induction, prednisolone, mycophenolate and either tacrolimus or cyclosporine were included and followed up for at least one year. Recipients of transplantations at other institutions or other immunosuppressive regimens were excluded. Patient and graft outcomes and adverse effects were collected. Results: Overall, 120 patients on tacrolimus and 49 on cyclosporine were included. Patients on tacrolimus were older. This group had more deceased donor transplants, a higher proportion with donor-specific antibodies (DSAs) present and more HLA mismatches. There were no differences in patient and graft survival, graft function and acute rejections at one year, despite adjusting for age, transplant type, presence of DSAs and total HLA mismatches. The tacrolimus group had more infectious admissions (odds ratio=0.27, 95% confidence interval 0.098–0.73, p=0.01) after adjusting for age, transplant type, HLA mismatches, presence of DSAs and acute rejections, with increased severity and more opportunistic infections. More patients on cyclosporine required a change to alternative immunosuppressants (p=0.003). Conclusion: Our study demonstrated comparable short-term post-transplant outcomes between cyclosporine and tacrolimus. Tacrolimus appears more tolerable but may be associated with infection risks.
Keywords	Medicine ; R
Subject code	610
Language	English
Publishing date	2020-12-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
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Article ; Online: COVID-19 vaccine acceptance among kidney transplant recipients in Singapore.

Liew, Ian Tatt / Kadir, Hanis Abdul / Thangaraju, Sobhana / Ho, Quan Yao / Ng, Eleanor / Foo, Fiona / Kee, Terence

Singapore medical journal

2023

Abstract: Introduction: A successful vaccination programme forms the cornerstone of controlling coronavirus disease 2019 (COVID-19). The unprecedented speed of COVID-19 vaccine development and lack of long-term data have raised fears regarding its safety and ... ...

Abstract	Introduction: A successful vaccination programme forms the cornerstone of controlling coronavirus disease 2019 (COVID-19). The unprecedented speed of COVID-19 vaccine development and lack of long-term data have raised fears regarding its safety and efficacy. Vaccine hesitancy can undermine the uptake, and hence success of the vaccination programme. Given the high complication rates of COVID-19 infections in kidney transplant recipients, it is particularly important to identify and address vaccine hesitancy in this population. Methods: We conducted a cross-sectional survey among kidney transplant recipients attending transplant clinic between 5 April and 5 May 2021. The survey assessed attitudes towards COVID-19, willingness/hesitancy towards COVID-19 vaccination, vaccination concerns and prompts to vaccination. This was scored on a Likert scale with scores ranging from 'strongly disagree' - 1 point to 'strongly agree' - 5 points. Results: One hundred and one completed responses were captured. Of these, 86% respondents reported to agree or strongly agree to vaccination. This was despite significant concerns of allograft rejection (mean score 4.12, standard deviation [SD] 0.97) and decreased immunosuppressant efficacy (mean score 4.14, SD 0.96) with vaccination. Multivariable model showed a positive association with transplant vintage of ≥ 5 years (median 2.41), lower educational levels of secondary school or less (median 5.82) and healthcare provider advocacy (median 1.88) in predicting vaccine acceptance. Conclusions: Vaccine acceptance rate was high among kidney transplant recipients. Vaccine hesitancy remains a concern in those with a transplant vintage of less than 5 years and those with tertiary educational level. Healthcare provider advocacy is important in improving vaccine acceptance rates.
Language	English
Publishing date	2023-04-26
Publishing country	India
Document type	Journal Article
ZDB-ID	604319-7
ISSN	2737-5935 ; 0037-5675
ISSN (online)	2737-5935
ISSN	0037-5675
DOI	10.4103/singaporemedj.SMJ-2021-332
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Article ; Online: Unrepresented human leucocyte antigen alleles in single-antigen bead assays: A single-centre cohort study.

Ho, Quan Yao / Phang, Chew Yen / Liew, Ian Tatt / Lai, May Ling / Tien, Carolyn Shan-Yeu / Thangaraju, Sobhana / Chan, Marieta / Kee, Terence

International journal of immunogenetics

2023 Volume 50, Issue 6, Page(s) 306–315

Abstract: Human leucocyte antigen (HLA) alleles may generate antibodies that are undetectable by routine single-antigen beads (SABs) assays if their unique epitopes are unrepresented. We aimed to describe the prevalence and explore the potential impact of ... ...

