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Article ; Online: Lessons on dietary biomarkers from twin studies.

Menni, Cristina

The Proceedings of the Nutrition Society

2017 Volume 76, Issue 3, Page(s) 303–307

Abstract: Metabolomic and microbiome profiling are promising tools to identify biomarkers of food intake and health status. The individual's genetic makeup plays a significant role on health, metabolism, gut microbes and diet and twin studies provide unique ... ...

Abstract	Metabolomic and microbiome profiling are promising tools to identify biomarkers of food intake and health status. The individual's genetic makeup plays a significant role on health, metabolism, gut microbes and diet and twin studies provide unique opportunities to untangle gene-environment effects on complex phenotypes. This brief review discusses the value of twin studies in nutrition research with a particular focus on metabolomics and the gut microbiome. Although, the twin model is a powerful tool to segregate the genetic component, to date, very few studies combine the twin design and metabolomics/microbiome in nutritional sciences. Moreover, since the individual's diet has a strong influence on the microbiome composition and the gut microbiome is modifiable (60 % of microbiome diversity is due to the environment), future studies should target the microbiome via dietary interventions.
MeSH term(s)	Biomarkers/metabolism ; Biomedical Research/methods ; Biomedical Research/trends ; Congresses as Topic ; Diet/adverse effects ; Dietetics/methods ; Dietetics/trends ; Gastrointestinal Microbiome ; Humans ; Metabolomics/methods ; Metabolomics/trends ; Nutrigenomics/methods ; Nutrigenomics/trends ; Nutrition Assessment ; Nutritional Sciences/methods ; Nutritional Sciences/trends ; Societies, Scientific ; Twin Studies as Topic
Chemical Substances	Biomarkers
Language	English
Publishing date	2017-01-30
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	391142-1
ISSN	1475-2719 ; 0029-6651
ISSN (online)	1475-2719
ISSN	0029-6651
DOI	10.1017/S0029665116002810
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Article ; Online: Blood pressure pharmacogenomics: gazing into a misty crystal ball.

Menni, Cristina

Journal of hypertension

2015 Volume 33, Issue 6, Page(s) 1142–1143

MeSH term(s)	Antihypertensive Agents/therapeutic use ; DNA-Binding Proteins/genetics ; Humans ; Hydrochlorothiazide/therapeutic use ; Hypertension/drug therapy ; Hypertension/genetics ; Male ; Membrane Proteins/genetics ; Proto-Oncogene Proteins/genetics ; Sodium Chloride Symporter Inhibitors/therapeutic use
Chemical Substances	Antihypertensive Agents ; DNA-Binding Proteins ; Membrane Proteins ; Proto-Oncogene Proteins ; Sodium Chloride Symporter Inhibitors ; Hydrochlorothiazide (0J48LPH2TH)
Language	English
Publishing date	2015-06
Publishing country	England
Document type	Comment ; Editorial
ZDB-ID	605532-1
ISSN	1473-5598 ; 0263-6352 ; 0952-1178
ISSN (online)	1473-5598
ISSN	0263-6352 ; 0952-1178
DOI	10.1097/HJH.0000000000000574
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Article ; Online: Microbiome genetics links short-chain fatty acids to metabolic diseases.

Menni, Cristina / Valdes, Ana M

Nature metabolism

2019 Volume 1, Issue 4, Page(s) 420–421

Language	English
Publishing date	2019-11-15
Publishing country	Germany
Document type	Journal Article
ISSN	2522-5812
ISSN (online)	2522-5812
DOI	10.1038/s42255-019-0056-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Bacteriophages, gut bacteria, and microbial pathways interplay in cardiometabolic health.

Kirk, Daniel / Costeira, Ricardo / Visconti, Alessia / Khan Mirzaei, Mohammadali / Deng, Li / Valdes, Ana M / Menni, Cristina

Cell reports

2024 Volume 43, Issue 2, Page(s) 113728

Abstract: Cardiometabolic diseases are leading causes of mortality in Western countries. Well-established risk factors include host genetics, lifestyle, diet, and the gut microbiome. Moreover, gut bacterial communities and their activities can be altered by ... ...

Abstract	Cardiometabolic diseases are leading causes of mortality in Western countries. Well-established risk factors include host genetics, lifestyle, diet, and the gut microbiome. Moreover, gut bacterial communities and their activities can be altered by bacteriophages (also known simply as phages), bacteria-infecting viruses, making these biological entities key regulators of human cardiometabolic health. The manipulation of bacterial populations by phages enables the possibility of using phages in the treatment of cardiometabolic diseases through phage therapy and fecal viral transplants. First, however, a deeper understanding of the role of the phageome in cardiometabolic diseases is required. In this review, we first introduce the phageome as a component of the gut microbiome and discuss fecal viral transplants and phage therapy in relation to cardiometabolic diseases. We then summarize the current state of phageome research in cardiometabolic diseases and propose how the phageome might indirectly influence cardiometabolic health through gut bacteria and their metabolites.
MeSH term(s)	Humans ; Bacteriophages ; Gastrointestinal Microbiome ; Bacteria ; Fecal Microbiota Transplantation ; Cardiovascular Diseases/therapy
Language	English
Publishing date	2024-01-31
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2024.113728
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Lessons on dietary biomarkers from twin studies

Menni, Cristina

Proceedings of the Nutrition Society. 2017 Aug., v. 76, no. 3

2017

Abstract	Metabolomic and microbiome profiling are promising tools to identify biomarkers of food intake and health status. The individual's genetic makeup plays a significant role on health, metabolism, gut microbes and diet and twin studies provide unique opportunities to untangle gene–environment effects on complex phenotypes. This brief review discusses the value of twin studies in nutrition research with a particular focus on metabolomics and the gut microbiome. Although, the twin model is a powerful tool to segregate the genetic component, to date, very few studies combine the twin design and metabolomics/microbiome in nutritional sciences. Moreover, since the individual's diet has a strong influence on the microbiome composition and the gut microbiome is modifiable (60 % of microbiome diversity is due to the environment), future studies should target the microbiome via dietary interventions.
Keywords	dietary markers ; food intake ; health status ; intestinal microorganisms ; metabolism ; metabolomics ; microbiome ; nutrition research ; nutritional intervention ; phenotype
Language	English
Dates of publication	2017-08
Size	p. 303-307.
Publishing place	Cambridge University Press
Document type	Article
ZDB-ID	391142-1
ISSN	1475-2719 ; 0029-6651
ISSN (online)	1475-2719
ISSN	0029-6651
DOI	10.1017/S0029665116002810
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Effect of Sodium Bicarbonate on Systolic Blood Pressure in CKD: A Systematic Review and Meta-Analysis.

Beynon-Cobb, Beverley / Louca, Panayiotis / Hoorn, Ewout J / Menni, Cristina / Padmanabhan, Sandosh

Clinical journal of the American Society of Nephrology : CJASN

2023 Volume 18, Issue 4, Page(s) 435–445

Abstract: Background: Individuals with CKD are at a higher risk of cardiovascular morbidity and mortality. Acidosis is positively correlated with CKD progression and elevated systolic BP. Sodium bicarbonate is an efficacious treatment of acidosis, although this ... ...