Abstract	Human leucocyte antigen (HLA) alleles may generate antibodies that are undetectable by routine single-antigen beads (SABs) assays if their unique epitopes are unrepresented. We aimed to describe the prevalence and explore the potential impact of unrepresented HLA alleles in standard SAB kits in our cohort. All individuals who had undergone two-field HLA typing (HLA-A/B/C/DRB1/DQA1/-DQB1/-DPA1/-DPB1) from February 2021 to July 2023 were included. Two-field HLA-DRB3/4/5 typing was imputed. Each unrepresented allele was compared with the most similar represented allele in the standard LABScreen, LABScreen ExPlex (One Lambda) and the LIFECODES (Immucor) SAB kits. Differences in eplet expression (HLA Eplet Registry) were identified. Differences in three-dimensional molecular structures were visualized using generated models (SWISS-MODEL). Two-field HLA typing was performed for 116 individuals. Overall, 16.7% of all HLA alleles, found in 36.2% of individuals, were unrepresented by all SAB test kits. Four eplets, found in 12.9% of individuals, were unrepresented in at least 1 SAB kit. Non-Chinese individuals were more likely to have unrepresented HLA alleles and eplets than Chinese individuals. There were differences in HLA allele and eplet representation amongst the different SAB test kits. Use of supplementary SAB test kits may improve HLA allele and eplet representation. Although some HLA alleles were unrepresented, most epitopes were represented in current SAB kits. However, some unrepresented alleles may contain epitopes which may generate undetectable antibodies. Further studies may be needed to investigate the potential clinical impact of these unrepresented alleles and eplets, especially in certain ethnic populations or at-risk individuals.
MeSH term(s)	Humans ; Alleles ; Cohort Studies ; Antibodies ; Epitopes ; Histocompatibility Testing ; HLA Antigens
Chemical Substances	Antibodies ; Epitopes ; HLA Antigens
Language	English
Publishing date	2023-09-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2177883-8
ISSN	1744-313X ; 1744-3121
ISSN (online)	1744-313X
ISSN	1744-3121
DOI	10.1111/iji.12639
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Zs.A 994: Show issues

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Article ; Online: Complications of Percutaneous Kidney Allograft Biopsy: Systematic Review and Meta-analysis.

Ho, Quan Yao / Lim, Cynthia Ciwei / Tan, Hui Zhuan / Sultana, Rehena / Kee, Terence / Htay, Htay

Transplantation

2022 Volume 106, Issue 7, Page(s) 1497–1506

Abstract: Background: Kidney biopsy is important to guide the management of allograft dysfunction but has a risk of complications. This review aimed to determine the incidence and risk factors of complications after kidney allograft biopsy.: Methods: This is a ...

Abstract	Background: Kidney biopsy is important to guide the management of allograft dysfunction but has a risk of complications. This review aimed to determine the incidence and risk factors of complications after kidney allograft biopsy. Methods: This is a systematic review and meta-analysis of randomized controlled trials, cohort studies, or case-control studies indexed on PubMed, Embase, Cochrane Central Register of Controlled Trials, World Health Organization International Clinical Trials Registry, and ClinicalTrials.gov, limited to the English language, from January 2000 to December 2020, including adult and pediatric kidney allograft biopsies. Primary outcomes were gross hematuria, bleeding requiring transfusion, and major complications (requiring interventions such as blood transfusion or surgical or radiological interventions). Results: The review included 72 studies (40 082 biopsies). The quality of included studies was suboptimal. Pooled rates of gross hematuria, bleeding requiring transfusion, and major complications were 3.18% [95% confidence interval (95% CI), 2.31-4.19], 0.31% (95% CI, 0.15-0.52) and 0.89% (95% CI, 0.61-1.22), respectively. Gross hematuria rates were lower in high-income compared with middle-income countries (2.59% versus 6.44%, P < 0.01) and biopsies performed by radiology as compared with nephrology departments (1.25% versus 3.71%, P < 0.01). Blood transfusion rates were lower in pediatrics than adults (0.0% versus 0.65%, P < 0.01). Major complications were lower in biopsies performed by specialists as compared with trainees (0.02% versus 3.64%, P < 0.01). Graft loss and mortality were extremely rare. Limitations included missing data, few randomized controlled trials, and possible publication bias. Conclusions: The risk of complications after kidney allograft biopsy was low. Given the low quality of included studies, risk factors for complications should be further examined in future studies.
MeSH term(s)	Adult ; Allografts ; Biopsy/adverse effects ; Child ; Hematuria/epidemiology ; Hematuria/etiology ; Hematuria/pathology ; Hemorrhage/epidemiology ; Hemorrhage/etiology ; Humans ; Kidney/pathology
Language	English
Publishing date	2022-01-10
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	208424-7
ISSN	1534-6080 ; 0041-1337
ISSN (online)	1534-6080
ISSN	0041-1337
DOI	10.1097/TP.0000000000004033
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Zs.A 488: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 509: Show issues

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Article ; Online: Nodular glomerulosclerosis in a kidney transplant recipient with impaired glucose tolerance: diabetic or idiopathic? A case report and literature review.

Liew, Zhong Hong / Tan, Puay Hoon / Foo, Marjorie / Kee, Terence / Ho, Quan Yao

CEN case reports

2021 Volume 10, Issue 2, Page(s) 273–280

Abstract: Nodular glomerulosclerosis, typically diagnosed in patients with diabetes mellitus, has been reported in native kidneys of pre-diabetic patients but similar cases in kidney transplant recipients are lacking. We describe a case of nodular ... ...