Abstract	Background: Individuals with CKD are at a higher risk of cardiovascular morbidity and mortality. Acidosis is positively correlated with CKD progression and elevated systolic BP. Sodium bicarbonate is an efficacious treatment of acidosis, although this may also increase systolic BP. In this systematic review and meta-analysis, we summarize the evidence evaluating systolic BP and antihypertensive medication change (which may indicate systolic BP change) in response to sodium bicarbonate therapy in individuals with CKD. Methods: Medical Literature Analysis and Retrieval System Online, Excerpta Medica database, Cumulative Index to Nursing and Allied Health Literature, Allied and Complementary Medicine Database, Cochrane Central Register of Controlled Trials, and World Health Organization (WHO) trials registry databases were searched for randomized control trials where sodium bicarbonate was compared with placebo/usual care in CKD stage G1-5 non-dialysis-dependent populations. Random effects meta-analyses were used to evaluate changes in systolic BP and BP-modifying drugs after sodium bicarbonate intervention. Results: Fourteen randomized control trials (2110 individuals, median follow-up 27 [interquartile range 97] weeks, mean age 60 [SD 10] years, mean systolic BP 136 [SD 17] mm Hg, mean eGFR 38 [SD 10] ml/min, mean serum bicarbonate 22 [SD 4] mmol/L) were eligible for inclusion. Meta-analysis suggested that sodium bicarbonate did not influence systolic BP in individuals with CKD stage G1-5. Results were consistent when stratifying by dose of sodium bicarbonate or duration of intervention. Similarly, there was no significant increase in the use of antihypertensive medication or diuretics in individuals taking sodium bicarbonate, whereas there was a greater decrease in antihypertensive medication use in individuals taking sodium bicarbonate compared with controls. Conclusions: Our results suggest, with moderate certainty, that sodium bicarbonate supplementation does not adversely affect systolic BP in CKD or negatively influence antihypertensive medication requirements.
MeSH term(s)	Humans ; Middle Aged ; Blood Pressure ; Sodium Bicarbonate/therapeutic use ; Antihypertensive Agents/adverse effects ; Kidney Failure, Chronic/drug therapy ; Acidosis/drug therapy ; Hypertension/drug therapy
Chemical Substances	Sodium Bicarbonate (8MDF5V39QO) ; Antihypertensive Agents
Language	English
Publishing date	2023-03-09
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2226665-3
ISSN	1555-905X ; 1555-9041
ISSN (online)	1555-905X
ISSN	1555-9041
DOI	10.2215/CJN.0000000000000119
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Article ; Online: The role of short-chain fatty acids in the interplay between gut microbiota and diet in cardio-metabolic health.

Nogal, Ana / Valdes, Ana M / Menni, Cristina

Gut microbes

2021 Volume 13, Issue 1, Page(s) 1–24

Abstract: The gut microbiota plays an important role in cardio-metabolic diseases with diet being among the strongest modulators of gut microbiota composition and function. Resistant dietary carbohydrates are fermented to short-chain fatty acids (SCFAs) by the gut ...

Abstract	The gut microbiota plays an important role in cardio-metabolic diseases with diet being among the strongest modulators of gut microbiota composition and function. Resistant dietary carbohydrates are fermented to short-chain fatty acids (SCFAs) by the gut bacteria. Fiber and omega-3 rich diets increase SCFAs production and abundance of SCFA-producing bacteria. Likewise, SCFAs can improve gut barrier integrity, glucose, and lipid metabolism, regulate the immune system, the inflammatory response, and blood pressure. Therefore, targeting the gut microbiota with dietary strategies leading to increased SCFA production may benefit cardio-metabolic health. In this review, we provide an overview of the association between diet, SCFAs produced by the gut microbiota and cardio-metabolic diseases. We first discuss the association between the human gut microbiota and cardio-metabolic diseases, then investigate the role of SCFAs and finally explore the beneficial effects of specific dietary interventions that can improve cardio-metabolic outcomes through boosting the SCFA production.
MeSH term(s)	Bacteria/metabolism ; Cardiometabolic Risk Factors ; Cardiovascular Diseases/metabolism ; Cardiovascular Diseases/microbiology ; Cardiovascular Diseases/prevention & control ; Diet ; Energy Metabolism ; Fatty Acids, Volatile/metabolism ; Gastrointestinal Microbiome/physiology ; Gastrointestinal Tract/microbiology ; Gastrointestinal Tract/physiology ; Humans ; Metabolic Syndrome/metabolism ; Metabolic Syndrome/microbiology ; Metabolic Syndrome/prevention & control
Chemical Substances	Fatty Acids, Volatile
Language	English
Publishing date	2021-03-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2575755-6
ISSN	1949-0984 ; 1949-0984
ISSN (online)	1949-0984
ISSN	1949-0984
DOI	10.1080/19490976.2021.1897212
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Inflammatory markers and mediators in heart disease.

Valdes, Ana M / Menni, Cristina

Aging

2018 Volume 10, Issue 11, Page(s) 3061–3062

MeSH term(s)	Biomarkers ; Female ; Gastrointestinal Microbiome ; Heart Diseases/blood ; Heart Diseases/genetics ; Heart Diseases/metabolism ; Humans ; Inflammation/blood ; Inflammation/metabolism ; Male ; Polysaccharides/blood ; Polysaccharides/metabolism ; Risk Factors
Chemical Substances	Biomarkers ; Polysaccharides
Language	English
Publishing date	2018-11-07
Publishing country	United States
Document type	Editorial ; Research Support, Non-U.S. Gov't
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.101640
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Genomic Determinants of Hypertension With a Focus on Metabolomics and the Gut Microbiome.

Louca, Panayiotis / Menni, Cristina / Padmanabhan, Sandosh

American journal of hypertension

2020 Volume 33, Issue 6, Page(s) 473–481

Abstract: Epidemiologic and genomic studies have progressively improved our understanding of the causation of hypertension and the complex relationship with diet and environment. The majority of Mendelian forms of syndromic hypotension and hypertension (HTN) have ... ...

Abstract	Epidemiologic and genomic studies have progressively improved our understanding of the causation of hypertension and the complex relationship with diet and environment. The majority of Mendelian forms of syndromic hypotension and hypertension (HTN) have all been linked to mutations in genes whose encoded proteins regulate salt-water balance in the kidney, supporting the primacy of the kidneys in blood pressure regulation. There are more than 1,477 single nucleotide polymorphisms associated with blood pressure and hypertension and the challenge is establishing a causal role for these variants. Hypertension is a complex multifactorial phenotype and it is likely to be influenced by multiple factors including interactions between diet and lifestyle factors, microbiome, and epigenetics. Given the finite genetic variability that is possible in humans, it is likely that incremental gains from single marker analyses have now plateaued and a greater leap in our understanding of the genetic basis of disease will come from integration of other omics and the interacting environmental factors. In this review, we focus on emerging results from the microbiome and metabolomics and discuss how leveraging these findings may facilitate a deeper understanding of the interrelationships between genomics, diet, and microbial ecology in humans in the causation of essential hypertension.
MeSH term(s)	Animals ; Bacteria/metabolism ; Blood Pressure ; Diet ; Essential Hypertension/genetics ; Essential Hypertension/microbiology ; Essential Hypertension/physiopathology ; Gastrointestinal Microbiome ; Gene-Environment Interaction ; Genetic Predisposition to Disease ; Genetic Variation ; Humans ; Metabolomics ; Risk Factors
Language	English
Publishing date	2020-02-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	639383-4
ISSN	1941-7225 ; 1879-1905 ; 0895-7061
ISSN (online)	1941-7225 ; 1879-1905
ISSN	0895-7061
DOI	10.1093/ajh/hpaa022
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Article ; Online: Cardiometabolic health, diet and the gut microbiome: a meta-omics perspective.

Valles-Colomer, Mireia / Menni, Cristina / Berry, Sarah E / Valdes, Ana M / Spector, Tim D / Segata, Nicola

Nature medicine

2023 Volume 29, Issue 3, Page(s) 551–561

Abstract: Cardiometabolic diseases have become a leading cause of morbidity and mortality globally. They have been tightly linked to microbiome taxonomic and functional composition, with diet possibly mediating some of the associations described. Both the ... ...

Abstract	Cardiometabolic diseases have become a leading cause of morbidity and mortality globally. They have been tightly linked to microbiome taxonomic and functional composition, with diet possibly mediating some of the associations described. Both the microbiome and diet are modifiable, which opens the way for novel therapeutic strategies. High-throughput omics techniques applied on microbiome samples (meta-omics) hold the unprecedented potential to shed light on the intricate links between diet, the microbiome, the metabolome and cardiometabolic health, with a top-down approach. However, effective integration of complementary meta-omic techniques is an open challenge and their application on large cohorts is still limited. Here we review meta-omics techniques and discuss their potential in this context, highlighting recent large-scale efforts and the novel insights they provided. Finally, we look to the next decade of meta-omics research and discuss various translational and clinical pathways to improving cardiometabolic health.
MeSH term(s)	Humans ; Gastrointestinal Microbiome ; Metabolomics/methods ; Diet ; Metabolome ; Cardiovascular Diseases/metabolism
Language	English
Publishing date	2023-03-17
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1220066-9
ISSN	1546-170X ; 1078-8956
ISSN (online)	1546-170X
ISSN	1078-8956
DOI	10.1038/s41591-023-02260-4
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