Abstract	Nodular glomerulosclerosis, typically diagnosed in patients with diabetes mellitus, has been reported in native kidneys of pre-diabetic patients but similar cases in kidney transplant recipients are lacking. We describe a case of nodular glomerulosclerosis in a kidney transplant recipient who had not been found to be diabetic despite regular screening and discuss the implications for the pathogenesis and diagnosis of nodular glomerulosclerosis and screening of post-transplant diabetes mellitus.
MeSH term(s)	Diabetes Mellitus/diagnosis ; Diabetic Nephropathies/diagnosis ; Glucose Intolerance ; Humans ; Kidney Transplantation ; Mass Screening ; Transplant Recipients
Language	English
Publishing date	2021-01-03
Publishing country	Japan
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	2660492-9
ISSN	2192-4449 ; 2192-4449
ISSN (online)	2192-4449
ISSN	2192-4449
DOI	10.1007/s13730-020-00546-x
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Article ; Online: COVID-19 Infected Kidney Transplant Patients Outpatient Management-A Single-center Experience With a Hospital-at-home Program.

Liew, Ian Tatt / Tan, Woei Jen Michelle / Ho, Quan Yao / Thangaraju, Sobhana / Yong, Jin Hua / Ng, Eleanor / He, Xia / Kwan, Natelie / Kee, Terence

Transplantation

2022 Volume 106, Issue 12, Page(s) e525–e527

MeSH term(s)	Humans ; COVID-19 ; Kidney Transplantation/adverse effects ; Outpatients ; SARS-CoV-2 ; Transplant Recipients ; Hospitals
Language	English
Publishing date	2022-09-29
Publishing country	United States
Document type	Letter
ZDB-ID	208424-7
ISSN	1534-6080 ; 0041-1337
ISSN (online)	1534-6080
ISSN	0041-1337
DOI	10.1097/TP.0000000000004379
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Zs.A 488: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Impact of COVID-19 infections among kidney transplant recipients.

Chung, Shimin Jasmine / Ho, Quan Yao / Liew, Ian Tatt / Thien, Siew Yee / Chan, Yvonne Fu Zi / Cherng, Benjamin Pei Zhi / Wong, Hei Man / Chua, Ying Ying / Kee, Terence / Tan, Thuan Tong

Annals of the Academy of Medicine, Singapore

2022 Volume 51, Issue 2, Page(s) 122–126

MeSH term(s)	COVID-19 ; Humans ; Kidney Transplantation ; Retrospective Studies ; SARS-CoV-2 ; Transplant Recipients
Language	English
Publishing date	2022-02-10
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	604527-3
ISSN	0304-4602
ISSN	0304-4602
DOI	10.47102/annals-acadmedsg.2021422
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Zs.B 2420: Show issues

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Article ; Online: Coronavirus disease 2019 in kidney transplant recipients: a systematic review and meta-analysis.

Ho, Quan Yao / Sultana, Rehena / Lee, Tung Lin / Thangaraju, Sobhana / Kee, Terence / Htay, Htay

Singapore medical journal

2021 Volume 64, Issue 10, Page(s) 593–602

Abstract: Introduction: The clinical presentation and outcomes of coronavirus disease 2019 (COVID-19) in kidney transplant recipients (KTRs) have not been well studied.: Methods: We performed a meta-analysis to examine the presenting features, outcomes and the ...

Abstract	Introduction: The clinical presentation and outcomes of coronavirus disease 2019 (COVID-19) in kidney transplant recipients (KTRs) have not been well studied. Methods: We performed a meta-analysis to examine the presenting features, outcomes and the effect of treatment on outcomes of KTRs with COVID-19. Database search was performed up to 5 September 2020 through PubMed, Embase, Web of Science, Scopus and CENTRAL. Results: Overall, 23 studies (1,373 patients) were included in the review and meta-analysis. The most common presenting symptoms included fever (74.0%, 95% confidence interval [CI] 65.3-81.1), cough (63.3%, 95% CI 56.5-69.6) and dyspnoea (47.5%, 95% CI 39.6-55.6). Pooled rates of mortality and critical illness were 21.1% (95% CI 15.3-28.4) and 27.7% (95% CI 21.5-34.8), respectively. Acute kidney injury occurred in 38.9% (95% CI 30.6-48.1) and dialysis was required in 12.4% (95% CI 8.3-18.0) of the cases. Conclusion: Kidney transplant recipients with COVID-19 have a similar clinical presentation as the general population, but they have higher morbidity and mortality. It is uncertain whether high-dose corticosteroid or hydroxychloroquine reduces the risks of mortality in KTRs with COVID-19.
Language	English
Publishing date	2021-10-19
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	604319-7
ISSN	2737-5935 ; 0037-5675
ISSN (online)	2737-5935
ISSN	0037-5675
DOI	10.11622/smedj.2021171
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